Article
Clinical Neurology
Benjamin Wipper, Christopher Romero-Gutierrez, John W. Winkelman
Summary: This study demonstrates an increase in restless legs syndrome (RLS) symptom severity during the early stage of the COVID-19 pandemic. Patients with worsened RLS symptoms were significantly more likely to experience increased sleep disturbance, depression, and anxiety. These findings provide a basis for future investigations in other patient populations and suggest that clinicians should pay attention to RLS symptoms during times of socioeconomic and/or political uncertainty.
Article
Psychiatry
Saad Mohammed AlShareef
Summary: A survey conducted in Saudi Arabian adults revealed that restless legs syndrome (RLS) is common in adults and is often comorbid with moderate to severe depressive symptoms. Due to their potential negative impact, healthcare workers should actively inquire and alleviate the burden caused by RLS and depression in Saudi Arabia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Sofiene Chenini, Lucie Barateau, Lily Guiraud, Claire Denis, Ana Laura Rassu, Regis Lopez, Isabelle Jaussent, Yves Dauvilliers
Summary: The study found that the frequency of depressive symptoms and suicidal thoughts was significantly higher in patients with restless legs syndrome (RLS) compared to controls. Current major depressive episode and suicide risk were also high, with associations with factors such as young age, female sex, insomnia symptoms, and urgency.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Szymon Suwala, Jakub Rzeszuto, Rafal Glonek, Magdalena Krintus, Roman Junik
Summary: The study aims to compare the prevalence of restless legs syndrome (RLS) in patients with thyroid gland diseases and individuals with a healthy thyroid gland. The results show that RLS is more common in patients with thyroid disease, particularly in those with Hashimoto's disease.
Review
Clinical Neurology
C. Trenkwalder, M. Tinelli, G. K. Sakkas, Y. Dauvilliers, R. Ferri, R. Rijsman, W. Oertel, J. Jaarsma
Summary: Restless legs syndrome (RLS) imposes significant personal and social burden, while achieving adequate diagnosis and treatment of RLS can bring substantial economic savings.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Ferhat Balgetir, Murat Gonen, Ayse Berilgen, Emrah Aytac, Caner Feyzi Demir, Bulent Mungen
Summary: A retrospective study of 460 patients diagnosed with RLS at Firat University Medical School revealed a new variant of the disease affecting the head region, with most cases also involving the arms. Treatment with dopaminergic therapy alleviated symptoms in all patients, suggesting that this variant could be labeled as restless head syndrome.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Sehnaz Basaran, Halil Ibrahim Tas
Summary: The study found that patients with Restless Legs Syndrome (RLS) had significantly higher scores on affective temperament, depression, and anxiety scales compared to healthy controls. Anxious temperament scores were positively related to longer disease duration, while disease severity and lower educational status were correlated with anxiety profiles.
SLEEP AND BREATHING
(2022)
Article
Health Care Sciences & Services
Stefania Diaconu, Laura Irincu, Larisa Ungureanu, Bogdan Ciopleias, Diana Tint, Cristian Falup-Pecurariu
Summary: In this cross-sectional study of 131 Parkinson's disease patients, 26.71% met the diagnostic criteria for restless legs syndrome (RLS). RLS was associated with poorer sleep quality and significant correlations were found between RLS and certain types of pain (especially nocturnal pain), physical fatigue, and probable sleep-disordered breathing.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Nada Ahmed, Mohamed Kandil, Mohamed Elfil, Abdalla Jamal, Brian B. Koo
Summary: Restless legs syndrome (RLS) is more prevalent in individuals with hypothyroidism, and hypothyroidism is more common in individuals with RLS. There is a significant association between RLS and thyroid disease, which may shed light on the complex biological mechanisms underlying RLS.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Clinical Neurology
Mingyang Tang, Qingqing Sun, Yanan Zhang, Huimin Li, Dong Wang, Ying Wang, Zan Wang
Summary: Restless legs syndrome (RLS) is a sensorimotor disorder with a distinct circadian rhythm, and this review explores the possible causes for the fluctuation of symptoms, including levels of iron, dopamine, melatonin, melanocortin, and thyroid-stimulating hormone in the brain, as well as conditions such as peripheral hypoxia and microvascular function disorders. Metabolic disturbances of these substances can create a pathological imbalance, which is further exacerbated by physiological fluctuations of circadian rhythms, leading to the worsening of RLS symptoms at night. The review concludes with suggestions for RLS treatment and future research directions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Katarzyna Wachowska, Piotr Galecki, Janusz Szemraj, Janusz Smigielski, Agata Orzechowska
Summary: This study found that depressed patients had higher levels of IL-1 and IL-6 in their serum, as well as higher levels of psychoticism and neuroticism in their personality traits, compared to healthy participants.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Yuan Xu, Hongbin Wen, Jie Li, Jing Yang, Kai Luo, Liying Chang
Summary: The study found that patients with restless legs syndrome (RLS) are prone to sleep disorders, anxiety, and depression. As the severity of RLS increases, sleep disorders worsen and have an impact on cognitive function. Sleep disorders are closely related to RLS severity and depression.
