Article
Chemistry, Multidisciplinary
Han-yuan Zheng, Yu-dun Liu, Yu-lei Zhang, Qing-hua Shi, Xue-li Hou, Lin An
Summary: In this study, a supramolecular drug delivery system based on PDCA micelles has been developed to transport CPT to the therapeutic target. The CPT@PDCA micelles show high encapsulation efficiency and pH-responsive release behavior. CPT-loaded PDCA exhibits decreased toxicity to normal cells and comparable inhibitory effect on tumor proliferation compared with CPT alone.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Mamina Bhol, Guilhem Claude, Maximilian Roca Jungfer, Ulrich Abram, Malaichamy Sathiyendiran
Summary: In this study, calix[4]arene-analogous technetium supramolecules and rhenium-based macrocycles were successfully assembled by using specific ligands and starting materials. The structures of these molecules were characterized in detail.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Lucinda R. B. Wilson, Marco Coletta, Mukesh K. Singh, Simon J. Teat, Adam Brookfield, Muralidharan Shanmugam, Eric J. L. McInnes, Stergios Piligkos, Scott J. Dalgarno, Euan K. Brechin
Summary: The reaction of 2,2'-bis-p-Bu-t-calix[4]arene (H8L) with Cu(NO3) (2)center dot 3H(2)O and N-methyldiethanolamine (MedeaH(2)) in a basic dmf/MeOH mixture results in the formation of [Cu-II (16)(L)(2)(Me-dea)(4)(mu(4)-NO3)(2)(mu-OH)(4)(dmf)(3.5)(MeOH)(0.5)(H2O)(2)] (H6L)center dot 16dmf center dot 4H(2)O (4). The metallic skeleton of the compound consists of a tetracapped square prism, [Cu-12], with Cu-II ions housed in the calix[4]arene polyphenolic pockets. Magnetic measurements show antiferromagnetic exchange interactions and a ground state of S = 1, while EPR indicates a large zero-field splitting.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Xu Ying, Zhenhua Zhu, Xiao-Lei Li, Jinkui Tang
Summary: We report two pairs of enantiomers of Co(II)and Zn(II)-based metallacycles constructed by coordination-driven self-assembly between homochiral 1,1 '-bi-2-naphthol-derived ligands featuring two kinds of coordination pockets and transition metal ions. Remarkably, they exhibit calix[4]arene-like topological structures and fascinating chiral cavities, having potential in enantioselective recognition.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Physical
Horacio Gomez-Machuca, Cinthia Quiroga-Campano, Carolina Jullian, Claudio Saitz
Summary: In this study, a calix[4]arene-based bifunctional receptor with amide and benzoxazolinone units was synthesized and evaluated for ionic recognition. The results showed selectivity in the recognition of copper, fluoride, cyanide, and acetate ions. Advanced techniques such as 1HNMR and FT-IR analysis were used to elucidate its binding ability and mechanism. The findings suggest that this bifunctional receptor has promising potential as an ion sensor for detecting specific ions in environmental and biological samples.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Biochemistry & Molecular Biology
Anton A. Muravev, Alexandra D. Voloshina, Anastasia S. Sapunova, Farida B. Gabdrakhmanova, Oksana A. Lenina, Konstantin A. Petrov, Sergey Shityakov, Ekaterina V. Skorb, Svetlana E. Solovieva, Igor S. Antipin
Summary: In this study, a series of calixarenes derivatized with 3-phenyl-1H-pyrazole units were synthesized and characterized. These compounds showed specific cytotoxicity for M-HeLa cells with low mutagenicity and haemotoxicity. Compound 7b and 7c induced apoptosis in M-HeLa cells through the mitochondrial pathway and arrested the cell cycle at G0/G1 phase. The overexpression of DNA damage markers in pyrazole-treated M-HeLa cells suggested that calixarene pyrazoles target DNA, which was supported by the interactions between calixarenes and ctDNA at the air-water interface.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Vladimir Burilov, Egor Makarov, Diana Mironova, Elza Sultanova, Islamiya Bilyukova, Kevser Akyol, Vladimir Evtugyn, Daut Islamov, Konstantin Usachev, Timur Mukhametzyanov, Svetlana Solovieva, Igor Antipin
Summary: This paper presents the synthesis of new water-soluble calixarene triazoles and investigates their aggregation behavior, as well as their binding and compaction abilities towards DNA. The results suggest that the tetradecyl-substituted calix[4]arene exhibits the best performance in terms of DNA binding and compaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Grazia Maria Letizia Consoli, Giuseppe Granata, Giovanna Ginestra, Andreana Marino, Giovanni Toscano, Antonia Nostro
Summary: The high incidence of antibiotic resistance and biofilm-associated infections necessitates the search for new antimicrobial drugs and strategies. This study found that a self-assembling amphiphilic choline-calix[4]arene derivative (Chol-Calix) exhibited inherent antibacterial effects against Gram negative bacteria, including antibiotic-resistant strains, and affected bacterial biofilm and motility. The activity is likely due to the amphipathicity and cationic surface of Chol-Calix nanoassembly.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Wenliang Wang, Sangni Jiang, Shengran Li, XinXin Yan, Sanrong Liu, Xiaobo Mao, Xifei Yu
Summary: The novel bioorthogonal zwitterionic lipid CP was synthesized and demonstrated enhanced cellular uptake efficiency and therapeutic effects. CP lipids can be used for targeted cancer treatment and have potential applications in other fields.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Saber Mirzaei, Sergey Lindeman, Denan Wang, M. Saeed Mirzaei, Qadir K. Timerghazin
Summary: The discovery of a novel metastable polymorph of a calix[4]arene molecule undergoing distinct transformations, including a reversible thermal-induced rotation and irreversible dissolvation/recrystallization, demonstrates the unique structural changes and packing arrangements that can be achieved.
