Article
Oncology
Elena Diaz-Garcia, Sara Garcia-Tovar, Raquel Casitas, Ana Jaureguizar, Ester Zamarron, Begona Sanchez-Sanchez, Ana Sastre-Perona, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: The study shows that patients with obstructive sleep apnea (OSA) exhibit elevated levels of PSPC1, which is cleaved from monocytes by MMP2 and released into the plasma. Intermittent hypoxia (IH) promotes the expression of PSPC1, TGF beta, and MMP2 in monocytes, leading to increased expression of genes driving epithelial-to-mesenchymal transition. These findings suggest a mechanism by which hypoxemia contributes to tumor progression and aggressiveness in OSA patients.
Article
Physiology
Ming Deng, Yi-teng Huang, Jian-qing Xu, Xiao Ke, Yi-fei Dong, Xiao-shu Cheng
Summary: The study found that patients with severe OSAHS were more likely to have hypertension and higher LV mass and LV mass index. The association between intermittent hypoxia and left ventricular remodeling was significant, with oxygen desaturation index (ODI) being the most relevant parameter to LV remodeling among various intermittent hypoxia parameters.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-Pang Chuang, Huang-Pin Wu, Li-Ang Lee, Li-Chung Chiu, Shih-Wei Lin, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Jung-Wei Tsai, Jong-Hwei Su Pang
Summary: This study found that under intermittent hypoxia conditions, the expression of IL-8 was enhanced in monocytes of adult OSA patients, leading to an increase in the migration ability of monocytes towards IL-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Yang Ji, Yingmin Liang, Judith C. W. Mak, Mary S. M. Ip
Summary: Obesity is a strong risk factor for both obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD). Intermittent hypoxia plays an important role in the development of NAFLD in OSA. Understanding the roles of obesity and intermittent hypoxia in NAFLD is crucial for gaining more knowledge about the health consequences of OSA and devising effective therapeutic strategies.
Article
Biochemistry & Molecular Biology
Tehila Dahan, Shahd Nassar, Olga Yajuk, Eliana Steinberg, Ofra Benny, Nathalie Abudi, Inbar Plaschkes, Hadar Benyamini, David Gozal, Rinat Abramovitch, Alex Gileles-Hillel
Summary: Obstructive sleep apnea (OSA) is a common disease associated with dyslipidemia, insulin resistance, and metabolic syndrome. Brown adipose tissue (BAT) is believed to affect systemic glucose tolerance through adaptive thermogenesis, while chronic hypoxia affects the function and metabolism of BAT. This study shows that chronic hypoxia leads to browning of BAT, but also tissue-specific and systemic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bilgehan Ozcan, Britanny Blachot-Minassian, Stephanie Paradis, Lucile Maziere, Marie Chambion-Diaz, Sophie Bouyon, Jean-Louis Pepin, Vincent Pialoux, Claire Arnaud, Christophe Moinard, Elise Belaidi
Summary: Intermittent hypoxia, a hallmark of obstructive sleep apnea, triggers oxidative stress and contributes to cardiovascular consequences. Citrulline supplementation has shown protective effects on the cardiovascular system. This study demonstrates that citrulline significantly reduces blood pressure and infarct size under intermittent hypoxia, indicating its potential as a pharmacological strategy for high-risk OSA patients.
Review
Neurosciences
Andrew E. Beaudin, Patrick J. Hanly, Jill K. Raneri, Magdy Younes, Matiram Pun, Todd J. Anderson, Marc J. Poulin
Summary: Exposure to intermittent hypoxia (IH) is believed to increase the risk of cerebrovascular and cardiovascular disease, but sleep accompanied by IH does not significantly alter vascular responses to hypoxia and hypercapnia in healthy young individuals. However, IH sleep does lead to an increased heart rate response to hypoxia upon waking.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Elida Duenas-Meza, Maria Isabel Escamilla-Gil, Maria Angelica Bazurto-Zapata, Elizabeth Caparo, Miguel Suarez Cuartas, Laura Rincon Martinez, Lizbeth Pernett Buenaver, Ariana Rojas Ortega, Jorge Torres, Sonia Restrepo-Gualteros, Andrea Parra Buitrago, Mauricio Gonzalez-Garcia
Summary: This study found that preterm infants born at high altitudes have a greater impact on oxygen saturation and intermittent hypoxia during sleep compared to full-term infants. These preterm infants have a higher rate of respiratory events and lower oxygen saturation, indicating the need for timely diagnosis and treatment of respiratory disturbances during sleep.
