Article
Health Care Sciences & Services
Seung-Su Ha, Dong-Kyu Kim
Summary: The study proposes an ultra-short-term analysis method to assess the balance of autonomic nervous system (ANS) activity in patients with obstructive sleep apnea (OSA). The results show that this method is more effective in revealing the association between sympathetic overactivity and OSA severity, and it exhibits higher consistency compared to the traditional short-term analysis method.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Rosario Statello, Stefano Rossi, Francesco Pisani, Matteo Bonzini, Roberta Andreoli, Agnese Martini, Monica Puligheddu, Pierluigi Cocco, Michele Miragoli
Summary: This study found altered cardiac autonomic regulation in patients with obstructive sleep apnea (OSA) during nighttime and suggested that nighttime HRV could potentially be used as a predictor of sleep breathing disorders. These findings have important clinical implications for the diagnosis and prognosis of OSA.
Article
Clinical Neurology
Xiaolong Zhao, Huajun Xu, Chuan Dong, Jiangang Fan, Gang He, Jianyin Zou, Lili Meng, Huaming Zhu, Kaiming Su, Mingpo Yang, Hongliang Yi, Jian Wang, Shankai Yin, Jian Guan
Summary: The study found that glycolipid metabolic disorders are nonlinearly related to CAD risk in OSA patients, with CAD risk increasing as OSA severity increases. The research also revealed how glycolipid metabolic disorders promote the development of CAD and further deteriorate cardiac function.
NATURE AND SCIENCE OF SLEEP
(2021)
Review
Physiology
Sona Gresova, Martina Gaborova, Judita Stimmelova, Igor Peregrim, Pavol Svorc, Viliam Donic, Maria Pallayova
Summary: In patients with obstructive sleep apnea, obstructive events can lead to changes in the autonomic nervous system, including increased sympathetic tone and decreased parasympathetic dominance. These results indicate autonomic dysfunction in these patients and the need for appropriate treatment.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Yunhan Shi, Hongfei Lou, Huijun Wang, Yi Zhou, Li Wang, Yanru Li, Demin Han
Summary: This study aimed to explore the regulatory mechanisms of nasal resistance (NR) in patients with obstructive sleep apnea (OSA) during postural changes. The results showed that during postural changes from sitting to supine positions, the NR increased in the control group, but did not change significantly in the OSA group. Furthermore, sympathetic activity-related HRV parameters were higher in the NR-unchanged subgroup, particularly in the OSA group.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Hua Qin, Brendan T. Keenan, Diego R. Mazzotti, Fernando Vaquerizo-Villar, Jan F. Kraemer, Niels Wessel, Sergio Tufik, Lia Bittencourt, Peter A. Cistulli, Philip de Chazal, Kate Sutherland, Bhajan Singh, Allan Pack, Ning-Hung Chen, Ingo Fietze, Thorarinn Gislason, Steven Holfinger, Ulysses J. Magalang, Thomas Penzel
Summary: This study found an association between heart rate variability (HRV) during wakefulness and the severity of obstructive sleep apnea (OSA) in a large clinical sample. Patients with severe OSA exhibited significantly reduced and less complex HRV in time-domain and nonlinear measures. Frequency-domain measures showed a shift to sympathetic dominance only in obese OSA patients, indicating additional information about cardiovascular physiology in OSA patients during wakefulness.
Article
Clinical Neurology
Wei-Lun Lin, Chun-Ting Lai, Shinya Yamada, Shin-Huei Liu, Wen-Han Cheng, Yu-Hui Chou, Cheryl C. H. Yang, Terry B. J. Kuo, Shih-Ann Chen, Li-Wei Lo
Summary: This study investigated the effects of renal denervation (RDN) on cardiac autonomic activity and sleep patterns in rats with myocardial infarction (MI). The results showed that sympathetic hyperactivity and sleep fragmentation were observed after MI, and RDN prevented autonomic dysfunction and sleep disorders. RDN may have the potential to reduce sleep apnea and sleep-related sudden cardiac death after MI.
Article
Pharmacology & Pharmacy
Yanling Hong, Yan Kou, Mingli Xie, Yong Wan, Yuyan Zhang
Summary: A total of 110 patients with obstructive sleep apnea hypoventilation syndrome were observed. The study showed that the heart rate variability indicators in patients with obstructive sleep apnea hypopnea syndrome were significantly lower than those in the control group, and the proportion of NN50 and high frequency in group C were lower than in both group A and B, while the low frequency was higher than in group A, group B, and the control group. The results of this study suggest that Holter-monitoring can be an affordable and non-invasive method for testing autonomic nervous function in patients with obstructive sleep apnea hypopnea syndrome.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Clinical Neurology
Hasthi U. Dissanayake, Yu Sun Bin, Kate Sutherland, Seren Ucak, Philip de Chazal, Peter A. Cistulli
Summary: Treatment for obstructive sleep apnea (OSA) can improve autonomic function, particularly by reducing sympathetic activity. This may help reduce the risk of cardiovascular disease in patients with OSA.
