Article
Agriculture, Multidisciplinary
Yanping Wu, Niu Zhang, Ze-Yuan Deng, Hong Zhang, Jing Li
Summary: The study investigated the effects of structured triacylglycerols and their mixtures on lipid metabolism in LO2 cells, finding that OPL and M3 groups led to higher lipid accumulation compared to other groups. The expression levels of crucial proteins involved in lipid metabolism were also affected by the different triacylglycerols and mixtures, suggesting potential impacts on infant growth and development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Gabriel G. Dorighello, Leandro H. P. Assis, Thiago Rentz, Joseane Morari, Monique F. M. Santana, Marisa Passarelli, Neale D. Ridgway, Anibal E. Vercesi, Helena C. F. Oliveira
Summary: The expression of CETP in macrophages modulates mitochondrial structure and function, promotes an intracellular antioxidant state and oxidative metabolism, and reduces the expression of inflammatory genes and cholesterol accumulation.
Article
Cardiac & Cardiovascular Systems
Nick S. Nurmohamed, Ann Marie Navar, John J. P. Kastelein
Summary: Novel therapies targeting LDL-C, including inclisiran, bempedoic acid, ANGPTL3 inhibitors, and CETP inhibitors, provide important tools for the prevention of cardiovascular disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Food Science & Technology
Azam Ahmadi Vasmehjani, Seyed Mostafa Seyed Hosseini, Sayyed Saeid Khayyatzadeh, Farzan Madadizadeh, Mahta Mazaheri-Naeini, Mahdie Yavari, Zahra Darabi, Sara Beigrezaei, Marzieh Taftian, Vahid Arabi, Maryam Motallaei, Amin Salehi-Abargouei, Azadeh Nadjarzadeh
Summary: The association between CETP Taq1B polymorphism and metabolic traits is still debated. This study aimed to investigate the interaction between adherence to dietary indices and this polymorphism on the severity of coronary artery stenosis and serum lipid parameters. The results showed no significant interaction between the Taq1B variant and high adherence to dietary indices on lipid levels and coronary artery stenosis scores.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Zhiyun Hao, Yuzhu Luo, Jiqing Wang, Jon G. H. Hickford, Huitong Zhou, Jiang Hu, Xiu Liu, Shaobin Li, Jiyuan Shen, Na Ke, Weiwei Liang, Zhaochun Huang
Summary: The study demonstrated that miR-432 inhibits the proliferation of OMECs by targeting the genes SCD and LPL involved in milk fat synthesis. Transfection with miR-432 mimic reduced the expression of milk fat synthesis marker genes and triglyceride content in OMECs, while miR-432 inhibitor had the opposite effect. This study provides insights into the biological mechanisms of miR-432 in inhibiting milk fat synthesis in sheep.
Article
Environmental Sciences
Milena Andelkovic, Aleksandra Buha Djordjevic, Dragana Javorac, Katarina Baralic, Danijela Dukic-Cosic, Aleksandra Repic, Aleksandra Zeljkovic, Jelena Vekic, Natasa Colakovic, Zorica Bulat
Summary: This study found higher lead levels in the healthy tissues of breast cancer patients compared to cancerous tissues. Blood lead levels in breast cancer women did not differ significantly from the control group. Additionally, there were significantly higher triglyceride levels in the lipid profile of breast cancer patients, and triglycerides were identified as a significant predictor of breast cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Genetics & Heredity
Carine Ayoub, Yara Azar, Dina Maddah, Youmna Ghaleb, Sandy Elbitar, Yara Abou-Khalil, Selim Jambart, Mathilde Varret, Catherine Boileau, Petra El Khoury, Marianne Abifadel
Summary: Familial chylomicronemia syndrome is a rare genetic disorder characterized by abnormal lipoprotein metabolism and high triglyceride levels. A study on a Syrian family revealed different expression patterns of the LPL gene mutation causing the disease, emphasizing the importance of early diagnosis and management to prevent serious complications.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zijuan Wu, Danling Gu, Ruixin Wang, Xiaoling Zuo, Huayuan Zhu, Luqiao Wang, Xueying Lu, Yi Xia, Shuchao Qin, Wei Zhang, Wei Xu, Lei Fan, Jianyong Li, Hui Jin
Summary: This study elucidates the expression and metabolic patterns of circular RNAs (circRNAs) in chronic lymphocytic leukemia (CLL) for the first time. It reveals that circRIC8B regulates lipid metabolism abnormalities and the development of CLL through the miR-199b-5p/LPL axis. CircRIC8B may serve as a promising prognostic marker and therapeutic target, enhancing sensitivity to ezetimibe in CLL.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Egidio Imbalzano, Federica Ilardi, Luana Orlando, Basilio Pintaudi, Gianluigi Savarese, Giuseppe Rosano
