Article
Medicine, General & Internal
Jae Hyuk Choi, Eunkyu Lee, Sang Duk Hong, Seung Kyu Chung, Yong Gi Jung, Hyo Yeol Kim
Summary: A retrospective analysis of OSA patients undergoing CPAP therapy showed significant improvements in laryngopharyngeal reflux symptoms and examination findings, independent of body mass index or OSA severity.CPAP treatment has the potential to reduce laryngeal reflux symptoms and improve laryngeal examination results in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Gino S. Panza, Shipra Puri, Ho-Sheng Lin, M. Safwan Badr, Jason H. Mateika
Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Clinical Neurology
Yoko Fujino, Yasunori Oka, Tomoko Wakamura
Summary: This study found that seasonal differences can impact the CPAP adherence of patients with obstructive sleep apnea. Patients in the adherent group had lower CPAP use rate and shorter duration in summer, while the non-adherent group showed significant differences between winter and summer.
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Article
Medicine, General & Internal
Baixin Chen, Miaolan Guo, Yueksel Peker, Neus Salord, Luciano F. Drager, Geraldo Lorenzi-Filho, Xiangdong Tang, Yun Li
Summary: CPAP treatment leads to a significant decrease in total cholesterol but has no effect on other lipid profiles in patients with obstructive sleep apnea. Factors such as age, gender, body mass index, daytime sleepiness, OSA severity, follow-up duration, CPAP compliance, and presence of cardiometabolic disease do not moderate the effects of CPAP treatment on lipid profiles.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Shahrokh Javaheri, Sogol Javaheri
Summary: This review provides a comprehensive overview of the current knowledge of obstructive sleep apnea (OSA) and congestive heart failure (HF), including the pathophysiologic mechanisms, observational data, treatment options, and future research needs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Wojciech Trzepizur, Peter A. Cistulli, Martin Glos, Bruno Vielle, Kate Sutherland, Peter J. Wijkstra, Aarnoud Hoekema, Frederic Gagnadoux
Summary: This study compared the treatment effects of CPAP and MAD in patients with severe OSA. Results showed that MAD had similar impact to CPAP on sleepiness and quality of life, while CPAP was more effective in reducing AHI and ODI. Both treatments had similar impact on sleep structure, but patients preferred MAD for treatment adherence and preference.
Article
Pediatrics
Sarah Benke, Caroline U. A. Okorie, MaryAnne A. Tablizo
Summary: The study aimed to assess the safety and efficacy of autoCPAP in pediatric patients with obesity and OSAS, finding that autoCPAP use was effective and safe, potentially reducing treatment delays. Further research is needed to verify the long-term effectiveness of autoCPAP in this population.
Article
Critical Care Medicine
Susanna S. S. Ng, Vincent W. S. Wong, Grace L. H. Wong, Winnie C. W. Chu, Tat-On Chan, Kin-Wang To, Fanny W. S. Ko, Ka-Pang Chan, David S. Hui
Summary: This study aimed to investigate the effects of autoadjusting CPAP versus subtherapeutic CPAP on NAFLD in patients with concomitant OSA, showing no significant differences in primary and secondary endpoints between the two treatment groups. Weight change correlated with changes in intrahepatic triglyceride and CAP, suggesting weight reduction through lifestyle modification may be beneficial for improving NAFLD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Pediatrics
Kelly K. Hady, Caroline U. A. Okorie
Summary: Pediatric obstructive sleep apnea syndrome is a disorder characterized by breathing difficulties during sleep, affecting 2-4% of children worldwide. Surgical intervention is the primary treatment, but positive airway pressure therapy is often used for those not suitable for surgery or with residual symptoms. This therapy is effective, but additional considerations exist for pediatric patients.
Article
Medicine, General & Internal
Xinyao Li, Xinbin Zhou, Xiaoming Xu, Jin Dai, Chen Chen, Lan Ma, Jiaying Li, Wei Mao, Min Zhu
Summary: The study found that CPAP therapy can significantly reduce the risk of AF recurrence or progression, especially for patients with OSA. Compared to patients without OSA, CPAP nonusers had a higher rate of AF recurrence or progression.
Article
Medicine, General & Internal
Hyunjin Jo, Sujung Choi, Dongyeop Kim, Eunyeon Joo
Summary: Patients with epilepsy have milder characteristics of obstructive sleep apnea (OSA), but because of the high coexistence of OSA and epilepsy, continuous positive airway pressure (CPAP) therapy can reduce the frequency of seizures. Therefore, it is important to evaluate the presence of OSA in patients with epilepsy and provide concurrent treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Angela Fidler Pfammatter, Bonnie Olivia Hughes, Becky Tucker, Harry Whitmore, Bonnie Spring, Esra Tasali
Summary: This study developed a mobile health tool that integrated weight loss features with novel CPAP adherence tracking for patients with OSA. The tool tracked CPAP wear time relative to time spent in bed and included push notifications to foster adherence. Future research is needed to evaluate the effectiveness of this tool in improving OSA treatment adherence.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Editorial Material
Clinical Neurology
Martino F. Pengo, David Gozal, Miguel Angel Martinez-Garcia
Summary: The majority of current international OSA guidelines recommend CPAP treatment based on symptoms, but controversy exists for non-sleepy patients. A proposed algorithm attempts to phenotype non-sleepy OSA patients and consider clinically relevant elements before deciding on CPAP treatment. Extensive validation is needed before implementing this algorithm in clinical settings.
Review
Medicine, General & Internal
Yinghua Xu, Haiyan Wu, Xiaoling Lu
Summary: This meta-analysis investigated the influence of continuous positive airway pressure (CPAP) on lipid profiles of patients with obstructive sleep apnea (OSA). The results showed that CPAP treatment did not affect the lipid profiles, including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL), of OSA patients, regardless of the duration of CPAP treatment.
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.