Article
Clinical Neurology
Davide Sparasci, Raffaele Ferri, Anna Castelnovo, Silvia Miano, Kosuke Tanioka, Naoko Tachibana, Chiara Carelli, Gianna Riccitelli, Giulio Disanto, Chiara Zecca, Claudio Gobbi, Mauro Manconi
Summary: Restless legs syndrome (RLS) is highly frequent in patients with multiple sclerosis (MS), with a comparable frequency of periodic limb movements during sleep (PLMS) to the general population. The low percentage of patients with RLS having a high PLMS index, together with the absence of correlation between RLS and clinical and polysomnography parameters, indicates the existence of a distinct symptomatic form of RLS in MS.
Article
Clinical Neurology
Lourdes M. DelRosso, Raffaele Ferri, Maida L. Chen, Vidhi Kapoor, Richard P. Allen, Maria Paola Mogavero, Daniel L. Picchietti
Summary: The study evaluated the effectiveness and tolerability of intravenous ferric carboxymaltose (IV FCM) in children with restless legs syndrome (RLS) or periodic limb movement disorder (PLMD), showing improvements in clinical symptoms and iron indices with well-tolerated treatment. Adverse events were minimal.
Article
Clinical Neurology
Milca A. Morais, Beatriz Franco, Alessandro S. S. Holanda, Lais Angelica de Paula Simino, Mauro Manconi, Adriana Torsoni, Andrea M. Esteves
Summary: The study verified the impact of pramipexole on the expression of the PTPRD protein in the spinal cord and improvement of the animals' sleep pattern, providing a feasible approach for treating restless legs syndrome.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Clinical Neurology
Silvia Riccardi, Raffaele Ferri, Corrado Garbazza, Silvia Miano, Mauro Manconi
Summary: The study systematically reviewed the literature to determine the effectiveness of different drug categories in suppressing PLMS. Dopamine agonists were found to be the most effective, followed by L-dopa and other dopamine agonists. Alpha2delta ligands and opioids also showed moderate effectiveness, while valproate and carbamazepine had no significant effect. There is a lack of sufficient data on other drugs such as clonazepam, perampanel, dypiridamole, and iron supplementation.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Pediatrics
Lourdes M. DelRosso, Maria P. Mogavero, Raffaele Ferri
Summary: Sleep-related movement disorders, including restless legs syndrome, periodic limb movements of sleep, and restless sleep disorder, affect sleep quality. While advancements have been made in adults, research on the phenomenology and consequences of sleep-related movements in children is just beginning, necessitating new approaches and diagnostic standards.
PEDIATRIC PULMONOLOGY
(2022)
Article
Psychiatry
Judit Cabana-Dominguez, Barbara Torrico, Andreas Reif, Noelia Fernandez-Castillo, Bru Cormand
Summary: Psychiatric disorders exhibit clinical and genetic overlap, with dopaminergic and serotonergic neurotransmission playing important roles. This study assessed the genetic contribution of these systems to eight psychiatric disorders using GWAS analyses, identifying several associated genes and gene sets.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Milca A. Morais, Beatriz Franco, Alessandro S. S. Holanda, Lais Angelica de Paula Simino, Mauro Manconi, Adriana Torsoni, Andrea M. Esteves
Summary: This study investigated the effects of pramipexole (PPX) and exercise on genes and proteins associated with restless leg syndrome (RLS) and sleep patterns. The findings suggest that the combined use of exercise and PPX can increase PTPRD protein levels, decrease tyrosine hydroxylase (TH) protein levels, and improve sleep parameters. However, the use of PPX alone has negative effects on PTPRD and TH mRNA and protein levels, but can improve sleep patterns in the light cycle. In the dark cycle, PPX use worsens symptoms.