Article
Public, Environmental & Occupational Health
Li-Ang Lee, Hai-Hua Chuang, Hui-Shan Hsieh, Chao-Yung Wang, Li-Pang Chuang, Hsueh-Yu Li, Tuan-Jen Fang, Yu-Shu Huang, Guo-She Lee, Albert C. Yang, Terry B. J. Kuo, Cheryl C. H. Yang
Summary: This retrospective case series investigated the effects of adenotonsillectomy on heart rate variability (HRV) indices in children with obstructive sleep apnea (OSA). The results showed that adenotonsillectomy improved HRV indices, indicating improvements in cardiac autonomic function in children with OSA.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Clinical Neurology
Seren Ucak, Hasthi U. Dissanayake, Kate Sutherland, Philip de Chazal, Peter A. Cistulli
Summary: Obstructive sleep apnea (OSA) is a common condition that increases the risk of cardiovascular diseases, with sympathetic overactivity being a primary contributing factor. Heart rate variability (HRV) can evaluate shifts in the autonomic nervous system, aiding in treatment response and cardiovascular risk detection in OSA patients. New technologies aim to enhance HRV analysis efficiency for quicker processing, improved diagnosis of OSA, and better detection of cardiovascular risk.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Biology
Yi-Chia Shan, Wei Fang, Jih-Huah Wu
Summary: A feasible and integrated system was proposed to measure and affect the autonomic nervous system (ANS) status. The test results show that stimulating the Neiguan (PC6) acupoint can inhibit the sympathetic nervous system (SNS), while stimulating the Shenmen (HT7) acupoint can activate the SNS.
Article
Engineering, Biomedical
Xuehong Yang, Fanmeng Kong, Ronglong Xiong, Guangyuan Liu, Wanhui Wen
Summary: This study analyzed the autonomic nervous patterns during sleep deprivation and used machine learning methods to detect its effects. The results showed significant physiological and heart rate variability changes during sleep deprivation, with differences observed between genders.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Pharmacology & Pharmacy
Elisabetta Zampogna, Nicolino Ambrosino, Federico Mattia Oliva, Monica Rudi, Giovanni Sotgiu, Laura Saderi, Antonio Spanevello, Dina Visca
Summary: This study evaluated the impact of pulmonary rehabilitation on heart rate recovery (HRR) in individuals with asthma compared to those with COPD. The findings showed that individuals with asthma had a lower prevalence of slow HRR than those with COPD. However, exercise training significantly improved exercise capacity in both populations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Weijun Huang, Xiaoman Zhang, Xiaoting Wang, Tianjiao Zhou, Xiaolong Zhao, Huajun Xu, Xinyi Li, Jian Guan, Hongliang Yi, Shankai Yin
Summary: In our large-scale study, we found that obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep is correlated with cardiac autonomic dysfunction. This correlation was assessed using standard polysomnography (PSG) to measure OSA and heart rate variability (HRV) to evaluate cardiac autonomic dysfunction. Our study also found that a higher apnea-hypopnea index during REM sleep (AHIREM) is associated with increased cardiovascular disease (CVD) risk. Mediation analysis showed that this association is mediated by the ratio of low-frequency and high-frequency (LF/HF) and low frequency in normalized units (LF (n.u.)). These findings suggest that OSA during REM sleep may be a marker for increased CVD risk due to its impact on cardiac autonomic dysfunction.
JOURNAL OF SLEEP RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Marco Guazzi, Ross Arena
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica Zannoni, Marco Guazzi, Valentina Milani, Francesco Bandera, Eleonora Alfonzetti, Ross Arena
Summary: Cardiorespiratory fitness is important and can be assessed through cardiopulmonary exercise testing. Peak oxygen consumption and minute ventilation/carbon dioxide production slope are key measures. Further research is needed to understand the role of this assessment in primary care.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Ross Arena
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Ross Arena, Cemal Ozemek, Justin M. Canada, Carl J. Lavie, Audrey Borghi-Silva, Samantha Bond, Dejana Popovic, Paola Argiento, Marco Guazzi
Summary: Cardiorespiratory fitness is an important predictor of health trajectory and quality of life, supported by evidence. The role of right ventricular cardiac output in peak oxygen consumption response is often overlooked.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro D. Heubel, Erika Z. Kabbach, Naiara T. Leonardi, Nathany S. Schafauser, Debora M. O. Kawakamia, Anna Claudia Sentanin, Valeria A. Pires Di Lorenzoa, Audrey Borghi Silva, John R. Hurst, Renata G. Mendes
Summary: Patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may experience decreased exercise capacity, and this study found that respiratory and peripheral muscle strength can influence the recovery of exercise capacity. Specifically, quadriceps muscle strength was closely associated with the recovery of exercise capacity.
