Article
Engineering, Multidisciplinary
Alejandro Rodriguez-Barroso, Guillermo Camacho, Oscar Martinez-Cano, Jose Rafael Morillas, Juan de Vicente
Summary: In this study, we demonstrate the control of magnetophoretic force magnitude and homogeneity by placing appropriate magnetic materials between the electromagnetic inductors and the sample. Through optimization, large and homogeneous magnetophoretic forces can be generated over a wide area for multiplexed microrheology tests.
Article
Physics, Multidisciplinary
Andrew B. Matheson, Tania Mendonca, Graham M. Gibson, Paul A. Dalgarno, Amanda J. Wright, Lynn Paterson, Manlio Tassieri
Summary: This study investigated the effect of anisotropic optical traps on microrheology measurements and found that using highly anisotropic optical traps for viscosity measurements will lead to erroneous results. It introduced a new analytical approach for anisotropic traps with two axes of symmetry and identified a threshold level of anisotropy in optical trap strength. The outcomes of this study may have important practical ramifications on how all microrheology measurements should be conducted and analyzed in the future.
FRONTIERS IN PHYSICS
(2021)
Article
Polymer Science
Mike E. Dwyer, Rae M. Robertson-Anderson, Bekele J. Gurmessa
Summary: Actin maintains the stability and motility of biological cells. This study investigates the impact of actin-binding proteins on the mechanical properties of actin networks. It is found that crosslinking and stabilization can synergistically or antagonistically affect the network's resistance to strain. The study also reveals that stabilization can switch the initial force response from stress stiffening to softening. These findings shed light on the diverse mechanical properties of the cytoskeleton and bio-inspired materials.
Article
Physics, Multidisciplinary
N. Honda, K. Shiraki, F. van Esterik, S. Inokuchi, H. Ebata, D. Mizuno
Summary: This study aims to investigate the microscopic mechanical response of semiflexible biopolymer networks using microrheology experiments. The research reveals an affine elastic response of the cytoskeleton, which shows stiffening upon local forcing and collapses onto a single master curve when scaled with parameters describing semiflexible networks. The underlying physics of the general microscopic response is presented, and its potential implications for elucidating cell mechanics are discussed.
NEW JOURNAL OF PHYSICS
(2022)
Article
Physics, Applied
Hongqing Dai, Baizhan Xia, Dejie Yu
Summary: Acoustic topological insulators enable non-contact particle manipulations, such as microparticle trapping and separation. Based on the SSH model, we can separate particles of the same size and density.
APPLIED PHYSICS LETTERS
(2021)
Article
Multidisciplinary Sciences
Arnav Solanki, Zak Griffin, Purab Ranjan Sutradhar, Karisha Pradhan, Caiden Merritt, Amlan Ganguly, Marc Riedel
Summary: This paper introduces an integrated circuit based on microfluidics that can perform complex operations on data stored in DNA. The system is suitable for high-density, throughput-demanding bio-compatible applications.
Article
Chemistry, Physical
Rajkumar Biswas, Vaibhav Raj Singh Parmar, Anson G. Thambi, Ranjini Bandyopadhyay
Summary: Optical tweezers can detect pico-Newton range forces on colloidal particles and have been used to study complex systems. We investigated the forced movements of a trapped colloidal probe particle in an aging Laponite suspension, and found that the mechanical responses are affected by the evolving microstructures.
Article
Biophysics
Konrad Berghoff, Wolfgang Gross, Manuel Eisentraut, Holger Kress
Summary: Phagocytosis is a crucial process in innate immunity where cells engulf bacteria and other extracellular objects. Despite extensive molecular-level studies, a fundamental understanding of the mechanics of phagocytosis is still limited due to technical constraints. Researchers have proposed a technique to characterize the mechanical properties of cells and applied it to study the early stages of phagocytosis, shedding light on the cellular response and dynamics during this process.