Summary: This study found that the use of PCSK9 inhibitors (alirocumab and evolocumab) can significantly reduce the risk of major cardiovascular events in patients with diabetes, and improve lipid profiles. It was also observed that the use of PCSK9 inhibitors is associated with a reduction in LDL cholesterol, HDL cholesterol, triglycerides, non-HDL cholesterol, total cholesterol, lipoprotein(a), and apolipoprotein B levels.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yizhen Zhao, Dongxiao Hao, Yifan Zhao, Shengli Zhang, Lei Zhang, Zhiwei Yang
Summary: This study compared the structural characteristics of authentic CETP and mutant CETP through molecular dynamics simulations, revealing that authentic CETP exhibits greater flexibility and curvature in lipid transport. A ligand identified through virtual screening and simulations was found to bind to the N- and C-termini of CETP, inducing structural changes unfavorable to lipid transport. This study sheds new light on the relationship between the structural and functional mechanisms of CETP and provides novel ideas for precise regulation of CETP functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Christie M. Ballantyne, Puja Banka, Gustavo Mendez, Raymundo Garcia, Julio Rosenstock, Anthony Rodgers, Geraldine Mendizabal, Yale Mitchel, Alberico L. Catapano
Summary: MK-0616, an oral PCSK9 inhibitor, effectively reduces LDL-C levels and is well tolerated in the treatment of hypercholesterolemia according to a Phase 2b clinical trial.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xi Zhang, Heng Xu, Jizhang Yu, Jikai Cui, Zhang Chen, Yuan Li, Yuqing Niu, Song Wang, Shuan Ran, Yanqiang Zou, Jie Wu, Jiahong Xia
Summary: This study reveals that PCSK9 is elevated during heart transplant rejection in both murine and human recipients. PCSK9 ablation prolongs graft survival and mitigates inflammatory cell infiltration and alloreactive T cell expansion. PCSK9 is primarily produced and upregulated in the recipient liver, leading to signaling changes and modulation of macrophage phenotype and function via the PCSK9/CD36 pathway.
Review
Cardiac & Cardiovascular Systems
Nick S. Nurmohamed, Marc Ditmarsch, John J. P. Kastelein
Summary: Cholesteryl ester transfer protein (CETP) is a liver-synthesized glycoprotein that facilitates the transfer of cholesterol esters and triglycerides between different lipoprotein particles. Recent studies have shown that the benefit of CETP inhibitors in atherosclerotic cardiovascular disease (ASCVD) is primarily due to the reduction of LDL-C and apoB, rather than an increase in HDL-C. Genetic evidence supports the use of CETP inhibitors, as they achieve similar reductions in ASCVD risk as other lipid-lowering medications. The newest generation of CETP inhibitors not only lower LDL-C, but also reduce the risk of new-onset diabetes and improve glucose tolerance and insulin sensitivity.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Valentin Blanchard, Kevin Chemello, Tim Hollstein, Clement Chong-Hong-Fong, Friederike Schumann, Thomas Grenkowitz, Brice Nativel, Stefan Coassin, Mikael Croyal, Ursula Kassner, Claudia Lamina, Elisabeth Steinhagen-Thiessen, Gilles Lambert
Summary: The size of apo(a) is an independent determinant of the response to PCSK9i, and each additional kringle domain is associated with a 3% additional reduction in Lp(a). This partly explains the variable efficacy of PCSK9i and allows for the identification of patients who will benefit most from these therapies in terms of Lp(a) lowering.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medicine, Research & Experimental
Francesca Innocenti, Anna Maria Gori, Betti Giusti, Camilla Tozzi, Chiara Donnini, Federico Meo, Irene Giacomelli, Maria Luisa Ralli, Alice Sereni, Elena Sticchi, Irene Tassinari, Rossella Marcucci, Riccardo Pini
Summary: The study evaluates the prognostic value of early PCSK9 levels in non-intubated septic patients in the emergency department. The results suggest a relationship between PCSK9 levels measured at different time points and mortality rates, with patients in intermediate levels showing better prognosis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Sport Sciences
Masouda Rahim, Miguel Lacerda, Malcolm Collins, Michael Posthumus, Alison V. September
Summary: This study aimed to explore the interactions between interleukins and the angiogenesis signalling pathway, identifying VEGFA, age, and BMI as the most significant predictors of ACL rupture risk.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Endocrinology & Metabolism
Julia H. Goedecke, Kim A. Nguyen, Clement Kufe, Maphoko Masemola, Tinashe Chikowore, Amy E. Mendham, Shane A. Norris, Nigel J. Crowther, Fredrik Karpe, Tommy Olsson, Andre Pascal Kengne, Lisa K. Micklesfield
Summary: This study demonstrates for the first time that the IDF Europid WC thresholds are not appropriate for an African population, and African-specific WC thresholds perform better than the IDF Europid thresholds to predict incident dysglycaemia and T2D.
