Article
Clinical Neurology
Eric Yu, Lynne A. Krohn, Jennifer Ruskey, Farnaz Asayesh, Dan Spiegelman, Zalak Shah, Ruth Chia, Isabelle Arnulf, Michele T. M. Y. Hu, Jacques Montplaisir, Jean-Francois Gagnon, Alex Desautels, Yves Dauvilliers, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Birgit Hoegl, Ambra Stefani, Abubaker Ibrahim, Anna Heidbreder, Karel Sonka, Petr Dusek, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Doering, Valerie Cochen De Cock, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz F. Abril, Bradley A. Boeve, Guy B. Rouleau, Ronald W. Postuma, Sonja Scholz, Ziv Gan-Or
Summary: This study found that the human leukocyte antigen (HLA) locus may play a role in synucleinopathies-related disorders such as isolated/idiopathic REM sleep behavior disorder (iRBD) and Lewy body dementia (LBD). The results showed that HLA-DRB1*11:01 was the only allele passing FDR correction in iRBD. Associations were also discovered between iRBD and HLA-DRB1 70D, 70Q, and 71R. Positions 70 and 71 were linked to iRBD. These findings suggest that the HLA locus may have different roles in various synucleinopathies.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Paulo Bugalho, Filipa Ladeira, Raquel Barbosa, Joao Pedro Marto, Claudia Borbinha, Laurete da Conceicao, Manuel Salavisa, Marlene Saraiva, Bruna Meira, Marco Fernandes
Summary: This study suggests that PSG data could be valuable for predicting the progression of cognitive and sleep dysfunction in PD patients. Lower N3 percentage at baseline was associated with cognitive decline, while baseline PLMS index and presence of RBD were linked to worsening daytime sleep dysfunction. Severity of RBD was a predictor for nighttime sleep symptom progression.
Article
Clinical Neurology
Luigi Ferini-Strambi, Claudio Liguori, Brendan P. Lucey, Bryce A. Mander, Adam P. Spira, Aleksandar Videnovic, Christian Baumann, Oscar Franco, Mariana Fernandes, Oriella Gnarra, Paul Krack, Mauro Manconi, Daniela Noain, Smita Saxena, Ulf Kallweit, Winfried Randerath, C. Trenkwalder, Ivana Rosenzweig, Alex Iranzo, Claudio Bassetti
Summary: Sleep abnormalities may be an independent risk factor for neurodegeneration. Decreased sleep efficiency and slow wave activity, as well as increased amyloid-beta (Aβ) concentrations, are associated with cognitive impairment and Alzheimer's disease (AD). Obstructive sleep apnea (OSA) is a risk factor for dementia. Circadian sleep-wake rhythm disorders (CSWRD) predict caregiver stress and institutionalization.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Regis Lopez, Sofiene Chenini, Lucie Barateau, Anna-Laura Rassu, Elisa Evangelista, Beatriz Abril, Julien Fanielle, Nicolas Vitello, Isabelle Jaussent, Yves Dauvilliers
Summary: The study found that sleep-related head jerks are common in the general population, but their clinical significance is unclear. Severe symptomatic forms of SRHJ may be categorized as a new sleep-related movement disorder, distinct from RBD and periodic leg movements.
Article
Clinical Neurology
Kristian Staer, Alex Iranzo, Miriam Hojholt Terkelsen, Morten Gersel Stokholm, Erik Hvid Danielsen, Karen Ostergaard, Monica Serradell, Marit Otto, Kristina B. Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Moller, Carles Gaig, David J. Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pavese
Summary: This study found that the severity of brain cholinergic dysfunction in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) increases significantly over 3 years, and these changes are more severe in patients with a decline in cognitive test scores.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Ambra Stefani, Birgit Hoegl
Summary: Nightmare disorder and isolated sleep paralysis are common REM sleep disorders that can cause distress. Nightmare disorder is related to emotion regulation and hyperarousal, with imagery rehearsal therapy being an effective nonmedication treatment; isolated sleep paralysis may result from REM atonia persisting into wakefulness, and therapy mainly involves avoiding predisposing factors.
