Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rui Gao, Kaixin Du, Jinhua Liang, Yi Xia, Jiazhu Wu, Yue Li, Bihui Pan, Li Wang, Jianyong Li, Wei Xu
Summary: This study aims to evaluate the prognostic value of cholesterol levels in CLL and develop a prognostic nomogram that incorporates lipid metabolism. The results showed that lower cholesterol levels at diagnosis were associated with worse prognosis, and post-therapeutic elevation of cholesterol levels correlated with better survival. Therefore, cholesterol profiles can be used as a cheap and readily accessible tool for predicting prognosis in CLL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Makoto Honda, Yosuke Shigematsu, Mihoko Shimada, Yoshiko Honda, Katsushi Tokunaga, Taku Miyagawa
Summary: This study provides evidence that abnormal fatty acid metabolism is involved in the pathophysiology of narcolepsy type 1 (NT1) and other hypersomnia, shedding new light on the understanding of the underlying mechanisms of these disorders.
Review
Medicine, General & Internal
Chen Gurevitz, Eitan Auriel, Avishay Elis, Ran Kornowski
Summary: Excessive levels of LDL-C are a risk factor for atherosclerosis, but low LDL-C levels are associated with intracerebral hemorrhage. Individualized therapy should be considered for patients with high risk of ICH when aggressive LDL reduction is being considered.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Andrew J. Brown, Laura J. Sharpe, Michael J. Rogers
Summary: Oxysterols are oxygenated forms of cholesterol generated via autooxidation by free radicals and enzymes, playing key roles in health and disease through binding to effector proteins and regulating transcriptional programmes affecting cell metabolism and function at low concentrations in vivo.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Jia Gu, Neng Zhu, Hong-Fang Li, Tan-Jun Zhao, Chan-Juan Zhang, Duan-Fang Liao, Li Qin
Summary: The dysregulation of LDLR in cancer and its role in cholesterol homeostasis imbalance provides new therapeutic opportunities. LDLR plays a crucial role in cancer progression by modulating cholesterol balance and may serve as a novel target for anti-cancer drug development. The expression and regulation of LDLR vary in different types of cancer, suggesting the importance of personalized treatment approaches.
Article
Biochemistry & Molecular Biology
Yun Cheng, Xiao-Zhuo Kang, Pearl Chan, Pak-Hin Hinson Cheung, Tao Cheng, Zi-wei Ye, Chi-Ping Chan, Cheng-Han Yu, Dong-Yan Jin
Summary: The study revealed that FACI protein interacts with the AP2 complex and facilitates LDL endocytosis. Overexpression of FACI enhances LDL uptake, while depletion of FACI impairs endocytosis.
CELL AND BIOSCIENCE
(2023)
Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Medical Laboratory Technology
Na Xu, Deshan Yuan, Yi Yao, Lin Jiang, Jingjing Xu, Xiaofang Tang, Ying Song, Lijian Gao, Jue Chen, Lei Song, Xueyan Zhao, Jilin Chen, Yuejin Yang, Bo Xu, Runlin Gao, Jinqing Yuan
Summary: This study investigated the relationship between increased Lp(a) and long-term outcomes in patients undergoing PCI, as well as the influence of different LDL-C concentrations. The results showed that increased Lp(a) was associated with an increased risk of poor prognosis, but this association varied depending on the LDL-C concentration.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Liu Shi, Dongmei Zhang, Jianqing Ju, Anlu Wang, Tianyi Du, Xuanye Chen, Yewen Song, Zhuye Gao, Hao Xu
Summary: In the general US adult population, remnant cholesterol (RC) is associated with hypertension beyond LDL-C levels. Elevated RC levels are linked to a higher prevalence of hypertension, independent of BMI, LDL-C, HDL-C, or triglycerides.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Yiyi Zhang, Jaejin An, Kristi Reynolds, Monika M. Safford, Paul Muntner, Andrew E. Moran
Summary: This survey study examines the distribution and trend of low-density lipoprotein cholesterol and the prevalence of screening and awareness of high cholesterol among young adults in the United States.
Article
Multidisciplinary Sciences
Gozde Erturk Zararsiz, Serkan Bolat, Ahu Cephe, Necla Kochan, Serra Ilayda Yerlita, Halef Okan Dogan, Gokmen Zararsiz
Summary: Multiple studies have shown a high prevalence of dyslipidemia in children, emphasizing the importance of early recognition to prevent future coronary heart disease. Among the various equations for estimating LDL-C, the extended Martin-Hopkins formula was found to provide the most reliable results in a large pediatric population.
