Article
Clinical Neurology
Raffaele Ferri, Maria P. Mogavero, Oliviero Bruni, Giuseppe Plazzi, Carlos H. Schenck, Lourdes M. DelRosso
Summary: The study found that selective serotonin reuptake inhibitor (SSRI) antidepressants can modify chin electromyogram (EMG) tone in children during sleep, and different SSRI medications may have differential effects on chin tone during sleep.
Article
Clinical Neurology
Raffaele Ferri, Maria P. Mogavero, Oliviero Bruni, Giuseppe Plazzi, Carlos H. Schenck, Lourdes M. DelRosso
Summary: The study found that children taking SSRI antidepressants had significantly reduced chin EMG tone during sleep, while children diagnosed with narcolepsy type 1 performed the worst in terms of chin EMG tone. In addition, different SSRI medications may have different effects on chin EMG tone during sleep.
Article
Neurosciences
Shuntaro Uchida, Shingo Soya, Yuki C. Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
Summary: This study identified a specific subpopulation of Gly(VMM) neurons in the ventromedial medulla that are involved in generating muscle atonia during REM sleep. Silencing this circuit resulted in REM sleep without muscle atonia and reduced time spent in cataplexy-like episodes. Additionally, Gly(VMM) neurons also play a crucial role in maintaining sleep and cataplexy.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Utku Ogan Akyildiz, F. Irsel Tezer, Guray Koc, Sevda Ismailogullari, Aylin Bican Demir, Aysin Kisabay Ak, Gulin Sunter, Kezban Aslan Kara, Deniz Tuncel Berktas, Aysenur Sahin, Filiz Azman, Bulent Devrim Akcay, Duygu Kurt Gok, Hikmet Yilmaz, Kadriye Agan, Yavuz Bekmezci, Sinan Yetkin, Murat Aksu, Derya Karadeniz, Gulcin Benbir Senel
Summary: This study aimed to evaluate the characteristics of REM sleep in patients with narcolepsy. The results showed that the increase in REM density during REM sleep may be a major correlate of RSWA. There was a positive correlation between the total duration of REMs and the mean durations of RSWA. The REMs index demonstrated moderate sensitivity and specificity in the diagnosis of RSWA.
Article
Clinical Neurology
Markus H. Schmidt, Claudio L. A. Bassetti
Summary: Three papers published in SLEEP using different mouse models of narcolepsy indicate significant gender differences in the expression of narcolepsy symptoms. Female mice exhibit more cataplexy events and greater overall cataplexy expression compared to males. Additionally, female mice in the neurotoxic DTA mouse model experience cataplexy symptoms earlier than males during the loss of Hcrt cells. Furthermore, the occurrence of cataplexy is twice as frequent during the estrous phase in females. These findings highlight the need for further research on gender differences in human narcolepsy.
Review
Clinical Neurology
Jung-Ick Byun, Tae-Won Yang, Jun-Sang Sunwoo, Won Chul Shin, Oh-Young Kwon, Ki-Young Jung
Summary: Manual quantification of rapid eye movement (REM) sleep without atonia (RWA) using chin or phasic flexor digitorum superficialis (FDS) activity shows the best diagnostic performance for REM sleep behavior disorder (RBD). The automatic REM atonia index (RAI) method may be useful for screening RBD patients.
Review
Neurosciences
Mortimer Mamelak
Summary: Sodium oxybate is a medication used to treat narcolepsy with cataplexy. It acts as a weak GABAB agonist and an antioxidant, improving alertness and correcting neuronal imbalance.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai
Summary: The sleep cycle involves alternating non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. A transient increase of dopamine in the basolateral amygdala terminates NREM sleep and initiates REM sleep, playing a critical role in sleep cycle generation. This mechanism is also implicated in cataplectic attacks in narcoleptics.
