Article
Medicine, General & Internal
Yongjun Liu, Xiangyou Yu, Duming Zhu, Jun Zeng, Qinhan Lin, Bin Zang, Chuanxi Chen, Ning Liu, Xiao Liu, Wei Gao, Xiangdong Guan
Summary: This study demonstrates that Ciprofol has comparable tolerability and efficacy to propofol for sedation in mechanically ventilated patients. The plasma concentration-time curves for both drugs were similar.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Xinyi Chen, Xiong Lei, Xin Xu, Yu Zhou, Man Huang
Summary: This retrospective study analyzed the frequency and characteristics of intensive care unit-acquired weakness (ICU-AW) in patients with extracorporeal membrane oxygenation (ECMO) support. The prevalence of ICU-AW in the ECMO population was found to be 80%. Mechanical ventilation time, deep sedation time, deep sedation time during ECMO operation, APACHE II, and lowest albumin level were identified as risk factors for ICU-AW in ECMO patients. ECMO itself was not an independent risk factor for ICU-AW.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Khaled Ahmed Yassen, Matthieu Jabaudon, Hussah Abdullah Alsultan, Haya Almousa, Dur Shahwar, Fatimah Yousef Alhejji, Zainab Yaseen Aljaziri
Summary: Based on a review of literature published between 2005 and 2023, inhaled sedation has been found to reduce extubation and weaning time for mechanically ventilated patients in the ICU, as well as decrease opioid and muscle relaxant consumption. It also has potential cardio-protective, anti-inflammatory, and bronchodilator properties, but careful monitoring and management are required to prevent potential risks.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Y. H. Wang, Xiuming Xi
Summary: The study showed that in mechanically ventilated patients in the intensive care unit, the combination of remifentanil and dexmedetomidine can effectively achieve analgesia and sedation, improve vital signs, shorten treatment time, and have fewer adverse reactions.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Critical Care Medicine
Mariana Luz, Bruna Brandao Barreto, Roberta Esteves Vieira de Castro, Jorge Salluh, Felipe Dal-Pizzol, Caio Araujo, Audrey De Jong, Gerald Chanques, Sheila Nainan Myatra, Eduardo Tobar, Carolina Gimenez-Esparza Vich, Federico Carini, Eugene Wesley Ely, Joanna L. Stollings, Kelly Drumright, John Kress, Pedro Povoa, Yahya Shehabi, Wilson Mphandi, Dimitri Gusmao-Flores
Summary: This survey investigated the current practices of sedation, analgesia, and delirium management in adult intensive care units (ICUs) before and during the COVID-19 pandemic. The study found that most practices remained comparable before and during the pandemic, with the intensive care specialty being associated with best practices during the pandemic.
ANNALS OF INTENSIVE CARE
(2022)
Article
Critical Care Medicine
Matthew A. Roginski, Matthew C. Carroll, Micah L. Trautwein, Evan D. Watkins, Alyson M. Esteves
Summary: The study aimed to assess the impact of deep versus light sedation during critical care transport on mechanically ventilated patients. The results showed that deep sedation during transport did not affect sedation levels or outcomes during hospitalization.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Pei Shang, Jiachun Feng, Wei Wu, Hong-Liang Zhang
Summary: Guillain-Barre syndrome (GBS) is an acute polyneuropathy characterized by acute flaccid paralysis, with current treatment options including immunotherapies and mechanical ventilation in the ICU setting which are largely empirical. This review emphasizes the importance of ICU care and treatment for severe GBS patients, summarizing the latest knowledge on pharmacological therapies and ICU management.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Critical Care Medicine
Zhidong Qi, Sibo Yang, Jingdong Qu, Ming Li, Junbo Zheng, Rui Huang, Zhenyu Yang, Qiuyuan Han, Haibo Li
Summary: Nurse-led sedation protocols in ICUs were found to result in decreased durations of mechanical ventilation, reduced length of ICU stay, lower ICU mortality, decreased incidence of ventilator-associated pneumonia, delirium, and extubation failure.
