Article
Orthopedics
Fater A. Khadour, Younes A. Khadour, Ling Meng, Lixin Cui, Xu Tao
Summary: This hospital-based retrospective study described the epidemiological characteristics of traumatic spinal cord injury in Wuhan, China. Findings revealed a higher proportion of males, with falls and traffic accidents being the leading causes. Farmers and workers were the most vulnerable occupations, and attention should be paid to the fall risk among the elderly. The importance of SCI rehabilitation should be highlighted.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Rehabilitation
Daniela Mitiyo Odagiri Utiyama, Fabio Marcon Alfieri, Vinicius Delgado Ramos, Linamara Rizzo Battistella
Summary: This study surveyed individuals with spinal cord injury in south-eastern Brazil. The majority of participants were male and paraplegic, and spasticity and neuropathic pain were the most frequently reported health conditions. Despite reporting a good quality of life, they still encountered disabling environmental barriers and only a small proportion were able to return to work.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Review
Neurosciences
Jonathon Chon Teng Chio, Katherine Jiaxi Xu, Phillip Popovich, Samuel David, Michael G. Fehlings
Summary: Spinal cord injury has complex pathophysiology, with neuroinflammation playing a major role in secondary injury. The use of systemic immunosuppressants is the primary pharmacological treatment, but its impact is complex, prompting the need for a superior approach. Comprehensive understanding of neuroinflammation and systemic immune responses is crucial for improving treatment methods.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Cell Biology
Katherine Locke, Margo Randelman, Daniel Hoh, Lyandysha Zholudeva, Michael Lane
Summary: This review focuses on the study of respiratory plasticity in animal models, aiming to shed light on preclinical work that can influence future clinical investigations and treatments for spinal cord injury. Despite extensive research in animal models, relatively few treatments have made it through to clinical application.
NEURAL REGENERATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Soukaina Bahsoun, Jan-Herman Kuiper, Charlotte H. Hulme, Angus J. Armstrong Twigg, Wagih El Masri, Clive Glass, Bakul Soni, Naveen Kumar, Joy Roy Chowdhury, Aheed Osman, Karina T. Wright
Summary: A questionnaire was developed to assess patients' perspectives on research for improving functions and overcoming complications associated with spinal cord injury (SCI). Most participants were willing to be involved in research or clinical trials, but the likelihood of participation decreased when potential risks were explained. The willingness to participate in research studies could not be predicted based on severity of injury or other factors.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ciara M. Walsh, Khadija Gull, Dearbhaile Dooley
Summary: Traumatic spinal cord injury (SCI) has a significant impact on motor, sensory and autonomic function in patients. Despite the lack of a curative therapy, modulation of the inflammatory response through motor rehabilitation can improve recovery in SCI models. This review discusses the effect of motor rehabilitation on inflammatory mediators in both preclinical and human SCI studies and highlights the potential of using motor rehabilitation as an immunomodulatory therapy to improve patient outcome after SCI.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Cardiac & Cardiovascular Systems
Aletta E. Schutte, Tazeen H. Jafar, Neil R. Poulter, Albertino Damasceno, Nadia A. Khan, Peter M. Nilsson, Jafar Alsaid, Dinesh Neupane, Kazuomi Kario, Hind Beheiry, Sofie Brouwers, Dylan Burger, Fadi J. Charchar, Myeong Chan Cho, Tomasz J. Guzik, Ghazi F. Haji Al-Saedi, Muhammad Ishaq, Hiroshi Itoh, Erika S. W. Jones, Taskeen Khan, Yoshihiro Kokubo, Praew Kotruchin, Elizabeth Muxfeldt, Augustine Odili, Mansi Patil, Udaya Ralapanawa, Cesar A. Romero, Markus P. Schlaich, Abdulla Shehab, Ching Siew Mooi, U. Muscha Steckelings, George Stergiou, Rhian M. Touyz, Thomas Unger, Richard D. Wainford, Ji-Guang Wang, Bryan Williams, Brandi M. Wynne, Maciej Tomaszewski
Summary: Hypertension is the leading cause of preventable death globally, but there are significant challenges in its detection, treatment, and control, particularly in low-resource settings. Disparities based on resources, sociodemographic environment, and race contribute to the disproportionate burden of hypertension-related outcomes. Immediate action is needed to address these challenges and reduce inequities in hypertension care.
CARDIOVASCULAR RESEARCH
(2023)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Lucie Bourguignon, Bobo Tong, Fred Geisler, Martin Schubert, Frank Rohrich, Marion Saur, Norbert Weidner, Rudiger Rupp, Yorck-Bernhard B. Kalke, Rainer Abel, Doris Maier, Lukas Grassner, Harvinder S. Chhabra, Thomas Liebscher, Jacquelyn J. Cragg, John Kramer, Armin Curt, Catherine R. Jutzeler
Summary: Despite changes in the epidemiological characteristics of traumatic spinal cord injury, neurological and functional recovery has remained stable over the last two decades. This study provides an important resource for informing clinical practice and implementing new clinical trials.