Article
Clinical Neurology
Lourdes M. DelRosso, Maria P. Mogavero, Amy Fickensher, Oliviero Bruni, Carlos H. Schenck, Raffaele Ferri
Summary: This study aims to evaluate the effects of bupropion on periodic limb movements during sleep (PLMS) and chin electromyography tone in children with mood disorders, compared to SSRIs and the combination of bupropion and SSRIs. The results show that SSRIs significantly increase PLMS, while bupropion only slightly increases nonperiodic leg movements during sleep. Bupropion appears to counteract the SSRI-induced increase in PLMS when administered in combination, but has no effect on the effects of SSRIs on chin electromyography tone.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Lourdes M. DelRosso, Maria P. Mogavero, Oliviero Bruni, Carlos H. Schenck, Amy Fickenscher, Raffaele Ferri
Summary: This study aimed to compare the effects of trazodone and selective serotonin reuptake inhibitors (SSRIs) on sleep in children. The results showed that children taking SSRIs had increased leg movements during sleep, while the trazodone group had slightly higher leg movements than the normal control group. In addition, chin electromyogram atonia was decreased in the SSRIs group. This suggests that the assessment of periodic limb movement disorder and REM sleep without atonia may be influenced by SSRIs.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Samantha Mombelli, Francois Ricordeau, Lea Gillard, Rosa Lecca, Tiphaine Vidal, Bruno Pereira, Patricia Beudin, Nicolas Vitello, Helene Bastuji, Laure Peter-Derex, Maria Livia Fantini
Summary: REM sleep behaviour disorder (RBD) is common in narcolepsy type 1 (NT1), and abnormalities in the reward system have been observed in NT1 patients with RBD. However, no differences were found between NT1 patients with and without RBD in neuropsychological variables except for impaired objective attention in NT1-RBD patients. NT1 patients showed higher depression, apathy, and impulsivity compared with controls, and these measures correlated with the severity of REM sleep without atonia (RSWA).
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Clinical Neurology
Ambra Stefani, Birgit Hoegl
Summary: Nightmare disorder and isolated sleep paralysis are common REM sleep disorders that can cause distress. Nightmare disorder is related to emotion regulation and hyperarousal, with imagery rehearsal therapy being an effective nonmedication treatment; isolated sleep paralysis may result from REM atonia persisting into wakefulness, and therapy mainly involves avoiding predisposing factors.
Article
Clinical Neurology
A. Romigi, M. Caccamo, F. Testa, D. Ticconi, S. Cappellano, B. Di Gioia, G. Vitrani, I. Rosenzweig, D. Centonze
Summary: This study aimed to determine the changes in muscle tone (atonia index, AI) at different levels of vigilance during the multiple sleep latency test (MSLT) and each nap in narcolepsy patients. The results showed that AI during wakefulness was significantly higher in narcolepsy patients compared to other hypersomnia patients. AI during REM sleep and wakefulness in naps with sudden onsets of REM sleep periods were lower in NT1 than in NT2. AI during wakefulness had a high diagnostic value in distinguishing patients with other hypersomnias, while AI during REM sleep and wakefulness in naps with SOREMP showed a poor ability to differentiate NT1 and NT2.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Charles J. Bae, Phyllis C. Zee, Eileen B. Leary, Douglas S. Fuller, Wayne Macfadden, Shawn Candler, Teresa L. Steininger, Aatif M. Husain
Summary: The TENOR study aimed to provide real-world insight into the experience of individuals with narcolepsy transitioning from sodium oxybate to low-sodium oxybate. The findings showed that the effectiveness and tolerability remained stable during the transition from sodium oxybate to low-sodium oxybate treatment.
Article
Chemistry, Analytical
Mo H. Modarres, Jonathan E. Elliott, Kristianna B. Weymann, Dennis Pleshakov, Donald L. Bliwise, Miranda M. Lim
Summary: Surface electromyography (EMG) is important in defining sleep stages and certain disease states. A digitized signal processing method using spectral power ratio was developed to evaluate EMG signals. Through further refinement and validation, an accurate automated EMG quantification approach was achieved.