AUSTRALIAN CRITICAL CARE
(2021)
Article
Critical Care Medicine
Mikaela M. Hofer, Patrick M. Wieruszewski, Scott D. Nei, Kristin Mara, Nathan J. Smischney
Summary: There are differences in sedation practices among different types of ICUs, with Propofol being the most commonly used sedative. Patients in the medical ICU spent more time deeply sedated with multiple agents, which was associated with a higher proportion of delirium.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Hua-Ze Ding, Yi-Ling Dong, Kai-Yue Zhang, Jia-Yu Bai
Summary: Dexmedetomidine administration had no significant effect on 28/30-day mortality and ventilator-free days in septic patients, but it could shorten the length of ICU stay.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aliza K. De Nobrega, Eric J. Noakes, Natalie A. Storch, Alana P. Mellers, Lisa C. Lyons
Summary: Sleep deprivation increases alcohol-induced mortality in fruit flies and abolishes functional tolerance. Chronic sleep deprivation increases alcohol mortality. Pharmacologically inducing sleep decreases alcohol toxicity in middle-aged flies, flies with disrupted circadian clocks, and flies with short sleep.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Andrew J. Casamento, Ary Serpa Neto, Marcus Young, Mervin Lawrence, Christina Taplin, Glenn M. Eastwood, Angajendra Ghosh, Rinaldo Bellomo
Summary: The study compared the effects of fentanyl and morphine on ventilated patients and found that fentanyl infusion significantly increased ventilator-free days at Day 28 compared to morphine. ICU-free days were also greater and length of ICU stay shorter in the fentanyl group. Further investigation is needed to understand the clinical implications of choosing between different opioid infusion agents.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Mamoru Takeuchi, Shintaro Nemoto, Yasuyuki Suzuki, Naoki Takahashi, Nobuko Takenaka, Ami Takata, Mihoko Kobayashi
Summary: The study demonstrated the efficacy, safety, and pharmacokinetics of dexmedetomidine as a sedative for pediatric surgery patients in the ICU. Age-specific dose regimens achieved adequate sedation levels without clinically significant adverse events within the therapeutic range of dexmedetomidine plasma concentration.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Review
Nursing
Tenzin Yiewong, Margarita Corry, Mary Mooney
Summary: This systematic review aimed to evaluate the effectiveness of early administration of dexmedetomidine infusion in preventing delirium, reducing agitation, and improving sleep quality among post-operative adults in ICU. The result indicated a reduction in delirium incidence among the dexmedetomidine group, but data on agitation and sleep quality were limited. Rating: 8/10
NURSING IN CRITICAL CARE
(2023)
Article
Critical Care Medicine
L. Imeen van der Wal, Chloe C. A. Grim, Michael R. del Prado, David J. van Westerloo, E. Christiaan Boerma, Hilda G. Rijnhart-de Jong, Auke C. Reidinga, Bert G. Loef, Pim L. J. van der Heiden, Marnix J. Sigtermans, Frederique Paulus, Alexander D. Cornet, Maurizio Loconte, F. Jeannette Schoonderbeek, Nicolette F. de Keizer, Ferishta Bakhshi-Raiez, Saskia Le Cessie, Ary Serpa Neto, Paolo Pelosi, Marcus J. Schultz, Hendrik J. F. Helmerhorst, Evert de Jonge
Summary: A low-oxygenation strategy did not result in a reduction of 28-day mortality compared with a high-oxygenation strategy in mechanically ventilated ICU patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Clinical Neurology
Lucie Barateau, Regis Lopez, Isabelle Arnulf, Michel Lecendreux, Patricia Franco, Xavier Drouot, Smaranda Leu-Semenescu, Isabelle Jaussent, Yves Dauvilliers
Letter
Critical Care Medicine
Arnaud W. Thille, Ana Cordoba-Izquierdo, Bernard Maitre, Laurent Boyer, Laurent Brochard, Xavier Drouot
INTENSIVE CARE MEDICINE
(2018)
Letter
Critical Care Medicine
Arnaud W. Thille, Faustine Reynaud, Damien Marie, Stephanie Barrau, Ludivine Rousseau, Christophe Rault, Xavier Drouot
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Respiratory System
Arnaud W. Thille, Faustine Reynaud, Damien Marie, Stephanie Barrau, Ludivine Rousseau, Christophe Rault, Veronique Diaz, Jean-Claude Meurice, Remi Coudroy, Jean-Pierre Frat, Rene Robert, Xavier Drouot
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Multidisciplinary Sciences