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jie Qin, Jian Mo, Yi Chen, Jie Han, Xinjian Feng, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Linxuan Han, Rongyu Lan, Haixuan Deng, Huihui Yao, Zhongquan Qi, Hongjun Gao, Lishan Wei, Shuai Ren
Summary: This study tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal models and developed a new clinical procedure called vascular pedicle hemisected spinal cord transplantation (vSCT) for the treatment of paraplegic patients. The results demonstrated the feasibility and efficacy of vSCT in re-establishing the continuity of spinal nerve fibers, potentially restoring motor, sensory, and autonomic nervous functions in paraplegic patients. Further clinical trials are needed to validate these findings.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Health Care Sciences & Services
Allyson G. Hall, Aizhan Karabukayeva, Carmen Rainey, Reena J. Kelly, Jonathan Patterson, Jamie Wade, Sue S. Feldman
Summary: This study explored the experiences of individuals living with SCI and gathered perspectives from therapists working with SCI patients. The findings revealed that SCI patients face challenges in planning for future life, intrinsic motivation, environmental and financial barriers among others. There is a need for more information and tailored plans to help manage their health condition effectively.
DISABILITY AND HEALTH JOURNAL
(2021)
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Medicine, General & Internal
Pringgodigdo Nugroho, Hubert Andrew, Kelvin Kohar, Chairina Azkya Noor, Aida Lydia Sutranto
Summary: The burden of hypertension remains a significant problem worldwide, particularly in low- and middle-income countries. Clinical practice guidelines play a crucial role in managing hypertension, but simply adopting guidelines from high-income countries is not a solution for LMICs. This review compares the recommendations from the guidelines published by the World Health Organisation and the International Society of Hypertension and discusses the implications of the differences found between the two guidelines in both LMICs and high-income countries.
ANNALS OF MEDICINE
(2022)
Article
Clinical Neurology
Nicolaj J. Holm, Fin Biering-Sorensen, Lone H. Schou, Tom Moller
Summary: The study demonstrated high test-retest reliability of an individualized approach for peak oxygen uptake testing in a clinical setting, accommodating inpatients with heterogeneous levels of physical functioning. Individualized test modalities yielded optimal results for a diverse sample during rehabilitation.
Article
Clinical Neurology
Camilla M. Larsen, Birgit Juul-Kristensen, Helge Kasch, Jan Hartvigsen, Lars H. Frich, Eleanor Boyle, Lasse Ostengaard, Fin Biering-Sorensen
Summary: The study described the socio-demographics, injury characteristics, prevalence of shoulder and neck symptoms, participation in leisure time physical activity, and quality of life of individuals with spinal cord injury in Denmark. A high prevalence of self-reported shoulder and neck symptoms was found, which may limit physical function and social activities among individuals with spinal cord injury. Future studies using data from this cohort will investigate patterns and associations between shoulder/neck symptoms, use of assistive mobility devices, LTPA and QoL.
Article
Clinical Neurology
Lene Weber, Nanna Hoffgaard Voldsgaard, Nicolaj Jersild Holm, Lone Helle Schou, Fin Biering-Sorensen, Tom Moller
Summary: Transitioning from the SCI unit to the home environment involves a multidimensional change of context in which most participants' previous life roles have changed. This has a decisive influence on balancing loss and acceptance, facing external structural barriers, and the strength of social relationships when applying knowledge and skills acquired at the unit in a meaningful everyday life.
Article
Clinical Neurology
Huayi Xing, Nan Liu, Andrei V. Krassioukov, Fin Biering-Sorensen
Summary: The study investigated medical students' baseline knowledge of autonomic functions and the ISAFSCI, finding that self-study using the ISAFSCI booklet alone was not sufficient to obtain baseline knowledge. Formal lecture or presentation is recommended to improve the effectiveness of learning the ISAFSCI for medical students.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Clinical Neurology
Rudiger Rupp, Christian Schuld, Fin Biering-Sorensen, Kristen Walden, Gianna Rodriguez, Steven Kirshblum
Summary: The study design committee reached a consensus on a taxonomy for standardized documentation of non-SCI-related conditions in ISNCSCI, with the aim of increasing classification accuracy. The new taxonomy includes guidelines on how to handle sensory and motor scores impacted by non-SCI conditions, improving consistency in scoring and classification.
Article
Clinical Neurology
Vesna Miloshevska Jakimovska, Fin Biering-Sorensen, Ingeborg Beate Lidal, Emil Kostovski
Summary: This study is the first to describe community-dwelling individuals with tSCI in North Macedonia. The study found that individuals with tSCI mostly reported health issues related to pain, spasms, urinary tract infections, and pressure injuries. They lacked follow-ups, faced physical barriers and poor social inclusion, lacked financial support, and were often socially isolated and fully dependent on their families.
