Article
Clinical Neurology
Ashley L. Garrett, Jason Burch, Yue Zhang, Haojia Li, Krishna M. Sundar, Robert J. Farney
Summary: This retrospective study compared standard AASM criteria with alternative criteria to better measure sleep-disordered breathing induced by VNS and assessed clinically relevant outcome variables and response to positive airway pressure therapy. The study found that the AASM scoring criteria significantly underestimated the degree of respiratory disturbances caused by VNS, and VNS events were not associated with increased arousals or significant hypoxemia. PAP therapy was ineffective in treating this population.
Article
Sport Sciences
Kathleen H. Miles, Brad Clark, Peter M. Fowler, Madeleine J. Gratwicke, Kristy Martin, Marijke Welvaert, Joanna Miller, Kate L. Pumpa
Summary: Supplementation with A-LAC significantly improves sleep and performance recovery in female athletes after evening competitions, particularly in terms of non-rapid eye movement stage 2 sleep and Yo-Yo Intermittent Recovery Test Level 1 distance.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Editorial Material
Medicine, General & Internal
Scott Hoff, Nancy Collop
Summary: A 50-year-old patient with epilepsy, hypertension, loud snoring, recent 50-lb weight gain, and abrupt awakenings with a feeling of breathlessness but no headaches or excessive daytime sleepiness presented with concerns. What would you do next?
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Elizabeth Harrison, Robert H. Roth, Jennifer M. Lobo, Hyojung Kang, Jeongok Logan, Sanjay R. Patel, Vishesh K. Kapur, Younghoon Kwon
Summary: Objective sleep quality was assessed in patients undergoing laboratory-based polysomnography, revealing that older age, male gender, and severe obstructive sleep apnea were associated with shorter sleep duration and lower sleep efficiency. Antidepressant use was found to have a protective effect against short sleep duration.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Review
Hospitality, Leisure, Sport & Tourism
Angelos Vlahoyiannis, George Aphamis, Gregory C. Bogdanis, Giorgos K. Sakkas, Eleni Andreou, Christoforos D. Giannaki
Summary: This systematic review examined objective sleep parameters for athletes under different conditions and found that athletes had shorter sleep duration and lower sleep efficiency compared to non-athlete healthy adults. Young athletes were particularly prone to sleep issues, and sleep quality and architecture varied across different training periods.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2021)
Article
Clinical Neurology
Ze-Fei Zhang, Xian Su, Yi Zhao, Chong-Lin Zhong, Xiao-Qian Mo, Rui Zhang, Kun Wang, Sai-Nan Zhu, Yan-E Shen, Cheng Zhang, Dong-Xin Wang
Summary: In this randomized trial, researchers found that mini-dose dexmedetomidine supplemented analgesia improved sleep structure in older patients recovering from major surgery without increasing sedation.
Article
Clinical Neurology
Minh Khoa Truong, Mathieu Berger, Jose Haba-Rubio, Francesca Siclari, Pedro Marques-Vidal, Raphael Heinzer
Summary: Current smokers exhibit poorer objective sleep quality, with a dose-dependent decrease in delta power and an increase in alpha power during non-REM sleep. These findings suggest a negative association between smoking intensity and sleep quality, supporting the importance of smoking cessation for overall wellbeing.
Article
Critical Care Medicine
L. J. Delaney, E. Litton, K. L. Melehan, H. -C. C. Huang, V. Lopez, F. Van Haren
Summary: This study investigated the feasibility and reliability of using actigraphy for sleep monitoring in intensive care unit patients. Results showed that actigraphy had a moderate level of agreement with polysomnography in distinguishing between sleep and wakeful states, especially among non-ventilated patients. The study suggests that actigraphy may be a reasonable alternative to measure sleep in intensive care settings.
Article
Clinical Neurology
Yan Ma, Michael R. Goldstein, Roger B. Davis, Gloria Y. Yeh
Summary: This study found significant subjective-objective sleep discrepancy in patients with insomnia and comorbid OSA, with insomnia having the strongest association with sleep discrepancy and negative impact on QOL. Patients with comorbid OSA reported the greatest sleep discrepancy and lowest QOL. Further research is needed to understand individual profiles of misperception and insomnia phenotypes.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Medicine, General & Internal
Maximilian Wollsching-Strobel, Iris Anna Bauer, Johannes Julian Baur, Daniel Sebastian Majorski, Friederike Sophie Magnet, Jan Hendrik Storre, Wolfram Windisch, Sarah Bettina Schwarz
Summary: Non-invasive ventilation therapy does not decrease sleep quality in COPD patients and can even improve health-related quality of life, decrease daytime sleepiness and respiratory disturbance index (RDI), especially in patients with comorbid obstructive sleep apnea syndrome (OSAS).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Wei Yang Lim, Kay Choong See
Summary: Obstructive sleep apnea (OSA) is a highly prevalent condition worldwide and if left untreated, it can lead to multiple medical complications and a decreased quality of life. Using total bed time instead of total sleep time to quantify OSA severity may underestimate the severity of the disease. A study found that risk factors for underestimating OSA severity include age and body-mass index.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Line Pickering, Katharina M. Main, Astrid Sehested, Rene Mathiasen, Ulla Feldt-Rasmussen, Marianne Klose, Suresh Kotagal, Poul J. Jennum
Summary: This study found that children with brain tumours involving the sleep-wake regulatory areas were sleepier/fatigued, had more emotional and mental health problems, and had poorer quality of life compared to those with tumours that did not involve these areas.
