Article
Clinical Neurology
Suchanya Sithirungson, Nuntigar Sonsuwan, Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: Obstructive sleep apnea is a common breathing disorder during sleep, causing sleep fragmentation and excessive daytime sleepiness. Orexin, an important neurotransmitter, plays a role in sleep and arousal regulation. This review summarizes current evidence on the association between orexin and obstructive sleep apnea, including in vitro, in vivo, and clinical data. The effects of orexin on sleep apnea and the impact of obstructive sleep apnea on the orexin system function are discussed, along with contradictory findings.
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katharina Bahr-Hamm, Nabin Koirala, Marsha Hanif, Haralampos Gouveris, Muthuraman Muthuraman
Summary: Intensity of respiratory cortical arousals (RCA) is a pathophysiologic trait in obstructive sleep apnea (OSA) patients. Brain oscillatory features related to respiratory arousals were investigated in moderate and severe OSA patients. Severe OSA patients showed a decrease in EEG signal amplitude and spectral entropy during RCA, compared to moderate OSA patients. These findings could be helpful in differentiating severe OSA from moderate OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Elisabet Martinez-Ceron, Raquel Casitas, Raul Galera, Begona Sanchez-Sanchez, Ester Zamarron, Aldara Garcia-Sanchez, Ana Jaureguizar, Carolina Cubillos-Zapata, Francisco Garcia-Rio
Summary: The prevalence of dyslipidemia in patients with obstructive sleep apnea (OSA) increases with the severity of the disease. In OSA patients, smoking, apnea-hypopnea index (AHI), and mean nocturnal saturation are factors independently associated with dyslipidemia. Additionally, sleep fragmentation and increased sympathetic activity may contribute to lipid dysregulation in OSA patients.
Article
Clinical Neurology
Shiqian Zha, Xu Liu, Hao Chen, Yueying Hao, Jingyi Zhang, Qingfeng Zhang, Ke Hu
Summary: In this study, the effects of acute intermittent hypoxia and acute continuous hypoxia on patients with mild-moderate obstructive sleep apnea were investigated. The results showed that acute intermittent hypoxia had better efficacy in improving apnea-hypopnea index and oxygen desaturation index compared to acute continuous hypoxia. Therefore, further validation of intermittent hypoxia in patients with obstructive sleep apnea is needed.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Cinthya Pena-Orbea, Lu Wang, Puntarik Srisawart, Nancy Foldvary-Schaefer, Reena Mehra
Summary: This study found sex-specific disparities in inpatient sleep testing, with women having milder OSA and lower hypoxia levels. The predictive value of sleep study type for diagnosing OSA varied by sex and severity. The findings highlight the importance of considering sex-specific differences in sleep testing.
Article
Clinical Neurology
Jacqueline H. Geer, Guido J. Falcone, Kevin N. Vanent, Audrey C. Leasure, Daniel Woo, Jennifer R. Molano, Lauren H. Sansing, Carl D. Langefeld, Margaret A. Pisani, Henry K. Yaggi, Kevin N. Sheth
Summary: The study found that obstructive sleep apnea (OSA) is associated with the risk of intracerebral hemorrhage (ICH). Cases with OSA were more likely to be male and have hypertension, heart disease, hyperlipidemia, and higher body mass index compared to those without OSA. Logistic regression analysis showed that OSA is a risk factor for ICH.
Article
Respiratory System
Jay T. Guevarra, Bresne Castillo, Himanshu Joshi, Ankit Parekh, Indu Ayappa, David M. Rapoport
Summary: This study aims to test the reproducibility of identifying inspiratory flow limitation (IFL) events and their termination, as well as determine the frequency of immediate physiological responses to their occurrence. The results showed that most IFL events resulted in immediate physiological responses, and no single consequence reliably occurred after every event. The scoring of IFL events can be used to assess the diagnosis and severity of obstructive sleep apnea (OSA).