Article
Geriatrics & Gerontology
Hong-Ju Zhang, Sheng-Hui Wang, Ying-Ying Bai, Jie-Wen Zhang, Shuai Chen
Summary: In idiopathic REM sleep behavior disorder (iRBD) patients, cognitive deficits were found in attention/working memory, executive function, immediate memory, and visuo-spatial ability. Abnormal spontaneous brain activities in the striatum (right caudate, left pallidum, and bilateral putamen) were observed in iRBD patients. Functional connectivity analysis showed decreased striatum-related FCs in various brain regions and deficits in attention/working memory, executive function, and immediate memory were associated with abnormal striatal-cortical FCs.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Neurosciences
Michelle Herberts, Bhanuprakash Kolla, Travis Paul, Praveen Mekala, Meghna P. Mansukhani
Summary: Sleep apnea is associated with autonomic dysfunction, rapid eye movement sleep behavior disorder, and dementia. Autonomic dysfunction caused by sleep apnea may contribute to the development of dementia. Treatment of sleep apnea may have an impact on autonomic dysfunction and cognitive outcomes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Dario Arnaldi, Francesco Fama, Nicola Girtler, Andrea Brugnolo, Matteo Pardini, Pietro Mattioli, Riccardo Meli, Federico Massa, Beatrice Orso, Maria Pia Sormani, Maria Isabella Donegani, Matteo Bauckneht, Silvia Morbelli, Flavio Nobili
Summary: The study explored the feasibility of a neuroprotection trial in prodromal synucleinopathy using iRBD as the target population and I-123-FP-CIT-SPECT as a biomarker of disease progression. Results showed differences in the emergence of parkinsonism and/or dementia after 30 months between the treatment and control groups, with the treatment group having less decrease in putamen uptake on I-123-FP-CIT-SPECT.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Paulo Bugalho, Bruna Meira, Marta Magrico
Summary: It is unclear whether seasonal variation affects sleep in patients with alpha-synucleinopathies. This study aimed to investigate the relationship between month of the year and polysomnography (PSG) data in patients with Parkinson's disease (PD), Lewy Body Dementia (LBD), and isolated REM sleep behavior disorder (iRBD). The results showed that there were significant variations in N2 and N3 sleep stages in alpha-synucleinopathies patients throughout the year, while the control group exhibited decreased total sleep time and sleep efficiency during winter, increased N2 sleep time and REM percentage in April and May, and peaked apnea-hypopnea index in June.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Avi Gadoth, Michelle F. Devine, Sean J. Pittock, Andrew McKeon, W. Oliver Tobin, Thomas R. Gossard, Elena F. D. Cattaneo, Stuart J. McCarter, Erik K. St. Louis
Summary: This study aimed to describe prominent sleep disturbances and polysomnography findings in six patients with dipeptidyl-peptidase-like protein-6 (DPPX) autoimmunity syndrome. The patients exhibited significant gastrointestinal disturbances, a range of neuropsychiatric disturbances, and various sleep disorders including insomnia, obstructive sleep apnea, periodic leg movements, and REM sleep behavior disorder. Polysomnography indicated REM sleep-atonia loss and mixed features of wakefulness, NREM, and REM sleep. Immunotherapy led to neurological improvement and partial improvement in sleep disturbances in most patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Dario Arnaldi, Pietro Mattioli, Matteo Pardini, Silvia Morbelli, Elena Capriglia, Annalisa Rubino, Valter Rustioni, Michele Terzaghi, Elisa Casaglia, Alessandra Serra, Michela Figorilli, Claudio Liguori, Mariana Fernandes, Fabio Placidi, Luca Baldelli, Federica Provini, Luigi Ferini-Strambi, Sara Marelli, Giuseppe Plazzi, Elena Antelmi, Valerio Brunetti, Enrica Bonanni, Monica Puligheddu, FARPRESTO Consortium
Summary: The FARPRESTO project in Italy aims to identify risk factors for phenoconversion in iRBD patients and facilitate clinical trial enrollment. The study found that older age, motor and cognitive impairment, constipation, urinary and sexual dysfunction, depression, and quantification of brain images can predict phenoconversion. The project is still ongoing.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Stephen Joza, Michele T. Hu, Ki-Young Jung, Dieter Kunz, Dario Arnaldi, Jee-Young Lee, Luigi Ferini-Strambi, Elena Antelmi, Friederike Sixel-Doering, Valerie Cochen De Cock, Jacques Y. Montplaisir, Jessica Welch, Han-Joon Kim, Frederik Bes, Pietro Mattioli, Kyung Ah Woo, Sara Marelli, Giuseppe Plazzi, Brit Mollenhauer, Amelie Pelletier, Jamil Razzaque, Jun-Sang Sunwoo, Nicola Girtler, Claudia Trenkwalder, Jean-Francois Gagnon, Ronald B. Postuma
Summary: Isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) is a powerful early predictor of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). This study demonstrates that attention and executive dysfunction strongly predict dementia in iRBD and begin declining several years prior to phenoconversion.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Fangzheng Chen, Yuanyuan Li, Guanyu Ye, Liche Zhou, Xiaolan Bian, Jun Liu
Summary: The presence of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease patients may indicate a worse prognosis, with an increased likelihood of developing cognitive impairment. A prognostic model was developed to predict mild cognitive impairment (MCI) in PD-RBD patients, showing good discrimination and calibration in predicting PD-MCI. Larger samples and external validation sets are needed to further validate this model.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Alejandra Collia, Alex Iranzo, Monica Serradell, Amaia Munoz-Lopetegi, Gerard Maya, Joan Santamaria, Raquel Sanchez-Valle, Carles Gaig
Summary: A study found that former professional football players are more likely to develop Parkinson's disease and dementia with Lewy bodies after being diagnosed with isolated REM sleep behavior disorder (IRBD). The researchers suggest that screening for IRBD in retired professional football players may help identify individuals with underlying neurodegenerative diseases.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.