Article
Clinical Neurology
Marie-Laure Ancelin, Isabelle Jaussent, Karen Ritchie, Alain Besset, Joanne Ryan, Yves Dauvilliers
Summary: This study examines the association between BDNF variants and promoter I methylation with sleep disturbances in older adults. The results show that wake time after sleep onset (WASO) is associated with four SNPs in participants not taking psychotropic drugs, while the associations are either not significant or in the reverse direction in participants taking drugs. Higher BDNF methylation levels are found in participants with long WASO, and this varies depending on psychotropic drug use.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Sofiene Chenini, Lucie Barateau, Lily Guiraud, Marie-Lou Rollin, Regis Lopez, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: One-third of patients with restless legs syndrome reported a decrease in symptoms during cognitive activities, and this improvement was confirmed during a sustained cognitive task.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Lourdes M. DelRosso, Jodi Mindell, Oliviero Bruni, Maria P. Mogavero, Raffaele Ferri
Summary: Sleep disturbances are common in infants, and sleep-related movement disorders can contribute to sleep disruption. This study found that preterm infants had higher periodic limb movement index and lower ferritin levels compared to infants with Down syndrome, Prader-Willi syndrome, or without diagnosis. Hemoglobin and ferritin were negatively correlated with periodic limb movement index, and iron deficiency is associated with increased leg movements during sleep in infants.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Clinical Neurology
Raffaele Ferri, Simon J. G. Lewis, Valerie Cochen De Cock, Naoko Tachibana, Clete A. Kushida, Carlos H. Schenck
Article
Clinical Neurology
Giuliano De Meo, Melania Martucci, Maria Ausilia Musumeci, Miriam Aric, Martina Forlani, Lourdes M. DelRosso, Raffaele Ferri, Oliviero Bruni
Summary: Restless sleep disorder (RSD) is a separate condition characterized by frequent large muscle movements (LMM) per hour of sleep. This study compared the scoring of LMM using video-PSG (vPSG) and PSG criteria in children with RSD. Results showed that PSG criteria detected more LMM than vPSG, indicating higher sensitivity. These findings suggest that PSG criteria should be considered for inclusion in the current sleep scoring manual.
Article
Clinical Neurology
Yves Dauvilliers, Thomas Roth, Richard Bogan, Michael J. Thorpy, Anne Marie Morse, Asim Roy, Jordan Dubow, Jennifer Gudeman
Summary: This study evaluated the efficacy of extended-release once-nightly sodium oxybate (ON-SXB; FT218) compared to placebo for daytime sleepiness and disrupted nighttime sleep in narcolepsy type 1 (NT1) and 2 (NT2). The results showed significant improvements in sleep latency, sleep quality, nocturnal arousals, and daytime sleepiness for both NT1 and NT2 subgroups treated with ON-SXB compared to placebo.
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Lanza, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso, Fabio Galvano, Sabrina Castellano
Summary: The increase in life expectancy has led to a higher prevalence of age-related neurological diseases, such as cognitive impairment, dementia, and Alzheimer's disease. This study aimed to examine the association between specific categories and subcategories of dietary fats and cognitive status in older Italian adults. The results showed that moderate consumption of certain types of saturated fatty acids and monounsaturated fatty acids was associated with a lower risk of cognitive impairment, while moderate intake of linoleic acid was associated with a higher risk of cognitive impairment.
Article
Biochemistry & Molecular Biology
Akeem Sanni, Mona Goli, Jingfu Zhao, Junyao Wang, Chloe Barsa, Samer El Hayek, Farid Talih, Bartolo Lanuzza, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Stefania Mondello, Raffaele Ferri, Yehia Mechref
Summary: This study aimed to identify potential serum biomarkers for narcolepsy type 1 (NT1), a life-threatening disorder characterized by a sleep-wake cycle disorder. A proteomics analysis was conducted, which revealed 36 differentially expressed proteins associated with NT1. These findings provide insights into the pathophysiological effects and important biochemical pathways involved in NT1.
Article
Neurosciences
Anna Castelnovo, Silvia Miano, Raffaele Ferri, Alberto Raggi, Michelangelo Maestri, Valentina Bottasini, Matteo Anelli, Marco Zucconi, Vincenza Castronovo, Luigi Ferini-Strambi, Mauro Manconi
Summary: The study aimed to evaluate the neuropsychological and neurophysiological profile of chronic insomniacs taking long-term high doses of benzodiazepine. The results showed that patients with chronic insomnia and benzodiazepine use disorder exhibited significant frontal lobe executive dysfunction, particularly in the cognitive flexibility domain, while their working memory, short-term memory, and long-term memory were relatively preserved. Compared to the control group, patients had a decrease in P300 amplitude, mainly in the frontal regions. Therefore, careful evaluation and management of long-term high-dose benzodiazepine intake should be considered for this specific patient population, especially regarding risky activities.