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Cardiac & Cardiovascular Systems
Jin Chen, Shu Lin, Yiming Zeng
Summary: The research on obstructive sleep apnea (OSA) and its link to atherosclerosis has gained importance as OSA prevalence and mortality rates increase. Despite ongoing debates, further fundamental and clinical research is necessary to better understand the complex mechanism between OSA and atherosclerosis in order to suggest newer diagnostic and treatment options.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Badran, Shawn B. Bender, David Gozal
Summary: Obstructive sleep apnea (OSA) is associated with oxidative stress, inflammation, and fibrosis, leading to cardiovascular complications. Current treatments for OSA are not effective in improving cardiovascular outcomes. Inappropriate activation of mineralocorticoid receptor (MR) in cardiovascular tissues is implicated in various cardiovascular diseases. However, the causal involvement of MR signaling in OSA-related cardiovascular disease has not been studied extensively. This article suggests MR-targeted therapy as a potential approach to mitigate the adverse cardiovascular consequences of OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Henna Pitkanen, Brett Duce, Timo Leppanen, Samu Kainulainen, Antti Kulkas, Sami Myllymaa, Juha Toyras, Henri Korkalaineno
Summary: This study investigated the differences in gamma power of respiratory arousals between different types and severities of respiratory events and different sleep stages. The results showed that gamma power of respiratory arousals increased towards deeper sleep and as the severity of the related respiratory event increased in terms of type and duration of obstruction, and presence of desaturation.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Endocrinology & Metabolism
Mahmoud I. Mahmoud, Raed K. Alotaibi, Rayyan Almusally, Hanaa Shafiek, Yasir Elamin, Ziad Alhaj, Waleed AlBaker, Alaeldin Elfaki, Hatem Qutub, Suha J. Albahrani, Fatima M. Alabdrabalnabi, Zahra A. Al Saeed, Reem Al Argan, Fatima Al Rubaish, Yousef D. Alqurashi, Noor-Ahmed Jatoi, Abdullah H. Alharmaly, Zainab Z. Almubarak, Abir H. Al Said, Nada Albahrani
Summary: This study investigated the association between glycosylated hemoglobin (HbA1c) levels and nocturnal hypoxemia and apnea-hypopnea index (AHI) in Saudi patients with obstructive sleep apnea (OSA) and diabetes mellitus (DM). The findings suggest that nocturnal hypoxemia may be an important factor affecting glycemic control in patients with OSA and DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Yanru Ou, Dandan Zong, Ruoyun Ouyang
Summary: This article explores the relationship between obstructive sleep apnea (OSA) and epigenetics, and provides better diagnostic methods and treatment options. Epigenetic modifications, including post-translational modifications in DNA and histone proteins, and regulation of non-coding RNAs, are involved in the progression of OSA and various multiorgan injuries. This article offers deeper insights into the disease mechanism of OSA and potential applications of targeted diagnosis, treatment, and prognosis in OSA complications.
CHINESE MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Bertien Buyse, Alexandros Kalkanis, Dries Testelmans
Summary: This study describes a peculiar groaning entity called Catathrenia, which has not been previously described. Patients experience expiratory groaning episodes during sleep, which occur after a cortical arousal and rescue respiration following obstructive events. Positive airway pressure eliminates these events.
