Article
Medicine, General & Internal
Enric Sanchez, Esther Sapina-Beltran, Ricard Gavalda, Ferran Barbe, Gerard Torres, Ariadna Sauret, Mireia Dalmases, Carolina Lopez-Cano, Liliana Gutierrez-Carrasquilla, Marcelino Bermudez-Lopez, Elvira Fernandez, Francisco Purroy, Eva Castro-Boque, Cristina Farras-Salles, Reinald Pamplona, Didac Mauricio, Cristina Hernandez, Rafael Simo, Albert Lecube, ILERVAS Project Collaborators
Summary: The study found that individuals in the prediabetes stage exhibited higher abnormal sleep breathing parameters compared to those with normal glucose metabolism, with a significant increase in apnea events and hypoxemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yoshinari Nakatsuka, Kimihiko Murase, Kazuhiro Sonomura, Yasuharu Tabara, Tadao Nagasaki, Satoshi Hamada, Takeshi Matsumoto, Takuma Minami, Osamu Kanai, Hirofumi Takeyama, Hironobu Sunadome, Naomi Takahashi, Isuzu Nakamoto, Kiminobu Tanizawa, Tomohiro Handa, Taka-Aki Sato, Naoko Komenami, Tomoko Wakamura, Satoshi Morita, Osamu Takeuchi, Takeo Nakayama, Toyohiro Hirai, Yoichiro Kamatani, Fumihiko Matsuda, Kazuo Chin
Summary: In this study, researchers identified 20 metabolites related to sleep disordered breathing (SDB) using gas chromatography-mass spectrometry analysis. These metabolites were found to be closely related to fructose metabolism. Further analysis revealed that moderate-severe SDB was a significant factor for increased plasma fructose levels, and CPAP treatment can lower plasma fructose levels.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Carlos O'Connor-Reina, Jose Maria Ignacio Garcia, Laura Rodriguez Alcala, Elisa Rodriguez Ruiz, Maria Teresa Garcia Iriarte, Juan Carlos Casado Morente, Peter Baptista, Guillermo Plaza
Summary: The study found that Myofunctional therapy (MT) delivered through a mobile health app had good adherence and was effective in improving the apnoea-hypopnoea index (AHI), with improvements correlating with tongue strength and tongue-tie improvement.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Casper Schwartz Riedel, Joachim Birch Milan, Marianne Juhler, Poul Jennum
Summary: The study found a high prevalence of SDB in patients with iNPH, confirming previous findings. Additionally, the prevalence of SDB in patients with other types of hydrocephalus was not significantly different from that in the general population. No elevations of CO2 associated with SDB or CO2 retention during sleep were found.
Article
Clinical Neurology
Yuhang Chen, Gang Ma, Miao Zhang, Shuchen Yang, Jiayong Yan, Zhiming Zhang, Wenliang Zhu, Yanfang Dong, Lirong Wang
Summary: This paper proposes a screening method for sleep apnea based on breathing vibration signals, which can be done at home and has great potential as a simple screening tool for sleep apnea.
Article
Cardiac & Cardiovascular Systems
Beste Ozsezen, Nagehan Emiralioglu, Alev Ozon, Onur Akin, Dilber Ademhan Tural, Birce Sunman, Aysel Hejiyeva, Mina Hizal, Ayfer Alikasifoglu, Pelin Ozlem Simsek Kiper, Koray Boduroglu, Gulen Eda Utine, Ebru Yalcin, Deniz Dogru, Nural Kiper, Ugur Ozcelik
Summary: The majority of PWS patients in the study had severe sleep apnea syndrome characterized mainly by hypopneas accompanied by central apneas. Patients with deletions had a more severe impact on oxygen parameters and total AHI.
RESPIRATORY MEDICINE
(2021)
Article
Clinical Neurology
Ph Meurin, A. Ben Driss, C. Defrance, R. Dumaine, H. Weber, N. Renaud, L. Bonnevie, S. Mouram, J. Y. Tabet
Summary: This study found that ticagrelor administration may promote the occurrence of central sleep apnea hypopnea syndrome (CSAHS) in patients after acute coronary syndrome (ACS), with high prevalence of CSAHS post-ACS. The results suggest a potential association between ticagrelor use and CSAHS, warranting further investigation for safety concerns.
