Article
Pharmacology & Pharmacy
Xuyang Hu, Jinxin Huang, Yiteng Li, Lei Dong, Yihao Chen, Fangru Ouyang, Jianjian Li, Ziyu Li, Juehua Jing, Li Cheng
Summary: This study demonstrated that TAZ is significantly upregulated and mainly expressed in microglia after spinal cord injury (SCI). It accumulates in the nuclei of microglia and promotes their migration, leading to the formation of microglial scars and functional recovery.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Raban Arved Heller, Julian Seelig, Helena Lucia Crowell, Maximilian Pilz, Patrick Haubruck, Qian Sun, Lutz Schomburg, Volker Daniel, Arash Moghaddam, Bahram Biglari
Summary: This study aimed to evaluate the correlation between remission after traumatic spinal cord injury and the dynamics of monocyte subsets, lymphocytes' responsive potential, cytokine expression, patterns of trace element concentration, and clinical covariates. Clinical research findings suggest that early dynamics in monocyte subsets can predict recovery from traumatic spinal cord injury.
Article
Medicine, General & Internal
Xiangcheng Gao, Yining Gong, Bo Zhang, Dingjun Hao, Baorong He, Liang Yan
Summary: This study analyzed the factors affecting the instant recovery of neurological function in patients with motor complete traumatic spinal cord injury (TSCI) treated in hospital. The results showed that the ASIA score on admission, fracture or dislocation, treatment protocol, and inpatient rehabilitation were independently associated with the recovery of neurological function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mohammad-Masoud Zavvarian, James Hong, Mohamad Khazaei, Jonathon Chon Teng Chio, Jian Wang, Anna Badner, Michael G. Fehlings
Summary: This study demonstrated that intraperitoneal injection of midostaurin in injured rats led to alterations in local inflammasome and gene expression, resulting in enhanced recovery and improved coordination between forelimbs and hindlimbs after injury. Histological analysis also indicated improved tissue preservation and functionality in treated animals during the chronic phase of injury. Overall, systemic administration of midostaurin proved to be an effective strategy for mitigating cervical secondary SCI damage.
Review
Clinical Neurology
Ya-yun Zhang, Min Yao, Ke Zhu, Rui-rui Xue, Jin-hai Xu, Xue-jun Cui, Wen Mo
Summary: This systematic review indicates that EPO can promote the recovery of locomotor function in rats with SCI and has antioxidant effects. Mechanism exploration of EPO needs to be verified through experiments, and carefully designed randomized controlled trials are needed to further explore its neural recovery effects.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Laurel Rauschenbach, Alejandro N. Santos, Adrian Engel, Angelina Olbrich, Arnau Benet, Yen Li, Boerge Schmidt, Oliver Gembruch, Neriman Oezkan, Ramazan Jabbarli, Karsten H. Wrede, Adrian Siegel, Michael T. Lawton, Ulrich Sure, Philipp Dammann
Summary: This observational study found that patient selection and timing of surgery for spinal cavernous malformations (SCM) have not been clearly defined. Performing surgery within 3 months after intramedullary hemorrhage (IMH) can lead to better clinical outcomes, and lesions located ventrally may increase the risk of postoperative deficits.
EUROPEAN SPINE JOURNAL
(2023)
Article
Cell Biology
Yi-Xin Chen, Talifu Zuliyaer, Bin Liu, Shuang Guo, De-Gang Yang, Feng Gao, Yan Yu, Ming-Liang Yang, Liang-Jie Du, Jian-Jun Li
Summary: This study found that sodium selenite can improve locomotive function in rats with spinal cord injury by inhibiting ferroptosis through the specificity protein 1/glutathione peroxidase 4 pathway.
NEURAL REGENERATION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yihui Bi, Wenxiu Duan, Jing Chen, Tao You, Shuya Li, Wei Jiang, Min Li, Gang Wang, Xueyin Pan, Jiang Wu, Dan Liu, Jun Li, Yucai Wang
Summary: Post spinal cord injury, using neutrophil membrane-coated nanoparticles as decoys can reduce local neutrophil infiltration and alleviate oxidative stress, leading to improved neural regeneration and functional recovery in injured spinal cords.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Taoyang Yuan, Yu Shao, Xu Zhou, Qian Liu, Zhichao Zhu, Bini Zhou, Yuanchen Dong, Nicholas Stephanopoulos, Songbai Gui, Hao Yan, Dongsheng Liu
Summary: Researchers have developed a DNA hydrogel to repair spinal cord gap in rats, promoting proliferation and differentiation of stem cells for functional recovery. This hydrogel system shows great potential in clinical trials and could be adaptable to other tissue regeneration applications.
ADVANCED MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Soshi Samejima, Richard Henderson, Jared Pradarelli, Sarah E. Mondello, Chet T. Moritz
Summary: Spinal cord injuries often result in permanent physical impairments despite being incomplete disruptions. However, remaining connections between the brain and spinal cord can induce neural plasticity to improve sensorimotor function, even years post-injury. This review provides an overview of evidence for motor recovery, plasticity, and interventions in spinal cord stimulation for motor control restoration. It discusses both open-loop and closed-loop stimulation approaches, as well as mechanisms of spinal cord neuromodulation for sensorimotor recovery, aiming to advance rehabilitation for spinal cord injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Yanpeng Sun, Yingjie Zhou, Xiangqin Shi, Xiaoran Ma, Xiaodong Peng, Yan Xie, Xiangyang Cao
Summary: The research revealed that circular RNA circTYW1 plays a crucial role in neurological recovery following spinal cord injury, by regulating the miR-380/FGF9/ERK1/2 axis to impact the recovery process.
Article
Biotechnology & Applied Microbiology
Sisi Mi, Xue Wang, Jiaxin Gao, Yu Liu, Zhongquan Qi
Summary: After spinal cord injury (SCI), the microenvironment inhibits neural regeneration due to the abundance of inhibitory factors and lack of factors promoting nerve regeneration. This study developed a bioactive material, hp-SHED sheet, to mimic the natural spinal cord structure and enhance nerve cell attachment and migration. Implantation of hp-SHED sheet in SCI rats promoted nerve regeneration, axonal remyelination, and inhibited glial scarring, leading to the restoration of sensory and motor functions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jian Kang, Yan Guo
Summary: This study explored the therapeutic effect of exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC) on spinal cord injury. The results demonstrated that exosome treatment could improve motor function through anti-apoptosis and anti-inflammatory effects, with the involvement of BCL2/Bax and Wnt/β-catenin signaling pathways.
NEUROCHEMICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Gaetan Poulen, Emilie Aloy, Claire M. Bringuier, Nadine Mestre-Frances, Emaelle V. F. Artus, Maida Cardoso, Jean-Christophe Perez, Christophe Goze-Bac, Hassan Boukhaddaoui, Nicolas Lonjon, Yannick N. Gerber, Florence E. Perrin
Summary: By using the CSF1R inhibitor GW2580, transient reduction of microglia proliferation can improve motor function recovery in SCI patients. The treatment also helps reduce neuroinflammation and enhance tissue protection.