Article
Engineering, Biomedical
Wenjianlong Zhou, Yuanwen Jiang, Qin Xu, Liangpeng Chen, Hui Qiao, Yi-Xuan Wang, Jian-Cheng Lai, Donglai Zhong, Yuan Zhang, Weining Li, Yanru Du, Xuecheng Wang, Jiaxin Lei, Gehong Dong, Xiudong Guan, Shunchang Ma, Peng Kang, Linhao Yuan, Milin Zhang, Jeffrey B. -H. Tok, Deling Li, Zhenan Bao, Wang Jia
Summary: Soft conducting polymer electrodes were developed for continuous and precise localization of a target nerve during microsurgeries, leading to improved post-operative prognoses after tumour-resection surgeries in rats. The electrodes offered higher signal-to-noise ratios and reduced invasiveness compared to handheld clinical probes, allowing for continuous recording of near-field action potentials. The system enabled precise identification of neural anatomy throughout the procedure, enhancing the overall outcomes of the surgeries.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Biology
Tanya B. Lauridsen, Christian Brandt, Jakob Christensen-Dalsgaard
Summary: Hearing sensitivity has been extensively studied using various methods, with the masked ABR method showing the most sensitive results, followed by the tone burst ABR method, while the long-duration tone method is not suitable for studying hearing thresholds above 1000 Hz.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Neurosciences
Justin Tan, Dion Kaiserman, Stephen J. O'Leary, Phillip I. Bird
Summary: Inactivating mutations of the SERPINB6 gene in humans lead to progressive hearing loss, while studies in mouse models have shown that the loss of the Serpinb6a gene results in early onset hearing loss. However, transferring this gene mutation to a different mouse strain background can significantly delay the onset of hearing loss.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Wei Ren, Cong Xu, Fan-jun Zheng, Ting-ting Lin, Peng Jin, Yue Zhang, Wei-wei Guo, Chuan-hong Liu, Xiao-yang Zhou, Lu-lu Wang, Yong Wang, Hui Zhao, Shi-ming Yang
Summary: This study described and studied the population statistics, hearing phenotype, and pathological changes of a porcine congenital single-sided deafness (CSSD) pedigree. The inbred porcine strain exhibited high and stable prevalence of CSSD, resembling human non-syndromic CSSD disease. The study concluded that this porcine model could be used for further exploration of the etiology of CSSD and as a tool for studying the effects of single-sided hearing deprivation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Zoe L. Owrutsky, John Peacock, Daniel J. Tollin
Summary: Objective assessment of spatial and binaural hearing deficits remains challenging in clinical practice. This study proposes a new method to improve the measurement of the binaural interaction component (BIC) in auditory brainstem response (ABR) by using more optimal stimuli. The findings suggest that level-specific chirp stimuli can enhance BIC detectability and reduce variability in human BIC measurements.
Article
Medicine, General & Internal
Jun Ma, Jae-Hyun Seo, Il Joon Moon, Moo Kyun Park, Jong Bin Lee, Hantai Kim, Joong Ho Ahn, Jeong Hun Jang, Jong Dae Lee, Seong Jun Choi, Min Hong
Summary: This article proposes an image preprocessing process for constructing an efficient image dataset for deep learning models using auditory brainstem response data. The ABR images are standardized and classified using the VGG16 model, and the accuracy of the proposed method is analyzed.
Article
Biochemistry & Molecular Biology
Tammy B. Pham, Ely Cheikh Boussaty, Antonio Currais, Pamela Maher, David R. Schubert, Uri Manor, Rick A. Friedman
Summary: In the SAMP8 mouse model, CMS121 protects against age-related hearing impairment by inhibiting oxidative stress-induced premature senescence. This study demonstrates that CMS121 treatment significantly reduces hearing threshold shifts and preserves inner hair cell ribbon synapses in mid-range frequencies.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Tomoharu Suzuki, Junki Maruyama, Rebecca Cook, Shinji Urata, Slobodan Paessler, Tomoko Makishima
Summary: The STAT1 KO mouse model is used to mimic human viral and bacterial diseases, with the Lassa fever model showing similar phenotypes seen in human patients. Auditory analysis of the STAT1 KO mice revealed that both male and female mice have similar auditory performance suitable for studying viral infection-induced hearing loss.