S. Senova, C. Poupon, J. Dauguet, H. J. Stewart, G. P. Dugue, C. Jan, K. Hosomi, G. S. Ralph, L. Barnes, X. Drouot, C. Pouzat, J. F. Mangin, F. Pain, I. Doignon, R. Aron-Badin, E. Brouillet, E. S. Boyden, K. A. Mitrophanous, P. Hantraye, S. Palfi
SCIENTIFIC REPORTS
(2018)
Article
Critical Care Medicine
John W. Devlin, Yoanna Skrobik, Celine Gelinas, Dale M. Needham, Arjen J. C. Slooter, Pratik P. Pandharipande, Paula L. Watson, Gerald L. Weinhouse, Mark E. Nunnally, Bram Rochwerg, Michele C. Balas, Mark van den Boogaard, Karen J. Bosma, Nathaniel E. Brummel, Gerald Chanques, Linda Denehy, Xavier Drouot, Gilles L. Fraser, Jocelyn E. Harris, Aaron M. Joffe, Michelle E. Kho, John P. Kress, Julie A. Lanphere, Sharon McKinley, Karin J. Neufeld, Margaret A. Pisani, Jean-Francois Payen, Brenda T. Pun, Kathleen A. Puntillo, Richard R. Riker, Bryce R. H. Robinson, Yahya Shehabi, Paul M. Szumita, Chris Winkelman, John E. Centofanti, Carrie Price, Sina Nikayin, Cheryl J. Misak, Pamela D. Flood, Ken Kiedrowski, Waleed Alhazzani
CRITICAL CARE MEDICINE
(2018)
Editorial Material
Anesthesiology
Gerald Chanques, Xavier Drouot, Jean-Francois Payen
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2018)
Article
Critical Care Medicine
Martin Dres, Magdy Younes, Nuttapol Rittayamai, Tetyana Kendzerska, Irene Telias, Domenico Luca Grieco, Tai Pham, Detajin Junhasavasdikul, Edmond Chau, Sangeeta Mehta, M. Elizabeth Wilcox, Richard Leung, Xavier Drouot, Laurent Brochard
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Critical Care Medicine
Christophe Rault, Aude Sangare, Veronique Diaz, Stephanie Ragot, Jean-Pierre Frat, Mathieu Raux, Thomas Similowski, Rene Robert, Arnaud W. Thille, Xavier Drouot
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Review
Critical Care Medicine
Kimia Honarmand, Hammad Rafay, Jamie Le, Sindu Mohan, Bram Rochwerg, John W. Devlin, Yoanna Skrobik, Gerald L. Weinhouse, Xavier Drouot, Paula L. Watson, Sharon McKinley, Karen J. Bosma
CRITICAL CARE MEDICINE
(2020)
Letter
Critical Care Medicine
Christophe Rault, Quentin Heraud, Stephanie Ragot, Rene Robert, Xavier Drouot
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Willy-Paul Westphal, Christophe Rault, Rene Robert, Stephanie Ragot, Jean-Philippe Neau, Pierre-Olivier Fernagut, Xavier Drouot
Summary: Sleep deprivation impairs vagal tone adaptation during inspiratory effort in healthy individuals, decreasing inspiratory endurance. The lack of vagal tonal response to inspiratory load under sleep deprivation results in higher heart rate and reduced inspiratory endurance during the trial.
Article
Critical Care Medicine
Arnaud W. Thille, Stephanie Barrau, Clement Beuvon, Damien Marie, Faustine Reynaud, Justine Bardin, Adrien Pepin-Lehalleur, Vanessa Bironneau, Jean-Claude Meurice, Remi Coudroy, Jean-Pierre Frat, Rene Robert, Christophe Rault, Xavier Drouot
Summary: A study conducted in a medical ICU in France found that sleep time drastically decreased after extubation, with no significant differences in sleep patterns between patients who were successfully extubated and those who developed post-extubation respiratory failure or required reintubation.
ANNALS OF INTENSIVE CARE
(2021)
Article
Critical Care Medicine
Melissa P. Knauert, Najib T. Ayas, Karen J. Bosma, Xavier Drouot, Mojdeh S. Heavner, Robert L. Owens, Paula L. Watson, M. Elizabeth Wilcox, Brian J. Anderson, Makayla L. Cordoza, John W. Devlin, Rosalind Elliott, Brian K. Gehlbach, Timothy D. Girard, Biren B. Kamdar, Kenneth Kiedrowski Amy S. Korwin, Elizabeth R. Lusczek, Sairam Parthasarathy, Claudia Spies, Jag Sunderram, Irene Telias, Gerald L. Weinhouse, Phyllis C. Zee
Summary: Sleep and circadian disruption (SCD) is common and severe in the ICU, and it has a profound negative impact on patient outcomes. Establishing research priorities to advance understanding of ICU SCD is urgent.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Clinical Neurology
Christophe Rault, Quentin Heraud, Stephanie Ragot, Jean-Pierre Frat, Arnaud W. Thille, Xavier Drouot
Summary: Due to the noisy environment, many patients in intensive care units suffer from severe sleep disruption, which can lead to prolonged assisted ventilation or even death. Sleep scoring in critical care is challenging and limited to experienced teams. We developed a real-time automated sleep scoring system and compared it with visual scoring.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)