Review
Medicine, General & Internal
Nathaniel F. F. Watson, Ruth M. M. Benca, Andrew D. D. Krystal, William V. V. McCall, David N. N. Neubauer
Summary: Determining the most effective insomnia medication may require trials of different medications, considering side effects, interactions, and declining efficacy. Guidelines were developed to inform clinicians on best practices for deprescribing or transitioning between insomnia medications. Tapering and additional CBT-I are recommended for benzodiazepine hypnotic drugs, while Z-drugs and off-label antidepressants should be gradually reduced during discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Seonghui Kim, Duhyeon Kim, Min Young Um, Minseok Yoon, Jae-Suk Choi, Yung Hyun Choi, Suengmok Cho
Summary: Insomnia is a common sleep disorder and natural sleep aids are gaining popularity as alternatives to prescription drugs. Recent studies have shown that marine polyphenols, specifically phlorotannins found in brown algae, have sedative-hypnotic effects. These effects are mediated through the gamma-aminobutyric acid type A-benzodiazepine receptor. The supplement containing phlorotannins from Ecklonia cava has been approved for improving sleep quality.
Article
Medicine, Research & Experimental
Tae-Ho Kim, Katrina Joy Bormate, Raly James Perez Custodio, Jae Hoon Cheong, Bo Kyung Lee, Hee Jin Kim, Yi-Sook Jung
Summary: The study found that rosmarinic acid, as an A1R agonist, has a hypnotic effect by reducing sleep fragmentation and onset latency to NREM sleep. This effect may be achieved through regulating neuronal activity in specific brain regions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Yu-Ting Peng, Ying-Hsin Hsu, Ming-Yueh Chou, Che-Sheng Chu, Chen-San Su, Chih-Kuang Liang, Yu-Chun Wang, Tsan Yang, Liang-Kung Chen, Yu-Te Lin
Summary: Insomnia is highly prevalent among older adults, particularly in females. Significant differences are found between genders in factors associated with insomnia and insomnia-related symptoms. Understanding gender differences may help clinicians modify associated factors when managing older adults with insomnia.
Article
Public, Environmental & Occupational Health
Juan Luo, Minglu Ji, Mengyuan Li, Anning Wang
Summary: This study examined the impact of children's support on the mental health of older adults in rural China. The findings indicate that financial support from children contributes to the maintenance of mental health among rural older adults. Additionally, the study highlights the significant influence of individual characteristics on the mental health of older adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
Rikke Wesselhoeft, Lotte Rasmussen, Peter Bjodstrup Jensen, Poul Jorgen Jennum, Svetlana Skurtveit, Ingeborg Hartz, Johan Reutfors, Per Damkier, Mette Bliddal, Anton Pottegard
Summary: The use of hypnotic drugs, especially melatonin and sedating antihistamines, increased among young Scandinavians from 2012 to 2018, with Sweden showing the largest increase compared to Norway and Denmark. The variation in hypnotic use between Scandinavian countries may be due to differences in sleep problems prevalence, healthcare access, or clinical practice.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Editorial Material
Geriatrics & Gerontology
Camille P. Vaughan, Alayne D. Markland, Alison J. Huang, Cathy A. Alessi, Andrew Guzman, Jennifer L. Martin, Donald L. Bliwise, Theodore M. Johnson Ii, Kathryn L. Burgio, Constance H. Fung
Summary: Nocturia and chronic insomnia disorder often coexist in older adults, and existing medication treatments carry risks. The integrated cognitive behavioural treatment mentioned in the translation provides an effective approach to address both conditions simultaneously.
Article
Clinical Neurology
Isabelle A. Tully, Jane P. Kim, Norah Simpson, Latha Palaniappan, Joshua Tutek, Nicole B. Gumport, Jessica R. Dietch, Rachel Manber
Summary: This study aims to examine beliefs about prescription sleep medications among individuals with insomnia seeking cognitive behavioral therapy and factors predicting a desire to reduce usage. The results indicate that despite strong beliefs about necessity and lower concerns, the majority of users expressed a wish to reduce their intake of prescription hypnotics.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Kai-Tak Poon, Rheal S. W. Chan, Jieshuang Liang, Liman Man Wai Li
Summary: This study found that conspiracy mentality is related to perceived control, insomnia, psychological well-being, and psychological distress. Conspiracy mentality has negative effects on perceived control and psychological well-being, while positively affecting insomnia and psychological distress. These findings contribute to the understanding of conspiracy beliefs and offer potential intervention strategies to improve well-being and reduce psychological distress.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Psychiatry
Shoki Okuda, Zaina P. Qureshi, Yukiko Yanagida, Chie Ito, Yuji Homma, Shigeru Tokita
Summary: This study analyzed the prescribing patterns of hypnotics for treating insomnia in Japan using a claims database. The results showed that new users were mostly prescribed GABA(A)-receptor agonists, while long-term users preferred melatonin receptor agonists and orexin receptor antagonists. The findings suggest that more clinical evidence is needed to guide physicians in making optimal treatment decisions.
