Article
Pediatrics
Eszter Csabi, Veronika Gaal, Emese Hallgato, Rebeka Anna Schulcz, Gabor Katona, Palma Benedek
Summary: This study aimed to assess the behavioral consequences of sleep disturbances in children with sleep-disordered breathing. The results showed that children with sleep-disordered breathing exhibited higher levels of inattentiveness, hyperactive behavior, and internalizing and externalizing problems. The study suggests that even mild sleep-disordered breathing, such as snoring and mild obstructive sleep apnea, may increase the risk of behavioral and emotional dysfunctions in children.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Review
Clinical Neurology
Bethanie Menzies, Arthur Teng, Mary Burns, Suncica Lah
Summary: This systematic review with meta-analysis found that children with sleep disordered breathing (SDB) have significant impairments in multiple neurocognitive domains, with intelligence being the most affected. The severity of SDB, body mass index, age at testing, measurement method, and control group usage were identified as moderating factors. The study emphasizes the importance of further research and interventions for children with SDB.
SLEEP MEDICINE REVIEWS
(2022)
Article
Pediatrics
Christy R. Sibarani, Lisa M. Walter, Margot J. Davey, Gillian M. Nixon, Rosemary S. C. Horne
Summary: Children with Down syndrome are at increased risk of sleep-disordered breathing, which has a greater impact on sleep quality in comparison to typically developing children. Early screening and treatment for SDB in children with DS is crucial.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Eduardo Machado Rossi-Monteiro, Laura Rodrigues Sefair, Marcos Correia Lima, Maria Fernanda Lima Nascimento, Daniel Mendes-Pinto, Lukas Anschuetz, Maria Gloria Rodrigues-Machado
Summary: This study aimed to compare cardiovascular parameters between healthy children and those with obstructive sleep-disordered breathing (oSDB), as well as identify predictors of arterial stiffness indices in children with oSDB. Children with oSDB showed higher reflection coefficient and augmentation index compared to controls, indicating increased arterial stiffness. Multiple regression analysis revealed age, female sex, reflection coefficient, and systolic volume as independent predictors of augmentation index, while higher pulse wave velocity was associated with poorer quality of life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Sarah Maessen, Elizabeth Schaughency, Patrick Dawes, Barbara Galland
Summary: This study aimed to explore the feasibility and treatment sensitivity of measures of preschool oral language and emergent literacy and numeracy in assessing developing skills of preschool children with sleep disordered breathing (SDB) in New Zealand. The results showed that the tasks were sensitive to treatment effects in oral language and emergent literacy, but not in early numeracy. Prior to surgery, case children exhibited more symptoms of SDB and behavioral and emotional difficulties compared to matched controls, with improvements observed in these areas post-surgery.
Article
Clinical Neurology
Shu-Juan Liu, Zhen-Zhen Liu, Ze-Ying Wang, Bao-Peng Liu, Shuo Cheng, Xianchen Liu, Cun-Xian Jia
Summary: The study found that symptoms of sleep disordered breathing (SDB) are an independent and significant predictor of depressive symptoms in adolescents. 4.5% of adolescents had persistent depressive symptoms, and the incidence rate of depressive symptoms at 1-year follow-up was 6.5%. Elevated frequency of any SDB symptoms was significantly associated with incident depressive symptoms after adjusting for potential confounders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Brandon G. Rocque, Mary Halsey Maddox, Betsy D. Hopson, Isaac C. Shamblin, Inmaculada Aban, Anastasia A. Arynchyna, Jeffrey P. Blount
Summary: This study found a high prevalence of sleep disordered breathing in children with myelomeningocele through screening polysomnography, suggesting the need for routine screening in this population. Children with higher neurological lesion levels were more likely to have sleep disordered breathing.
Article
Pediatrics
Neepa Gurbani, Christine L. Schuler, Daniel Ignatiuk, Jennifer Albrecht, Yuping Guo, Amanda Waits, Carolyn M. Kercsmar
Summary: A screening process for sleep disordered breathing (SDB) was successfully implemented using quality improvement methods in patients hospitalized for asthma exacerbation. The screening rate significantly increased, highlighting the importance of evaluating SDB in high-risk children.
