Article
Clinical Neurology
Fjola D. Sigurdardottir, Caroline Tonje Overby, Sami Nikkonen, Tuomas Karhu, Toril Dammen, Inger Hilde Nordhus, Thea Thorshov, Gunnar Einvik, Samu Kainulainen, Timo Leppanen, Erna Sif Arnardottir, Juha Toyras, Torbjorn Omland, Harald Hrubos-Strom
Summary: This study assessed the association between novel desaturation parameters and elevated cardiac troponin I and T levels. The results showed that these parameters can predict the elevation of cardiac troponin levels.
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Geetha Kandasamy, Tahani Almeleebia
Summary: This study aimed to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. The results showed a significant prevalence of obesity and high frequency of OSA in men, with polysomnography being the primary method for early detection and treatment of the condition.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Elie Gottlieb, Mohamed S. Khlif, Laura Bird, Emilio Werden, Thomas Churchward, Matthew P. Pase, Natalia Egorova, Mark E. Howard, Amy Brodtmann
Summary: In chronic stroke patients, 57% had undiagnosed moderate-severe obstructive sleep apnea and exhibited reduced slow-wave sleep with potentially compensatory increases in NREM 1-2 sleep compared to controls. Formal sleep studies are necessary after stroke, even in the absence of self-reported history of sleep-wake pathology.
Article
Clinical Neurology
Abhishek Goyal, Khushboo Saxena, Avishek Kar, Alkesh Khurana, Parneet Kaur Bhagtana, Chinta Siva Koti Rupa Sridevi, Abhijit Pakhare
Summary: The study found a high prevalence of moderate to severe OSA in patients with COVID-19 related acute respiratory distress syndrome, indicating a need for further evaluation of the role of OSA in the pathophysiology of COVID-19.
Article
Peripheral Vascular Disease
Min Ru Chee, Jesse Hoo, Renata Libianto, Stella M. Gwini, Garun Hamilton, Om Narayan, Morag J. Young, Peter J. Fuller, Jun Yang
Summary: This study found a high prevalence of possible or likely primary aldosteronism among patients with both obstructive sleep apnea and hypertension, suggesting that they should be routinely screened for PA. No correlation was found between aldosterone, renin, or aldosterone:renin ratio and the apnea-hypopnea index, indicating the need for further research on the relationship between these conditions.
Article
Clinical Neurology
Iulia Ioan, Diane Weick, Francois Sevin, Damien Sanlaville, Benedicte De Freminville, Cyril Schweitzer, Mohamed Akkari, Laurianne Coutier, Benjamin Putois, Sabine Plancoulaine, Marine Thieux, Patricia Franco
Summary: This study aimed to assess the cognitive function of children with DS, with and without OSAS, and determine the impact of therapeutic intervention on the cognitive function of children with OSAS. The findings suggest that OSAS may have a negative impact on children's cognitive function, but treatment can improve this impact. Children with DS have low intellectual abilities and a higher risk of developing OSAS, emphasizing the importance of early screening and management to prevent further cognitive delay.
