Article
Neurosciences
Elaine Pinggal, Paul M. Dockree, Redmond G. O'Connell, Mark A. Bellgrove, Thomas Andrillon
Summary: Sustained attention is modulated by arousal, and the intrusion of sleep-like slow waves during wakefulness may lead to attentional lapses. Pharmacological manipulations of the monoamine system showed effects on behavioral outcomes of sustained attention, improving performance, increasing impulsivity, or leading to missed trials. Specific slow waves patterns were associated with both misses and faster responses, suggesting a potential mechanistic link between decreased arousal and impulsivity or sluggishness.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Masaki Nishida, Atsushi Ichinose, Yusuke Murata, Kohei Shioda
Summary: The study found that napping in a bean bag chair may provide a comfortable napping environment involving muscle relaxation and proper regulation of the autonomic nervous function.
Article
Clinical Neurology
Jana C. Buenzli, Esther Werth, Christian R. Baumann, Anina Belvedere, Roland Renzel, Lennart H. Stieglitz, Lukas L. Imbach
Summary: In this study, the impact of continuous deep brain stimulation (DBS) on sleep in epilepsy patients was investigated. The findings showed that continuous high-frequency DBS leads to more consolidated and deeper slow wave sleep (SWS). The location of the stimulation contact within the anterior nucleus of the thalamus (ANT) was also found to be related to the changes in SWS.
Article
Multidisciplinary Sciences
Dan Guo, Robert J. Thomas, Yanhui Liu, Steven A. Shea, Jun Lu, Chung-Kang Peng
Summary: Spontaneous synchronization and de-synchronization of neurons during sleep, especially during slow wave sleep, has been studied. The current sleep classification model based on EEG has overlooked the accompanying physiological changes. Researchers propose a cluster synchronization model to explain the emergence of slow wave sleep in healthy individuals and develop an automated algorithm for sleep stage classification.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Charles W. Dickey, Ilya A. Verzhbinsky, Xi Jiang, Burke Q. Rosen, Sophie Kajfez, Brittany Stedelin, Jerry J. Shih, Sharona Ben-Haim, Ahmed M. Raslan, Emad N. Eskandar, Jorge Gonzalez-Martinez, Sydney S. Cash, Eric Halgren
Summary: Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby such binding of different components of mental events into unified representations occurs is unknown. This study found that brief high-frequency oscillations, known as ripples, occur in different brain areas and play a crucial role in memory recall and consolidation. These ripples phase-lock, co-occur, and show high-frequency correlations between widely distributed cortical locations, even between hemispheres. The findings suggest that cortical ripple co-occurrence and phase synchrony are essential for memory retrieval and potentially cognitive processes in general.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Miki Kakutani-Hatayama, Manabu Kadoya, Akiko Morimoto, Akio Miyoshi, Kae Kosaka-Hamamoto, Akinori Kanzaki, Kosuke Konishi, Yoshiki Kusunoki, Takuhito Syoji, Hidenori Koyama
Summary: This study found that long daytime napping may lead to decreased insulin sensitivity, particularly in individuals with shorter nighttime sleep.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Tomoyuki Fujiyama, Henri Takenaka, Fuyuki Asano, Kazuya Miyanishi, Noriko Hotta-Hirashima, Yukiko Ishikawa, Satomi Kanno, Patricia Seoane-Collazo, Hideki Miwa, Mikio Hoshino, Masashi Yanagisawa, Hiromasa Funato
Summary: In addition to motor control, the cerebellum is also involved in memory, cognition, addiction, and social behavior. Its role in sleep-wake control is unclear, but it may play a role in the generation of slow waves.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Chien-Yu Chen, Hung-Wei Chen
Summary: This study developed a novel hypnotic lighting system using dynamic CCT lighting to control sleep quality. The results showed that the sleep environment with dynamic CCT lighting was better than dim light and similar to a dark room, and it significantly improved work efficiency.