DIABETES OBESITY & METABOLISM
(2022)
Article
Sport Sciences
Javier Alvarez-Romero, Mary-Jessica N. Laguette, Kirsten Seale, Macsue Jacques, Sarah Voisin, Danielle Hiam, Julian A. Feller, Oren Tirosh, Eri Miyamoto-Mikami, Hiroshi Kumagai, Naoki Kikuchi, Nobuhiro Kamiya, Noriyuki Fuku, Malcolm Collins, Alison September, Nir Eynon
Summary: This study aims to investigate the association between the COL5A1 gene and anterior cruciate ligament (ACL) injury risk. The results suggest that a specific locus of the COL5A1 gene may be associated with ACL injury risk. However, further studies with larger cohorts are needed to validate these findings and explore the functional relevance to ligament and joint biomechanics.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Orthopedics
Daneil C. Feldmann, Masouda Rahim, Mathijs A. M. Suijkerbuijk, Mary-Jessica N. Laguette, Pawel Cieszczyk, Krzysztof Ficek, Kinga Huminska-Lisowska, Charlotte K. Hager, Evalena Stattin, Kjell G. Nilsson, Javier Alvarez-Rumero, Nir Eynon, Julian Feller, Oren Tirosh, Michael Posthumus, Emile R. Chimusa, Malcolm Collins, Alison September
Summary: Polymorphisms in VEGFA and KDR have been linked to ACL injury risk. Specific genotypes in the VEGFA gene were significantly associated with increased ACL risk, while certain haplotypes were linked to reduced risk, supporting the role of genetic factors in ACL susceptibility.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Mark R. Antrobus, Jon Brazier, Peter Callus, Adam J. Herbert, Georgina K. Stebbings, Stephen H. Day, Liam P. Kilduff, Mark A. Bennett, Robert M. Erskine, Stuart M. Raleigh, Malcolm Collins, Yannis P. Pitsiladis, Shane M. Heffernan, Alun G. Williams
Summary: This study investigated the association between elite rugby athlete status and concussion-associated risk polymorphisms. The findings showed that there were differences in the COMT rs4680 genotype, which could potentially affect stress resilience, behavioral traits, concussion risk, and recovery in elite rugby athletes. Evaluating the COMT rs4680 genotype may be beneficial for individualized management of concussion risk among athletes.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
Article
Endocrinology & Metabolism
Clement N. Kufe, Lisa K. Micklesfield, Maphoko Masemola, Tinashe Chikowore, Andre P. Kengne, Fredrik Karpe, Shane A. Norris, Nigel J. Crowther, Tommy Olsson, Julia H. Goedecke
Summary: Despite higher rates of overweight/obesity in Black South African women, the prevalence of type 2 diabetes does not differ between genders. This study found that men had lower insulin sensitivity and beta-cell function compared to women, and the association between adiposity and diabetes risk was stronger in men. These findings suggest that Black African men are at greater risk for type 2 diabetes with increasing adiposity.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Sport Sciences
Jon Brazier, Mark R. Antrobus, Adam J. Herbert, Peter C. Callus, Georgina K. Stebbings, Stephen H. Day, Shane M. Heffernan, Liam P. Kilduff, Mark A. Bennett, Robert M. Erskine, Stuart M. Raleigh, Malcolm Collins, Yannis P. Pitsiladis, Alun G. Williams
Summary: There is growing evidence that genetics play a role in tendon and ligament pathologies. This study found that 13 gene polymorphisms associated with tendon/ligament injury were also associated with elite rugby athlete status. Elite rugby athletes may have an inherited advantage that contributes to their resistance to soft tissue injury.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Genetics & Heredity
Mark R. Antrobus, Jon Brazier, Peter C. Callus, Adam J. Herbert, Georgina K. Stebbings, Praval Khanal, Stephen H. Day, Liam P. Kilduff, Mark A. Bennett, Robert M. Erskine, Stuart M. Raleigh, Malcolm Collins, Yannis P. Pitsiladis, Shane M. Heffernan, Alun G. Williams
Summary: This study investigated whether there are differences in concussion-associated polygenic profiles between elite rugby athletes and non-athletes, as well as between rugby union forwards and backs. The results suggest that elite rugby athletes do not have a more "preferable" concussion-associated polygenic profile than non-athletes, but there may be a genetic interaction between COMT (rs4680) and MAPT (rs10445337) that assists rugby athletes in achieving elite status.
