Article
Pharmacology & Pharmacy
Elien B. Uitvlugt, Marjo J. A. Janssen, Carl E. H. Siegert, Eva L. Kneepkens, Bart J. F. van den Bemt, Patricia M. L. A. van den Bemt, Fatma Karapinar-Carkit
Summary: This observational study assessed medication-related readmissions within 30 days post-discharge, finding 16% of readmissions were medication-related with 40% potentially preventable. Factors like medication changes at discharge and history of multiple hospitalizations were associated with preventable medication-related readmissions. Prescribing errors, non-adherence, and transition errors were the main contributors to preventable readmissions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Manea Musa Alahmari, Hassan M. AlShaiban, Syed E. Mahmood
Summary: This study aimed to estimate the prevalence and associated factors of periodontitis among type I and type II diabetes mellitus (DM) patients in Abha, Saudi Arabia. The prevalence of periodontitis was found to be 7.4% among type I DM patients and 46.4% among type II DM patients. Age and smoking were identified as potential associated factors for the prevalence of periodontitis in both types of DM patients.
Article
Biochemistry & Molecular Biology
Andreea Gherasim, Andrei C. Oprescu, Ana Maria Gal, Alexandra Maria Burlui, Laura Mihalache
Summary: Modern lifestyles have resulted in sedentary behavior, unhealthy diets, and increased stress, which have led to lower physical activity levels and negatively affected metabolic parameters in patients with type 2 diabetes. This study identified three dietary patterns and two lifestyle patterns, with the inadequate lifestyle pattern being associated with younger age, hypertension, and diabetic neuropathy, while the traditional lifestyle pattern was related to better postprandial blood glucose control. Sedentary individuals were more likely to be older and have higher glycated hemoglobin levels, while smokers were more likely to have poor glycemic and lipid profiles.
Article
Dermatology
Lawrence Sena Tuglo
Summary: The prevalence and determinants of lower extremity amputations among diabetic patients in the Volta Region, Ghana were investigated in this study. The prevalence rate of lower extremity amputations was 1.9%. Male gender, smoking, type I diabetes, family history of diabetes mellitus, diabetic foot ulcers, and obesity were found to be associated with lower extremity amputations.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cell & Tissue Engineering
Mahmoud Izadi, Anavasadat Sadr Hashemi Nejad, Maedeh Moazenchi, Safdar Masoumi, Ali Rabbani, Farzad Kompani, Amir Abbas Hedayati Asl, Fatemeh Abbasi Kakroodi, Neda Jaroughi, Mohammad Ali Mohseni Meybodi, Aria Setoodeh, Farzaneh Abbasi, Seyedeh Esmat Hosseini, Fatemeh Moeini Nia, Reza Salman Yazdi, Roghayeh Navabi, Ensiyeh Hajizadeh-Saffar, Hossein Baharvand
Summary: This study evaluated the safety and efficacy of autologous bone marrow-derived mesenchymal stem cells (MSCs) transplantation via intravenous injection in newly diagnosed type-1 diabetes (T1D) patients. The results showed that MSCs transplantation is safe, reduces hypoglycemic episodes, improves glycemic control and immune function, and enhances quality of life in T1D patients.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Ling-Jan Chiou, Hui-Chu Lang
Summary: This study aimed to explore the probabilities and predictors of potentially preventable hospital readmission after a patient's first stroke. The results showed that factors such as older age, stroke type, shorter length of hospital stay, higher comorbidity index and stroke severity index, hospital type, and lower urbanization level were significantly associated with 30-day readmission. Factors such as male gender, hospitalization year, and monthly income were significantly associated with 1-year readmission. Furthermore, the implementation of post-acute care programs and the long-term care plan-LTC 2.0 were found to be effective in reducing long-term readmission.
SCIENTIFIC REPORTS
(2022)
Review
Biology
Bandar Ali Al-Ghamdi, Jawhra M. Al-Shamrani, Ahmed M. El-Shehawi, Intisar Al-Johani, Bandar G. Al-Otaibi
Summary: Morbidity and mortality from diabetes mellitus and associated illnesses is a major global problem. Mitochondrial dysfunction has been linked to diabetes, specifically mitochondrial diabetes types like MIDD and DAD. Mutations in mitochondrial DNA (mtDNA), responsible for hereditary mitochondrial diseases, play a role in tissue-specific and harmful phenotypes. This study lists mtDNA mutations linked with diseases and explores their contribution to disease pathology.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ernestini Tyfoxylou, Nick Voulgaris, Chris Gravvanis, Sophia Vlachou, Athina Markou, Labrini Papanastasiou, Nikolaos Tentolouris, Eva Kassi, Gregory Kaltsas, George P. Chrousos, George P. Piaditis
Summary: This study aimed to investigate the prevalence of PA and exaggerated aldosterone response to stress in patients with DM-2, and found that a significant proportion of DM-2 patients had PA or an exaggerated aldosterone response to stress. Treatment with MRAs effectively reduced blood pressure.
