Article
Clinical Neurology
A. Gibbings, L. B. Ray, N. Berberian, T. Nguyen, A. Shahidi Zandi, A. M. Owen, F. J. E. Comeau, S. M. Fogel
Summary: The study shows that just one night of mild sleep loss significantly increases sleepiness and reduces vigilance. Furthermore, this sleep loss affects brain physiology in ways that indicate decreased arousal.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Erika M. Yamazaki, Caroline A. Antler, Charlotte R. Lasek, Namni Goel
Summary: The study aimed to investigate the recovery patterns and differences after total sleep deprivation (TSD) and chronic sleep restriction (SR). Results showed that deficits in cognitive performance, self-reported sleepiness, and other measures were reversed after recovery sleep, except for some measures which failed to completely recover. This suggests that TSD and SR induce sustained, differential biological, physiological, and/or neural changes that are not reversed with chronic, long-duration recovery sleep.
Article
Ergonomics
Jennifer M. Cori, Luke A. Downey, Tracey L. Sletten, Caroline J. Beatty, Brook A. Shiferaw, Shamsi Shekari Soleimanloo, Sophie Turner, Aqsa Naqvi, Maree Barnes, Jonny Kuo, Michael G. Lenne, Clare Anderson, Andrew J. Tucker, Alexander P. Wolkow, Anna Clark, Shantha M. W. Rajaratnam, Mark E. Howard
Summary: Extending the major rest break between shifts to 11 hours significantly increases sleep duration and has a modest positive impact on driver alertness and performance. However, lane departures per hour were increased under the 11-hour rest condition.
ACCIDENT ANALYSIS AND PREVENTION
(2021)
Article
Clinical Neurology
Sibylle Benderoth, Hans-Juergen Hoermann, Caroline Schiessl, Eva-Maria Elmenhorst
Summary: The study found that the 3-minute psychomotor vigilance task (PVT) is highly reliable and valid in assessing cognitive performance impairments induced by sleep loss and alcohol intake. It showed a high correlation with the 10-minute version and demonstrated applicability to aviation and transportation tasks.
Article
Clinical Neurology
Sibylle Benderoth, Hans-Jurgen Hoermann, Caroline Schiessl, Eva-Maria Elmenhorst
Summary: The study investigated the reliability and validity of a 3-min psychomotor vigilance task (PVT) in assessing sensitivity to sleep loss and alcohol compared to a standard 10-min PVT. Results showed that the 3-min PVT was highly correlated with the 10-min version, and demonstrated strong associations with aviation-related tasks and significant correlations with transportation-related tasks. The 3-min PVT showed high potential as a self-monitoring tool for cognitive performance impairments in applied settings.
Article
Clinical Neurology
Simon J. Schreiner, Esther Werth, Leonie Ballmer, Philipp O. Valko, Kai M. Schubert, Lukas L. Imbach, Christian R. Baumann, Angelina Maric, Heide Baumann-Vogel
Summary: This study found that excessive daytime sleepiness (EDS) in Parkinson disease (PD) is associated with nocturnal sleep disturbance, as indicated by reduced overnight slow-wave activity (SWA) decline and reduced spindle frequency activity.
Article
Multidisciplinary Sciences
Ajay P. Anvekar, Elizabeth A. Nathan, Dorota A. Doherty, Sanjay K. Patole
Summary: The study found that fatigue worsened after 12-hour day and night shifts in a tertiary neonatal intensive unit, with a greater change after night shifts. Sleep duration decreased before night shifts, and subjective sleepiness worsened after both day and night shifts.
Article
Clinical Neurology
Heide Baumann-Vogel, Sophia Hoff, Philipp O. Valko, Rositsa Poryazova, Esther Werth, Christian R. Baumann
Summary: This study highlights the challenges of diagnosing ISS in clinical practice and underscores the importance of actigraphy and polysomnography for accurate diagnosis.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Psychology, Applied
Mark E. McCauley, Peter McCauley, Samantha M. Riedy, Siobhan Banks, Adrian J. Ecker, Leonid V. Kalachev, Suresh Rangan, David F. Dinges, Hans P. A. Van Dongen
Summary: Research on fatigue biomathematical models for predicting subjective sleepiness showed high prediction accuracy. The study identified differences between subjective and objective outcomes predictions, highlighting potential risks in safety-sensitive operations such as commercial aviation. The validated model provides a useful quantitative tool to bridge this previously unrecognized gap.