BIOPHYSICAL JOURNAL
(2021)
Article
Chemistry, Applied
Lester C. Geonzon, Motoyoshi Kobayashi, Manlio Tassieri, Rommel G. Bacabac, Yasuhisa Adachi, Shingo Matsukawa
Summary: In this study, the hierarchical network structure of Iota carrageenan (IC) gels was investigated using passive and active microrheology performed by optical tweezers at 20 degrees C. The results showed that IC gels have a rubbery plateau of the elastic modulus, and the dynamics of the network decrease with increasing cluster density. This study provides novel insights into the meso- and microscale properties of IC gels that are not accessible by conventional bulk rheology and submicroscopic probe diffusion measurements.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Civil
E. Mahmoudpour, M. Esmaeili
Summary: This paper investigates the primary and secondary resonance of carbon nanotube conveying magnetic nanofluid under a longitudinal magnetic field with different boundary conditions. By comparing the results of stress-driven nonlocal integral model and strain gradient model, the study explores the effects of small scale parameters on the vibration behavior of carbon nanotube. The research also analyzes the influence of longitudinal magnetic field, magnetic nanofluid, and boundary conditions on the nonlinear free and forced vibration of carbon nanotube, highlighting the relationship between the intensity of the magnetic field and critical flow velocity.
THIN-WALLED STRUCTURES
(2021)
Article
Automation & Control Systems
Liushuai Zheng, Haibo Ji, Dong Sun
Summary: This article presents a magnetic tweezer system with a large workspace that can efficiently assemble, transport, and disassemble microswarms. The developed system allows for precise navigation and high transmission efficiency of the microswarms.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Physics, Multidisciplinary
Hunter Seyforth, Mauricio Gomez, W. Benjamin Rogers, Jennifer L. Ross, Wylie W. Ahmed
Summary: In this study, we investigated the dynamics of a passive colloidal probe in an active bath using an optical trap. The results revealed that the viscosity of the active bath exhibits shear thinning, shear thickening, and plateau effects depending on the value of the Peclet number. Additionally, we observed that the distribution of force fluctuations in the active bath is different from that in passive equilibrium baths. Moreover, the energy transfer rate from the active bath to the probe was measured.
PHYSICAL REVIEW RESEARCH
(2022)
Article
Mechanics
Shalaka K. Kale, Andrew J. Petruska, Joseph R. Samaniuk
Summary: Passive particle-tracking microrheology is limited to low modulus materials. To overcome this limitation, we have developed an active microrheology method using electromagnetic tweezers to induce artificial thermal noise and drive measurable displacements.
JOURNAL OF RHEOLOGY
(2022)
Article
Chemistry, Physical
Seyedeh Samaneh Ghasemi, Nadereh Golshan Ebrahimi, Abdollah Hajalilou
Summary: Magnetorheological (MR) fluid is an intelligent fluid influenced by an external magnetic field. Stable MR fluids based on carbonyl iron particles coated with silver nanoparticles and nickel-zinc ferrite nanoparticles as additives were synthesized. The density of the Ag-coated CI particles decreased compared to pristine CI particles. The MR fluid with a combination of silver-coated CI particles and nickel-zinc ferrite nanoparticles showed similar yield stress but higher stability compared to CI-based MR fluid.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Analytical
Gareth W. H. Evans, Wahida T. Bhuiyan, Susan Pang, Brett Warren, Kyriacos Makris, Sharon Coleman, Sammer-ul Hassan, Xize Niu
Summary: Real-time point-of-care monitoring of chemical biomarkers holds great potential in disease diagnostics and precision medicine. A prototype device described in this paper is capable of autonomously performing ELISA at a high frequency using droplet microfluidics, showing promising results for rapid and accurate detection of biomarkers like cortisol. This approach could serve as a platform technology for measurement or continuous monitoring of biomarkers at the point-of-care.