Article
Computer Science, Artificial Intelligence
Sara Rabhi, Frederic Blanchard, Alpha Mamadou Diallo, Djamal Zeghlache, Celine Lukas, Aurelie Berot, Brigitte Delemer, Sara Barraud
Summary: This study developed a deep learning model to predict retinopathy complications in patients with type 1 diabetes. The modeling of time gaps between medical records was found to be crucial in improving prediction performance.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Dana Hyassat, Saba Al-Saeksaek, Duha Naji, Awn Mahasneh, Yousef Khader, Mousa Abujbara, Mohammad El-Khateeb, Kamel Ajlouni
Summary: This study investigated the prevalence and patterns of dyslipidemia among patients with type 2 diabetes and its associated risk factors. The results showed that combined dyslipidemia, characterized by high triglycerides and low HDL-cholesterol, was the most common type. Factors such as diabetes duration, statin non-compliance, HbA1c level, and smoking were associated with different types of dyslipidemia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Silvana Kontogeorgos, Tatiana Zverkova Sandstrom, Annika Rosengren, Michael Fu
Summary: This study examined the impact of hospital readmissions on heart failure patients and found that the overall readmission rate remained unchanged. However, there was a significant increase in readmissions for non-cardiovascular causes, highlighting the importance of managing comorbidities.
Article
Biochemistry & Molecular Biology
Aleksejs Fedulovs, Lilian Tzivian, Polina Zalizko, Santa Ivanova, Renate Bumane, Jana Janevica, Lelde Kruzmane, Eduards Krustins, Jelizaveta Sokolovska
Summary: Little research has been conducted on the link between diabetic kidney disease progression and diabetic gastroenteropathy in type 1 diabetes. In this study, a cross-sectional study was performed involving 100 T1D patients, and it was found that patients with progressive DKD had higher gastrointestinal symptom scores compared to those with stable DKD. The scores were negatively correlated with eGFR and positively correlated with albuminuria, HbA1c, and diabetes duration. The most commonly reported histopathological findings in the enteric mucosa were infiltration with eosinophils, lymphocytes, plasmacytes, the presence of lymphoid follicles, and lymphoid aggregates.
Article
Multidisciplinary Sciences
Antonio Ramos-Martinez, Lina Marcela Parra-Ramirez, Ignacio Morras, Maria Carnevali, Lorena Jimenez-Ibanez, Manuel Rubio-Rivas, Francisco Arnalich, Jose Luis Beato, Daniel Monge, Uxua Asin, Carmen Suarez, Santiago Jesus Freire, Manuel Mendez-Bailon, Isabel Perales, Jose Loureiro-Amigo, Ana Belen Gomez-Belda, Paula Maria Pesqueira, Ricardo Gomez-Huelgas, Carmen Mella, Luis Felipe Diez-Garcia, Joaquim Fernandez-Sola, Ruth Gonzalez-Ferrer, Marina Aroza, Juan Miguel Anton-Santos, Carlos Lumbreras Bermejo
Summary: The rate of readmission for COVID-19 patients after hospital discharge was low. The main causes of readmission were worsening of pneumonia, bacterial infection, venous thromboembolism, and heart failure. Risk factors for readmission included age, comorbidities, and other factors.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Suvasish Das Shuvo, Md Toufik Hossen, Md Riazuddin, Md Sakhawot Hossain, Sanaullah Mazumdar, Rashida Parvin, Md Toufiq Elahi
Summary: This study aimed to estimate the prevalence of comorbidity and its associated factors among Bangladeshi type-2 diabetes (T2D) patients. The overall prevalence of comorbidity was found to be high among Bangladeshi T2D patients, with the most common comorbidities being hypertension, retinopathy, obesity, and oral problems. Male gender, older age, unemployment, longer duration of diabetes, obesity, and low physical activity levels were identified as factors associated with a higher risk of developing comorbidities.
Article
Medicine, Research & Experimental
Nicole Muschol, Anja Koehn, Katharina von Cossel, Ilyas Okur, Fatih Ezgu, Paul Harmatz, Maria J. de Castro Lopez, Maria Luz Couce, Shuan-Pei Lin, Spyros Batzios, Maureen Cleary, Martha Solano, Igor Nestrasil, Brian Kaufman, Adam J. Shaywitz, Stephen M. Maricich, Bernice Kuca, Joseph Kovalchin, Eric Zanelli
Summary: This study found that intracerebroventricular administration of tralesinidase alfa can effectively treat Sanfilippo type B and normalize HS and HS-NRE levels in brain tissues. This treatment also reduces hepatomegaly and improves cognitive development in patients.
JOURNAL OF CLINICAL INVESTIGATION
(2023)