Article
Clinical Neurology
Anusha Devarajan, Aditya Paliwal, Chad Ruoff, Philip J. Lyng, Matthew Lizak, Lois E. Krahn
Summary: This study demonstrates that alcohol consumption may interfere with the results of home sleep apnea tests utilizing peripheral arterial tone (PAT HSAT), leading to false negative results. Further investigations are needed to evaluate the performance of PAT HSATs with and without alcohol. In the meantime, testing should be conducted without alcohol and over multiple nights.
Article
Clinical Neurology
Bart Van Pee, Frederik Massie, Steven Vits, Pauline Dreesen, Susie Klerkx, Jagdeep Bijwadia, Johan Verbraecken, Jeroen Bergmann
Summary: This paper reports on the multicentric validation of a novel FDA-cleared home sleep apnea test based on peripheral arterial tonometry (PAT HSAT). Results showed strong agreement of PAT HSAT with PSG in terms of endpoint parameters and OSA severity categorization. Different brands of PAT HSAT may have distinct clinical performance characteristics.
Article
Critical Care Medicine
Geoffroy Solelhac, Manuel Sanchez-de-la-Torre, Margaux Blanchard, Mathieu Berger, Camila Hirotsu, Theo Imler, Alicia Sanchez-de-la-Torre, Jose Haba-Rubio, Nicola Andrea Marchi, Virginie Bayon, Sebastien Bailly, Francois Goupil, Adrien Waeber, Gregory Heiniger, Thierry Pigeanne, Esther Gracia-Lavedan, Andrea Zapater, Jorge Abad, Estrella Ordax, Maria Jose Masdeu, Valentin Cabriada-Nuno, Carlos Egea, Sandra Van Den Broecke, Peter Vollenweider, Pedro Marques-Vidal, Julien Vaucher, Giulio Bernardi, Monica Betta, Francesca Siclari, Ferran Barbe, Frederic Gagnadoux, Raphael Heinzer
Summary: This study investigated the value of pulse wave amplitude drops (PWADs) as a biomarker of cardiovascular risk in patients with obstructive sleep apnea (OSA). The results showed that patients with a low PWAD index and OSA had a higher incidence of cardiovascular events compared to other groups.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Clinical Neurology
Christopher J. Lyne, Garun S. Hamilton, Anthony R. E. Turton, Durda Stupar, Darren R. Mansfield
Summary: The study aimed to validate a disposable and reusable home sleep apnea test (HSAT) device for the diagnosis of obstructive sleep apnea (OSA) by comparing it to laboratory polysomnography (PSG). Data from 100 participants showed that both HSAT devices demonstrated satisfactory levels of agreement with minimal mean bias for determination of AHI and oxygen desaturation index 3% compared to PSG.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Pasquale Tondo, Riccardo Drigo, Giulia Scioscia, Andrea Ballarin, Emanuela Rossi, Ariel Fabian Floriani, Alessia Pauletti, Maria Pia Foschino Barbaro, Donato Lacedonia
Summary: This study compared the accuracy of a HSAT device and a wrist worn peripheral arterial tone signal device (WP) with PSG and RP in a low-risk population of OSA. The results showed a high correlation between WP and PSG, higher specificity for RP in identifying OSA, and the usefulness of WP for screening and follow-up in a low-risk population.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Physiology
Sho Okamura, Akinori Sairaku, Takehito Tokuyama, Yosaku Okubo, Yoshihiro Ikeuchi, Shunsuke Miyauchi, Yukihito Higashi, Yukiko Nakano
Summary: During the active standing test, changes in the Peripheral Arterial Tone (PAT) and low frequency to high frequency ratio (LF/HF) were observed, indicating that sympathetic nervous system activity and heart rate variability respond differently to orthostasis.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Physiology
Marco Ross, Pedro Fonseca, Sebastiaan Overeem, Ray Vasko, Andreas Cerny, Edmund Shaw, Peter Anderer
Summary: This study aimed to improve the diagnostic accuracy of home sleep apnea testing (HSAT) by using artificial intelligence to extract surrogate sleep and arousal information from autonomic nervous system activity. The results showed that by extracting the correlation between autonomic and cortical arousal indices and using sleep and arousal information to evaluate the apnea-hypopnea index (AHI), the classification accuracy of HSATs was significantly improved.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Clinical Neurology
Antonio Moffa, Lucrezia Giorgi, Luca Carnuccio, Carmen Mangino, Rodolfo Lugo, Peter Baptista, Manuele Casale
Summary: This review provides a comprehensive overview of studies validating the WatchPAT (WP) as a diagnostic tool for sleep-disordered breathing compared to polysomnography (PSG). The results show that the WP is an effective and convenient device for diagnosing obstructive sleep apnea (OSA), with good sensitivity and specificity.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Brian M. O'Reilly, Qing Wang, Jacob Collen, Panagiotis Matsangas, Christopher J. Colombo, Vincent Mysliwiec
Summary: The study found significant discordance between PAT-based home sleep apnea testing (HSAT) and polysomnography (PSG) among active-duty military personnel evaluated for OSA, indicating limited utility of PAT-based HSAT for diagnosing and grading OSA severity in this population.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Ahmed S. BaHammam, Fang Han, Ravi Gupta, Sy Duong-Quy, Mohammed A. Al-Abri, Haitham A. Jahrami, Pamela Song, Tayard Desudchit, Liyue Xu, Seung Bong Hong
Summary: With the rapid growth in sleep medicine's professional content, several countries have recognized sleep medicine as an independent specialty. The accreditation of sleep medicine specialists is crucial for patient care and training of physicians and technologists._ASSM has developed Asian accreditation practice guidelines for sleep medicine physicians and technologists to meet the increasing demand in Asian countries.
Article
Clinical Neurology
Baha Al-Shawwa, Jose Cruz, Zarmina Ehsan, David G. Ingram
Summary: The drop in pulse wave amplitude signal serves as a useful marker in identifying arousals in pediatric polysomnography, which can help in scoring respiratory events accurately and prevent underestimation of the severity of sleep-disordered breathing in children.
Article
Pediatrics
Eduardo Machado Rossi-Monteiro, Laura Rodrigues Sefair, Marcos Correia Lima, Maria Fernanda Lima Nascimento, Daniel Mendes-Pinto, Lukas Anschuetz, Maria Gloria Rodrigues-Machado
Summary: This study aimed to compare cardiovascular parameters between healthy children and those with obstructive sleep-disordered breathing (oSDB), as well as identify predictors of arterial stiffness indices in children with oSDB. Children with oSDB showed higher reflection coefficient and augmentation index compared to controls, indicating increased arterial stiffness. Multiple regression analysis revealed age, female sex, reflection coefficient, and systolic volume as independent predictors of augmentation index, while higher pulse wave velocity was associated with poorer quality of life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Nana Feng, Jundong Yang, Huajun Xu, Chujun Zhang, Fan Wang, Xiaolin Wu, Meizhen Gu
Summary: This study evaluated the associations between sleep architecture and metabolic parameters in 2,308 patients with suspected OSA, finding weak correlations between sleep quality and metabolic parameters such as weight, blood sugar, and cholesterol. The clinical impact of sleep structure on metabolism appears to be negligible, highlighting the need for further prospective studies to confirm these findings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Yibing Chen, Weifang Wang, Yutao Guo, Hui Zhang, Yundai Chen, Lixin Xie
Summary: The study aimed to investigate the feasibility and validity of a PPG-based smartwatch in OSA screening. The results showed that the PPG-based smartwatch outperformed in predicting moderate-to-severe OSA patients compared to HSAT device, with high accuracy, sensitivity, and specificity.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.