Article
Chemistry, Multidisciplinary
Masayuki Morie, Ryo Sekiya, Takeharu Haino
Summary: In this study, a triple-stranded metallohelicate was formed by self-assembly of 5,17-difunctionalized calix[4]arenes and metal cations, showing good encapsulation properties and selectivity. CD spectroscopy confirmed the preference of the metallohelicate for guest molecules. NMR, UV-vis experiments, and molecular mechanics calculations revealed the interaction mechanism between the metallohelicate and guest molecules.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Fazel Nasuhi Pur
Summary: The calix[4]arene-based active pharmaceutical ingredients show significant anticancer and anti-infective activities, possibly due to their multivalency, facial, conical structures, and synergistic effect of their four replicated units.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Multidisciplinary
Luke Hodson, Kevin J. Visagie, Michael-Phillip Smith, Leigh Loots, David Kuter, Tregen M. Snayer, Gareth E. Arnott
Summary: Inherently chiral calix[4]arenes with C-4-symmetry are rare and difficult to synthesise, but this study successfully obtained a high-yield product through a specific reaction. The use of a specific chiral group enabled the separation of the diastereomers formed, leading to the pure enantiomers.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Dandan Deng, Xu Yang, Jinying An, Kai Zhang, Shen Lin, XiangChao Dong
Summary: The study synthesized a new material SiO2@TiO2@SC4A for identifying lysine and arginine methylation in peptides, with higher levels of methylation showing stronger interactions. It also demonstrated selective extraction of methylated peptides from histone trypsin digestion and nuclear extracts of HeLa cells using the material, showing its potential in enrichment and identification of lysine methylations.
Article
Polymer Science
Jaehyeon Park, Sukyoung Kim, Shim Sung Lee, Jong-Hyun Kim, Joung-Man Park, Ji Ha Lee, Jong Hwa Jung
Summary: This study focused on controlling the stretching property of gels by adjusting the water content in the solvent system. The research found that the storage and loss moduli of gels prepared in solvent systems with different water contents exhibited significant changes. This novel approach shows potential for the development of new soft materials with finely controllable mechanical properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ryosuke Matsuno, Takamasa Ito, Shigeaki Takamatsu, Atsushi Takahara
Summary: The effect of silica coating on BaTiO3 particles was evaluated, showing that silica coating reduced ion migration and increased dielectric breakdown strength. Composite elastomers with HXNBR and silica-coated BaTiO3 exhibited higher generated stress, strain, and output energy density compared to conventional dielectric actuators.
Article
Biochemistry & Molecular Biology
Yuji Higaki, Kazutaka Kamitani, Takuji Ohigashi, Teruaki Hayakawa, Atsushi Takahara
Summary: Marine mussels efficiently adhere under wet conditions by precisely controlling the secretion of foot proteins on the adhesive plaque. Chemical analysis using spectromicroscopy has been performed on non-uniform plaque morphology, but the mesoscopic morphology has not been fully elucidated. STXM was used to investigate the chemical speciation in the non-uniform mussel plaque morphology, revealing high protein density in the matrix phase and low aromatic residue content in microdomains.
Article
Chemistry, Multidisciplinary
Ryosuke Matsuno, Yota Kokubo, Shigeaki Takamatsu, Atsushi Takahara
Summary: A dielectric elastomer actuator was prepared with a composite elastomer containing CN-modified and non-modified TiO2 particles, exhibiting a high relative dielectric constant and stress generation in a low electric field. By adjusting the content of CN-modified TiO2 particles, the relative dielectric constant of the composite elastomer can be increased.