Article
Mechanics
Sami Yamani, Gareth H. McKinley
Summary: The FENE-P dumbbell constitutive equation is commonly used for simulating viscoelastic shear flows and predicting macroscopic properties of dilute polymer solutions. By evaluating steady material functions, universal master curves for these functions, as well as the corresponding stress ratio, can be constructed, which helps in understanding the effects of finite extensibility of polymer chains.
JOURNAL OF NON-NEWTONIAN FLUID MECHANICS
(2023)
Article
Chemistry, Medicinal
Purnima N. Manghnani, Luke Schenck, Saif A. Khan, Patrick S. Doyle
Summary: The commercialization of promising active pharmaceutical ingredients (APIs) is hindered by poor bioavailability and challenging physical properties. This study presents a method to improve API physical properties by performing reactive crystallization of an API salt in the presence of a hydrogel microparticle. The use of spherical template hydrogel microparticles leads to composites loaded with micronized crystals, enhancing API physical properties without affecting bioavailability.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Mechanics
Joshua David John Rathinaraj, Gareth H. McKinley
Summary: Oscillatory rheometric techniques are widely used to characterize the viscoelastic properties of complex fluids. However, conventional Fourier transforms for analyzing oscillatory data are limited in studying shear-induced microstructural changes in time-evolving materials. In this study, the Gabor transform is explored as a more advanced signal processing technique to extract time-resolved frequency information from oscillatory data. The Gabor transform enables accurate measurement of rapid changes in storage and loss modulus, extraction of characteristic thixotropic/aging time scale, and extraction of useful viscoelastic data from initial transient response. The resulting test protocol, Gaborheometry, reduces the number of required experiments and data postprocessing time significantly.
JOURNAL OF RHEOLOGY
(2023)
Article
Mechanics
Esteban F. Medina-Banuelos, Benjamin M. Marin-Santibanez, Emad Chaparian, Crystal E. Owens, Gareth H. McKinley, Jose Perez-Gonzalez
Summary: It has been discovered that the steady fractal vane-in-cup (fVIC) flow of complex fluids using vanes with fractal cross sections can produce an almost axisymmetric flow field and rotation rate-independent effective radius, making it a reliable measurement tool for complex fluids. However, axial shearing/compression during the insertion of the rheometric tool in the sample also accelerates syneresis, leading to shear banding for Couette and fVIC flows.
JOURNAL OF RHEOLOGY
(2023)
Article
Polymer Science
Gauthier Legrand, Sebastien Manneville, Gareth H. McKinley, Thibaut Divoux
Summary: Nanocomposite gels formed by mixing hydrophobic colloidal soot particles and a sodium salt of carboxymethylcellulose (CMC), known as cellulose gum, exhibit different mechanical behaviors depending on the relative content of the two components. At low CMC concentration, the gel shows electric conductivity and glassy-like viscoelastic behavior, while at higher CMC concentration, the gel becomes nonconductive and displays power-law viscoelastic behavior. The CMC plays a crucial role in the gel's viscoelastic properties. These findings provide valuable insights for designing nanocomposite gels based on hydrophobic interactions.
Article
Physics, Multidisciplinary
Minaspi Bantawa, Bavand Keshavarz, Michela Geri, Mehdi Bouzid, Thibaut Divoux, Gareth H. McKinley, Emanuela Del Gado
Summary: Soft particulate gels consist of a small amount of particulate matter dispersed in a continuous fluid phase. The mechanical response and gel elasticity are determined by the particle volume fraction. However, the diverse range of functional dependencies reported experimentally has made it difficult to identify general scaling laws.
Article
Mechanics
Jelle J. J. Schoppink, Keerthana Mohan, Miguel A. A. Quetzeri-Santiago, Gareth McKinley, David Fernandez Rivas, Andrew K. K. Dickerson
Summary: By selectively coating hydrophobic strips on hydrophilic glass capillaries, the trajectory and characteristics of the microjet can be influenced and controlled.
