Review
Infectious Diseases
Jose Dominguez, Martin J. Boeree, Emmanuelle Cambau, Dumitru Chesov, Francesca Conradie, Vivian Cox, Keertan Dheda, Andrii Dudnyk, Maha R. Farhat, Sebastien Gagneux, Martin P. Grobusch, Matthias Groeschel, Lorenzo Guglielmetti, Irina Kontsevaya, Berit Lange, Frank van Leth, Christian Lienhardt, Anna M. Mandalakas, Florian P. Maurer, Matthias Merker, Paolo Miotto, Barbara Molina-Moya, Florence Morel, Stefan Niemann, Nicolas Veziris, Andrew Whitelaw, Charles R. Horsburgh Jr, Christoph Lange
Summary: Drug-resistant tuberculosis is a global concern and molecular methods provide rapid information on mutations associated with anti-tuberculosis drug resistance. This consensus document, developed by TBnet and RESIST-TB networks, establishes reporting standards for the clinical use of molecular drug susceptibility testing. The panel identified studies linking M tuberculosis mutations with treatment outcomes, and highlights the importance of implementing molecular testing for drug resistance prediction.
LANCET INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven M. Francque, Arun J. Sanyal, Fasiha Kanwal, Diana Romero, Manal F. Abdelmalek, Quentin M. Anstee, Juan Pablo Arab, Marco Arrese, Ramon Bataller, Ulrich Beuers, Jerome Boursier, Elisabetta Bugianesi, Christopher D. Byrne, Graciela E. Castro Narro, Abhijit Chowdhury, Helena Cortez-Pinto, Donna R. Cryer, Kenneth Cusi, Mohamed El-Kassas, Samuel Klein, Wayne Eskridge, Jiangao Fan, Samer Gawrieh, Cynthia D. Guy, Stephen A. Harrison, Seung Up Kim, Bart G. Koot, Marko Korenjak, Kris V. Kowdley, Florence Lacaille, Rohit Loomba, Robert Mitchell-Thain, Timothy R. Morgan, Elisabeth E. Powell, Michael Roden, Manuel Romero-Gomez, Marcelo Silva, Shivaram Prasad Singh, Silvia C. Sookoian, C. Wendy Spearman, Dina Tiniakos, Luca Valenti, Miriam B. Vos, Vincent Wai-Sun Wong, Stavra Xanthakos, Yusuf Yilmaz, Zobair Younossi, Ansley Hobbs, Marcela Villota-Rivas, Philip N. Newsome
Summary: This study aimed to determine if there was a need to change the nomenclature and definition of NAFLD and NASH. Through a Delphi process involving content experts and patient advocates, a consensus was reached to replace NAFLD with metabolic dysfunction-associated steatotic liver disease (MetALD) and modify the diagnostic criteria. The new nomenclature and criteria are widely supported, nonstigmatizing, and can improve awareness and patient identification.
Review
Immunology
Eva Montalva, Manuel Rodriguez-Peralvarez, Annabel Blasi, Santiago Bonanad, Olga Gavin, Loreto Hierro, Laura Llado, Elba Llop, Juan Carlos Pozo-Laderas, Jordi Colmenero
Summary: The increasing use of anticoagulation and antiplatelet therapies in liver transplant patients presents a challenge for transplant teams. The lack of scientific evidence makes it difficult to monitor their effectiveness and manage complications. The Spanish Society of Liver Transplantation and the Spanish Society of Thrombosis and Haemostasis aimed to address this issue and provide guidance through a consensus statement.
Article
Immunology
Christine Nguyen-Buckley, Dmitri S. Bezinover, Pooja Bhangui, Gianni Biancofiore, Annabel Blasi, Ryan Chadha, Aliaksei Pustavoitau, Antoni Sabate, Fuat H. Saner, Gebhard Wagener, Christopher L. Wray, Jeron Zerillo, Terry Ling Te Pan
Summary: This study aims to establish consensus on the essential skills, knowledge, and attributes that a liver transplant anesthesiologist should possess. Through the modified Delphi methodology, key competencies were identified in preoperative management, intraoperative management, crisis management, and postoperative care.
Article
Public, Environmental & Occupational Health
Bin Lin, Yangmin Hu, Ping Xu, Tao Xu, Chunyan Chen, Le He, Mi Zhou, Zhangzhang Chen, Chunhong Zhang, Xuben Yu, Luo Fang, Junfeng Zhu, Yanlan Ji, Qun Lin, Hengbin Cao, Youqin Dai, Xiaoyan Lu, Changcheng Shi, Li Li, Changjiang Wang, Xumei Li, Qiongyan Fang, Jing Miao, Zhengyi Zhu, Guangyong Lin, Haichao Zhan, Shiwen Lv, Yalan Zhu, Xinjun Cai, Yin Ying, Meng Chen, Qiong Xu, Yiwen Zhang, Yubin Xu, Pea Federico, Saiping Jiang, Haibin Dai
Summary: Through in-depth research on Linezolid, a team of experts from various disciplines has formed a consensus on the therapeutic drug monitoring and safe use of Linezolid.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Otorhinolaryngology
Cristina M. Baldassari, Derek J. Lam, Stacey L. Ishman, Boris Chernobilsky, Norman R. Friedman, Terri Giordano, Claire Lawlor, Ron B. Mitchell, Heather Nardone, James Ruda, Habib Zalzal, Adrienne Deneal, Nui Dhepyasuwan, Richard M. Rosenfeld
Summary: An expert consensus statement was developed for pediatric drug-induced sleep endoscopy (DISE) to clarify controversies and improve quality. A total of 26 consensus statements were achieved, covering indications, protocol, and outcomes for pediatric DISE, offering guidance for clinicians and highlighting areas for further research.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Medicine, General & Internal
Stephan A. Mayer, Jennifer A. Frontera, Brian Jankowitz, Christopher P. Kellner, Nathan Kuppermann, Bhiken I. Naik, Daniel K. Nishijima, Thorsten Steiner, Joshua N. Goldstein
Summary: Standardization of outcome measures in studies of intracranial bleeding and hemostatic therapy is crucial for supporting comparative effectiveness research and meta-analysis, with the aim of facilitating the translation of research into clinical practice. The proposed three outcome measures in this consensus statement could aid in this process by providing a framework for evaluating therapies aimed at reducing acute intracranial bleeding.
