Journal
ACS MACRO LETTERS
Volume 4, Issue 6, Pages 645-650Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.5b00227
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Funding
- National Heart Lung and Blood Institute of the National Institutes of Health as a Program of Excellence in Nanotechnology [HHSN268201000046C]
- National Science Foundation [CHE-1410272]
- Welch Foundation through the W. T. Doherty-Welch Chair in Chemistry [A-0001]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1410272] Funding Source: National Science Foundation
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A series of hydrolytically degradable fluorescent poly(ferulic acid-co-tyrosine)-g-mPEG graft copolymers were synthesized and shown to undergo self-assembly in aqueous media to yield fluorescent micelles. The polymers and their micellar assemblies exhibited greater fluorescence emission intensity than did their small molecular building blocks, which provides a self-reporting character that has potential for monitoring the polymer integrity and also for performing in theranostics applications. The amphiphilic graft-copolymers were synthesized by Cu-assisted azide-alkyne click addition of azido-functionalized mPEG polymers onto fluorescent degradable hydrophobic copolymers displaying randomly distributed alkyne side-chain groups along their biorenewably derived poly(ferulic acid-co-tyrosine) backbones. The morphologies and photophysical properties of the supramolecular assemblies generated in aqueous solutions were evaluated by DLS, TEM, AFM, and steady-state optical spectroscopies. The 15-30 nm sized micelles behaved as broad-band emitters in the 350-600 nm range, which highlights their potential as self-reporting nanomaterials for in vitro studies.
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