NEUROSCIENCE LETTERS
(2021)
Article
Acoustics
Jason Mulsow, James J. Finneran, Dorian S. Houser, Robert F. Burkard, Madelyn G. Strahan, Ryan Jones
Summary: Studies on dolphin auditory brainstem response (ABR) have shown that the response to sound offset includes contributions from at least two distinct responses, with one possibly arising from activation of neural units shifted basally relative to stimulus frequency, and the other representing a true offset response from afferent centers further up the auditory pathway.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Health Care Sciences & Services
Sungmin Jo, Moo Kyun Park, Jae-Hyun Seo, Ki-eun Lee, Jae Sang Han, Ji Hyung Lim, Jun Ho Lee, Seung-Ha Oh
Summary: This study compared the audiological performance of a smartphone-based hearing aid app (SHAA) with a conventional hearing aid (HA). The results showed that the SHAA had advantages over the HA in some aspects but performed worse in word recognition and noisy conditions. These findings are important for the treatment choice of patients with mild-to-moderate hearing loss.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Otorhinolaryngology
Burak Ozturk, Hatice Kavruk, Aysenur Aykul
Summary: This study aimed to investigate the effects of COVID-19 on the auditory system. The results suggest that COVID-19 may cause cochlear damage, especially at high frequencies.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Geriatrics & Gerontology
Nichtima Chayaopas, Pornthep Kasemsiri, Panida Thanawirattananit, Patorn Piromchai, Kwanchanok Yimtae
Summary: The study evaluated the diagnostic value of the Thai version of the Hearing Handicap Inventory for Elderly Screening (HHIE-ST) and the Thai Single Question (TSQ) surveys in screening hearing disability in Thai participants aged 60 years and older. Both tools were found to be sensitive and useful for screening hearing disability in older adults, with a combined test having better performance.
Article
Medicine, General & Internal
Minna Kraatari-Tiri, Maria K. Haanpaa, Tytti Willberg, Pia Pohjola, Riikka Keski-Filppula, Outi Kuismin, Jukka S. Moilanen, Sanna Hakli, Elisa Rahikkala
Summary: Sensorineural hearing loss (SNHL) is a common sensory deficit worldwide, and genetic factors contribute significantly to congenital hearing loss. This study identified TMC1 gene variants associated with different types of hearing loss. Early diagnosis and timely hearing rehabilitation can lead to good speech perception in noise for affected individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Audiology & Speech-Language Pathology
K. Elaine Ritter, Sloane M. Lynch, Ashley M. Gorris, Lisa A. Beyer, Lisa Kabara, David F. Dolan, Yehoash Raphael, Donna M. Martin
Summary: CHARGE syndrome is a developmental disorder with multiple anomalies, often characterized by sensory deficits including hearing loss. This study investigated the impact of early developmental delays caused by Chd7 haploinsufficiency on neurons, glial cells, and inner hair cell innervation in the mature cochlea using a mouse model. The results suggest that CHD7 plays an important role in glial cells in the inner ear, while cochlear neurons appear to differentiate normally in the setting of Chd7 haploinsufficiency. These findings contribute to understanding the pathology of CHARGE syndrome.
Review
Biology
Cyrus Motamed
Summary: There is a global trend of recommending quantitative neuromuscular monitoring in the operating room, which can help in rational use of muscle relaxants and avoid complications. A specific culture is necessary to integrate this monitoring as part of anesthesia in patients, including understanding the physiology, pharmacology, concept of monitoring, and choice of reversal agents like sugammadex.
Article
Otorhinolaryngology
Mario Sanna, Paolo Fois, Enrico Pasanisi, Alessandra Russo, Andrea Bacciu
AURIS NASUS LARYNX
(2010)
Article
Clinical Neurology
Maurizio Falcioni, Paolo Fois, Abdelkader Taibah, Mario Sanna
JOURNAL OF NEUROSURGERY
(2011)
Article
Medicine, Research & Experimental
Mario Sanna, Andrea Bacciu, Enrico Pasanisi, Paolo Piazza, Paolo Fois, Maurizio Falcioni
Article
Medicine, Research & Experimental
Mario Sanna, Fois Paolo, Alessandra Russo, Maurizio Falcioni
Editorial Material
Clinical Neurology
Paolo Fois, Lorenzo Lauda
OTOLOGY & NEUROTOLOGY
(2011)
Article
Otorhinolaryngology
Paolo Fois, Anna Lisa Giannuzzi, Carlo Terenzio Paties, Maurizio Falcioni
ENT-EAR NOSE & THROAT JOURNAL
(2014)