Article
Clinical Neurology
Pernille Langer Soendergaard, Anne Norup, Marie Kruse, Fin Biering-Sorensen
Summary: This study investigates the socioeconomic consequences of spinal cord injuries (SCI) on patients and their relatives, finding that survivors experience significantly increased healthcare costs, higher risk of job loss, and increased risk of divorce.
Article
Clinical Neurology
Nicolaj J. Holm, Randi Steensgaard, Lone H. Schou, Tom Moller, Helge Kasch, Fin Biering-Sorensen
Summary: The study found that overall BMI remained stable but higher than recommended in people with SCI undergoing rehabilitation at two national centers in Denmark. Participants with AIS D SCI had significantly higher BMI during rehabilitation compared to other groups, and their BMI increased from discharge to follow-up.
Article
Clinical Neurology
Fin Biering-Sorensen, Susan Charlifue, Yuying Chen, Peter W. New, Vanessa Noonan, Marcel W. M. Post, Rudiger Rupp, Lawrence Vogel
Summary: This study aimed to update the International Spinal Cord Injury (SCI) Core Data Set while maintaining standardized data reporting. Through expert opinion, feedback, and revisions, a final consensus was reached. The latest version of the data set consists of 21 variables, which can be used to uniformly describe SCI populations worldwide and facilitate result comparison.
Article
Clinical Neurology
Annette Halvorsen, Aslak Steinsbekk, Annelie Schedin Leiulfsrud, Marcel W. M. Post, Fin Biering-Sorensen, Kristine Pape
Summary: This study investigated the impact of spinal cord injury on labour market participation using data from the Norwegian SCI registry. The results showed that individuals with SCI had significantly lower rates of employment compared to the control group up to six years after injury.
Article
Public, Environmental & Occupational Health
Andreas D. Haas, Raphael Lienhard, Christiane Didden, Morna Cornell, Naomi Folb, Tebatso M. G. Boshomane, Luisa Salazar-Vizcaya, Yann Ruffieux, Patience Nyakato, Anja E. Wettstein, Mpho Tlali, Mary-Ann Davies, Per von Groote, Milton Wainberg, Matthias Egger, Gary Maartens, John A. Joska
Summary: We conducted a study in a South African private-sector HIV program to assess adherence and viral suppression rates among adolescents and adults living with HIV. Participants with mental health diagnoses had poorer adherence patterns and a higher risk of viral non-suppression. Males, adolescents, and young adults also had an increased risk of viral non-suppression. Our findings emphasize the need for psychosocial interventions and improved mental health services in HIV treatment programs.
Article
Clinical Neurology
Yuying Chen, Susan Charlifue, Vanessa K. Noonan, Peter W. New, Gopalkrishna Gururaj, Shinsuke Katoh, Hakon Leiulfsrud, Marcel W. Post, Fin Biering-Sorensen
Summary: A consensus-based study design was used to create an International SCI Socio-Demographic Basic Data Set. This data set includes variables such as date of data collection, marital status, household member count, years of formal education, and primary occupation. The data set will facilitate uniform data collection and reporting to enable evaluation and comparison across studies.
Review
Dermatology
Knaerke Soegaard, Martin Sollie, Dimitri Beeckman, Fin Biering-Sorensen, Jens Ahm-Sorensen
Summary: This scoping review aimed to provide an overview of initiatives, organisational components, and stakeholders' perspectives on pressure ulcer (PU) prevention in transitional care. Fifteen studies of various types were included, indicating that continuous tailored education and information, as well as follow-up services, are crucial for preventing PUs and rehabilitating patients with spinal cord injuries (SCI). However, there is a discrepancy between international recommendations, perceived needs, and the delivery of healthcare services, resulting in lower quality of life and higher risk of PUs for individuals with SCI.
JOURNAL OF TISSUE VIABILITY
(2023)
Article
Clinical Neurology
Eva Widerstrom-Noga, Fin Biering-Sorensen, Thomas N. Bryce, Diana D. Cardenas, Nanna B. Finnerup, Mark P. Jensen, J. Scott Richards, Jan Rosner, Julian Taylor
Summary: To update the International Spinal Cord Injury Pain Basic Data Set (ISCIPBDS version 2.0) and incorporate suggestions from the SCI pain clinical and research community, the study group revised the ISCIPBDS (Version 3.0) through expert opinion, feedback, revisions, and final consensus, making the dataset more flexible and useful.
Article
Rehabilitation
Mia Moth Wolffbrandt, Pernille Langer Soendergaard, Fin Biering-Sorensen, Linda Sundekilde, Amanda Kjeldgaard, Trine Schow, Juan Carlos Arango-Lasprilla, Anne Norup
Summary: This study aimed to explore the experiences of families participating in a family intervention targeting the consequences of acquired brain injury (ABI) or spinal cord injury (SCI). The intervention helped families strengthen communication and emotional control, acknowledge the changed life situation, and see each other as whole persons. It emphasized the importance of a family-centered approach in neurorehabilitation and the role of healthcare professionals in facilitating family cohesion.
DISABILITY AND REHABILITATION
(2023)