Article
Neurosciences
Claudio Babiloni, Susanna Lopez, Giuseppe Noce, Raffaele Ferri, Simonetta Panerai, Valentina Catania, Andrea Soricelli, Marco Salvatore, Flavio Nobili, Dario Arnaldi, Francesco Fama, Federico Massa, Carla Buttinelli, Franco Giubilei, Fabrizio Stocchi, Laura Vacca, Moira Marizzoni, Fabrizia D'Antonio, Giuseppe Bruno, Carlo De Lena, Bahar Guntekin, Ebru Yildirim, Lutfu Hanoglu, Goersev Yener, Deniz Yerlikaya, John Paul Taylor, Julia Schumacher, Ian Mckeith, Laura Bonanni, Patrizia Pantano, Claudia Piervincenzi, Nikolaos Petsas, Giovanni B. Frisoni, Claudio Del Percio, Filippo Carducci
Summary: This study examined the relationship between cortical default mode network (DMN) structural integrity and resting state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). The results showed a significant positive association between the DMN gray matter volume, rsEEG alpha source activity in the posterior DMN nodes, and global cognitive status in both ADD and normal elderly individuals. Compared to the normal elderly group, the ADD group had lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status.
Article
Clinical Neurology
Andrea Zagaria, Scarpelli Serena, Alessandro Musetti, Giada Rapelli, Luigi De Gennaro, Giuseppe Plazzi, Christian Franceschini
Summary: This study investigated changes in sleep problems during the COVID-19 pandemic and found a link between sleep hygiene practices and sleep disruptions. Improving sleep hygiene practices may help mitigate the negative impact of the COVID-19 pandemic on sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Nutrition & Dietetics
Maria P. Mogavero, Justyna Godos, Giuseppe Grosso, Filippo Caraci, Raffaele Ferri
Summary: This review focuses on the relationship between sleep-wake regulation and appetite control, emphasizing the inhibitory effect of OREXIN, a neurotransmitter, on REM sleep. It further examines the intricate relationship between OREXIN, REM sleep, and appetite regulation, shedding light on their interconnected nature in both physiological conditions and diseases. Understanding this complex relationship is crucial for unraveling the mechanisms underlying sleep-wake patterns and metabolic control, and for developing novel therapeutic approaches to sleep disorders and metabolic conditions associated with OREXIN dysregulation.
Article
Clinical Neurology
Oliviero Bruni, Maria Breda, Emanuela Malorgio, Paolo Brambilla, Flavia Ceschin, Andrea Di Pilla, Maurizio Elia, Raffaele Ferri
Summary: This study aimed to describe the use of melatonin by Italian pediatricians in healthy children with chronic insomnia. The results showed that a high percentage of pediatricians prescribed melatonin, especially in children aged 1-2 years. The most common dosage was 1 mg/day and it was usually recommended to be taken 30 minutes before bedtime. Melatonin was often combined with sleep hygiene and was found to be effective in reducing difficulties falling asleep.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Giuseppe Plazzi, Fabio Pizza, Michel Lecendreux, Paul Gringras, Lucie Barateau, Oliviero Bruni, Patricia Franco, Alex Iranzo, Poul Jennum, Ramin Khatami, Stine Knudsen-Heier, Silvia Miano, Lino Nobili, Markku Partinen, Paul Reading, Karel Sonka, Attila Szakacs, Massimo Zenti, Ulf Kallweit, Gert J. Lammers, Yves Dauvilliers, Claudio L. A. Bassetti
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Claudio Babiloni, Claudio Del Percio, Claudia Piervincenzi, Filippo Carducci, Raffaele Ferri, Paolo Onorati, Ginevra Toma, Stefano Ferracuti, Paolo Roma, Valentina Correr, Francesco Di Campli, Antonio Aceti, Marco Salvatore, Andrea Soricelli, Elisabetta Teti, Alfredo Pennica, Loredana Sarmati, Vincenzo Vullo, Gabriella D'Ettorre, Claudio Mastroianni, Nikolaos Petsas, Patrizia Pantano, Roberto Floris, Fabrizio Stocchi, Massimo Andreoni, Giovanni Di Perri, Andrea Calcagno, Giuseppe Noce
Summary: The abnormal connectivity of parietal resting-state electroencephalographic (rsEEG) alpha waves is associated with subcortical white matter vascular lesions in HIV-positive individuals, even without neurocognitive disorders. These rsEEG markers can be used to screen HIV-positive individuals at risk of neurocognitive disorders.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