APPLIED SCIENCES-BASEL
(2022)
Article
Clinical Neurology
Yuki Shiraishi, Masaya Tachibana, Ai Shirota, Ikuko Mohri, Masako Taniike, Takashi Yamashiro, Takafumi Kato
Summary: The study aimed to clarify the physiological relationships between rhythmic masticatory muscle activity (RMMA) and cyclic changes in cortical, autonomic, and arousal-motor activities during sleep in sleep bruxism (SB) children. The results showed that in primary SB children, the occurrence of RMMA was associated with transient arousal under cyclic sleep processes, with RMMA being most frequent in the last NREM segment before REM sleep and associated with increases in cortical beta activity and arousal; more than 70% of RMMA time-dependently occurred with cortical and motor arousals.
Article
Clinical Neurology
Yuki Shiraishi, Masaya Tachibana, Ai Shirota, Ikuko Mohri, Masako Taniike, Takashi Yamashiro, Takafumi Kato
Summary: The study found that children with sleep bruxism (SB) had a higher frequency of rhythmic masticatory muscle activity (RMMA) during sleep cycles, particularly in the last NREM segment before entering REM sleep. RMMA in SB children was associated with increased cortical beta activity and arousal, with more than 70% of RMMA occurrences linked to cortical and motor arousals.
Article
Multidisciplinary Sciences
Chieh-Wen Chen, Yam-Ting Kwok, Yu-Ting Cheng, Yu-Shan Huang, Terry B. J. Kuo, Cheng-Han Wu, Pei-Jing Du, Albert C. C. Yang, Cheryl C. H. Yang
Summary: Sleep problems and autonomic dysfunction are closely associated with Alzheimer's disease (AD), especially in the preclinical stage. This study found that mice with early-stage AD pathology had poor sleep quality, reduced autonomic activity, and higher levels of Aβ aggregation in the brain. These sleep and autonomic dysfunctions were also observed in mice with advanced-stage AD and significant cognitive deficits. The findings suggest that sleep quality and autonomic function during sleep-wake transitions may serve as biomarkers for early detection of AD.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Daphne Chylinski, Christian Berthomier, Eric Lambot, Sonia Frenette, Marie Brandewinder, Julie Carrier, Gilles Vandewalle, Vincenzo Muto
Summary: The study compared stage scoring of older individuals and found that variability between experts or algorithm may be higher than typically reported in the literature.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Kevin D. McGovney, Ashley F. Curtis, Christina S. McCrae
Summary: This study found that greater morning and afternoon physical activity is associated with greater sleep fragmentation and higher stage 1 sleep in individuals with fibromyalgia and insomnia complaints. The relationship between higher physical activity and higher stage 1 sleep is stronger for individuals with higher pain. These findings provide a theoretical basis for further research on the causal relationship between physical activity, activity pacing, and sleep in fibromyalgia.
BEHAVIORAL SLEEP MEDICINE
(2023)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: This study compared four deep breathing techniques and found that loaded breathing was associated with better cardiovascular effects, while pursed-lips breathing had better emotional responses. The findings suggest that different deep breathing techniques may have varying impacts on physiological and emotional states.