SLEEP AND BREATHING
(2022)
Article
Psychiatry
Maggie Kamila Kiraga, Kim P. C. Kuypers, Malin Vedoy Uthaug, Johannes G. Ramaekers, Natasha Leigh Mason
Summary: Anxiety disorders are the most common psychiatric disorders in Western countries. Psychedelic drug psilocybin may be effective in alleviating anxiety symptoms. This study investigated the effects of psilocybin on self-reported healthy volunteers' anxiety ratings in a supportive group setting. The results showed that psilocybin can rapidly and persistently reduce anxiety symptoms, with effects lasting up to one week. Additionally, psilocybin use increased mindfulness and decreased neuroticism.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Qing Lv, Xinlin Wang, Tetsuya Asakawa, Xiao Ping Wang
Summary: Restless legs syndrome is a neurological disorder characterized by a strong desire to move when at rest and paraesthesia in the lower legs. Current first-line treatment includes dopaminergic drugs but long-term use may lead to augmentation, prompting exploration of alternative therapies. The pathogenesis of RLS is not well understood and likely involves complex neural pathways with multiple genetic factors contributing to the disease.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Neurosciences
Christopher J. Earley, Byron C. Jones, Sergi Ferre
Summary: This article discusses the two main pathological elements of Restless Legs Syndrome (RLS): brain iron deficiency (BID) and altered dopaminergic system. Through research on diet-induced BID rodent models, it is possible to gain a better understanding of the effects of brain iron deficiency on the dopaminergic pathway and other potential pathways.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Mark A. Oldham, Keith A. Hawkins, I-Hsin Lin, Yanhong Deng, Qing Hao, Leslie M. Scoutt, David D. Yuh, Hochang B. Lee
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2019)
Article
Surgery
Charles H. Brown, Karin J. Neufeld, Jing Tian, Julia Probert, Andrew LaFlam, Laura Max, Daijiro Hori, Yohei Nomura, Kaushik Mandal, Ken Brady, Charles W. Hogue, Ashish Shah, Kenton Zehr, Duke Cameron, John Conte, O. Joseph Bienvenu, Rebecca Gottesman, Atsushi Yamaguchi, Michael Kraut
Article
Pediatrics
Clara Westwell-Roper, Kyle A. Williams, Jack Samuels, O. Joseph Bienvenu, Bernadette Cullen, Fernando S. Goes, Marco A. Grados, Daniel Geller, Benjamin D. Greenberg, James A. Knowles, Janice Krasnow, Nicole C. McLaughlin, Paul Nestadt, Yin-Yao Shugart, Gerald Nestadt, S. Evelyn Stewart
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2019)
Review
Psychiatry
Mark A. Oldham, Khushminder Chahal, Hochang B. Lee
GENERAL HOSPITAL PSYCHIATRY
(2019)
Article
Psychiatry
Patrick Triplett, C. Patrick Carroll, Ted Avi Gerstenblith, O. Joseph Bienvenu
GENERAL HOSPITAL PSYCHIATRY
(2019)
Editorial Material
Critical Care Medicine
Thomas Bein, O. Joseph Bienvenu, Ramona O. Hopkins
INTENSIVE CARE MEDICINE
(2019)
Article
Psychiatry
Evan B. Fletcher, Miriam T. Fox, Oscar Joseph Bienvenu, Brent C. Pottenger
Article
Clinical Neurology
