Article
Psychiatry
Kim T. Mueser, Rachel F. Sussman, Nicole R. Detore, Elizabeth S. Eberlin, Susan R. Mcgurk
Summary: Impaired cognitive functioning is a core feature of schizophrenia, and early intervention services have been shown to improve symptoms and functioning in first episode psychosis. This study evaluated the long-term effects of early intervention services on cognitive functioning in first episode psychosis patients. The results showed that while there were no improvements in cognitive functioning for older patients, younger patients showed significant improvements in working memory. Overall, interventions targeting cognition may be necessary to enhance cognitive functioning in most first episode psychosis patients.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Oihane Mentxaka, Maria Recio-Barbero, Eunate Arana-Arri, Rafael Segarra
Summary: Patients with first-episode psychosis (FEP) are not more likely to be involved in crimes than the general population. The types of violent acts committed by individuals with FEP are diverse, with extreme violence being uncommon.
Article
Psychiatry
N. R. DeTore, K. Bain, A. Wright, P. Meyer-Kalos, S. Gingerich, K. T. Mueser
Summary: This study evaluated the impact of early intervention services (EIS) on insight in first episode psychosis (FEP) patients. The results showed that EIS improved insight significantly more than usual community care (CC). Additionally, insight in the EIS group was more strongly associated with social relationships, suggesting a potential interaction between these two outcomes in treatment.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Lorenzo Pelizza, Emanuela Leuci, Emanuela Quattrone, Silvia Azzali, Simona Pupo, Giuseppina Paulillo, Pietro Pellegrini, Marco Menchetti
Summary: This study investigated the short-term service disengagement in Italian first-episode psychosis patients receiving early intervention services, and assessed the predictors of disengagement in the first year of treatment. The results showed that approximately 16% of patients disengaged from the program within the first year, and poor baseline treatment non-adherence, living with parents, and the presence of brief psychotic disorder or schizophreniform disorder at entry were strong predictors of service disengagement.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Clemente Garcia-Rizo, Bibiana Cabrera, Miquel Bioque, Gisela Mezquida, Antonio Lobo, Ana Gonzalez-Pinto, Covadonga M. M. Diaz-Caneja, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Maria Paz Garcia-Portilla, Miguel Gutierrez-Fraile, Roberto Rodriguez-Jimenez, Marina Garriga, Emilio Fernandez-Egea, Miguel Bernardo
Summary: Birth weight is associated with glucose values in first episode of psychosis patients, indicating the impact of early life events on metabolic outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Rigas F. Soldatos, Micah Cearns, Mette O. Nielsen, Costas Kollias, Lida-Alkisti Xenaki, Pentagiotissa Stefanatou, Irene Ralli, Stefanos Dimitrakopoulos, Alex Hatzimanolis, Ioannis Kosteletos, Ilias I. Vlachos, Mirjana Selakovic, Stefania Foteli, Nikolaos Nianiakas, Leonidas Mantonakis, Theoni F. Triantafyllou, Aggeliki Ntigridaki, Vanessa Ermiliou, Marina Voulgaraki, Evaggelia Psarra, Mikkel E. Sorensen, Kirsten B. Bojesen, Karen Tangmose, Anne M. Sigvard, Karen S. Ambrosen, Toni Meritt, Warda Syeda, Birte Y. Glenthoj, Nikolaos Koutsouleris, Christos Pantelis, Bjorn H. Ebdrup, Nikos Stefanis
Summary: A clinical prediction model was developed to predict short-term remission in patients with first-episode psychosis, using baseline clinical data and tested in independent Danish cohorts. The model showed reliability in predicting early remission status, indicating potential utility as a routine clinical tool.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychology, Developmental
Kathryn Albin, Cameron Albin, Clark D. Jeffries, Diana O. Perkins
Summary: The study found that 38% of subjects were not diagnosed with a psychotic disorder in their initial episode of care. The time to diagnosis for psychosis was similar for subjects that did and did not receive a diagnosis. Care episodes without a psychosis diagnosis more often involved outpatient and mental health services, but dangerousness indicators were similar.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Psychiatry
Lawrence H. Yang, Drew Blasco, Sarah A. Lieff, PhuongThao D. Le, YiPing Li, Marianne Broeker, Franco Mascayano, Iruma Bello, Ilana Nossel, Lisa Dixon
Summary: This article proposes a framework that outlines how various forms of stigma are linked to different stages of engagement in treatment services for first-episode psychosis. By specifying these linkages, the framework aims to guide EIS programs in addressing stigma explicitly to maximize recovery outcomes for individuals with first-episode psychosis.
HARVARD REVIEW OF PSYCHIATRY
(2021)
Article
Psychiatry
Kristin Fjelnseth Wold, Akiah Ottesen, Barthel Flaaten Camilla, Erik Johnsen, Trine Vik Lagerberg, Kristin Lie Romm, Carmen Simonsen, Torill Ueland, Line Widing, Gina Asbo, Ingrid Melle
Summary: This study investigates whether an adaptation of consensus criteria can be used to identify individuals with early signs of treatment resistance in first-episode psychosis, and examines the impact of different antipsychotic treatments on treatment outcomes. The findings suggest that the prevalence of early treatment resistance may be underestimated when using consensus criteria. Only a small proportion of patients classified as non-early clinical recovery met the full criteria for treatment resistance.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Delbert G. Robinson, Nina R. Schooler, Patricia Marcy, Robert D. Gibbons, C. Hendricks Brown, Majnu John, Kim T. Mueser, David L. Penn, Robert A. Rosenheck, Jean Addington, Mary F. Brunette, Christoph U. Correll, Sue E. Estroff, Piper S. Mayer-Kalos, Jennifer D. Gottlieb, Shirley M. Glynn, David W. Lynde, Susan Gingerich, Ronny Pipes, Alexander L. Miller, Joanne B. Severe, John M. Kane
Summary: This study examined the long-term effects of early intervention services for first-episode psychosis. The results showed that compared to community care, early intervention services significantly improved patients' quality of life and symptoms, and reduced the number of hospitalization days.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Medicine, General & Internal
Ragna Kristin Gudbrandsdottir, Oddur Ingimarsson
Summary: This study aimed to assess functional recovery and identify vocational predictors among young first episode psychosis patients registered in an early intervention psychosis center in Iceland. The results showed that despite intensive rehabilitation, almost half of the patients were not employed or in school at discharge. Vocational rehabilitation was found to be the strongest predictor for vocational outcomes, indicating the need for effective vocational rehabilitation at early intervention psychosis centers.
Article
Health Care Sciences & Services
Kara Dempster, Annie Li, Priyadharshini Sabesan, Ross Norman, Lena Palaniyappan
Summary: The study examined how using a <50% improvement threshold for total symptoms in first episode schizophrenia patients could best predict global functioning over a period of 5 years.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychiatry
Pei Ling Lim, Roselyne Shirley Pat Fong
Summary: This study provides a brief overview of young people presenting with first episode psychosis at a paediatric hospital in Singapore over the course of a year. It highlights the importance of joint initial assessment by paediatricians and child psychiatrists in determining clinical characteristics and guiding treatment decisions. Stigma and cultural beliefs were also identified as factors affecting delay in presentation and adherence to treatment.
ASIAN JOURNAL OF PSYCHIATRY
(2021)