Article
Critical Care Medicine
Gino S. Panza, Shipra Puri, Ho-Sheng Lin, M. Safwan Badr, Jason H. Mateika
Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Nutrition & Dietetics
Charlotte Breuillard, Sophie Moulin, Sophie Bouyon, Morgane Couchet, Christophe Moinard, Elise Belaidi
Summary: Obstructive sleep apnea syndrome (OSAS) is associated with chronic intermittent hypoxia (cIH) that causes slight impairment of nutritional status and immunity.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Yun-yun Yang, Hua-hui Yu, Xiao-lu Jiao, Lin-yi Li, Yun-hui Du, Juan Li, Qian-wen Lv, Hui-na Zhang, Jing Zhang, Chao-wei Hu, Xiao-ping Zhang, Yong-xiang Wei, Yan-wen Qin
Summary: The lack of ANGPTL8 can prevent CIH-induced aortic vascular remodeling, possibly through the inhibition of the ERS pathway. Therefore, ANGPTL8 may be a potential target in CIH-induced aortic vascular remodeling.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Hematology
Wojciech Trzepizur, Chloe Gerves-Pinquie, Baptiste Heudes, Margaux Blanchard, Nicole Meslier, Marie Jouvenot, Sandrine Kerbat, Raphael Le Mao, Eline Magois, Jean-Louis Racineux, AbdelKebir Sabil, Jeremie Thereaux, Francis Couturaud, Frederic Gagnadoux
Summary: This study aimed to evaluate the association between obstructive sleep apnea (OSA) and unprovoked venous thromboembolism (VTE). The results showed that patients with more severe nocturnal hypoxia are more likely to develop unprovoked VTE.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biology
Liasmine Haine, Juliette Bravais, Celine-Hivda Yegen, Jean-Francois Bernaudin, Dominique Marchant, Carole Planes, Nicolas Voituron, Emilie Boncoeur
Summary: The study found that intermittent hypoxia exacerbates lung fibrosis, especially when exposure to hypoxia precedes the induction of lung fibrosis. The enhancement of ER stress markers may be involved in the underlying mechanisms.
Article
Gastroenterology & Hepatology
Sha-Sha Tang, Cheng-Hong Liang, Ya-Lei Liu, Wei Wei, Xin-Ru Deng, Xiao-Yang Shi, Li-Min Wang, Li-Jun Zhang, Hui-Juan Yuan
Summary: For T2DM patients with OSAHS, IH may contribute to specific changes in the gut microbiota, which can affect the pathophysiological development of T2DM and its related complications.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Peripheral Vascular Disease
David C. Andrade, Camilo Toledo, Hugo S. Diaz, Katherin Pereyra, Karla G. Schwarz, Esteban Diaz-Jara, Claudia Melipillan, Angelica P. Rios-Gallardo, Atenea Uribe-Ojeda, Julio Alcayaga, Rodrigo A. Quintanilla, Rodrigo Iturriaga, Jean-Paul Richalet, Nicolas Voituron, Rodrigo Del Rio
Summary: The study demonstrated that cEpo treatment significantly reduced the carotid body chemoreflex and hypertension induced by CIH, and normalized breathing patterns. This suggests a potential therapeutic application of cEpo in treating cardiorespiratory disorders associated with CIH.
JOURNAL OF HYPERTENSION
(2021)