Article
Biochemistry & Molecular Biology
Shu-Yu Wu, Yuan-Hong Jiang, Jia-Fong Jhang, Yung-Hsiang Hsu, Han-Chen Ho, Hann-Chorng Kuo
Summary: This study investigated the changes in bladder urothelium protein expression in patients with spinal cord injury and recurrent urinary tract infections. The results showed that patients with spinal cord injury experience chronic bladder inflammation, increased apoptosis, and reduced barrier function, contributing to recurrent urinary tract infections.
Article
Health Care Sciences & Services
Shu-Yu Wu, Hann-Chorng Kuo
Summary: This study aimed to investigate the treatment outcome and satisfaction with bladder outlet surgeries in patients with spinal cord injury and voiding dysfunction. The results showed that most patients were satisfied with the initial surgery, but repeat interventions may be necessary.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pediatrics
Youko Ikeda
Summary: Research on human and animal models shows that the effective storage and expulsion of urine rely on the coordinated activity of the parasympathetic, sympathetic, and somatic nervous systems. However, congenital neurological or anatomical defects can impact the development of urinary control, leading to various urinary tract-related complications.
PEDIATRIC NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Abolhasan Yousefpour, Abbas Erfanian
Summary: The study introduces a closed-loop control of intraspinal microstimulation (ISMS) for efficient bladder voiding, utilizing asynchronous two-electrode stimulation to activate bladder motoneurons and inhibit urethral sphincter motoneurons. This approach achieves high voiding efficiency and presents a promising method for restoring bladder functions with a natural and robust motor neuroprosthesis device.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Uwe Bieri, Benedikt Kranzbuehler, Burkhardt Seifert, Birgit Maria Helmchen, Alexander Gu, Basil Kaufmann, Dejan Lavrek, Thomas Scherer, Marian S. Wettstein, Cedric Poyet, Thomas Hermanns
Summary: Patients with non-muscle invasive urothelial bladder cancer are at increased risk for a secondary upper-urinary-tract urothelial carcinoma. Routine upper-tract imaging surveillance during bladder cancer follow-up may not be useful in detecting these secondary cancers. Risk-adjusted follow-up strategies should be explored in the future.
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Medicine, General & Internal
Ralf Boethig, Christian Tiburtius, Wolfgang Schoeps, Michael Zellner, Oliver Balzer, Birgitt Kowald, Sven Hirschfeld, Roland Thietje, Aki Pietsch, Ines Kurze, Martin Forchert, Thura Kadhum, Klaus Golka
Summary: The study found that bladder cancer in SCI patients differs significantly from that in able-bodied patients, with bladder cancer in SCI patients occurring at a younger age, having a shorter survival time, and often presenting with more aggressive types. Bladder cancer is typically diagnosed in SCI patients after 10 years or more of injury. A decision-making aid based on the findings can be a useful tool in clinical practice for assessing the correlation between SCI and bladder cancer.