Article
Health Care Sciences & Services
Christopher Seifen, Johannes Pordzik, Katharina Bahr, Lisa Grosse-Brueggemann, Katharina Ludwig, Berit Hackenberg, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: Evidence suggests that the apnea-hypopnea index (AHI) increases with aging, especially in males. However, the impact of aging on sleep-related metrics, specifically AHI, has been less studied in different gender-specific subpopulations while considering confounding factors such as obstructive sleep apnea-related comorbidities and body mass index (BMI). A retrospective analysis of 186 first-time polysomnographic recordings and medical files was conducted, forming six groups based on age and gender. The older mixed-gender and female cohorts showed significantly higher AHI, apnea-index, and hypopnea-index values. Within the older male cohort, AHI and apnea-index were also significantly higher. No significant differences in BMI were found. The older male cohort had significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders. Conversely, the female subpopulation showed no significant differences in these comorbidities. In conclusion, sleep PSG-parameters increased in older subpopulations, possibly due to the accumulation of comorbidities in older males but not in females.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Satomi Imanari, Yasuhiro Tomita, Satoshi Kasagi, Fusae Kawana, Yuka Kimura, Sugao Ishiwata, Koji Narui, Takatoshi Kasai
Summary: The study found a modest correlation between AHI determined by the ASV device AutoSet CS (ASC) and that calculated by polysomnography (PSG) in patients with HF and SDB. However, the ASC device tended to overestimate AHI and showed moderate agreement with PSG results.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Abidan Abulimiti, Ryo Naito, Takatoshi Kasai, Sayaki Ishiwata, Miho Nishitani-Yokoyama, Akihiro Sato, Shoko Suda, Hiroki Matsumoto, Jun Shitara, Shoichiro Yatsu, Azusa Murata, Megumi Shimizu, Takao Kato, Masaru Hiki, Hiroyuki Daida, Tohru Minamino
Summary: Malnutrition often occurs together with heart failure, leading to negative consequences. Cheyne-Stokes respiration (CSR) is commonly found in heart failure patients. However, the impact of CSR and malnutrition on the long-term prognosis of patients with acute decompensated heart failure (ADHF) is still unclear.
Article
Engineering, Biomedical
Mehmet Balci, Sakir Tasdemir, Guzin Ozmen, Adem Golcuk
Summary: In this study, a classification system was developed using machine learning techniques and sleep monitoring data to simultaneously score different types of sleep-disordered breathing. The Random Forest algorithm showed the highest classification accuracy among the tested algorithms.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Clinical Neurology
Matthew P. Light, Kimberly Y. Kreitinger, Euyhyun Lee, Pamela N. DeYoung, Avni Lakhani, Brent Siegel, Lori B. Daniels, Atul Malhotra, Robert L. Owens
Summary: Sleep apnea severity and a central apnea pattern may be associated with myocardial injury. Respiratory polygraphy with serial biomarker assessment is feasible in this population, and combining this approach with interventions (e.g., positive airway pressure) may help establish if a link exists between sleep apnea and subclinical myocardial injury.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Adriano D. S. Targa, Ivan D. Benitez, Anna Moncusi-Moix, Farida Dakterzada, Olga Minguez, Rafaela Vaca, Mireia Dalmases, Manuel Sanchez-de-la-Torre, Ferran Barbe, Gerard Pinol-Ripoll
Summary: This study aims to evaluate the associations between sleep apnea events, sleep structure, levels of Alzheimer's disease markers, and cognitive decline. The results showed that obstructive and mixed apneas were associated with sleep structure and an increase in neurofilament light levels, while hypopneas were associated with an elevated phosphorylated-tau/amyloid-beta protein ratio. Additionally, hypopneas were found to be related to increased cognitive decline at the 12-month follow-up.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Marco Zaffanello, Giuliana Ferrante, Leonardo Zoccante, Marco Luigi Ciceri, Luana Nosetti, Laura Tenero, Michele Piazza, Giorgio Piacentini
Summary: Pediatric obstructive sleep apnea can have negative effects on neurocognitive function and development in children, hindering academic and adaptive goals. Questionnaires are useful for assessing neuropsychological symptoms in children with sleep-disordered breathing. This study aimed to compare the effectiveness of using the Oxygen Desaturation Index (ODI) to the Obstructive Apnea-Hypopnea Index in predicting long-term consequences of sleep-disordered breathing in children. The results showed that children with an ODI greater than one event per hour exhibited more symptoms at follow-up compared to those with an Obstructive Apnea-Hypopnea Index greater than one event per hour at diagnosis. The study also found a significant correlation between minimum SpO2 levels at diagnosis and various outcomes, suggesting that the ODI and minimum SpO2 levels could serve as valuable predictors of long-term symptoms and treatment outcomes in children with sleep-disordered breathing.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Hoang Thi Yen, Masaki Kurosawa, Tetsuo Kirimoto, Yukiya Hakozaki, Takemi Matsui, Guanghao Sun
Summary: This paper presents a system for monitoring vital signs using medical radar, which automatically evaluates signal quality and eliminates unsatisfactory signals, while extracting heartbeat and respiration signals using the singular value decomposition method. The system shows good performance in both laboratory testing and real medical practice.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Clinical Neurology
Jens Spiesshoefer, Nora Hegerfeld, Malte Frank Gerdes, Soeren Klemm, Martha Gorbachevski, Robert Radke, Izabela Tuleta, Claudio Passino, Xiaoyi Jiang, Paolo Sciarrone, Winfried Randerath, Michael Dreher, Matthias Boentert, Alberto Giannoni
Summary: Central apneas have different effects on sympathovagal balance during sleep depending on underlying systolic heart failure, with neutral effects in heart failure patients and increased sympathetic drive in those with idiopathic central apneas.