Article
Medicine, General & Internal
Istvan Reiber, Laszlo Mark, Gyorgy Paragh, Peter Toth
Summary: This study compares direct and calculated LDL-C levels, and evaluates the variation in remnant lipoprotein cholesterol. The results indicate that in some cases, the use of a new calculation method yields a more accurate LDL-C value.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, Legal
K. Wiskott, F. Gilardi, K. Michaud, M. Augsburger, C. Castiglioni, A. Carminati, S. Grabherr, A. Thomas, T. Fracasso
Summary: A biobank is a collection of biological material associated with a health database, and utilizing these samples for research can accelerate disease understanding and improve the quality of care. Forensic samples, which come from young and healthy individuals, are valuable for research. The creation of a forensic pathology biobank can standardize conservation practices, improve data management, and provide valuable biological material.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Article
Medicine, General & Internal
Chiara Donadei, Andrea Angeletti, Maria Cappuccilli, Massimiliano Conti, Diletta Conte, Fulvia Zappulo, Alessio De Giovanni, Deborah Malvi, Rita Aldini, Aldo Roda, Gaetano La Manna
Summary: This study found possible adaptive tubular mechanisms for bile acid transporters in response to cirrhosis-induced AKI through a rat model. The findings suggest that the kidneys may adjust their function in response to liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Marie Bellouard, Marie Gasser, Sebastien Lenglet, Federica Gilardi, Nasim Bararpour, Marc Augsburger, Aurelien Thomas, Jean-Claude Alvarez
Summary: This study evaluated the cytotoxicity of cobalt, chromium, and nickel on human hepatocytes and explored their cellular toxicity mechanisms through metabolomic analysis. The results showed that chromium was more toxic than cobalt and nickel, and these metals could induce oxidative stress and dysregulation of metabolic pathways in hepatocytes.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Chemistry, Medicinal
Sabina Sblano, Carmen Cerchia, Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Rosalba Leuci, Federica Gilardi, Aurelien Thomas, Massimo Genovese, Alice Santi, Paolo Tortorella, Paolo Paoli, Antonio Lavecchia, Fulvio Loiodice
Summary: This article presents a chemoinformatics search approach for identifying new ligands as PPAR pan-agonists. The identified compound has attractive activity profile in reducing lipid accumulation and improving insulin sensitivity, making it a potential lead for the treatment of dyslipidemic type 2 diabetes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bruce R. Branchini, Danielle M. Fontaine, Dawn Kohrt, Brian P. Huta, Allison R. Racela, Benjamin R. Fort, Tara L. Southworth, Aldo Roda
Summary: Researchers conducted experiments to compare the spectroscopic and luminescent properties of beetle Luc and substrates, identifying new Luc/substrate combinations with improved properties and providing live cell luminescent data relevant to in vivo imaging applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Valeria Gaspari, Camilla Ceccarani, Marco Severgnini, Gionathan Orioni, Tania Camboni, Luca Laghi, Sara Morselli, Claudio Foschi, Antonella Marangoni, Clarissa Consolandi, Bianca Maria Piraccini
Summary: This study analyzed the microbiome and metabolome profiles of first-void urines in women with Chlamydia trachomatis (CT) urethral infection. Regardless of CT infection, Lactobacillus was found to dominate the microbiome of first-void urines. During CT infection, samples showed reduced microbial biodiversity and a significant decrease in certain bacterial families and species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Marie Gasser, Sebastien Lenglet, Nasim Bararpour, Tatjana Sajic, Kim Wiskott, Marc Augsburger, Tony Fracasso, Federica Gilardi, Aurelien Thomas
Summary: Obesity is a major public health concern, and exposure to pollutants such as heavy metals can contribute to its development. This study found that cadmium can accumulate in adipose tissue and affect the development of metabolic disorders by altering gene expression and adipocyte functions.
Article
Oncology
Marica Cariello, Roberta Zerlotin, Emanuela Pasculli, Elena Piccinin, Claudia Peres, Emanuele Porru, Aldo Roda, Raffaella Maria Gadaleta, Antonio Moschetta
Summary: The activation of intestinal FXR can prevent both inflammation- and genetically-driven colorectal tumorigenesis by modulating the size and composition of bile acid pool, providing new possibilities for the therapeutic management of intestinal inflammation and tumorigenesis.
Article
Microbiology
Barbara Giordani, Angela Abruzzo, Carola Parolin, Claudio Foschi, Luca Laghi, Antonella Marangoni, Barbara Luppi, Beatrice Vitali
Summary: The cell-free supernatants from lactobacilli of vaginal origin can effectively stimulate the growth of Bifidobacterium spp. This is especially important for infants born by C-section. The CFS from Lactobacillus vaginalis BC17 shows the best bifidogenic behavior and can be used for preventing and treating breast sores in lactating women and promoting the growth of bifidobacteria in infants born mainly by C-section.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biology
Claudio Foschi, Beatrice Giorgi, Simone Ambretti, Tiziana Lazzarotto, Francesco Saverio Violante
Summary: This study aimed to evaluate the sanitizing effectiveness of a UVC device (SanificaAria 200) in various hospital settings during routine activities. The results showed that the UVC device was able to effectively reduce bacterial loads and inactivate the SARS-CoV-2 virus within one hour. Therefore, SanificaAria 200 has the potential to eliminate airborne pathogens and reduce health risks.
Article
Nutrition & Dietetics
Barbara Giordani, Carola Parolin, Angela Abruzzo, Claudio Foschi, Antonella Marangoni, Barbara Luppi, Beatrice Vitali
Summary: Intestinal microbiota plays a crucial role in the well-being and long-term health of newborns. This study explored the bifidogenic activity of a heat-killed vaginal strain and assessed its safety. The findings showed that the strain had bifidogenic effects and was safe for human health. Additionally, it had antibacterial activities against pathogens.
Article
Biochemistry & Molecular Biology
Rossana Comito, Emanuele Porru, Nicolo Interino, Matteo Conti, Rossella Terragni, Roberto Gotti, Marco Candela, Patrizia Simoni, Aldo Roda, Jessica Fiori
Summary: Bile acids play a key role in the gut-liver axis, and the study found that faecal oxo-metabolites from oxidation/epimerization reactions are associated with the occurrence of chronic inflammatory enteropathy.
Article
Biochemistry & Molecular Biology
Antonella Marangoni, Stefano Amadesi, Marielle Ezekielle Djusse, Claudio Foschi, Valeria Gaspari, Tiziana Lazzarotto, Paolo Gaibani
Summary: Lymphogranuloma venereum (LGV) is a systemic sexually transmitted infection mainly spreading within men who have sex with men (MSM). In this study, the whole genome of a C. trachomatis strain (LGV/17) responsible for a rectal LGV case was described. The LGV/17 strain showed a genomic structure similar to reference sequences and was closely related to other L2f strains, indicative of the long-distance dynamics of transmission.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)