Review
Clinical Neurology
Michelle A. Miller, Francesco P. Cappuccio
Summary: This study reviewed the relationship between OSA and COVID-19 outcomes, finding that risk factors associated with OSA are also linked to poor COVID-19 outcomes. Plausible mechanisms suggest OSA may independently increase the risk of death from COVID-19. The study also highlights the major impact of COVID-19 on the diagnosis and treatment of OSA.
SLEEP MEDICINE REVIEWS
(2021)
Article
Multidisciplinary Sciences
Michael S. H. Chou, Natasha C. H. Ting, Nicole El-Turk, Zinta Harrington, Claudia C. Dobler
Summary: This study found that patients using CPAP for OSA experience significant treatment burden, including healthcare tasks, consequences of healthcare tasks, exacerbating and alleviating factors of treatment burden. Patients commonly reported burden from attending healthcare appointments, treatment cost, lifestyle changes, treatment side effects and general discomfort.
Review
Biochemistry & Molecular Biology
Abdulmohsen Alterki, Mohamed Abu-Farha, Eman Al Shawaf, Fahd Al-Mulla, Jehad Abubaker
Summary: Obstructive sleep apnoea (OSA) is a prevalent but underdiagnosed disorder that disrupts the circadian rhythm and is characterized by frequent interruptions in breathing during sleep, leading to systemic consequences. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases, and it is also linked to obesity. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation, and metabolic dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
David Stevens, Chris Barr, Katherine Bassett, Aaron Oh, Stephen R. Lord, Maria Crotty, Kelsey Bickley, Sutapa Mukherjee, Andrew Vakulin
Summary: This study examined the effect of continuous positive airway pressure (CPAP) on fall risk markers in people over 65yrs diagnosed with obstructive sleep apnoea (OSA). The results showed that CPAP significantly reduced fall risk and improved visual contrast sensitivity and lower limb proprioception.
Review
Medicine, General & Internal
Frederico T. Barbosa, Michele P. Silva, Luis Eduardo S. Fontes, Daniela Pachito, Tamara Melnik, Rachel Riera
Summary: The study evaluated the effectiveness and acceptability of CPAP therapy for improving erectile dysfunction in OSAS patients. Uncertainty was found in the comparison of CPAP with no CPAP, while sildenafil may slightly improve erectile function at 12 weeks compared to CPAP.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Phoebe K. Yu, Jerilynn Radcliffe, H. Gerry Taylor, Raouf S. Amin, Cristina M. Baldassari, Thomas Boswick, Ronald D. Chervin, Lisa M. Elden, Susan L. Furth, Susan L. Garetz, Alisha George, Stacey L. Ishman, Erin M. Kirkham, Christopher Liu, Ron B. Mitchell, S. Kamal Naqvi, Carol L. Rosen, Kristie R. Ross, Jay Shah, Ignacio E. Tapia, Lisa R. Young, David A. Zopf, Rui Wang, Susan Redline
Summary: The relationship between the severity of obstructive sleep apnea and neurobehavioral morbidity is unclear. This study compares the neurobehavioral symptoms of mild sleep-disordered breathing and obstructive sleep apnea, finding that children with mild sleep-disordered breathing have more abnormal executive function scores and higher rates of inattention and hyperactivity compared to children with obstructive sleep apnea.
Review
Cardiac & Cardiovascular Systems
Miuni Athauda Arachchige, Joerg Steier
Summary: Obstructive Sleep Apnoea (OSA) is a common condition that can have a significant impact on physical and mental health, including an increased risk of cardiovascular diseases. Continuous Positive Airway Pressure (CPAP) therapy is the recommended treatment for moderate to severe OSA, but long-term adherence remains a challenge. There are alternative non-CPAP treatments available, such as lifestyle changes, surgical options, and nerve stimulation. When choosing long-term therapies, symptom control, patient-related outcomes, and long-term cardiovascular health should be prioritized.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pediatrics
Eduardo Machado Rossi-Monteiro, Laura Rodrigues Sefair, Marcos Correia Lima, Maria Fernanda Lima Nascimento, Daniel Mendes-Pinto, Lukas Anschuetz, Maria Gloria Rodrigues-Machado
Summary: This study aimed to compare cardiovascular parameters between healthy children and those with obstructive sleep-disordered breathing (oSDB), as well as identify predictors of arterial stiffness indices in children with oSDB. Children with oSDB showed higher reflection coefficient and augmentation index compared to controls, indicating increased arterial stiffness. Multiple regression analysis revealed age, female sex, reflection coefficient, and systolic volume as independent predictors of augmentation index, while higher pulse wave velocity was associated with poorer quality of life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biology
Konstantinos Chaidas, Kallirroi Lamprou, Amberley Munnings, John R. Stradling, Annabel H. Nickol
Summary: This study aimed to investigate the association between CPAP usage and nasal symptoms in patients with obstructive sleep apnoea. The findings suggested that runny nose was a predictive factor for poorer CPAP adherence and worsened after three months of high-CPAP usage.