SLEEP AND BREATHING
(2021)
Article
Clinical Neurology
Jens Spiesshoefer, Britta Bannwitz, Michael Mohr, Simon Herkenrath, Winfried Randerath, Paolo Sciarrone, Christian Thiedemann, Hartmut Schneider, Andrew T. Braun, Michele Emdin, Claudio Passino, Michael Dreher, Matthias Boentert, Alberto Giannoni
Summary: Nasal high flow therapy (NHF) has the potential to improve sleep-related breathing and sympathovagal balance (SVB) in patients with precapillary pulmonary hypertension, but the effects may vary depending on the flow rate used and tolerability. In contrast, positive airway pressure therapy (PAP) improves obstructive sleep apnea (OSA) but has heterogeneous effects on SVB and neutral effects on sleep outcomes.
SLEEP AND BREATHING
(2021)
Article
Cardiac & Cardiovascular Systems
Claudio Passino, Paolo Sciarrone, Giuseppe Vergaro, Chiara Borrelli, Jens Spiesshoefer, Francesco Gentile, Michele Emdin, Alberto Giannoni
Summary: The study assessed the impact of sacubitril-valsartan on apneic burden in heart failure patients and found that the drug combination therapy can reduce the apnea-hypopnea index, with a more pronounced effect on central apneas.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Stefano Albani, Davide Stolfo, Ashwin Venkateshvaran, Vlad Chubuchny, Federico Biondi, Antonio De Luca, Francesco Lo Giudice, Emilio M. Pasanisi, Christina Petersen, Edoardo Airo, Carolina Bauleo, Marco Ciardetti, Michele Coceani, Bruno Formichi, Jens Spiesshoefer, Gianluigi Savarese, Lars H. Lund, Michele Emdin, Gianfranco Sinagra, Aristomenis Manouras, Alberto Giannoni
Summary: The novel echocardiographic biventricular coupling index (BCI) based on the ratio between right ventricular stroke work index and left ventricular E/E' ratio was found to accurately identify patients with precapillary pulmonary hypertension (PH). BCI showed high accuracy in both the derivation and validation cohorts, outperforming traditional scoring systems like the D'Alto score and the echocardiographic pulmonary-to-left atrial ratio index.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Letter
Respiratory System
Jens Spiesshoefer, Simon D. Herkenrath, Katharina Harre, Florian Kahles, Anca Rezeda Florian, Michael Mohr, Matthew Naughton, Winfried J. Randerath, Michele Emdin, Claudio Passino, Binaya Regmi, Michael Dreher, Matthias Boentert, Alberto Giannoni
Article
Cardiac & Cardiovascular Systems
Francesco Gentile, Chiara Borrelli, Paolo Sciarrone, Francesco Buoncristiani, Jens Spiesshoefer, Francesca Bramanti, Giovanni Iudice, Giuseppe Vergaro, Michele Emdin, Claudio Passino, Alberto Giannoni
Summary: Central apneas (CA) are common comorbidities with worse prognosis in patients with heart failure (HF). However, the clinical and prognostic relevance of CA in each sex is unclear. This study found that CA is associated with a higher risk of adverse events in women with chronic HF, but not in men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Giannoni, Francesco Gentile, Francesco Buoncristiani, Chiara Borrelli, Paolo Sciarrone, Jens Spiesshoefer, Francesca Bramanti, Giovanni Iudice, Shahrokh Javaheri, Michele Emdin, Claudio Passino
Summary: This study assessed the clinical and prognostic significance of baroreflex sensitivity (BRS) and chemoreflex sensitivity (CRS) in patients with chronic heart failure (HF) on modern treatments. The results showed that decreased BRS and increased CRS were associated with adverse outcomes in HF patients.