Article
Clinical Neurology
Ofer Jacobowitz, Lamia Afifi, Thomas Penzel, Dalva Poyares, Marie Marklund, Clete Kushida
Summary: A task force evaluated the American Academy of Sleep Medicine's clinical practice guideline on the treatment of adult obstructive sleep apnea. The guideline was found to be relevant and applicable to the practice of sleep medicine in various regions of the world, with caveats for universal applicability.
Article
Multidisciplinary Sciences
J. Perrier, M. Duivon, P. Clochon, S. Rehel, F. Doidy, J. M. Grellard, C. Segura-Djezzar, J. Geffrelot, G. Emile, D. Allouache, C. Levy, S. Polvent, F. Viader, F. Eustache, F. Joly, B. Giffard
Summary: Sleep disturbance is common among breast cancer survivors, with differences in sleep structure compared to healthy controls, including increased awakenings, decreased Delta power during sleep deepening and recovery, increased Alpha and Beta power related to arousal during deep sleep, and decreased Theta power related to emotional regulation during dream sleep.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Clinical
Francesca Perini, Kian Foong Wong, Jia Lin, Zuriel Hassirim, Ju Lynn Ong, June Lo, Jason C. Ong, Kinjal Doshi, Julian Lim
Summary: This study compared Mindfulness-Based Therapy for Insomnia (MBTI) with a Sleep Hygiene, Education, and Exercise Program (SHEEP) in improving sleep quality in older adults. The results showed that MBTI was more effective in reducing insomnia severity and improving sleep quality compared to SHEEP.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Francesca Ghilotti, Rino Bellocco, Ylva Trolle Lagerros, Anna Thorson, Jenny Theorell-Haglow, Torbjorn Akerstedt, Eva Lindberg
Summary: The study found that sleep disturbances, specifically difficulties in falling asleep and waking up early, but not sleep duration, were associated with higher CRP levels. No association was found with IL-6 or TNF alpha. Higher amounts of REM sleep were associated with lower CRP levels, suggesting that inflammation may link sleep and health in women.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Gabriel Baldanzi, Ulf Hammar, Tove Fall, Eva Lindberg, Lars Lind, Solve Elmstahl, Jenny Theorell-Haglow
Summary: This population-based study found that proteins related to cardiometabolic risk were elevated in individuals with evening chronotype, providing guidance for future research on the relationship between chronotype and cardiometabolic disorders.
Article
Clinical Neurology
Ossur Ingi Emilsson, Hamza Al Yasiry, Jenny Theorell-Haglow, Mirjam Ljunggren, Eva Lindberg
Summary: Insufficient sleep and short sleep are associated with an increased risk of new-onset nocturnal gastroesophageal reflux (nGER). Women with insufficient or short sleep have a higher likelihood of developing nGER over a 10-year follow-up compared to those with sufficient sleep. Healthcare providers should inquire about sleep habits when treating women with nGER to identify insufficient sleep as a potential causative factor.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Mirjam Ljunggren, Tord Naessen, Jenny Theorell-Haglow, Karl A. Franklin, Eva Lindberg
Summary: Sleep apnea during REM sleep is associated with early signs of atherosclerosis, with a stronger association observed in women compared to men.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mona-Lisa Wernroth, Sari Peura, Anna M. Hedman, Susanne Hetty, Silvia Vicenzi, Beatrice Kennedy, Katja Fall, Bodil Svennblad, Ellika Andolf, Goran Pershagen, Jenny Theorell-Haglow, Diem Nguyen, Sergi Sayols-Baixeras, Koen F. Dekkers, Stefan Bertilsson, Catarina Almqvist, Johan Dicksved, Tove Fall
Summary: This study used 16S rRNA sequencing to analyze fecal and saliva samples from infants and their mothers at four time points during the first 2 years of life. The findings showed that gut microbiota in infants have low diversity and share some properties with the oral microbiota. The composition of gut microbiota undergoes a significant shift during the first 2 years of life, towards a more diverse adult-like microbiota.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Karl A. Franklin, Eva Lindberg, Johan Svensson, Christel Larsson, Bernt Lindahl, Caroline Mellberg, Carin Sahlin, Tommy Olsson, Mats Ryberg
Summary: A palaeolithic diet can be effective in reducing sleep apnoea in overweight postmenopausal females, but significant weight loss of 8 kg is necessary to see noticeable improvement.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Clinical Neurology