Review
Pediatrics
Melissa Borrelli, Adele Corcione, Chiara Cimbalo, Anna Annunziata, Simona Basilicata, Giuseppe Fiorentino, Francesca Santamaria, Jun Kohyama
Summary: Obstructive sleep-disordered breathing (SDB) has a significant impact on health, and a timely and accurate diagnosis is important. Current diagnostic methods for SDB in children include clinical assessment, medical history evaluation, questionnaires, and objective measurements. Polysomnography (PSG) is the gold standard, but it is time-consuming and expensive. Alternative techniques such as respiratory polygraphy and nocturnal oximetry have their limitations and further research is needed on their use in children. Laboratory biomarkers and radiological findings show potential but require standardization in clinical practice.
Article
Clinical Neurology
Sandeep Raut, Gaurav Gupta, Rajiv Narang, Animesh Ray, R. M. Pandey, Atul Malhotra, Sanjeev Sinha
Summary: The study found a significant association between OSA severity and ventricular function as well as cardiac injury assessed by hs-cTnI. There was a marginal positive correlation between AHI events and mitral E/e' ratio. The circulating levels of hs-cTnI were significantly associated with different severity grades of OSA.
Article
Pediatrics
Rahul J. Thomas, Samuel Dalton, Katharine Harman, Julie Thacker, Rosemary S. C. Horne, Margot J. Davey, Gillian M. Nixon
Summary: This study developed and validated a simple clinical tool, the Monash Obstructive Sleep Apnoea Video Score, to quantify abnormalities in breathing seen on short video recordings made on a smartphone. A low score rules out moderate-severe OSA and may be valuable in triaging children with symptoms of OSA.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Review
Respiratory System
Ama Johal, Mona M. Hamoda, Fernanda R. Almeida, Marie Marklund, Harishri Tallamraju
Summary: There is increasing recognition of the importance of dental sleep medicine and oral appliance therapy (OAT) in managing obstructive sleep apnoea (OSA). This review focuses on understanding the mode of action of OAT, exploring its anatomical and physiological impact, clinical guidelines, device design features, patient predictors, and the impact on health outcomes.
EUROPEAN RESPIRATORY REVIEW
(2023)
Review
Critical Care Medicine
Salam Zeineddine, James A. Rowley, Susmita Chowdhuri
Summary: Sleep-disordered breathing (SDB) has significant cardiovascular and neurological effects, with supplemental oxygen therapy showing mixed results in improving oxygen saturation and apnea severity compared to positive airway pressure therapy. Further research is needed to clarify the optimal dose and duration of nocturnal supplemental oxygen (NSO) and its combination with PAP in improving cardiovascular, sleep, and cognitive outcomes in SDB patients.
Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Rehabilitation
Xinyi Xu, Denise Shuk Ting Cheung, Robert Smith, Agnes Yuen Kwan Lai, Chia-Chin Lin
Summary: This study investigated the effects of rehabilitation before or after lung cancer surgery on postoperative pulmonary complications and hospital stay length. The findings indicate that preoperative rehabilitation can reduce postoperative pulmonary complications and hospital stay length, while short-term postoperative rehabilitation in inpatient settings may be ineffective.
CLINICAL REHABILITATION
(2022)
Article
Respiratory System
Wang Chun Kwok, Anthony Raymond Tam, James Chung Man Ho, David Chi Leung Lam, Terence Chi Chun Tam, King Pui Florence Chan, Julie Kwan Ling Wang, Mary Sau Man Ip, Ivan Fan Ngai Hung
Summary: Chronic illnesses, including asthma, have been found to be poor prognostic factors associated with severe illness and complications in COVID-19 infection. This study showed that regardless of asthma severity, it is an independent prognostic factor for COVID-19 and is associated with more severe disease and complications.
CLINICAL RESPIRATORY JOURNAL
(2022)
Article
Medicine, General & Internal
Si-Yeung Yu, Mary Sau-Man Ip, Xue Li, Ka-Shing Cheung, Qing-Wen Ren, Mei-Zhen Wu, Hang-Long Li, Pui-Fai Wong, Hung-Fat Tse, Kai-Hang Yiu
Summary: Low-dose aspirin use is associated with a lower risk of lung carcinoma and lung carcinoma-related mortality among COPD patients, but it also increases the risk of bleeding, particularly hemoptysis.
Correction
Public, Environmental & Occupational Health
Agnes Yuen-Kwan Lai, Shirley Man-Man Sit, Socrates Yong-Da Wu, Man-Ping Wang, Bonny Yee-Man Wong, Sai-Yin Ho, Tai-Hing Lam
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Respiratory System
Mary S. M. Ip, Huaping Dai
Article
Respiratory System
Pei-Hang Xu, Daniel Y. T. Fong, Macy M. S. Lui, David C. L. Lam, Mary Sau Man Ip
Summary: This study found that in Chinese patients, sleep time with oxygen saturation <90% (TST90) and mean heart rate related to obstructive sleep apnoea (OSA) - not apnoea-hypopnoea index (AHI) - were robust predictors of major adverse cardiovascular events (MACEs). Furthermore, a subgroup with a clinical phenotype was identified, where regular CPAP use was associated with a lower risk of MACEs.