Article
Cell Biology
Gaia Faustini, Francesca Longhena, Alessia Musco, Federica Bono, Edoardo Parrella, Luca La Via, Alessandro Barbon, Marina Pizzi, Franco Onofri, Fabio Benfenati, Cristina Missale, Maurizio Memo, Daniela Zizioli, Arianna Bellucci
Summary: This study suggests that polymorphisms in the Synapsin III (Syn III) gene may play a role in the development of ADHD and the response to medication. It was found that Syn III is involved in the early stages of dopaminergic neuron development, and this function is conserved in vertebrates. Additionally, in mammals, Syn III regulates dendrite development stimulated by BDNF and Cdk5.
Article
Clinical Neurology
Vidhi Kapoor, Raffaele Ferri, Mark A. Stein, Chris Ruth, Jennifer Reed, Lourdes M. DelRosso
Summary: The study found that insomnia is a common complaint in children with ADHD, but the actual prevalence of RSD is relatively low. The majority of insomnia symptoms are secondary and associated with other sleep disorders, psychiatric comorbidities, or medication use.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Review
Clinical Neurology
Ioanna Kouri, Mithri R. Junna, Melissa C. Lipford
Summary: This article provides summaries of restless legs syndrome (RLS), periodic limb movements of sleep, and periodic limb movement disorder. RLS is a common sleep disorder that affects 5% to 15% of the general population. RLS can occur in childhood and its prevalence increases with age. It can be caused by various factors such as iron deficiency, chronic renal failure, peripheral neuropathy, and certain medications. Treatment options include pharmacologic agents and nonpharmacologic therapies. Periodic limb movements of sleep often accompany RLS but can also occur independently. The clinical significance of these movements is still debated. Periodic limb movement disorder is a distinct sleep disorder that occurs in individuals without RLS and is diagnosed by exclusion.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Lais Angelica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteves
Summary: The pathophysiology of restless legs syndrome (RLS) is related to dopaminergic dysfunction, reduced iron, and variations in gene expression. This study used spontaneously hypertensive rats (SHR) as an animal model to evaluate gene and protein expression, sleep patterns, and cardiovascular parameters associated with RLS. The study found that SHR had higher blood pressure, altered sleep patterns, lower expression of certain proteins and genes, and lower serum concentrations of ferritin.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sri Jayanti, Camilla Dalla Verde, Claudio Tiribelli, Silvia Gazzin
Summary: Dopamine, a well-known neurotransmitter, plays a crucial role in Parkinson's disease and various mental and physical activities. Inflammation is recognized as a risk factor for neuronal malfunctioning and cell death in neurodegenerative diseases. Bilirubin, an endogenous defense, has been found to possess anti-inflammatory activity and prevent dopamine neuron demise. This review aims to understand the links between dopamine, inflammation (specifically TNFa), and bilirubin as an anti-inflammatory and explore strategies to preserve dopamine homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
D. P. Migueis, M. C. Lopes, E. Casella, P. V. Soares, L. Soster, K. Spruyt
Summary: This systematic review evaluates the association between attention deficit hyperactivity disorder (ADHD) and restless legs syndrome (RLS) based on PRISMA guidelines. After searching databases for relevant articles, 29 were included out of the 208 identified between 1996 and 2022. The findings suggest a strong co-occurrence between RLS and ADHD, and highlight sleep fragmentation as a common characteristic.
SLEEP MEDICINE REVIEWS
(2023)
Article
Clinical Neurology
Lucile Cathiard, Valerie Fraulob, Daniel D. Lam, Miguel Torres, Juliane Winkelmann, Wojciech Krezel
Summary: This study investigated the role of MEIS1 in striatal dopaminergic signaling and found that a null mutation of MEIS1 in DRD2(+) cells does not lead to RLS-like symptoms or dysfunction of the DRD2 pathway.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Neurosciences
Paul Curtin, Janina Neufeld, Austen Curtin, Manish Arora, Sven Bolte
Summary: This study investigated the periodic dynamics in the DMN of children with ASD and ADHD using nonlinear analytical methods. The findings suggest that synchronized periodicity in the DMN is related to both neurotypical function and ASD and/or ADHD, indicating the potential importance of dynamic analysis of network interconnectivity in future neuroimaging studies.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.