Article
Chemistry, Multidisciplinary
Daiki Ihara, Yuji Higaki, Norifumi L. Yamada, Fumiya Nemoto, Yasuhiro Matsuda, Ken Kojio, Atsushi Takahara
Summary: The molecular mechanisms underlying the cononsolvency of PMPC in ethanol-water mixtures were studied through a combination of statistical mechanical models and neutron reflectivity experiments. The preferential interaction of water and the strong cooperativity of ethanol were identified, resulting in the collapsed PMPC chains being more solvated with water than the bulk mixed solvent at an ethanol volume fraction of 0.90.
Editorial Material
Chemistry, Multidisciplinary
Atsushi Takahara, Walter Richtering, Gilbert C. Walker
Article
Materials Science, Multidisciplinary
Chien-Wei Chu, Yucheng Zhang, Tomohiro Kubo, Shiho Tanizaki, Ken Kojio, Kotaro Satoh, Atsushi Takahara
Summary: In this study, a catechol-containing polymer was prepared by copolymerizing a bioinspired acetate-protected vinyl catechol monomer with glycidyl methacrylate. The deprotection of acetate groups allowed for the direct usage of the polymer as a primer or additive, leading to strengthened interfacial interactions and improved lap shear strength of epoxy-adhesive-bonded metallic joints.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Kakeru Obayashi, Kazutaka Kamitani, Chien-Wei Chu, Ryosuke Kawatoko, Chao-Hung Cheng, Atsushi Takahara, Ken Kojio
Summary: The internal structure of polyurethane adhesive undergoes changes during lap shear deformation, with an increase in the spacing of hard segment domains and the merging of tilt angle with the stretching direction. These findings are of great significance for the practical design of adhesives.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Multidisciplinary Sciences
Xunwu Hu, Sona Rani Roy, Chengzhi Jin, Guanying Li, Qizheng Zhang, Natsuko Asano, Shunsuke Asahina, Tomoko Kajiwara, Atsushi Takahara, Bolu Feng, Kazuhiro Aoki, Chenjie Xu, Ye Zhang
Summary: Engineering peptide assembly that controls integrin ligand presentation on the molecular level is of great significance, expanding the perspective of ligand-density-dependent modulation and providing valuable insights for therapeutic innovations. The bottom-up nanofabrication strategy allows for precise control of ligand presentation and the production of multifunctional nanofilaments.
NATURE COMMUNICATIONS
(2022)
Article
Polymer Science
Ming-Chia Li, Masanao Sato, Fa-Chung Chen, Wei-Tsung Chuang, Tomoyasu Hirai, Atsushi Takahara, Rong-Ming Ho
Summary: This paper presents a facile method for fabricating a thin-film sample with a high asymmetry value of induced circularly polarized luminescence (iCPL). The method involves mixing stereoregular poly(methyl methacrylate) (PMMA) and chiral chromophore (TFAE) to form a complex with a dynamic helical conformation of PMMA associated with TFAE via hydrogen bonding. This results in a preferential one-handed helical conformation with a high value of iCPL from self-assembly.
Article
Polymer Science
Adchara Padermshoke, Tomoko Kajiwara, Yingjun An, Mamiko Takigawa, Toan Van Nguyen, Hiroyasu Masunaga, Yutaka Kobayashi, Hiroshi Ito, Sono Sasaki, Atsushi Takahara
Summary: This study investigates the effects of oxo-biodegradable additives on the photo-oxidation of four types of polyolefin polymers. The results suggest that the additives promote the photo-oxidative degradation of the polymers, particularly PE polymers. Among the additive-containing polymers, itPP exhibits the highest degradation rate, while HDPE has the slowest.
Editorial Material
Chemistry, Multidisciplinary
Hendrik Heinz, Yogesh M. Joshi, Hongbo Zeng, Heng-Kwong Tsao, Sissi J. A. de Beer, Erin Koos, Atsushi Takahara, Gilbert C. Walker
Article
Materials Science, Multidisciplinary
Yucheng Zhang, Koichi Hasegawa, Sota Kamo, Kiyoka Takagi, Atsushi Takahara
Summary: Epoxy adhesives are crucial in the manufacturing of various components and products in industrial and daily use. Modifying the surface of adherents with PGMA greatly improves the lap shear strength of epoxy adhesive-bonded joints. The effect of PGMA layer thickness on reinforcement is still uncertain.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sinan Feng, Yokajaksusri Nutthon, Hiroyasu Masunaga, Sono Sasaki, Roman Selyanchyn, Shigenori Fujikawa, Shinichi Murata, Atsushi Takahara
Summary: This study investigated the impact of morphology on the gas transport properties of a poly-(ether-block-amide) (PEBA) multiblock copolymer. Annealing temperature was varied to evaluate changes in microstructure and gas transport properties of PEBA. Time-resolved attenuated total reflection Fourier transform infrared spectroscopy was used to determine the diffusion coefficient of CO2 in PEBA. The findings revealed a 38% increase in CO2 permeability in the annealed sample, while maintaining a high CO2/N-2 permselectivity.