PEDIATRIC PULMONOLOGY
(2023)
Article
Clinical Neurology
Phoebe K. Yu, Jerilynn Radcliffe, H. Gerry Taylor, Raouf S. Amin, Cristina M. Baldassari, Thomas Boswick, Ronald D. Chervin, Lisa M. Elden, Susan L. Furth, Susan L. Garetz, Alisha George, Stacey L. Ishman, Erin M. Kirkham, Christopher Liu, Ron B. Mitchell, S. Kamal Naqvi, Carol L. Rosen, Kristie R. Ross, Jay Shah, Ignacio E. Tapia, Lisa R. Young, David A. Zopf, Rui Wang, Susan Redline
Summary: The relationship between the severity of obstructive sleep apnea and neurobehavioral morbidity is unclear. This study compares the neurobehavioral symptoms of mild sleep-disordered breathing and obstructive sleep apnea, finding that children with mild sleep-disordered breathing have more abnormal executive function scores and higher rates of inattention and hyperactivity compared to children with obstructive sleep apnea.
Article
Clinical Neurology
Jasneek Chawla, Margaret-Anne Harris, Robert Black, Marie-Josee Leclerc, Hannah Burns, Karen A. Waters, Anne Bernard, Kurt Lushington, Helen Heussler
Summary: This study compared neurocognitive and behavioral data in preschool children with symptomatic OSA and PS at recruitment, finding no significant differences between the two groups. The study suggests that symptoms and behavioral disturbances should be considered in addition to OAHI when determining the need for treatment.
SLEEP AND BREATHING
(2021)
Article
Otorhinolaryngology
Tiffany T. Pham, Shanlee M. Davis, Suhong Tong, Khaled A. Campa, Norman R. Friedman, Sarah A. Gitomer
Summary: A retrospective cross-sectional study found a high prevalence of obstructive sleep-disordered breathing (oSDB) in young patients with Turner syndrome (TS), with a four-fold increased risk compared to the general pediatric population. Risk factors for oSDB in TS included adenoid, tonsillar, and inferior turbinate hypertrophy, birthweight, failure to thrive, and older age at the last clinic visit. Screening for oSDB and performing polysomnography in TS patients with associated risk factors and symptoms is crucial due to the potential exacerbation of behavioral problems, neurocognitive deficits, and growth impairment associated with oSDB.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Katia Averbukh, Adi Goldbart, Aviv Goldbart, Asher Tal, Daniel M. Kaplan, Moshe Puterman, Sabri El-Saied, Ben-Zion Joshua
Summary: This study aims to compare the safety and long-term symptoms between tonsillectomy and subtotal tonsillectomy. The results show that tonsillectomy has an advantage in resolving snoring in the long term.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Review
Critical Care Medicine
Salam Zeineddine, James A. Rowley, Susmita Chowdhuri
Summary: Sleep-disordered breathing (SDB) has significant cardiovascular and neurological effects, with supplemental oxygen therapy showing mixed results in improving oxygen saturation and apnea severity compared to positive airway pressure therapy. Further research is needed to clarify the optimal dose and duration of nocturnal supplemental oxygen (NSO) and its combination with PAP in improving cardiovascular, sleep, and cognitive outcomes in SDB patients.
Article
Clinical Neurology
Thomas J. Dye, Sumalee Hantragool, Christopher Carosella, Guixia Huang, Md M. Hossain, Narong Simakajornboon
Summary: This study retrospectively reviewed the sleep disordered breathing in children receiving VNS therapy, and found that OSA and hypoventilation were relatively common in this population. Management mainly involves positive airway pressure therapy and upper airway surgeries.
Article
Anesthesiology
Carolyne Pehora, David Faraoni, Soichiro Obara, Reshma Amin, Brenda Igbeyi, Adel Al-Izzi, Aman Sayal, Aarti Sayal, Conor Mc Donnell
Summary: The study aimed to determine the incidence and risk factors of PRAEs in children with SDB undergoing general anesthesia. Factors associated with PRAEs were identified, suggesting potential for developing a predictive model and improving preoperative risk assessment.
ANESTHESIA AND ANALGESIA
(2021)
Article
Clinical Neurology
Rosemary S. C. Horne
Summary: Australian and New Zealand researchers have made significant contributions to the understanding of the consequences of paediatric sleep disordered breathing, highlighting the adverse effects on quality of life, behavior, neurocognition, and the cardiovascular system. Their research has led the world in this field and continues to provide evidence for improving the lives of children globally.
