Article
Medicine, General & Internal
Remigiusz Kazimierczyk, Ewelina Kazimierczyk, Malgorzata Knapp, Bozena Sobkowicz, Lukasz A. Malek, Piotr Blaszczak, Katarzyna Ptaszynska-Kopczynska, Ryszard Grzywna, Karol A. Kaminski
Summary: The study showed that the TAPSE/sPAP ratio in patients with pulmonary arterial hypertension (PAH) is a valuable prognostic parameter for assessing hemodynamic adaptation and predicting outcomes, providing an easy and reliable non-invasive tool for comprehensive evaluation of patients' condition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Serkan Unlu, Stephanie Bezy, Marta Cvijic, Jurgen Duchenne, Marion Delcroix, Jens Uwe Voigt
Summary: RVFW LS/sPAP ratio as a new prognostic echocardiographic marker significantly predicts all-cause mortality and heart-lung transplantation in patients with pre-capillary PAH, and is superior to other well-established parameters, providing important value in understanding the relationship between RV function and afterload.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Medicine, General & Internal
Mari Nishizaki, Aiko Ogawa, Hiromi Matsubara
Summary: The right ventricle is more sensitive to afterload than the left ventricle, and pulmonary arterial hypertension patients still exhibit abnormal pulmonary hemodynamic response during exercise despite specific therapy at rest. Further studies on the long-term effects are necessary to understand the potential risks and benefits of exercise training for these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Rebecca R. Vanderpool, Kendall S. Hunter, Michael Insel, Joe G. N. Garcia, Edward J. Bedrick, Ryan J. Tedford, Franz P. Rischard
Summary: In patients with advanced PAH, RV-pulmonary arterial coupling could not differentiate irreversible RV failure at presentation, but showed an improving trend by follow-up. Early change in Eed and baseline RV ejection fraction were the best predictors of therapeutic response.
Article
Cardiac & Cardiovascular Systems
Roberto Badagliacca, Beatrice Pezzuto, Silvia Papa, Roberto Poscia, Giovanna Manzi, Antonella Pascaretta, Cristiano Miotti, Federico Luongo, Gianmarco Scoccia, Francesco Ciciarello, Gavino Casu, Susanna Sciomer, Francesco Fedele, Robert Naeije, Carmine Dario Vizza
Summary: This study aimed to explore speckle tracking echocardiographic right ventricular post-systolic strain patterns in patients with idiopathic pulmonary arterial hypertension (PAH). Three distinct patterns were identified and were found to be associated with disease severity and prognosis, providing additional prognostic power when combined with clinical and hemodynamic variables.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Natalia J. J. Braams, Azar Kianzad, Lilian J. J. Meijboom, Jesper Westenberg, Onno A. A. Spruijt, Josien Smits, Anton Vonk Noordegraaf, Anco Boonstra, Esther J. J. Nossent, Frank Oosterveer, M. Louis Handoko, Petr Symersky, Frances S. S. de Man, Harm Jan Bogaard
Summary: Pulmonary endarterectomy (PEA) improves resting hemodynamics and right ventricular (RV) function in chronic thromboembolic pulmonary hypertension. However, exercise tolerance may remain impaired, suggesting that RV function may not normalize completely after PEA. This study investigates the effect of PEA on RV function during exercise through detailed invasive hemodynamic analysis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Carolina M. S. Messina, Eloara V. M. Ferreira, Inderjit Singh, Angelo X. C. Fonseca, Roberta P. Ramos, Luiz E. Nery, David M. Systrom, Rudolf K. F. Oliveira, Jaquelina S. Ota-Arakaki
Summary: The study revealed that peak RV stroke work index and Delta PA compliance significantly influence pVO2 in patients with idiopathic pulmonary arterial hypertension, highlighting the crucial role of hemodynamic coupling to exercise capacity in IPAH.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Franz P. Rischard, Roberto J. Bernardo, Rebecca R. Vanderpool, Deborah H. Kwon, Tushar Acharya, Margaret M. Park, Austin Katrynuik, Michael Insel, Saad Kubba, Roberto Badagliacca, A. Brett Larive, Robert Naeije, Joe G. N. Garcia, Gerald J. Beck, Serpil C. Erzurum, Robert P. Frantz, Paul M. Hassoun, Anna R. Hemnes, Nicholas S. Hill, Evelyn M. Horn, Jane A. Leopold, Erika B. Rosenzweig, W. H. Wilson Tang, Jennifer D. Wilcox
Summary: The aim of this study is to assess the clinical relevance of a proposed definition for RV functional recovery (RVFnRec). A decrease in RV end-diastolic volume of -15 mL and an increase in compliance had the best predictive value for RVFnRec. RVFnRec is associated with improvements in exercise capacity and clinical worsening.