Article
Environmental Sciences
Bo-Wen Chen, Wei-Jie Gong, Agnes Yuen-Kwan Lai, Shirley Man-Man Sit, Sai-Yin Ho, Man-Ping Wang, Nancy Xiaonan Yu, Tai-Hing Lam
Summary: The study identified three distinct patterns: indifferent (66.37%), harm (13.28%), and benefit (20.35%). Compared with the indifferent subgroup, the harm subgroup was younger, less happy, and had increased drinking, and hence might be at higher risk, whereas the benefit subgroup was more likely to be female, live with one or more cohabitants, have postsecondary education, be happier, and have decreased drinking, and could be more adaptive.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Shirley Man-Man Sit, Wei-Jie Gong, Sai-Yin Ho, Agnes Yuen-Kwan Lai, Bonny Yee-Man Wong, Man-Ping Wang, Tai-Hing Lam
Summary: This study examined the associations between COVID-19 information sharing methods, sociodemographic characteristics, perceived benefits of information communication and technology (ICT) methods, and family communication quality and well-being. The findings showed that using both traditional methods and ICTs for information sharing was associated with perceived benefits and better family communication quality and well-being. Sociodemographic differences in COVID-19 information sharing using ICTs were observed.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychiatry
Wei Jie Gong, Shirley Man Man Sit, Bonny Yee Man Wong, Socrates Yong Da Wu, Agnes Yuen Kwan Lai, Sai Yin Ho, Man Ping Wang, Tai Hing Lam
Summary: The study found that during the COVID-19 pandemic, the use of instant messaging and the presence of positive and supportive content may contribute to improved family wellbeing and personal happiness. Individuals who do not engage in family communication may require assistance.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Environmental Sciences
Agnes Y. K. Lai, George O. C. Cheung, Asa C. M. Choi, Man-Ping Wang, Polly S. L. Chan, Angie H. Y. Lam, Esther W. S. Lo, Chia-Chin Lin, Tai-Hing Lam
Summary: This study explored the association between students' mental health and their support system, identified preferred ways and sources of support, investigated the perceived usefulness of available university support, and recommended actionable strategies to enhance students' mental health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Shirley Man-Man Sit, Ellen Ng, Hilary Pui-Yee Ho, Peony Cheuk-Yeuk Wong, Man-Ping Wang, Sai-Yin Ho, Tai-Hing Lam, Agnes Yuen-Kwan Lai
Summary: Mindfulness-based art therapy has been shown to improve psychological well-being. This study explored the transition from face-to-face to online Zentangle workshops and analyzed participants' feedback and the acceptability of online approaches. The results showed high satisfaction among participants in both face-to-face and online workshops, and the online approach was found to facilitate convenient learning of Zentangle.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Hilary Pui-Yee Ho, Agnes Yuen-Kwan Lai, Ricky Yu-Kwong Kwok, Tai-On Kwok, Edward Chow, Teresa Yip, Wai-Yan Tang, Kam-Wing Leung, Eliza Lam, Kam-Yin Lam, Terry Shuk-Yin Tsui, Wai-Fong Lok, Pui-Wah Yam, Shuk-Fong Wong, Chiu-Man Wong, Kerin Kwok-Wing Cham, Bonny Yee-Man Wong, Sai-Yin Ho, Man-Ping Wang, Tai-Hing Lam
Summary: This study examined the use of information and communications technology (ICT) in family services, as well as its perceived benefits and barriers during the COVID-19 pandemic in Hong Kong. The results showed a significant increase in the use of ICT in family services, providing more convenient and accessible services.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Respiratory System
Raja Dhar, Chin Kook Rhee, Diahn-Warng Perng, Koichi Fukunaga, Mary Sau-Man Ip, Siwasak Juthong, Mariko Siyue Koh, Jing Li, Shubham Sharma, Wiwien Heru Wiyono
Summary: Most patients with asthma can manage their condition effectively with inhaled medications. However, those with severe or uncontrolled asthma may require systemic corticosteroids, which can have long-term adverse health outcomes. Studies suggest that there is an overuse of systemic corticosteroids in asthma management globally, including Asia, and coordinated changes are needed to reduce this burden.
Article
Respiratory System
Wang Chun Kwok, Ting Fung Ma, James Chung Man Ho, David Chi Leung Lam, Ko Yung Sit, Mary Sau Man Ip, Timmy Wing Kuk Au, Terence Chi Chun Tam
Summary: This study developed a prediction model based on readily available clinical information to accurately predict disease recurrence in stage I adenocarcinoma patients, which can help personalize follow-up strategies and future adjuvant therapy.
Article
Health Care Sciences & Services
Michelle Man Tung Suen, Agnes Yuen Kwan Lai, Man Ping Wang, Daniel Sai Yin Ho, Tai Hing Lam
Summary: The i-TLS platform, developed under the Hong Kong Jockey Club SMART Family-Link Project, has been found to be acceptable and impactful in facilitating the use of ICT in family services. The platform provides training, learning, and sharing components, attracting a significant number of social workers who actively engage in the modules and resources provided. Users' satisfaction with i-TLS has increased over time.
JMIR FORMATIVE RESEARCH
(2022)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