Review
Health Care Sciences & Services
Daniela Ferreira-Santos, Pedro Amorim, Tiago Silva Martins, Matilde Monteiro-Soares, Pedro Pereira Rodrigues
Summary: This study aimed to evaluate the effectiveness of using machine learning approaches for disease screening in adult patients with suspected obstructive sleep apnea (OSA). The results showed that various machine learning techniques were widely used, but there were still issues of lack of external validation and inconsistent OSA criteria definition.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Clinical Neurology
Nana Feng, Jundong Yang, Huajun Xu, Chujun Zhang, Fan Wang, Xiaolin Wu, Meizhen Gu
Summary: This study evaluated the associations between sleep architecture and metabolic parameters in 2,308 patients with suspected OSA, finding weak correlations between sleep quality and metabolic parameters such as weight, blood sugar, and cholesterol. The clinical impact of sleep structure on metabolism appears to be negligible, highlighting the need for further prospective studies to confirm these findings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Respiratory System
Nicole Pizzorni, Dejan Radovanovic, Marica Pecis, Rosaria Lorusso, Federica Annoni, Alice Bartorelli, Maurizio Rizzi, Antonio Schindler, Pierachille Santus
Summary: The study investigated the prevalence of dysphagia symptoms in OSA patients and their association with demographic and clinical factors. Female gender, excessive daily sleepiness, number of OSA symptoms, anxiety/depression, and symptoms of gastroesophageal reflux were significantly associated with dysphagia symptoms. The Eating-Assessment Tool questionnaire was found to be a useful tool to identify OSA patients at high risk for dysphagia.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, General & Internal
Hyunjin Jo, Sujung Choi, Dongyeop Kim, Eunyeon Joo
Summary: Patients with epilepsy have milder characteristics of obstructive sleep apnea (OSA), but because of the high coexistence of OSA and epilepsy, continuous positive airway pressure (CPAP) therapy can reduce the frequency of seizures. Therefore, it is important to evaluate the presence of OSA in patients with epilepsy and provide concurrent treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Mandip Kang, Fan Mo, Manisha Witmans, Vicente Santiago, Mary Anne Tablizo
Summary: Obstructive sleep apnea in children is associated with various problems, and diagnosing it accurately can be challenging. Alternative methods like home sleep testing are being researched.
Review
Medicine, General & Internal
Taylor B. Teplitzky, Audrey J. Zauher, Amal Isaiah
Summary: Diagnosis of obstructive sleep apnea (OSA) in children with sleep-disordered breathing (SDB) requires hospital-based, overnight level I polysomnography (PSG). Alternative methods such as wearable devices, single-channel recordings, and home-based PSG have not been validated as suitable replacements for PSG but may have potential roles in risk stratification or screening for pediatric OSA. Further studies are needed to determine if the combined use of these metrics could predict OSA.
Article
Cardiac & Cardiovascular Systems
Torbjorn Omland, Anna Randby, Harald Hrubos-Strom, Helge Rosjo, Gunnar Einvik
AMERICAN JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Julia Brox Skranes, Gunnar Einvik, Silje Kjeka Namtvedt, Anna Randby, Harald Hrubos-Strom, Jon Brynildsen, Tor-Arne Hagve, Virend K. Somers, Helge Rosjo, Torbjorn Omland
BMC CARDIOVASCULAR DISORDERS
(2016)
Article
Clinical Neurology
Maria Pedersen, Mirjam Ekstedt, Milada C. Smastuen, Vegard B. Wyller, Dag Sulheim, Even Fagermoen, Anette Winger, Edvard Pedersen, Harald Hrubos-Strom
JOURNAL OF SLEEP RESEARCH
(2017)
Article
Clinical Neurology
Maria Varendh, Morgan Andersson, Erla Bjornsdottir, Harald Hrubos-Strom, Arne Johannisson, Erna S. Arnardottir, Thorarinn Gislason, Sigurdur Juliusson
JOURNAL OF SLEEP RESEARCH
(2018)
Article
Otorhinolaryngology
Maria Varendh, Arne Johannisson, Harald Hrubos-Strom, Morgan Andersson
Article
Respiratory System
Nina F. Caspersen, Helge Rosjo, Allan Flyvbjerg, Mette Bjerre, Anna Randby, Harald Hrubos-Strom, Torbjorn Omland, Gunnar Einvik
BMC PULMONARY MEDICINE
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Benjamin Gardner, Anders Brostrom, Per Nilsen, Harald Hrubos Strom, Martin Ulander, Bengt Fridlund, Janna Skagerstrom, Peter Johansson