Article
Clinical Neurology
Katharine C. Simon, Elizabeth A. McDevitt, Rocco Ragano, Sara C. Mednick
Summary: This study examined the impact of relaxation-based progressive muscle relaxation (PMR) on sleep architecture and physiology during a nap. The results showed that PMR participants had longer duration of restorative slow-wave sleep and shorter duration of rapid eye movement sleep during the nap, indicating a more well-rested brain profile. The study also found that pre-sleep anxiety levels influenced the effectiveness of the intervention.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Anesthesiology
L. Devoize, P. Chalaye, S. Lafrenaye, S. Marchand, R. Dallel
EUROPEAN JOURNAL OF PAIN
(2016)
Review
Clinical Neurology
James A. Blackman, Camilla I. Svensson, Serge Marchand
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2018)
Article
Clinical Neurology
Nathalie Bitar, Serge Marchand, Stephane Potvin
PAIN RESEARCH & MANAGEMENT
(2018)
Article
Mathematical & Computational Biology
Roberto Colombo, Alessandra Mazzone, Carmen Delconte, Fabrizio Pisano
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
(2018)
Article
Anesthesiology
Catherine E. Ferland, Alisson R. Teles, Pablo Ingelmo, Neil Saran, Serge Marchand, Jean A. Ouellet
EUROPEAN JOURNAL OF PAIN
(2019)
Article
Medicine, General & Internal
Anais Le Fur Bonnabesse, Mathilde Cabon, Gildas L'Heveder, Aurelie Kermarrec, Bertrand Quinio, Alain Woda, Serge Marchand, Amandine Dubois, Marie-Agnes Giroux-Metges, Fabrice Rannou, Laurent Misery, Celine Bodere
Article
Engineering, Biomedical
R. Colombo, A. Raglio, M. Panigazzi, A. Mazzone, G. Bazzini, C. Imarisio, D. Molteni, C. Caltagirone, M. Imbriani
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2019)
Article
Orthopedics
Marco Godi, Marica Giardini, Ilaria Arcolin, Simona Ferrante, Antonio Nardone, Stefano Coma, Roberto Colombo
Article
Clinical Neurology
Nathalie Bitar, Jules R. Dugre, Serge Marchand, Stephane Potvin
JOURNAL OF PAIN RESEARCH
(2020)
Review
Behavioral Sciences
Elora Midavaine, Jerome Cote, Serge Marchand, Philippe Sarret
Summary: Chronic pain is a major global health issue with limited pharmacological treatment options available. Sex-specific differences in pain conditions are increasingly recognized, highlighting the importance of developing gender-specific pain medications. Research on sexually dimorphic pain responses is vital for advancing pain management strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Gael Villanueva-Charbonneau, Stephane Potvin, Serge Marchand, Alexander McIntyre, Diane McIntosh, Alain Bissonnette, Alain Gendron, Charles-edouard Giguere, Marie-eve Koue, Edouard Kouassi
Summary: This study found that mRNA expression of serotonin transporter (SERT) on the surface of peripheral blood mononuclear cells (PBMCs) was significantly reduced in subjects with major depression disorder (MDD), but not in those with fibromyalgia (FM) or FM + MDD. Although drug treatment improved symptoms, it had no significant effect on SERT mRNA expression.
Review
Health Policy & Services
Giulia Monardo, Chiara Pavese, Ines Giorgi, Marco Godi, Roberto Colombo
Summary: This experiential review explored the literature on assessment of patient motivation and satisfaction during technology-assisted rehabilitation from 1990 to 2019, identifying a wide range of questionnaires and validated tools used in research. Motivation and satisfaction were viewed as multidimensional concepts, with 29 domains assessed by 9 different tools.
GAMES FOR HEALTH JOURNAL
(2021)
Article
Psychology, Developmental
A. Dubois, M. Boudjarane, A. Le Fur-Bonnabesse, A. Dion, G. L'heveder, B. Quinio, M. Walter, S. Marchand, C. Bodere
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2020)
Article
Public, Environmental & Occupational Health
Marcello Imbriani, Giuseppe Taino, Monica Panigazzi, Edda Capodaglio, Enrico Oddone, Stefano M. Candura, Luca Chiovato, Danilo Cottica, Carlo Locatelli, Teresa Coccini, Antonio Meriggi, Ines Giorgi, Roberto Colombo, Alfredo Raglio, Giovanni Battista Migliori, Livia Visa, Elena Grignani, Nicola Montrone, Paola Spigno
GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA
(2019)
Article
Rehabilitation
Roberto Colombo, Fabrizio Pisano, Carmen Delconte, Alessandra Mazzone, Giuseppe Grioni, Marisa Castagna, Giacomo Bazzini, Chiara Imarisio, Giorgio Maggioni, Caterina Pistarini
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2017)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.