CIRCULATION-HEART FAILURE
(2023)
Article
Medicine, General & Internal
Yaling Dong, Yu Li, Laichun Song
Summary: This study compared the accuracy of E-es/E-a ratio measured by three different methods in patients with pulmonary artery hypertension and found that CMR combined volume method is a feasible and reliable way to quantitatively evaluate right ventricular function.
Article
Medicine, General & Internal
Vazhma Qaderi, Jessica Weimann, Lars Harbaum, Benedikt N. Schrage, Dorit Knappe, Jan K. Hennigs, Christoph Sinning, Renate B. Schnabel, Stefan Blankenberg, Paulus Kirchhof, Hans Klose, Christina Magnussen
Summary: The study aimed to identify echocardiographic right heart parameters associated with adverse outcomes in PAH patients and develop a non-invasive risk score. Results showed that integrating right heart function assessed by echocardiography improves the prediction of death or lung transplantation in PAH patients. Further validation of this finding is warranted.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sasha Z. Prisco, Megan Eklund, Daphne M. Moutsoglou, Anthony R. Prisco, Alexander Khoruts, E. Kenneth Weir, Thenappan Thenappan, Kurt W. Prins
Summary: Intermittent fasting (IF) improves right ventricular function, increases survival rate, reduces cardiomyocyte hypertrophy and fibrosis, prevents lipid accumulation, and enhances gut microbiota profile in pulmonary arterial hypertension (PAH), suggesting it may be a non-pharmacological approach to combat RV dysfunction in PAH.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas S. S. Hansen, Kristen J. J. Bubb, Gabriele G. G. Schiattarella, Martin Ugander, Timothy C. C. Tan, Gemma A. A. Figtree
Summary: This study evaluated the diagnostic performance of tricuspid annular plane systolic excursion (TAPSE), RV peak systolic myocardial velocity (s'), RV myocardial performance index (MPI), and RV fractional area change (FAC) in a mouse model of pulmonary hypertension. The results showed that these measures can be consistently measured in mice and are sensitive and specific indicators of pulmonary pressure and RV function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Raymond L. Benza, Hossein-Ardeschir Ghofrani, Ekkehard Grunig, M. Marius Hoeper, Pavel Jansa, Zhi-Cheng Jing, Nick H. Kim, David Langleben, Gerald Simonneau, Chen Wang, Dennis Busse, Christian Meier, Stefano Ghio
Summary: This post hoc analysis suggests that riociguat improves right ventricular function in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, with significant impact on long-term outcomes. Multiple parameters of right ventricular function were associated with survival and clinical worsening-free survival in the extension studies PATENT-2 and CHEST-2.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nils Kremer, Zvonimir Rako, Philipp Douschan, Henning Gall, Hossein A. Ghofrani, Friedrich Grimminger, Stefan Guth, Robert Naeije, Andreas Rieth, Rainer Schulz, Werner Seeger, Ryan J. Tedford, Istvan Vadasz, Rebecca Vanderpool, Christoph B. Wiedenroth, Manuel J. Richter, Khodr Tello
Summary: This study aimed to assess the physiological and prognostic impact of right ventricular (RV)-pulmonary arterial (PA) uncoupling during volume challenge in patients with precapillary pulmonary hypertension (PH). The results showed that RV-PA coupling significantly declined during fluid challenge in patients with PH and was associated with pulmonary resting hemodynamics and RV ejection fraction (RVEF). Furthermore, RV-PA uncoupling during fluid challenge and RVEF were predictors of clinical worsening.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Giuseppe Palmiero, Emanuele Monda, Federica Verrillo, Francesca Dongiglio, Martina Caiazza, Marta Rubino, Michele Lioncino, Gaetano Diana, Erica Vetrano, Adelaide Fusco, Annapaola Cirillo, Alfredo Mauriello, Giovanni Ciccarelli, Luigi Ascione, Maria Luisa De Rimini, Michele D'Alto, Giuseppe Cerciello, Antonello D'Andrea, Paolo Golino, Paolo Calabro, Eduardo Bossone, Giuseppe Limongelli
Summary: This study aimed to evaluate the prevalence and clinical significance of right ventricular pulmonary arterial (RV-PA) uncoupling in patients with cardiac amyloidosis (CA). The results showed that RV-PA uncoupling is common in CA patients, indicating advanced disease and worse outcomes. The study also suggested that the TAPSE/PASP ratio may improve risk stratification and guide management strategies in CA patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)