TRANSPORTATION RESEARCH PART F-TRAFFIC PSYCHOLOGY AND BEHAVIOUR
(2021)
Article
Public, Environmental & Occupational Health
Kiyoshi Tadakuma, Takashi Maruyama, Koji Mori, Nobuhiro Fujiki
Summary: This study demonstrated that reducing the number of crews in a 12-hour shift schedule has negative impacts on both subjective and objective indicators post-change, with only alertness indicators failing to recover at 1 year after the change. Assessments of worker performance and the continual implementation of health and safety programs for over a year are necessary for maintaining worker health following a shift schedule change.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Clinical Neurology
Elisa Evangelista, Anna Laura Rassu, Regis Lopez, Niccolo Biagioli, Sofiene Chenini, Lucie Barateau, Isabelle Jaussent, Yves Dauvilliers
Summary: This study aimed to determine whether the psychomotor vigilance task (PVT) can reliably measure sleep inertia in patients with idiopathic hypersomnia (IH) and other sleep disorders. The results showed that PVT is a reliable and objective measure of sleep inertia, and it may be useful for characterizing, managing, and monitoring IH.
Article
Clinical Neurology
Charmaine Diep, Gary Garcia-Molina, Jeff Jasko, Jessica Manousakis, Lynn Ostrowski, David White, Clare Anderson
Summary: The study shows that consecutive nights of acoustic stimulation can enhance slow wave activity, improve alertness and attention, indicating potential benefits for individuals with chronic sleep restriction.
Article
Psychology, Biological
A. Gibbings, L. B. Ray, S. Gagnon, C. A. Collin, R. Robillard, S. M. Fogel
Summary: In this study, the impact of mild, acute sleep loss on driving performance, vigilance, and brain activity was investigated. The results showed that a single night of mild sleep restriction led to increased sleepiness, longer brake response time, more missed braking events, and a higher frequency of crashes. Brain activity analysis revealed more intense bursts of alpha waves and significant changes in EEG spectral power frequencies associated with arousal. Importantly, increases in alpha wave amplitude and frequency predicted delays in reaction time when braking. These findings suggest that even a mild, acute sleep loss can have significant negative consequences on driving performance, vigilance, and brain physiology that reflect reduced arousal levels.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Clinical Neurology
Francisco G. Vital-Lopez, Thomas J. Balkin, Jaques Reifman
Summary: The study developed and validated mathematical models predicting sleep latency and duration, providing insights on the impact of small shifts in sleep onset timing on sleep duration. The models showed low prediction errors and can be applied to enhance performance, safety, and sustainability in civilian and military operations.
Article
Clinical Neurology
Michelle E. Stepan, Erik M. Altmann, Kimberly M. Fenn
Summary: Short naps may not mitigate the effects of sleep deprivation on cognitive processing, longer naps may be necessary. However, in participants who took naps, more time spent in slow-wave sleep was associated with reduced performance deficits.
Article
Multidisciplinary Sciences
Ya Chai, Zhuo Fang, Fan Nils Yang, Sihua Xu, Yao Deng, Andrew Raine, Jieqiong Wang, Meichen Yu, Mathias Basner, Namni Goel, Junghoon J. Kim, David A. Wolk, John A. Detre, David F. Dinges, Hengyi Rao
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Madison K. Titone, Brae Anne McArthur, Tommy H. Ng, Taylor A. Burke, Laura E. McLaughlin, Laura E. MacMullen, Namni Goel, Lauren B. Alloy
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Andrea M. Spaeth, Namni Goel, David F. Dinges
Review
Psychiatry
John F. Gottlieb, Namni Goel, Shenghao Chen, Michael A. Young
Summary: Sleep deprivation may be effective in treating bipolar depression, especially when used in conjunction with medication.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Susan Kohl Malone, Amy J. Peleckis, Laura Grunin, Gary Yu, Sooyong Jang, James Weimer, Insup Lee, Michael R. Rickels, Namni Goel
Summary: The study aimed to describe long-term changes in glycemic control and objective sleep in adults with type 1 diabetes and hypoglycemia unawareness after initiating hybrid closed loop (HCL) insulin delivery. Results showed that HCL significantly reduced hypoglycemia occurrences and improved hypoglycemia awareness, but also led to delayed onset and shortened duration of sleep.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Clinical Neurology
Yoko Suzuki, Fusae Kawana, Makoto Satoh, Takashi Abe
Summary: In a study of 30 healthy young participants, PAH was found to be relatively common, occurring frequently in non-rapid eye movement sleep. The number of PAHs correlated with the number of arousals and arousal indices, and was associated with an increase in the N3 sleep stage.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Clinical Neurology
Tess E. Brieva, Courtney E. Casale, Erika M. Yamazaki, Caroline A. Antler, Namni Goel
Summary: Various methods for defining cognitive deficits due to sleep restriction and total sleep deprivation are not equivalent. The Raw Score approach is a reliable method for distinguishing resilient and vulnerable groups during sleep loss based on performance in the Digit Symbol Substitution Test and Digit Span Test.
