Article
Ophthalmology
Maximilian Pawloff, Bianca S. S. Gerendas, Gabor Deak, Hrvoje Bogunovic, Anastasiia Gruber, Ursula Schmidt-Erfurth
Summary: The purpose of this study was to evaluate the reliability of automated fluid detection in identifying retinal fluid activity in OCT scans of patients treated with anti-VEGF therapy for neovascular age-related macular degeneration. The results showed that the concordance between human expert grading and automated algorithm performance was high, indicating that deep learning-based segmentation of retinal fluid performs reliably on OCT images.
Article
Multidisciplinary Sciences
Amrish Selvam, Sumit Randhir Singh, Supriya Arora, Manan Patel, Arnim Kuchhal, Stavan Shah, Joshua Ong, Mohammed Abdul Rasheed, Shanmukh Reddy Manne, Mohammed Nasar Ibrahim, Jose-Alain Sahel, Kiran Kumar Vupparaboina, Jay Chhablani
Summary: We conducted an automated analysis of pigment epithelial detachments (PEDs) in neovascular age related macular degeneration (nAMD) to estimate the areas of serous, neovascular, and fibrous tissues within the PEDs. By manually segmenting the PEDs and filtering the pixels using 2D kernels, we were able to classify them as serous, neovascular, or fibrous. Using specific PED composition indices, we calculated the relative areas of each tissue type within the PEDs. The accuracy of segmentation and classification was graded, and overall repeatability and reproducibility were high.
SCIENTIFIC REPORTS
(2023)
Review
Ophthalmology
Kai Xiong Cheong, Kelvin Yi Chong Teo, Chui Ming Gemmy Cheung
Summary: The influence of PED on visual acuity is controversial, with some studies showing PED may still be compatible with relatively good visual acuity. However, there is currently no strong evidence that the presence of PED or aspects of its morphology significantly impact visual acuity. More well-designed studies are needed to evaluate the relationship between PED and visual acuity.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Wontae Yoon, Jihyun Yoon, Seung Kwan Na, Jihyun Lee, Jaemin Kim, Jong Woo Kim, Han Joo Cho
Summary: The presence of macular fluid features, specifically subretinal fluid, in type 3 macular neovascularization patients did not show significant correlation with visual and anatomical outcomes during anti-VEGF treatment. Regardless of the presence of subretinal fluid, the incidence of macular atrophy and changes in visual acuity were similar among the groups after 12 months of treatment.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Hoseok Yeom, Hye Ji Kwon, Yoon Jeon Kim, Junyeop Lee, Young Hee Yoon, Joo Yong Lee
Summary: This retrospective study assessed the safety and effectiveness of switching to intravitreal brolucizumab for refractory nAMD. The results showed that the majority of patients experienced improved anatomical outcomes or extended injection intervals after switching. Certain structural biomarkers were identified as predictors of treatment response, aiding in the selection of an appropriate therapeutic strategy.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Levon M. Khachigian, Gerald Liew, Kelvin Y. C. Teo, Tien Y. Wong, Paul Mitchell
Summary: Neovascular age-related macular degeneration (nAMD) is a leading cause of visual impairment and blindness, but current anti-VEGF therapies have limitations. This article discusses the need for new and improved therapies for nAMD and explores the efficacy of multi-targeted therapies that target both the VEGF pathway and other pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Junyeop Lee, You Na Kim, June-Gone Kim
Summary: Monthly alternating injections of aflibercept and bevacizumab were effective in preventing deterioration in patients with neovascular age-related macular degeneration who were not responding to bimonthly injections.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Frank G. Holz, Piotr Oleksy, Federico Ricci, Peter K. Kaiser, Joachim Kiefer, Steffen Schmitz-Valckenberg
Summary: This study demonstrated the clinical equivalence of the proposed biosimilar FYB201 and reference ranibizumab in treating patients with nAMD. Both treatments showed improvement in visual acuity and had comparable rates of adverse events.
Article
Ophthalmology
Mariano Cozzi, Davide Monteduro, Salvatore Parrulli, Federica Ristoldo, Federico Corvi, Federico Zicarelli, Giovanni Staurenghi, Alessandro Invernizzi
Summary: This study aimed to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) in patients with neovascular age-related macular degeneration (nAMD). The size of the cleft increased with MNV reactivation and decreased after treatment, suggesting it could represent an accumulation of fluid actively exudating from the MNV, serving as a sign of nAMD activity.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi
Summary: The study quantitatively evaluated retinal pigment epithelium changes in patients with age-related macular degeneration using prototype multi-contrast optical coherence tomography. The results showed that multi-contrast OCT is useful for objective evaluation of changes in the retinal pigment epithelium.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Pravin U. Dugel, Rishi P. Singh, Adrian Koh, Yuichiro Ogura, Georges Weissgerber, Kinfemichael Gedif, Glenn J. Jaffe, Ramin Tadayoni, Ursula Schmidt-Erfurth, Frank G. Holz
Summary: The study reported the 96-week outcomes of nAMD patients treated with brolucizumab and aflibercept, showing that brolucizumab was more effective in improving vision and reducing retinal fluid compared to aflibercept. The results from both studies confirmed that the efficacy observed at 48 weeks was maintained at 96 weeks.
