QTc modification after risperidone administration – insight into the mechanism of action with use of the modeling and simulation at the population level approach

Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

(2014) Christian Wagner et al.   CLINICAL PHARMACOKINETICS

Effect of risperidone metabolism and P-glycoprotein gene polymorphism on QT interval in patients with schizophrenia

(2014) Y Suzuki et al.   PHARMACOGENOMICS JOURNAL

Model of the Distribution of Diastolic Left Ventricular Posterior Wall Thickness in Healthy Adults and Its Impact on the Behavior of a String of Virtual Cardiomyocytes

(2014) Kamil Fijorek et al.   Journal of Cardiovascular Translational Research

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

(2014) Gary R. Mirams et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level

(2013) Kamil Fijorek et al.   Computational and Mathematical Methods in Medicine

In vitro–in vivo extrapolation of drug-induced proarrhythmia predictions at the population level

(2013) Sebastian Polak et al.   DRUG DISCOVERY TODAY

Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study

(2013) Kamil Fijorek et al.   Theoretical Biology and Medical Modelling

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Selective acquired long QT syndrome (saLQTS) upon risperidone treatment

(2012) Maciej Jakub Lazarczyk et al.   BMC Psychiatry

Tox-Database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

(2012) Sebastian Polak et al.   BMC Pharmacology & Toxicology

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Virtual tissue engineering of the human atrium: Modelling pharmacological actions on atrial arrhythmogenesis

(2011) Oleg V. Aslanidi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone

(2011) Yutaro Suzuki et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Virtual population generator for human cardiomyocytes parameters:in silicodrug cardiotoxicity assessment

(2011) Sebastian Polak et al.   TOXICOLOGY MECHANISMS AND METHODS

A step towards characterisation of electrophysiological profile of torsadogenic drugs

(2011) Pascal Champeroux et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Pharmacokinetics of intravenous amiodarone and its electrocardiographic effects on healthy Japanese subjects

(2010) Tsuyoshi Shiga et al.   HEART AND VESSELS

Effects of CYP2D6 Genotype on the Pharmacokinetics, Pharmacodynamics, and Safety of Risperidone in Healthy Volunteers

(2010) Jesús Novalbos et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

hERG in vitro interchange factors—development and verification

(2009) Barbara Wiśniowska et al.   TOXICOLOGY MECHANISMS AND METHODS

Collation, assessment and analysis of literaturein vitrodata on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

(2008) Sebastian Polak et al.   JOURNAL OF APPLIED TOXICOLOGY