JACC-HEART FAILURE
(2022)
Review
Physiology
Jens Spiesshoefer, Binaya Regmi, Matteo Maria Ottaviani, Florian Kahles, Alberto Giannoni, Chiara Borrelli, Claudio Passino, Vaughan Macefield, Michael Dreher
Summary: This article provides a comprehensive assessment of sympathetic and vagal nerve activity in humans and focuses on the mechanisms and clinical significance of sympathetic activity increase in chronic obstructive pulmonary disease (COPD). The underlying physiological mechanisms responsible for sympathoexcitation in COPD are still poorly understood. A systematic approach to measuring sympathetic activity increase and assessing the underlying mechanisms is needed for a better understanding of this phenomenon.
FRONTIERS IN PHYSIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Jens Spiesshoefer, Binaya Regmi, Stefan Orwat, Hans-Joachim Kabitz, Alberto Giannoni, Michael Dreher, Matthias Boentert, Gerhard Paul Diller
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kirsten Thiele, Paul Balfanz, Tobias Mueller, Bojan Hartmann, Jens Spiesshoefer, Julian Grebe, Dirk Mueller-Wieland, Nikolaus Marx, Michael Dreher, Ayham Daher
Summary: This study aimed to determine cardiopulmonary limitations in COVID-19 survivors 6 months after their recovery. It found that fatigue was the most prevalent long-Covid symptom, leading to worse quality of life due to limited mobility and high symptom burden. Although most patients had normal pulmonary function and left ventricular ejection fraction, subtle myocardial dysfunction was observed, which was not related to the presence of fatigue.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Jens Spiesshoefer, Alberto Giannoni, Chiara Borrelli, Paolo Sciarrone, Imke Husstedt, Michele Emdin, Claudio Passino, Florian Kahles, Tye Dawood, Binaya Regmi, Matthew Naughton, Michael Dreher, Matthias Boentert, Vaughan G. Macefield
Summary: This study found that periodic breathing patterns with shorter periods of hyperventilation are associated with increased sympathetic nerve activity and decreased heart rate variability. Simulated periodic breathing with short hyperventilation resulted in a significant increase in sympathetic nerve activity compared to normal breathing. However, there was no change in sympathetic nerve activity during periodic breathing with long hyperventilation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Binaya Regmi, Janina Friedrich, Benedikt Joern, Mehdi Senol, Alberto Giannoni, Matthias Boentert, Ayham Daher, Michael Dreher, Jens Spiesshoefer
Summary: Dyspnea is a persistent symptom after COVID-19, and this study found that diaphragm muscle weakness is associated with dyspnea on exertion in COVID-19 patients. After 15 months of hospital discharge, approximately two-thirds of patients still experienced moderate or severe dyspnea on exertion. The study highlights the importance of assessing diaphragm muscle strength in COVID-19 patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Respiratory System
Jens Spiesshoefer, Alexander Kersten, Jonathan Enriquez Geppert, Binaya Regmi, Mehdi Senol, Hans Joachim Kabitz, Michael Dreher
Summary: This article explains and updates the knowledge on ventilator-induced diaphragm dysfunction (VIDD), and discusses the diagnostic approaches and treatment options.
Editorial Material
Critical Care Medicine
Jens Spiesshoefer, Michael Dreher
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Respiratory System
Jens Spiesshoefer, Janina Friedrich, Binaya Regmi, Jonathan Geppert, Benedikt Joern, Alexander Kersten, Alberto Giannoni, Matthias Boentert, Gernot Marx, Nikolaus Marx, Ayham Daher, Michael Dreher
Summary: A study found that one year after discharge, some COVID-19 patients may still experience diaphragm dysfunction and impaired voluntary activation, which may be related to exertional dyspnea.
RESPIRATORY RESEARCH
(2022)