Article
Infectious Diseases
Abdirahman Mohamed Hassan Dirie, Sedat Colakoglu, Osman Muhyadin Abdulle, Bashir Mohamud Abdi, Mohamed Abdi Osman, Abdiaziz Mohamud Shire, Abdinafic Mohamud Hussein
Summary: The study found a prevalence of MDR-TB among pulmonary TB patients in Banadir, Somalia, which is similar to some eastern African countries.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Multidisciplinary Sciences
Morven Cunningham, Marco Iafolla, Yada Kanjanapan, Orlando Cerocchi, Marcus Butler, Lillian L. Siu, Philippe L. Bedard, Kendra Ross, Bettina Hansen, Anna Spreafico, Jordan J. Feld
Summary: This study investigated liver enzyme elevation in patients receiving immune checkpoint inhibitors (ICI) and found that immunotoxicity was one of the causes, with a distinct biochemical signature compared to other causes. A diagnostic approach was proposed to help identify patients at higher likelihood of immunotoxicity without the need for liver biopsy in most cases.
Review
Pharmacology & Pharmacy
Xinghui Li, Jiaqi Ni, Li Chen
Summary: This review focuses on the diagnosis, screening, and management of Acetaminophen (APAP)-induced liver injury (AILI), which is a significant cause of drug-induced liver injury and acute liver failure. It summarizes recent research progress, highlights current issues, and provides recommendations for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Orthopedics
Brandon J. Erickson, Eoghan T. Hurley, Edward S. Mojica, Laith M. Jazrawi
Summary: The purpose of this study was to establish consensus on the treatment of UCL injuries and determine if agreement could be reached on specific topics. A modified consensus technique was used with 26 elbow surgeons and 3 physical therapists/athletic trainers. The results showed unanimous agreement on risk factors, advanced imaging, lack of evidence for orthobiologics, and various aspects of operative management and return to sport criteria. The level of evidence was classified as expert opinion.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2023)
Article
Veterinary Sciences
Marnin A. Forman, Joerg M. Steiner, P. Jane Armstrong, Melinda S. Camus, Lorrie Gaschen, Steve L. Hill, Caroline S. Mansfield, Katja Steiger
Summary: Diagnosis and management of pancreatitis in cats present many challenges and require further research support. Diagnosis of pancreatitis in cats is more focused than treatment, with acute pancreatitis easier to diagnose compared to chronic pancreatitis.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Harshad Devarbhavi, Guruprasad Aithal, Sombat Treeprasertsuk, Hajime Takikawa, Yimin Mao, Saggere M. Shasthry, Saeed Hamid, Soek Siam Tan, Cyriac Abby Philips, Jacob George, Wasim Jafri, Shiv K. Sarin
Summary: Idiosyncratic drug-induced liver injury, common in Asia, may be due to hepatotoxicity from tuberculosis treatment and the widespread use of traditional and complimentary medicine in Asian countries. The consequences of this type of liver injury can range from asymptomatic to severe, often lacking pathognomonic diagnostic serological markers, highlighting the need for awareness and early detection.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Melissa Palmer, David E. Kleiner, Zachary Goodman, Elizabeth Brunt, Mark I. Avigan, Arie Regev, Paul H. Hayashi, James H. Lewis, Ruby Mehta, Stephen A. Harrison, Massimo Siciliano, Charles A. McWherter, Raj Vuppalanchi, Cynthia Behling, Veronica Miller, Naga Chalasani, Arun J. Sanyal
Summary: This article discusses the appropriate utilization of liver biopsy as part of the causality assessment of suspected drug-induced liver injury (DILI) during metabolic dysfunction-associated steatohepatitis (MASH) clinical trials. It provides expert opinions, guidance, and recommendations, and summarizes lessons learned from prior MASH programs and identified gaps for improvement.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Mohammed Eslam, Naim Alkhouri, Pietro Vajro, Ulrich Baumann, Ram Weiss, Piotr Socha, Claude Marcus, Way Seah Lee, Deirdre Kelly, Gilda Porta, Mohamed A. El-Guindi, Anna Alisi, Jake P. Mann, Nezha Mouane, Louise A. Baur, Anil Dhawan, Jacob George
Summary: The proposed framework for pediatric fatty liver diseases includes an age-appropriate MAFLD definition based on sex and age percentiles, recognizing the possibility of other coexisting systemic fatty liver diseases in children. This new MAFLD diagnostic criteria provide pediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, aligning with a definition that is valid across the lifespan.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