Article
Surgery
Reyaz M. Singaporewalla, Thomas P. Thamboo, Abu Rauff, Wei K. Cheah, Jagat J. Mukherjee
ASIAN JOURNAL OF SURGERY
(2009)
Article
Otorhinolaryngology
Reyaz M. Singaporewalla, Jagat J. Mukherjee, Thomas P. Thamboo, Wei K. Cheah
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2011)
Article
Medicine, General & Internal
Florence Tan, Ah Chuan Thai, Wei Keat Cheah, J. J. Mukherjee
SOUTHERN MEDICAL JOURNAL
(2009)
Article
Endocrinology & Metabolism
Sujoy Majumdar, Binayak Sinha, Biswajit Ghosh Dastidar, Kalyan Kumar Gangopadhyay, Samit Ghoshal, Jagat Jyoti Mukherjee, Anirban Mazumdar, Subir Ray, Samir Dasgupta, Kingshuk Bhattacharjee
Summary: Depression is common in Type 2 Diabetes Mellitus patients, with predictors including younger age, female sex, low socioeconomic status, poor compliance, hypoglycemia, and difficulty in managing day-to-day activities. Suicidal ideation is associated with repeated hypoglycemia episodes, while patients with lower HbA1C levels have less suicidal ideation.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Sujoy Majumdar, Jagat Jyoti Mukherjee, Subir Ray, Soumik Goswami, Edward Jude, Ajoy Biswas, Ajay Hanumanthu, Mathew John, Binayak Sinha, Samit Ghoshal, Sunil Kota, Surendra Kumar Sharma, Jubbin Jagan Jacob
Summary: The study provided ten recommendations on diagnosis and management of men with type 2 diabetes mellitus and functional hypogonadism.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Endocrinology & Metabolism
Ashok Kumar Das, Banshi Saboo, Rajeev Chawla, S. R. Aravind, Rajesh Rajput, Awadhesh K. Singh, J. J. Mukherjee, Ashok Jhingan, Parag Shah, Vaishali Deshmukh, Shailaja Kale, Shalini Jaggi, G. R. Sridhar, Rajnish Dhediya, Kumar Gaurav
Summary: Sulfonylureas (SU) are important oral hypoglycemic agents for managing type 2 diabetes mellitus (T2DM), with modern SU (gliclazide and glimepiride) considered safe and effective choices. The lack of a national guideline and the presence of multiple international guidelines pose challenges for physicians in choosing the appropriate treatment strategy. This consensus aims to reaffirm the role and benefits of SU in diabetes management in India and provide expert recommendations to improve knowledge and enhance patient outcomes.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Endocrinology & Metabolism
Subir Ray, Awadhesh Kumar Singh, Jagat Jyoti Mukherjee, Raja Ramachandran, Upal Sengupta, Anil Kumar Virmani, Arup Ratan Dutta, Surendra Kumar Sharma, Sanjay Lal Srivastava, Masood Batin
Summary: Most guidelines recommend protein restriction in adults with chronic kidney disease (CKD), but it is controversial to advise protein restriction for every person with CKD. The study aimed to reach a consensus on this topic, especially among Indian adults with CKD.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2023)
Review
Endocrinology & Metabolism
Jagat Jyoti Mukherjee, Rajesh Rajput, Sujoy Majumdar, Banshi Saboo, Sanjay Chatterjee
Summary: This document provides recommendations on essential but less discussed aspects of insulin therapy, including storage, travel management, driving use, and dose adjustments during illness. Recommendations include storing unopened insulin in a refrigerator, adjusting doses only when flying across more than five time zones, and carefully adjusting doses based on self-monitoring during illness.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Letter
Endocrinology & Metabolism
Jagat J. Mukherjee, Kalyan K. Gangopadhyay, Subir Ray
LANCET DIABETES & ENDOCRINOLOGY
(2020)
Letter
Endocrinology & Metabolism
S. Ray, J. J. Mukherjee
Article
Medicine, General & Internal
F. Tan, J. J. Mukherjee, K. O. Lee, P. Lim, C. F. Liew
SINGAPORE MEDICAL JOURNAL
(2010)
Article
Medicine, General & Internal
F. L. W. Ho, E. C. Cunanan, S. C. Wang, J. J. Mukherjee
SINGAPORE MEDICAL JOURNAL
(2009)
Article
Medicine, General & Internal
Mary Jean Tan, Florence Tan, Robert Hawkins, Wei-Keat Cheah, J. J. Mukherjee
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2006)
Article
Endocrinology & Metabolism
JJ Mukherjee, ML Villa, L Tan, KO Lee
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2005)
