Journal
SKIN PHARMACOLOGY AND PHYSIOLOGY
Volume 26, Issue 4-6, Pages 213-216Publisher
KARGER
DOI: 10.1159/000351930
Keywords
Ceramides; Historical overview; Skin barrier morphology; Skin permeability; Stratum corneum fat layer
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It was recently shown that the stratum corneum fat layer, i.e. the skin permeability barrier, has a unique molecular arrangement - stacked bilayers of fully extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety. We here give a brief historical perspective to the field of skin permeability barrier research and specifically address some selected contributions to the current understanding of skin barrier morphology. (c) 2013 S. Karger AG, Basel
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