Editorial Material
Clinical Neurology
Rosemary S. C. Horne
Article
Pediatrics
Alicia K. Yee, Leon S. Siriwardhana, Gillian M. Nixon, Lisa M. Walter, Flora Y. Wong, Rosemary S. C. Horne
Summary: The study aimed to investigate the amount of time spent in periodic breathing and its consequences in infants born preterm before and after hospital discharge. The results showed no significant changes in the percentage of sleep time spent in periodic breathing between different time points. Infants who had a high percentage of periodic breathing at 32-36 weeks of gestational age also had a high percentage at 36-40 weeks and 6 months of corrected age.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Alicia K. Yee, Leon S. Siriwardhana, Gillian M. Nixon, Lisa M. Walter, Flora Y. Wong, Rosemary S. C. Horne
Summary: The study aimed to investigate the frequency and severity of periodic breathing (PB) in clinically stable very preterm infants. The majority of infants exhibited PB when they were off respiratory support, and the time spent in PB varied greatly between infants and was associated with significant hypoxia in some infants. Shorter duration on respiratory support was associated with increased frequency and severity of PB.
PEDIATRIC PULMONOLOGY
(2023)
Editorial Material
Pediatrics
Rosemary S. C. Horne
PEDIATRIC PULMONOLOGY
(2023)
Article
Clinical Neurology
Marisha Shetty, Amanda Perera, Mary Kadar, Brendan Tan, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne
Summary: The study aims to investigate the relationship between sleep spindle activity and sleep quality, neurocognition, and behavior. It found that children with obstructive sleep disordered breathing (SDB) had reduced spindle activity during sleep, which may contribute to negative effects on attention, learning, and memory.
Article
Clinical Neurology
Rosemary S. C. Horne, Marisha Shetty, Margot J. Davey, Lisa M. Walter, Gillian M. Nixon
Summary: Children with Down syndrome have an increased risk of obstructive sleep disordered breathing, which can negatively impact their daytime functioning. This study aimed to examine the effects of treatment on sleep quality and daytime functioning in these children, and found that treatment improved symptoms, sleep disturbance, and quality of life, but had no direct impact on actigraphic sleep measures or daytime behavior. In contrast, untreated children experienced increased sleep disruption and no change in quality of life, despite having less severe baseline symptoms.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Pediatrics
Alicia K. Yee, Marisha Shetty, Leon S. Siriwardhana, Flora Y. Wong, Lisa M. Walter, Rosemary S. C. Horne
Summary: This study aimed to investigate whether apnoea and periodic breathing in preterm infants were associated with changes in autonomic control, exacerbating the consequences of respiratory disturbance. The results showed that periodic breathing can affect autonomic cardiovascular control.
Article
Obstetrics & Gynecology
Alicia K. Yee, Leon S. Siriwardhana, Gillian M. Nixson, Lisa M. Walter, Flora Y. Wong, Rosemary S. C. Horne
Summary: This study examined the correlation between respiratory events before and after hospital discharge and developmental outcomes at 6 months corrected age in preterm infants. The results showed that the percentage of total sleep time with respiratory events at term was a significant predictor of language and motor development at 6 months, regardless of gestational age, birth weight, and sex.
JOURNAL OF PERINATOLOGY
(2023)
Article
Clinical Neurology
Brendan Tan, Knarik Tamanyan, Lisa Walter, Gillian M. M. Nixon, Margot J. J. Davey, Michael Ditchfield, Rosemary S. C. Horne
Summary: This study investigated the impact of obstructive sleep disordered breathing (SDB) on cortical thickness and volumetric changes in children, as well as the relationship between these changes and behavioral and cognitive deficits. Results showed significant increases in cortical thickness in the right caudal anterior cingulate and right cuneus regions, as well as volumetric increases in the left caudal middle frontal, bilateral rostral anterior cingulate, and bilateral caudate brain regions in children with SDB compared to controls. However, these changes did not correlate with behavioral or cognitive measures.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Pediatrics
Marisha Shetty, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne
Summary: Children with Down syndrome have lower sleep spindle activity compared to typically developing children, which is negatively correlated with daytime functioning and quality of life.
PEDIATRIC RESEARCH
(2023)
Editorial Material
Respiratory System
Gillian M. Nixon, Rosemary S. C. Horne
Article
Clinical Neurology
Rosemary S. C. Horne, Marisha Shetty, Moya Vandeleur, Margot J. Davey, Lisa M. Walter, Gillian M. Nixon
Summary: This study compared sleep measurements in children with Down syndrome using actigraphy, sleep diary, and polysomnography. The results showed that parental sleep diaries overestimated total sleep time while accurately reporting bed and wake times. Children with Down syndrome exhibited more regular sleep patterns compared to typically developing children.
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