Review
Biology
William J. Ribbans, Alison September, Malcolm Collins
Summary: Genetic variations play a role in tendon and ligament injury risk, affecting their structure, function, load-bearing ability, and repair or regeneration. However, our current understanding of these genetic factors is still incomplete, requiring further research to address current knowledge challenges and assess their clinical utility.
Article
Multidisciplinary Sciences
Siphiwe N. Dlamini, Shane A. Norris, Amy E. Mendham, Asanda Mtintsilana, Kate A. Ward, Tommy Olsson, Julia H. Goedecke, Lisa K. Micklesfield
Summary: Although appendicular skeletal muscle mass (ASM) and handgrip strength (HGS) are key components of sarcopenia, their underlying biological mechanisms remain poorly understood. This study aimed to investigate associations of circulating biomarkers with ASM and HGS in middle-aged black South Africans. The results showed that most biomarkers were associated with ASM and not HGS, and the associations of biomarkers with ASM and HGS displayed sex-specificity in middle-aged black South Africans. It is suggested that future research should consider sexual dimorphism in the pathophysiology of sarcopenia for the development of sex-specific treatment and diagnostic methods.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Amy E. Mendham, Lisa K. Micklesfield, Fredrik Karpe, Andre Pascal Kengne, Tinashe Chikowore, Clement N. Kufe, Maphoko Masemola, Nigel J. Crowther, Shane A. Norris, Tommy Olsson, Solve Elmstahl, Tove Fall, Lars Lind, Julia H. Goedecke
Summary: Using a targeted proteomics approach, this study aimed to identify and validate circulating proteins associated with impaired glucose metabolism and type 2 diabetes in a Black South African cohort. The results identified 34 proteins associated with type 2 diabetes, of which 11 were associated with measures of type 2 diabetes pathophysiology. This study highlights the similarity of biomarkers between different populations and emphasizes the need for validation in African cohorts.
Article
Sport Sciences
Senanile B. Dlamini, Colleen J. Saunders, Mary-Jessica N. Laguette, Andrea Gibbon, Junaid Gamieldien, Malcolm Collins, Alison V. September
Summary: We developed a Biomedical Knowledge Graph model that integrates knowledge from multiple domains in a graph database to identify potential new risk genes for anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy (AT). Through a case-control study, we found that the ITGB2 gene is associated with ACL rupture risk. This study highlights the efficiency of using prior knowledge-driven in silico approach and recommends a multistep approach for genomics technologies in musculoskeletal soft tissue injuries.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Lindokuhle P. P. Phiri, Lisa K. K. Micklesfield, Amy E. E. Mendham, Julia H. H. Goedecke, Anniza de Villiers
Summary: Black South African women have a higher acceptance of larger body sizes but still show interest in community-based exercise programs. Economic factors play an important role in participation, while improving mental well-being can increase their attraction and retention in exercise programs.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2022)
Correction
Public, Environmental & Occupational Health
A. E. Mendham, J. H. Goedecke, N. C. Kufe, M. Soboyisi, A. Smith, K. Westgate, S. Brage, L. K. Micklesfield
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2022)
Article
Sport Sciences
Lisa K. Micklesfield, Kate Westgate, Antonia Smith, Clement N. Kufe, A. M. Y. E. Mendham, T. I. M. Lindsay, Katrien Wijndaele, Julia H. Goedecke, Soren Brage
Summary: This study described the physical activity behaviors of middle-age South African men and women and developed a method of combining hip and thigh accelerometery signals to quantify and describe these behaviors. The study found that men spent more time in moderate- to vigorous-intensity physical activity and sitting/lying, while women spent more time standing. Age, weight, and socioeconomic status were associated with physical activity behaviors.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