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2014)
Article
Clinical Neurology
Maria Varendh, Morgan Andersson, Erla Bjornsdottir, Erna S. Arnardottir, Thorarinn Gislason, Allan Pack, Harald Hrubos-Strom, Arne Johannisson, Sigurdur Juliusson
JOURNAL OF SLEEP RESEARCH
(2019)
Article
Clinical Neurology
Fjola D. Sigurdardottir, Magnus N. Lyngbakken, Kristian Hveem, Harald Hrubos Strom, Helge Rosjo, Susan Redline, Torbjorn Omland
Summary: Insomnia symptoms are associated with increased risk of heart failure and cardiovascular mortality. However, there is no direct association between insomnia symptoms and subclinical myocardial injury based on biochemical evidence from cTnI levels. Further research is needed to understand the relationship between insomnia symptoms and cardiac biomarkers.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Sport Sciences
Cameron McIntosh, Hege H. Clemm, Nicola Sewry, Harald Hrubos-Strom, Martin P. Schwellnus
Summary: Protecting the respiratory health of athletes is crucial for their overall performance, with nasal conditions potentially impacting their quality of life and athletic abilities. Athletes are more prone to mucosal inflammation in the nose compared to the general population, highlighting the importance of addressing nasal health for improved athlete well-being and sports performance.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2021)
Article
Clinical Neurology
Thorarinn Arnar Olafsson, Eivind Andreas Steinsvik, Gregor Bachmann-Harildstad, Harald Hrubos-Strom
Summary: This study aimed to validate the automatically scored results of an esophageal probe-based polygraph system against manually scored polysomnography results. The ApneaGraph Spiro performed acceptably when OSA was defined by an AHI of 15, although it tended to overestimate mild OSA and underestimate severe OSA compared to polysomnography.
SLEEP AND BREATHING
(2022)
Article
Clinical Neurology
Ilona Merikanto, Yves Dauvilliers, Frances Chung, Brigitte Holzinger, Luigi De Gennaro, Yun Kwok Wing, Maria Korman, Markku Partinen
Summary: This protocol paper outlines the second survey conducted by the International Covid Sleep Study (ICOSS) group, aiming to investigate the associations between SARS-CoV-2 infection and sleep, sleepiness, and circadian problems as potential predisposing factors for more severe COVID-19 and Long-COVID in the general population. The survey will include 47 questions covering various aspects related to sleep, health, and socio-economic status, and will be administered online in multiple countries from May to November 2021. Data collected from the survey will provide valuable insights into COVID-19 risk factors, symptomatology, evolution of Long-COVID, and other long-term consequences of the pandemic.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Fjola D. Sigurdardottir, Caroline Tonje Overby, Sami Nikkonen, Tuomas Karhu, Toril Dammen, Inger Hilde Nordhus, Thea Thorshov, Gunnar Einvik, Samu Kainulainen, Timo Leppanen, Erna Sif Arnardottir, Juha Toyras, Torbjorn Omland, Harald Hrubos-Strom
Summary: This study assessed the association between novel desaturation parameters and elevated cardiac troponin I and T levels. The results showed that these parameters can predict the elevation of cardiac troponin levels.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Purbanka Pahari, Henri Korkalainen, Tuomas Karhu, Marika Rissanen, Erna Sif Arnardottir, Harald Hrubos-Strom, Brett Duce, Juha Toyras, Timo Leppanen, Sami Nikkonen
Summary: Intermittent hypoxaemia related to obstructive sleep apnea (OSA) can increase the risk of OSA comorbidities, such as cardiovascular disease. However, it is unclear whether intermittent hypoxaemia is associated with impaired vigilance. This study aimed to compare the desaturation characteristics between non-impaired vigilance and impaired vigilance patient groups and evaluate the association with traditional OSA severity parameters.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Harald Hrubos-Strom, Joel Bergqvist, Ding Zou
Summary: This article reviews the literature on the management of treatment-resistant OSA and proposes a management plan for this patient group, focusing on reducing cardiovascular risk and relieving symptoms. Future diagnostic trends in OSA and a decision-aid tool are also discussed.
CURRENT SLEEP MEDICINE REPORTS
(2023)