Article
Clinical Neurology
Ryuji Furihata, Rei Otsuki, Naomi Hasegawa, Takashi Tsuboi, Shusuke Numata, Norio Yasui-Furukori, Hiroko Kashiwagi, Hikaru Hori, Shinichiro Ochi, Hiroyuki Muraoka, Toshiaki Onitsuka, Hiroshi Komatsu, Masahiro Takeshima, Akitoyo Hishimoto, Tatsuya Nagasawa, Yoshikazu Takaesu, Toshinori Nakamura, Takeshi Asami, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Yuka Yasuda, Hitoshi Iida, Kazuyoshi Ogasawara, Naoki Hashimoto, Kayo Ichihashi, Hisashi Yamada, Koichiro Watanabe, Ken Inada, Ryota Hashimoto
Summary: Prescription of hypnotic agents is highly frequent among inpatients with psychiatric disorders, especially those with schizophrenia and major depressive disorder. The use of two or more antipsychotic agents is commonly associated with the use of hypnotic medication.
Review
Clinical Neurology
Alexander Sweetman, Stacey Putland, Leon Lack, R. Doug McEvoy, Robert Adams, Ron Grunstein, Nigel Stocks, Billingsley Kaambwa, Emer Van Ryswyk, Christopher Gordon, Andrew Vakulin, Nicole Lovato
Summary: Although CBTi is the recommended first-line treatment for insomnia, most patients are initially treated with sedative-hypnotic medications. Guidelines suggest limiting prescriptions of sedative-hypnotics to short-term use due to the associated risks, and utilizing CBTi techniques to facilitate withdrawal from these medications. The current review integrates multiple studies to provide recommendations for reducing sedative-hypnotic use and increasing access to CBTi as an effective treatment for insomnia.
SLEEP MEDICINE REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Yun-Fang Hao, Ting Luo, Zhong-Yu Lu, Chun-Yan Shen, Jian-Guo Jiang
Summary: Rhodiola rosea extracts have sedative and hypnotic effects by regulating neurotransmitters, hormones, and inflammation cytokines, with potential involvement of the serotonergic, GABAergic, and immune systems.
Article
Oncology
Jacob C. Cogan, Rohit R. Raghunathan, Melissa P. Beauchemin, Melissa K. Accordino, Yongmei Huang, Elena B. Elkin, Alexander Melamed, Jason D. Wright, Dawn L. Hershman
Summary: There is a high rate of breast cancer patients receiving adjuvant chemotherapy becoming new persistent users of sedative-hypnotic medications. Shorter durations of chemotherapy and receipt of opioid prescriptions are associated with new persistent use.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Multidisciplinary Sciences
Hind A. Beydoun, May A. Beydoun, Jordan Weiss, Rana S. Gautam, Sharmin Hossain, Brook T. Alemu, Alan B. Zonderman
Summary: This longitudinal study aims to construct a prediction model for Covid-19 level of concern among U.S. older adults using socio-demographic, lifestyle, and health risk characteristics, and to examine the contributions of obesity-related cardiometabolic health characteristics. The study analyzed data from 2,872 participants in the Health and Retirement Study from 2006 to 2020. The results showed that diabetes, stroke, cardiometabolic risk factors and/or chronic conditions were associated with higher Covid-19 level of concern, while factors such as female sex, birth cohort, minority race, Hispanic ethnicity, total wealth, depressive symptoms, and education were associated with different levels of Covid-19 concern.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Christina S. McCrae, Wai Sze Chan, Ashley F. Curtis, Chelsea B. Deroche, Melissa Munoz, Stephanie Takamatsu, Julie E. Muckerman, Nicole Takahashi, Dillon McCann, Kevin McGovney, Pradeep Sahota, Micah O. Mazurek
Article
Clinical Neurology
Wai Sze Chan, Natalie D. Dautovich, Joseph P. H. McNamara, Ashley Stripling, Joseph M. Dzierzewski, Karin McCoy, Christina S. McCrae
Summary: The study found that a brief behavioral therapy for older adults with chronic insomnia was effective in reducing sleep discrepancy, especially in reducing the discrepancy in sleep onset latency.
BEHAVIORAL SLEEP MEDICINE
(2021)
Article
Clinical Neurology
Ashley F. Curtis, Alicia J. Roth, Samuel F. Sears, Jamie B. Conti, Richard B. Berry, Joseph M. Dzierzewski, Christina S. McCrae
Article
Clinical Neurology
Earl Charles Crew, Kelly Glazer Baron, Michael A. Grandner, Carolyn E. Ievers-Landis, Christina S. McCrae, Michael R. Nadorff, Sara Nowakowski, Skye Ochsner Margolies, Kathryn Hansen
BEHAVIORAL SLEEP MEDICINE
(2020)
Article
Clinical Neurology
Mary Beth Miller, Chelsea B. Deroche, Lindsey K. Freeman, Chan Jeong Park, Nicole A. Hall, Pradeep K. Sahota, Christina S. McCrae
Summary: The study aimed to test the feasibility and short-term efficacy of CBT-I among binge-drinking young adults with insomnia, as well as the relationship between improvement in insomnia and improvement in alcohol use outcomes. CBT-I participants showed greater improvements in insomnia severity compared to the SH group, and the impact of CBT-I on alcohol use outcomes was mediated through its effect on posttreatment insomnia severity.