MILITARY MEDICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Sheng-Fu Chen, Yu Khun Lee, Hann-Chorng Kuo
Summary: This study investigated long-term satisfaction and complications in chronic spinal cord injury patients after different bladder management strategies and surgical procedures for urinary incontinence treatment. Surgical procedures aimed at improving urinary continence in chronic SCI patients yielded higher overall satisfaction compared to conservative bladder management. Appropriate surgical procedures improved urinary continence and overall bladder and voiding condition in chronic SCI patients with neurogenic lower urinary tract dysfunction and urological complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yu-Hua Fan, Yuan-Chi Shen, Chih-Chen Hsu, Po-Ming Chow, Po-Chih Chang, Yu-Hua Lin, Shang-Jen Chang, Yuan-Hong Jiang, Chun-Hou Liao, Chung-Cheng Wang, Chun-Te Wu, Hann-Chorng Kuo
Summary: This study presents a comprehensive review of the efforts made by a workgroup in Taiwan to address urologic surgery for patients with chronic spinal cord injury and neurogenic lower urinary tract dysfunction (NLUTD). Surgical procedures, categorized based on purpose, include reducing bladder pressures, reducing urethra resistance, increasing urethra resistance, and urinary diversion. The choice of surgery depends on the type of NLUTD determined through urodynamic tests, as well as factors such as cognitive function, hand motility, comorbidities, surgical efficacy, and related complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nursing
Yielin Kim, Mi Hwa Cho, Kyungmin Do, Hye Jin Kang, Jin Ju Mok, Mi Kyoung Kim, Gwang Suk Kim
Summary: This study investigated the incidence of urinary tract infection and its risk factors among hospitalised patients with spinal cord injury. The results showed that sex, completeness of injury, type of bladder emptying, detrusor function and urethral pressure were significant factors affecting urinary tract infection. Patients who were male and those with injury classifications A, B and C had higher risk of urinary tract infection.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Neurosciences
Andrea M. Sartori, Anna-Sophie Hofer, Myriam Scheuber, Ruslan Rust, Thomas M. Kessler, Martin E. Schwab
Summary: Neurogenic lower urinary tract dysfunction commonly occurs after spinal cord injury, characterized by detrusor overactivity and detrusor-sphincter-dyssynergia. Changes in spinal cord anatomy, including increased C-fiber afferents and decreased CRF-positive and 5-HT-positive neuronal projections, contribute to the development of lower urinary tract symptoms.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Food Science & Technology
Po-Cheng Chen, Kau-Han Lee, Wei-Chia Lee, Ting-Chun Yeh, Yuh-Chen Kuo, Bing-Juin Chiang, Chun-Hou Liao, En Meng, Yao-Lin Kao, Yung-Chin Lee, Hann-Chorng Kuo
Summary: Lower urinary tract symptoms (LUTS) significantly impact the quality of life (QoL) of patients with spinal cord injury (SCI). Botulinum toxin A (BoNT-A) injection shows promising therapeutic effects for treating urinary incontinence or difficulty voiding in these patients, but it also has inevitable adverse effects. Therefore, it is crucial to evaluate the pros and cons of BoNT-A injection and provide an optimal management strategy for SCI patients.
Article
Engineering, Biomedical
Fei Hao, Fan Jia, Peng Hao, Hongmei Duan, Zijue Wang, Yubo Fan, Wen Zhao, Yudan Gao, Orion R. Fan, Fuqiang Xu, Zhaoyang Yang, Yi E. Sun, Xiaoguang Li
Summary: Activation of endogenous neurogenesis using bioactive materials can restore sensory/motor function in complete spinal cord injury patients through the formation of new neural circuits. The wiring logic of newborn neurons in the adult central nervous system remains unknown. This study demonstrated that neurotrophin3-loaded chitosan biomaterial effectively restored bladder function after spinal cord injury. The use of neuro-circuitry tracing technologies revealed that newborn neurons were integrated into micturition neural circuits and reconnected brain and spinal cord centers for voiding control, facilitating the restoration of lower urinary tract function.
Article
Gastroenterology & Hepatology
Bradley A. White, Brian J. Linder, Lawrence A. Szarka, David O. Prichard
Summary: Most young men with defecatory disorders (DDs) experience lower urinary tract symptoms (LUTS) which may respond to bowel-directed physical therapy. Patients with DD and urinary symptoms have increased odds of voiding dysfunction.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Adam W. Doelman, Femke Streijger, Steve J. A. Majerus, Margot S. Damaser, Brian K. Kwon
Summary: Neurogenic bladder dysfunction is a common condition after spinal cord injury, and animal models are crucial for studying its mechanisms and testing potential therapies. This review summarizes the use of animal models, particularly cystometry testing, in assessing SCI-related NLUTD. The advantages, disadvantages, and future research opportunities of different animal models are also discussed.