Article
Clinical Neurology
Courtney E. Casale, Erika M. Yamazaki, Tess E. Brieva, Caroline A. Antler, Namni Goel
Summary: This study aimed to compare different methods for defining resilience and vulnerability based on subjective metrics. The results showed that only the Raw Score approach consistently distinguished Resilient and Vulnerable groups, while the other approaches differed in their categorizations. The study suggests using the Raw Score approach as an effective method for subjective resilience/vulnerability categorization.
Article
Clinical Neurology
Tianxin Mao, David Dinges, Yao Deng, Ke Zhao, Zijing Yang, Hui Lei, Zhuo Fang, Fan Nils Yang, Olga Galli, Namni Goel, Mathias Basner, Hengyi Rao
Summary: Sleep deprivation impairs neurobehavioral functions such as vigilant attention and inhibition control. This study found that deficits in vigilant attention contribute to impairments in inhibition control after one night of total sleep deprivation and two nights of partial sleep restriction.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Clinical Neurology
Erika M. Yamazaki, Courtney E. Casale, Tess E. Brieva, Caroline A. Antler, Namni Goel
Summary: This study examined the impact of sleep loss on vigilant attention and categorized individuals' resiliency/vulnerability using three different approaches. The results showed that the approaches yielded similar results in classifying PVT lapses but had differences for 1/RT. Therefore, selecting appropriate methods and metrics is crucial for defining vigilant attention resiliency/vulnerability to sleep loss.
Review
Oncology
Elizabeth B. Klerman, Allison Brager, Mary A. Carskadon, Christopher M. Depner, Russell Foster, Namni Goel, Mary Harrington, Paul M. Holloway, Melissa P. Knauert, Monique K. LeBourgeois, Jonathan Lipton, Martha Merrow, Sara Montagnese, Mingming Ning, David Ray, Frank A. J. L. Scheer, Steven A. Shea, Debra J. Skene, Claudia Spies, Bart Staels, Marie-Pierre St-Onge, Steffen Tiedt, Phyllis C. Zee, Helen J. Burgess
Summary: The manuscript provides guidance on measuring metrics of endogenous circadian rhythms in humans and advocates for the inclusion of circadian rhythms assessments in health and disease studies. It describes protocols and analyses commonly used for studying human daily rhythms and recommends definitions and examples of circadian terminology.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Psychiatry
Logan T. Smith, Rachel F. L. Walsh, Namni Goel, Lauren B. Alloy
Summary: Social jetlag is significantly associated with differences in trajectories and lability of mood symptoms, particularly in individuals with high reward sensitivity and bipolar spectrum disorder. This study adds to the literature with methodological strengths such as ecological momentary assessment design and assessment of symptom and reward responsiveness trajectories.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Biological
Tianxin Mao, Zhuo Fang, Ya Chai, Yao Deng, Joy Rao, Peng Quan, Namni Goel, Mathias Basner, Bowen Guo, David F. Dinges, Jianghong Liu, John A. Detre, Hengyi Rao
Summary: Sleep loss may impact risky decision-making by attenuating neural responses to decision outcomes and impairing the relationship between brain and behavior.
Review
Genetics & Heredity
Courtney E. Casale, Namni Goel
Summary: This paper discusses the impact of genotype on neurobehavioral responses to sleep deprivation, emphasizing the importance of the candidate gene approach in studying resilience and vulnerability in humans. Potential genetic indicators and the efficacy of countermeasures for sleep loss are also addressed in the review. Discovery of novel genetic markers has critical implications for future research in the field of sleep and circadian science.
Article
Clinical Neurology
Erika M. Yamazaki, Caroline A. Antler, Charlotte R. Lasek, Namni Goel
Summary: The study aimed to investigate the recovery patterns and differences after total sleep deprivation (TSD) and chronic sleep restriction (SR). Results showed that deficits in cognitive performance, self-reported sleepiness, and other measures were reversed after recovery sleep, except for some measures which failed to completely recover. This suggests that TSD and SR induce sustained, differential biological, physiological, and/or neural changes that are not reversed with chronic, long-duration recovery sleep.