Editorial Material
Cardiac & Cardiovascular Systems
Ross Arena, Grenita Hall, Deepika Laddu
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Ross Arena, Grenita Hall, Deepika R. Laddu, Shane A. Phillips, Tanvi Bhatt, Mark Faghy, Carl J. Lavie
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Ross Arena, Annamaria Arena
MAYO CLINIC PROCEEDINGS
(2023)
Article
Oncology
Justin M. Canada, John McCarty, Jennifer H. Jordan, Cory R. Trankle, Kevin DeCamp, Josh D. West, Mary Ann Reynolds, Rachel Myers, Katey Sweat, Virginia McGhee, Ross Arena, Antonio Abbate, W. Gregory Hundley
Summary: This study used ExeCMR + CPET technique to measure peak oxygen consumption (VO2) in hematologic cancer patients and compared it with healthy controls. The results showed that hematologic cancer survivors with fatigue had lower peak VO2 and cardiac index, but no significant difference in arteriovenous oxygen content difference.
Review
Cardiac & Cardiovascular Systems
Ross Arena, Nicolaas P. Pronk, Colin Woodard
Summary: This commentary discusses the unsuccessful attempts to address physical inactivity and obesity pandemics in the United States, focusing on the intersections of politics, socioeconomics, race, and culture. The study found that counties where the Democratic presidential candidate received more votes had lower rates of physical inactivity and obesity, higher educational attainment, higher Black population, and higher median household income. Regional variations in cultural identities and partisan demographics were identified as potential explanations for the inconsistencies in physical inactivity and obesity prevalence across the country.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hayanne O. Pauletti, Walter Jose Gomes, Isadora S. Rocco, Marcela Viceconte, Bruna Caroline Matos Garcia, Natasha O. Marcondi, Caroline B. Bublitz, Ariele dos Santos Costa, Thamara Pequeno de Paiva, Giovanna Domingues Spina, Isis Begot, Celia Camelo Silva, Rita Simone L. Moreira, Joao Nelson Rodrigues Branco, Guilherme Flora Vargas, Nelson A. Hossne Jr, Ross Arena, Solange Guizilini
Summary: This study investigates the use of six-minute walk distance (6MWD) as a prognostic marker for midterm clinical outcomes after coronary artery bypass grafting (CABG). The study identifies predictors of fall in 6MWD in the early postoperative period and establishes the percentage fall in early postoperative 6MWD. The findings suggest that a cutoff value of 34.6% in percentage fall of 6MWD can predict poorer clinical outcomes at three months after CABG.
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2023)
Review
Medicine, General & Internal
Lidija Mikic, Arsen Ristic, Natasa Markovic Nikolic, Milorad Tesic, Djordje G. Jakovljevic, Ross Arena, Thomas G. Allison, Dejana Popovic
Summary: This review highlights the importance of cardiopulmonary exercise testing (CPET) in patients with hypertrophic cardiomyopathy (HCM). CPET allows for a comprehensive evaluation of the pathophysiology, severity, risk stratification, and differentiation of HCM from other forms of cardiac hypertrophy. It also aids in selecting patients for various treatment options and monitoring therapy and exercise prescription.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Lisiane Fernanda Simeao de Azevedo, Andre Pontes-Silva, Renata Goncalves Mendes, Claudio Donisete da Silva, Walkiria Shimoya-Bittencourt, Jussara Almeida de Oliveira Baggio, Maria Claudia Goncalves, Rita de Cassia Mendonca de Miranda, Almir Vieira Dibai-Filho, Daniela Bassi-Dibai
Summary: The aim of this study was to assess the measurement properties of the Kidney Symptom Questionnaire for the Brazilian population. The results showed that the questionnaire has excellent reliability, adequate internal consistency, and construct validity. It is a suitable tool for evaluating chronic/occult kidney disease in patients who do not require renal replacement therapy.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Letter
Medicine, General & Internal
Ricardo Alexandre Faria, Cassia da Luz Goulart, Polliana B. dos Santos, Renan Shida Marinho, Stella Maris Firmino, Fabiola P. G. Rizzatti, Renata G. Mendes, Audrey Borghi-Silva, Meliza Goi Roscani
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Ross Arena, Nicolaas P. Pronk, Colin Woodard
Summary: This commentary examines the relationship between physical inactivity, obesity, and election results, socioeconomic factors, race, and regional culture in the United States. The study found that counties where the Democratic candidate received more votes had lower levels of physical inactivity and obesity, higher median national incomes, a higher proportion of Black population, and a higher percentage of people with higher education. However, there were variations in this relationship across different cultural regions in the United States.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)