Article
Chemistry, Physical
Ken Kojio, Aya Fujimoto, Chigusa Nagano, Shuhei Nozaki, Kazutoshi Yokomachi, Kazutaka Kamitani, Hirohmi Watanabe, Atsushi Takahara
Summary: In this study, the specific deformation behavior of crystalline polymer films under a multiaxial stress field was investigated. The experiments revealed that the string-shaped crystalline polymer chain structure produces local anisotropic uniaxial stress, leading to changes in the aggregation structure of the films.
Article
Chemistry, Multidisciplinary
Masaru Mukai, Akihiko Takada, Ayumi Hamada, Tomoko Kajiwara, Atsushi Takahara
Summary: Imogolite/chitosan hybrid films prepared with PLP as an interfacial modifier showed strong interactions between PLP and imogolite/chitosan, resulting in significant improvement in mechanical properties compared to pristine chitosan/imogolite hybrid films.
Article
Chemistry, Physical
Yiping Yin, Zhe Wang, Hua Zou
Summary: This study presents a novel method for preparing dimpled polymer-silica nanocomposite particles using interfacial swelling-based seeded polymerization. The optimized conditions allow for a relatively high percentage of dimpled particles to be achieved.
Article
Chemistry, Physical
Brenden D. Hoehn, Elizabeth A. Kellstedt, Marc A. Hillmyer
Summary: Porous materials with nanometer-scale pores have important applications as nanoporous membranes. In this study, ABA triblock copolymers were used as precursors to produce nanoporous polymeric membranes (NPMs) in thin film form by degrading the end blocks. Polycyclooctene (PCOE) NPMs with tunable pore sizes were successfully prepared using solvent casting technique. Oxygen plasma etching was employed to improve the surface porosity and hydrophilicity of the membranes. This study provides a straightforward method to produce tough NPMs with high porosity and hydrophilic surface properties.
Article
Chemistry, Physical
Vladislav S. Petrovskii, Stepan I. Zholudev, Igor I. Potemkin
Summary: This article investigates the behavior of linear and ring polypeptide chains in aqueous solution and explores the properties of the complexes formed by these chains with oppositely charged surfactants. The results demonstrate that the complexes of linear supercharged unfolded polypeptides and the corresponding surfactants exhibit impressive adhesive properties.
Article
Chemistry, Physical
Merve Cevik, Serkan Dikici
Summary: Cardiovascular diseases are a leading cause of death globally, and vascular grafts are a promising treatment option. This study focuses on tissue-engineered vascular grafts (TEVGs) using decellularized parsley stems as a potential biomaterial. The decellularized parsley stems showed suitable properties for TEVGs, providing a suitable environment for human endothelial cells to form a pseudo endothelium. This study showcases the potential of using parsley stems for TEVGs.
Article
Chemistry, Physical
Gustavo A. Vasquez-Montoya, Tadej Emersic, Noe Atzin, Antonio Tavera-Vazquez, Ali Mozaffari, Rui Zhang, Orlando Guzman, Alexey Snezhko, Paul F. Nealey, Juan J. de Pablo
Summary: The optical properties of liquid crystals are typically controlled by electric fields. In this study, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and optical response of nematic liquid crystals. We identify several previously unknown structures and explain them through calculations and simulations. These findings hold promise for the development of new systems combining sound, flow, and confinement.
Article
Chemistry, Physical
Xinjun Wu, Xin Guan, Shushu Chen, Jiangpeng Jia, Chongyi Chen, Jiawei Zhang, Chuanzhuang Zhao
Summary: This research presents a novel shape memory hydrogel with a remodelable permanent shape and programmable cold-induced shape recovery behavior. The hydrogel is prepared using specific treatment methods to achieve shape fixation by heating and shape recovery by cooling. Additionally, deformable devices can be obtained by assembling hydrogel blocks with different concentrations.
Article
Chemistry, Physical
Rebecca Hengsbach, Gerhard Fink, Ulrich Simon
Summary: This study examines the properties of DNA functionalized pNipmam microgels and pure pNipmam microgels at different concentrations of sodium chloride and in PBS solutions using temperature dependent H-1-NMR measurements. The results show that DNA modification affects the volume phase transition temperature and the addition of salt and PBS further enhances this effect.
Article
Chemistry, Physical
Ningyi Li, Junhong Li, Lijingting Qing, Shicheng Ma, Yao Li, Baohui Li
Summary: This paper investigates the self-assembly behavior of colloids with competing interactions under spherical confinement and finds that different ordered structures can be formed under different sized spherical confinements. Moreover, more perforated structures are formed in smaller spheres.