Article
Nanoscience & Nanotechnology
Jake Song, Sungjin Kim, Olivia Saouaf, Crystal Owens, Gareth H. McKinley, Niels Holten-Andersen
Summary: This study presents a novel design strategy for the synthesis of high-concentration soft magnetic hydrogels by in situ mineralization of iron oxide nanoparticles within polymer hydrogels. The resulting hydrogels exhibit softness, viscoelasticity, and strong magnetic actuation, making them suitable for biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Mechanics
Simon J. Haward, Stylianos Varchanis, Gareth H. McKinley, Manuel A. Alves, Amy Q. Shen
Summary: Part I presents a microfluidic device for generating near-homogeneous uniaxial and biaxial elongational flows. In Part II, this device is used to examine the extensional rheology of dilute polymer solutions compared to measurements made under planar extension. The extension rate and tensile stress difference generated in the fluid are measured using micro-particle image velocimetry and excess pressure drop measurements. The results show that at higher polymer concentrations, the experimental measurements deviate from the model predictions due to intermolecular interactions as the polymer chains unravel in the extensional flows.
JOURNAL OF RHEOLOGY
(2023)
Article
Engineering, Biomedical
Lucas Attia, Liang-Hsun Chen, Patrick S. Doyle
Summary: A novel dual-responsive gelation process that combines thermo-responsive and ion-responsive gelations is introduced in this study. This process synthesizes core-shell hydrogel particles and encapsulates drug-laden nanoemulsions, allowing in situ crystallization of drug nanocrystals in the polymeric core and templating of a kinetically stable amorphous solid dispersion in the shell. The study demonstrates programmable drug release for various therapeutic applications and independent control over drug loading between the shell and the core. This flexible formulation approach offers biocompatible materials, facile synthesis, and precise drug release performance.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Rishabh V. More, Reid Patterson, Eugene Pashkovski, Gareth H. McKinley
Summary: By studying the rod-climbing effect, we can measure the elasticity of complex fluids, including factors such as rotation rate, fluid elasticity, surface tension, and inertia. Our results show that by combining small amplitude oscillatory shear flow measurements and commercial rheometer measurements, we can accurately measure the normal stress differences of complex fluids.
Article
Physics, Multidisciplinary
Indresh Yadav, Dana Al Sulaiman, Patrick S. Doyle
Summary: The molecular topology of polymers has a significant impact on their physical properties. In this study, the effects of topology on the static and dynamic properties of a 2D network of DNA rings called a kinetoplast were investigated. By selectively cutting and removing rings from the network using restriction enzymes, the molecular topology was modified while maintaining the overall structural integrity. It was found that topology had minimal effects on the spatial extension of the network but significantly influenced its relaxation behavior.
PHYSICAL REVIEW RESEARCH
(2023)
Article
Chemistry, Physical
Joshua David John Rathinaraj, Kyle R. Lennon, Miguel Gonzalez, Ashok Santra, James W. Swan, Gareth H. McKinley
Summary: Clay slurries are widely used in the oil exploration industry as drilling fluids. However, modeling the rheological behavior of these suspensions is challenging due to their thermal-driven evolution and non-linear viscoelastic properties. This study presents a new approach for modeling the linear viscoelastic response of aging bentonite suspensions, which effectively solves the problem by transforming the time domain and material domain. Experimental measurements support the validity of this model.
Article
Engineering, Biomedical
Matthew L. Tan, Niaa Jenkins-Johnston, Sarah Huang, Brittany Schutrum, Sandra Vadhin, Abhinav Adhikari, Rebecca M. Williams, Warren R. Zipfel, Jan Lammerding, Jeffrey D. Varner, Claudia Fischbach
Summary: Endothelial cells promote breast cancer invasion into the stroma by reprogramming tumor cell metabolism. They secrete pro-migratory factors that direct tumor cells towards microvessels, and restricting glucose availability reduces tumor cell invasion.