Peter J. Johansson, Patrick Crowley, John Axelsson, Karl Franklin, Anne Helene Garde, Pasan Hettiarachchi, Andreas Holtermann, Goran Kecklund, Eva Lindberg, Mirjam Ljunggren, Emmanuel Stamatakis, Jenny Theorell Haglow, Magnus Svartengren
Summary: Accelerometers placed on the thigh provide accurate measures of daily physical activity types, postures, and sedentary behaviors. However, their ability to estimate sleep duration or quality has not been thoroughly evaluated. This study developed an algorithm to estimate sleep using thigh-worn accelerometers and compared it with polysomnography. The algorithm had good sensitivity and specificity in estimating sleep periods, although sleep intervals and total sleep time were slightly underestimated.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Respiratory System
Andreas Rydell, Elisabet Nerpin, XingWu Zhou, Lars Lind, Eva Lindberg, Jenny Theorell Haglow, Tove Fall, Christer Janson, Karin Lisspers, Solve Elmstahl, Suneela Zaigham, Olle Melander, Peter M. Nilsson, Johan Arnlov, Andrei Malinovschi
Summary: This study found that several inflammatory and cardiovascular disease-related plasma proteins were associated with impaired lung function. Specifically, four proteins were negatively associated with FEV1 and FVC, while four proteins were positively associated with FVC. No proteins were associated with FEV1/FVC ratio. Additional studies are needed to investigate the underlying mechanisms for these findings.
Article
Critical Care Medicine
Gabriel Baldanzi, Sergi Sayols-Baixeras, Jenny Theorell-Haglow, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Yi-Ting Lin, Shafqat Ahmad, Jacob Bak Holm, Henrik Bjorn Nielsen, Louise Brunkwall, Christian Benedict, Jonathan Cedernaes, Sanna Koskiniemi, Mia Phillipson, Lars Lind, Johan Sundstrom, Goran Bergstrom, Gunnar Engstrom, J. Gustav Smith, Marju Orho-Melander, Johan Arnlov, Beatrice Kennedy, Eva Lindberg, Tove Fall
Summary: This study explores the relationship between obstructive sleep apnea (OSA) and the composition and potential functions of the human gut microbiota. The results show that OSA-related hypoxia is associated with specific gut microbiota species and functions, and can lead to a decrease in microbial diversity. These findings provide a foundation for future research on the health effects of OSA on the gut microbiota.
Article
Medicine, General & Internal
Andreas Palm, J. Theorell-Haglow, Johan Isakson, Mirjam Ljunggren, Josefin Sundh, Magnus Per Ekstrom, Ludger Grote
Summary: This cross-sectional study investigated the association between OSA measures and cancer prevalence in a large patient cohort in Sweden. The results showed that OSA patients with cancer had higher AHI and ODI compared to matched OSA patients without cancer. Subgroup analysis also revealed higher ODI in OSA patients with lung cancer, prostate cancer, and malignant melanoma.
Article
Medicine, General & Internal
Ludger Grote, Carl-Peter Anderberg, Danielle Friberg, Gert Grundstrom, Kerstin Hinz, Goran Isaksson, Tarmo Murto, Zarita Nilsson, Jonas Spaak, Goran Stillberg, Karin Soderberg, Ake Tegelberg, Jenny Theorell-Haglow, Martin Ulander, Jan Hedner
Summary: This paper describes the development of Swedish Guidelines for OSA treatment, which includes a novel treatment matrix based on treatment effects rather than the traditional parameter of Apnea Hypopnea Index (AHI). The matrix considers factors such as OSA-related symptoms, comorbidities, respiratory event frequency, and age to determine the indication for treatment. The implementation of this matrix is currently ongoing nationwide and is being monitored through the Swedish Sleep Apnea Registry.
Meeting Abstract
Respiratory System
M. E. Ljunggren, T. Naessen, J. Theorell-Haglow, K. Franklin, E. Lindberg
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
A. Palm, J. Theorell-Haglow, J. Isaksson, M. Ljunggren, J. Sundh, M. Ekstrom, L. Grote
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
B. Delshad, M. Ljunggren, X. Zhou, J. Theorell-Haglow, C. Janson, D. Zou, J. Hedner, L. Grote, A. Blomberg, K. A. Franklin, C. Sahlin, A. Malinovschi, E. Lindberg
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
A. Rydell, E. Nerpin, X. W. Zhou, L. Lind, E. Lindberg, J. Theorell Haglow, T. Fall, C. Janson, K. Lisspers, S. Elmstahl, S. Zaigham, O. Melander, P. Nilsson, M. Orh U-Melander, J. Arnlov, A. Malinovschi
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.