4.5 Article

Preparation of γ-Fe2O3/SiO2-capsule composites capable of using as drug delivery and magnetic targeting system from hydrophobic iron acetylacetonate and hydrophilic SiO2-capsule

Journal

SOLID STATE SCIENCES
Volume 34, Issue -, Pages 49-55

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.solidstatesciences.2014.05.006

Keywords

SiO2-capsule; gamma-Fe2O3; Iron acetylacetonate; Calcination

Funding

  1. Chinese National Foundation

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Series of nanocomposites with gamma-Fe2O3 supported on SiO2-capsules were prepared by adsorption of hydrophobic iron acetylacetonate on the hydrophilic surface of SiO2-capsules in the evaporation process of the solvent and then calcination the complex at 450 degrees C. The adsorption and calcination conditions were studied and the resultant nanaoparticles were characterized by XRD, XRF and TEM in detail. The results indicated that gamma-Fe2O3 loaded discontinuously but uniformly on the surface of SiO2-capsules at appropriate content. The specific surface area characterization and doxorubicin hydrochloride release shown although the surface area of the target composites decreased slightly, the nanoparticles still had large potential using as drug delivery and magnetic targeting system. (C) 2014 Elsevier Masson SAS. All rights reserved.

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