APL BIOENGINEERING
(2023)
Review
Chemistry, Physical
Jake Song, Niels Holten-Andersen, Gareth H. Mckinley
Summary: This study introduces the non-Maxwellian linear stress relaxation observed in soft matter systems and discusses its physical origins. Suitable mathematical models are proposed to describe this phenomenon. The research is important for understanding and modeling the mechanical relaxation of soft materials.
Article
Chemistry, Physical
Yiping Yin, Zhe Wang, Hua Zou
Summary: This study presents a novel method for preparing dimpled polymer-silica nanocomposite particles using interfacial swelling-based seeded polymerization. The optimized conditions allow for a relatively high percentage of dimpled particles to be achieved.
Article
Chemistry, Physical
Brenden D. Hoehn, Elizabeth A. Kellstedt, Marc A. Hillmyer
Summary: Porous materials with nanometer-scale pores have important applications as nanoporous membranes. In this study, ABA triblock copolymers were used as precursors to produce nanoporous polymeric membranes (NPMs) in thin film form by degrading the end blocks. Polycyclooctene (PCOE) NPMs with tunable pore sizes were successfully prepared using solvent casting technique. Oxygen plasma etching was employed to improve the surface porosity and hydrophilicity of the membranes. This study provides a straightforward method to produce tough NPMs with high porosity and hydrophilic surface properties.
Article
Chemistry, Physical
Vladislav S. Petrovskii, Stepan I. Zholudev, Igor I. Potemkin
Summary: This article investigates the behavior of linear and ring polypeptide chains in aqueous solution and explores the properties of the complexes formed by these chains with oppositely charged surfactants. The results demonstrate that the complexes of linear supercharged unfolded polypeptides and the corresponding surfactants exhibit impressive adhesive properties.
Article
Chemistry, Physical
Merve Cevik, Serkan Dikici
Summary: Cardiovascular diseases are a leading cause of death globally, and vascular grafts are a promising treatment option. This study focuses on tissue-engineered vascular grafts (TEVGs) using decellularized parsley stems as a potential biomaterial. The decellularized parsley stems showed suitable properties for TEVGs, providing a suitable environment for human endothelial cells to form a pseudo endothelium. This study showcases the potential of using parsley stems for TEVGs.
Article
Chemistry, Physical
Gustavo A. Vasquez-Montoya, Tadej Emersic, Noe Atzin, Antonio Tavera-Vazquez, Ali Mozaffari, Rui Zhang, Orlando Guzman, Alexey Snezhko, Paul F. Nealey, Juan J. de Pablo
Summary: The optical properties of liquid crystals are typically controlled by electric fields. In this study, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and optical response of nematic liquid crystals. We identify several previously unknown structures and explain them through calculations and simulations. These findings hold promise for the development of new systems combining sound, flow, and confinement.
Article
Chemistry, Physical
Xinjun Wu, Xin Guan, Shushu Chen, Jiangpeng Jia, Chongyi Chen, Jiawei Zhang, Chuanzhuang Zhao
Summary: This research presents a novel shape memory hydrogel with a remodelable permanent shape and programmable cold-induced shape recovery behavior. The hydrogel is prepared using specific treatment methods to achieve shape fixation by heating and shape recovery by cooling. Additionally, deformable devices can be obtained by assembling hydrogel blocks with different concentrations.
Article
Chemistry, Physical
Rebecca Hengsbach, Gerhard Fink, Ulrich Simon
Summary: This study examines the properties of DNA functionalized pNipmam microgels and pure pNipmam microgels at different concentrations of sodium chloride and in PBS solutions using temperature dependent H-1-NMR measurements. The results show that DNA modification affects the volume phase transition temperature and the addition of salt and PBS further enhances this effect.
Article
Chemistry, Physical
Ningyi Li, Junhong Li, Lijingting Qing, Shicheng Ma, Yao Li, Baohui Li
Summary: This paper investigates the self-assembly behavior of colloids with competing interactions under spherical confinement and finds that different ordered structures can be formed under different sized spherical confinements. Moreover, more perforated structures are formed in smaller spheres.