Article
Medicine, General & Internal
Christina S. McCrae, Ashley F. Curtis, Jason Craggs, Chelsea Deroche, Pradeep Sahota, Chokkalingam Siva, Roland Staud, Michael Robinson
Article
Clinical Neurology
Adaixa Padron, Christina S. McCrae, Michael E. Robinson, Lori B. Waxenberg, Michael H. Antoni, Richard B. Berry, Jacqueline Castagno, Gregory Schultz, Elizabeth L. Kacel, Chantel Ulfig, Stephanie Garey, Seema Patidar, Timothy Sannes, Laura Trinastic, Shan Wong, Deidre B. Pereira
Summary: Cognitive Behavioral Therapy (CBT) shows significant improvement in the sleep outcomes of insomnia and pain patients, including subjective sleep efficiency, sleep quality, and sleep onset latency. Compared to psychoeducation, CBT has a more pronounced effect on sleep in patients with gynecologic cancers.
BEHAVIORAL SLEEP MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Melanie A. Stearns, Carolyn E. Ievers-Landis, Christina S. McCrae, Stacey L. Simon
Summary: Pediatric sleep changes during the COVID-19 pandemic have been identified, highlighting the need for refined screening strategies and behavioral interventions to support sleep health in children.
CHILDRENS HEALTH CARE
(2022)
Article
Health Care Sciences & Services
Christina S. McCrae, Ashley F. Curtis, Amelia Cottle, David B. Beversdorf, Joel Shenker, Brian P. Mooney, Mihail Popescu, Marilyn Rantz, Maureen Groer, Phyllis Stein, Mojgan Golzy, Melanie A. Stearns, Angelynn Simenson, Neetu Nair, Meredeth A. Rowe
Summary: This trial aims to evaluate the acceptability, feasibility, and short-term and long-term effects of a web-based cognitive behavioral therapy for insomnia (CBT-I) for rural caregivers. By improving insomnia and restoring central stress processing, this treatment has the potential to improve caregiver health and functioning.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Clinical Neurology
Kevin D. McGovney, Ashley F. Curtis, Christina S. McCrae
Summary: This study found that greater morning and afternoon physical activity is associated with greater sleep fragmentation and higher stage 1 sleep in individuals with fibromyalgia and insomnia complaints. The relationship between higher physical activity and higher stage 1 sleep is stronger for individuals with higher pain. These findings provide a theoretical basis for further research on the causal relationship between physical activity, activity pacing, and sleep in fibromyalgia.
BEHAVIORAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Amy N. Costa, Ashley F. Curtis, Madison Musich, Alan A. Guandique, Christina S. McCrae
Summary: Poor subjective evaluation of cognition and sleep is associated with cognitive decline in older adults. This study examines the relationships among self-reported cognition, sleep, and cognitive domains, and finds a congruent association between attention/processing speed and self-reported cognition, particularly in individuals with poorer sleep quality.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Psychology, Multidisciplinary
Wai Sze Chan, Christina S. McCrae, Albe Sin-Ying Ng
Summary: Chronic insomnia is a common sleep disorder that can be effectively treated with cognitive behavioral therapy for insomnia (CBT-I). This meta-analysis reviewed 43 randomized controlled trials and found that CBT-I can increase sleep duration by about 30 minutes, although the findings may vary depending on the measurement method.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Christina S. McCrae, Ashley F. Curtis, Melanie A. Stearns, Neetu Nair, Mojgan Golzy, Joel Shenker, David Q. Beversdorf, Amelia Cottle, Meredeth A. Rowe
Summary: The research team translated a 4-session standard CBT-I content protocol into a digital format, creating NiteCAPP CARES for dementia caregivers in rural areas. The adapted intervention was found to have high usability and satisfaction ratings, and showed promising preliminary effects on caregiver sleep and related health outcomes.
Article
Clinical Neurology
Kevin D. McGovney, Ashley F. Curtis, Christina S. McCrae
Summary: In patients with fibromyalgia, increased afternoon and early evening physical activity is associated with sleep disturbance, especially in individuals with higher pain intensity.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Psychology, Developmental
Christina S. McCrae, Wai Sze Chan, Ashley F. Curtis, Neetu Nair, Chelsea B. Deroche, Melissa Munoz, Stephanie Takamatsu, Deija McLean, Mattina Davenport, Julie E. Muckerman, Nicole Takahashi, Dillon McCann, Kevin McGovney, Pradeep Sahota, Micah O. Mazurek
Summary: The study tested telehealth delivery of cognitive behavioral treatment for childhood insomnia in children with autism, showing promising results in improving sleep for both children and parents, as well as reducing children's behavioral issues and arousal, and parental fatigue. Further randomized controlled trials are needed to confirm these findings.
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