Stephan Ehrhardt, Anton P. Porsteinsson, Cynthia A. Munro, Paul B. Rosenberg, Bruce G. Pollock, Davangere P. Devanand, Jacobo Mintzer, Tarek K. Rajji, Zahinoor Ismail, Lon S. Schneider, Sheriza N. Baksh, Lea T. Drye, Dimitri Avramopoulos, David M. Shade, Constantine G. Lyketsos, Constantine G. Lyketsos, Anton P. Porsteinsson, Dimitri Avramopoulos, Cynthia Munro, Ho-chang (Ben) Lee, Nicholas Bienko, Dave Shade, Stephan Ehrhardt, Jennifer Jones, Anne Shanklin Casper, Constantine Frangakis, Andy Lears, Sheriza Baksh, Jamie Perin, Laurie Ryan, Alvin D. McKelvy, Paul Rosenberg, Milap Nowrangi, Sarah Lawrence, Meghan Schultz, Nimra Jamil, D. P. Devanand, Laura Simon-Pearson, Gregory Pelton, Jacobo Mintzer, Olga Brawman-Mintzer, Arthur Williams, Anthony Awkar, Anton P. Porsteinsson, Melanie Keltz, Nancy Kowalski, Kaitlyn Lane, Kim Martin, Susan Salem-Spencer, Asa Widman, Bruce G. Pollock, Sanjeev Kumar, Lillian Lourenco, Benoit H. Mulsant, Kyle Lago, Tarek K. Rajji, Lon S. Schneider, Maurcio Becerra, Karen Dagerman, Sonia Pawluczyk, Liberty Teodoro
ALZHEIMERS & DEMENTIA
(2019)
Article
Psychiatry
Ted Avi Gerstenblith, Ashley Jaramillo-Huff, Tuua Ruutiainen, Paul S. Nestadt, Jack F. Samuels, Marco A. Grados, Bernadette A. Cullen, Mark A. Riddle, Kung-Yee Liang, Benjamin D. Greenberg, Steven A. Rasmussen, Scott L. Rauch, James T. McCracken, John Piacentini, James A. Knowles, Gerald Nestadt, O. Joseph Bienvenu
COMPREHENSIVE PSYCHIATRY
(2019)
Editorial Material
Critical Care Medicine
O. Joseph Bienvenu
CRITICAL CARE MEDICINE
(2019)
Article
Health Care Sciences & Services
Johan H. Vlake, Jasper van Bommel, Evert-Jan Wils, Joe Bienvenu, Merel E. Hellemons, Tim I. M. Korevaar, Anna F. C. Schut, Joost A. M. Labout, Lois L. H. Schreuder, Marten P. van Bavel, Diederik Gommers, Michel E. van Genderen
Summary: This study aimed to investigate the effects of ICU-VR on mental health and ICU aftercare in COVID-19 ICU survivors. The results showed that ICU-VR improved satisfaction with and rating of ICU aftercare, but had limited impact on psychological recovery and quality of life.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Psychiatry
O. Joseph Bienvenu
Summary: ICU is not just a place for critical patient care, but also plays a key role in disaster response. The COVID-19 pandemic has highlighted the potential long-term mental health impacts on survivors of critical illness, with some experiencing symptoms of PTSD. New interventions such as ICU follow-up clinics and psychological support may help prevent long-term consequences.
INTERNATIONAL REVIEW OF PSYCHIATRY
(2021)
Article
Neurosciences
Elizabeth J. Prince, Daniel J. Siegel, C. Patrick Carroll, Kenneth J. Sher, O. Joseph Bienvenu
Summary: The study found that high neuroticism in young adulthood may be a true risk factor or marker of risk for first-onset anxiety and depressive disorders, while low extraversion may be a risk factor for agoraphobia.
ANXIETY STRESS AND COPING
(2021)
Article
Critical Care Medicine
Megan M. Hosey, Jeannie-Marie S. Leoutsakos, Ximin Li, Victor D. Dinglas, O. Joseph Bienvenu, Ann M. Parker, Ramona O. Hopkins, Dale M. Needham, Karin J. Neufeld
Article
Cardiac & Cardiovascular Systems
K. Barrie, A. Cornick, S. Debreuil, E. Lee, B. M. Hiebert, R. A. Manji, O. J. Bienvenu, B. McDonald, R. K. Singal, R. C. Arora
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2019)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