Editorial Material
Ophthalmology
Utku Limon, Betul Ilkay Sezgin Akcay
Summary: Simultaneous intravitreal injection of bevacizumab and dexamethasone implant effectively treated treatment-resistant neovascular serous pigment epithelial detachment, leading to a significant reduction in detachment height and improved visual acuity. Further studies are needed to confirm the effectiveness and safety of this novel treatment approach.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jose Navarro-Partida, Juan Carlos Altamirano-Vallejo, Luis Abraham Aceves Franco, Jesus Gonzalez-Cortes, Sergio Hernandez-Da Mota, Jose Gerardo Garcia-Aguirre, Carlos David Azuara-Galindo, Carlos Rodrigo Castro-Castaneda, Juan Armendariz-Borunda, Arturo Santos
Summary: A study evaluated the safety and efficacy of using a triamcinolone-loaded liposome formulation as an adjuvant to intravitreal ranibizumab therapy in treatment-naive patients with neovascular age-related macular degeneration. The results showed a significant reduction in the average number of ranibizumab injections when using the liposome formulation, with optimal visual and anatomic outcomes.
Article
Ophthalmology
Tommes Riemer, Dominique Berndt, Alexander Boeker, Josefine Urban, Ulrike Schrifl, Saskia Rau, Anne Lehmann, Antonia M. Joussen, Oliver Zeitz
Summary: This study analyzes the assumption of interchangeability of bevacizumab, ranibizumab, and aflibercept by assessing the effects of switching from aflibercept or ranibizumab to bevacizumab in real-world conditions. The results show a decrease in visual acuity and an increase in retinal edema after the switch, suggesting that the drugs are not freely interchangeable in this cohort.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Chemistry, Medicinal
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang, Qing Peng
Summary: The study investigated cytokine and chemokines profiling in the aqueous humor of nAMD patients, finding lower levels of basic fibroblast growth factor and RANTES, and higher levels of VEGF-A compared to the control group. After IVR treatment, levels of Eotaxin increased while VEGF-A decreased in nAMD patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Ophthalmology
Rebecca R. Soares, Anand D. Gopal, Devayu Parikh, Charlotte N. Shields, Samir Patel, John Hinkle, James Sharpe, Allen C. Ho, Carl D. Regillo, Julia Haller, Yoshihiro Yonekawa
Summary: This study identified geographic access disparities of clinical trial sites for nAMD in the United States, with driving distance and time over 60 miles or 60 minutes mainly associated with rural locations, the Midwest, the South, lower educational levels, higher proportions of certain ethnicities, and lower poverty levels in census tracts.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Artur V. Cideciyan, Samuel G. Jacobson, Allen C. Ho, Alexandra V. Garafalo, Alejandro J. Roman, Alexander Sumaroka, Arun K. Krishnan, Malgorzata Swider, Michael R. Schwartz, Aniz Girach
Summary: Treatment of Leber congenital amaurosis due to CEP290 ciliopathy using antisense oligonucleotide (AON) sepofarsen shows significant efficacy, with sustained efficacy observed at 15 months despite a reduction from peak response. The efficacy kinetics can be explained by the balance of AON-driven new CEP290 protein synthesis and the slow natural rate of CEP290 protein degradation in human fovea cone photoreceptors.
Article
Ophthalmology
Matthew R. Starr, David Xu, Nicholas Boucher, Namrata Saroj, Luv G. Patel, Michael Ammar, Ravi R. Pandit, Thomas L. Jenkins, Allen C. Ho
Summary: This study aimed to assess the incidence of conversion to bilateral neovascular age-related macular degeneration (nAMD) following treatment of nAMD in the initial eye, revealing that fellow eyes had better vision at conversion and 1 year following conversion. Regular monitoring of fellow eyes is recommended to detect signs of neovascularization.
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2021)
Article
Medicine, General & Internal
Allen C. Ho, Jeffrey S. Heier, Nancy M. Holekamp, Richard A. Garfinkel, Byron Ladd, Carl C. Awh, Rishi P. Singh, George E. Sanborn, Jennifer H. Jacobs, Michael J. Elman, Anat Loewenstein, David A. Eichenbaum
Summary: The study evaluated the real-world performance of a home telemonitoring strategy for patients with iAMD who converted to nAMD and found it to be similar to the device arm of the AREDS2-HOME study. The results showed that the home telemonitoring system can significantly increase early detection of conversion to nAMD, leading to better visual outcomes for patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Samuel G. Jacobson, Artur Cideciyan, Allen C. Ho, Igor Peshenko, Alexandra Garafalo, Alejandro J. Roman, Alexander Sumaroka, Vivian Wu, Arun K. Krishnan, Rebecca Sheplock, Sanford L. Boye, Alexander M. Dizhoor, Shannon E. Boye
Summary: The ongoing first-in-human clinical trial of gene therapy for Leber congenital amaurosis due to mutations in the GUCY2D gene has shown promising early results, demonstrating safety and efficacy in both rod and cone photoreceptor function.
Article
Ophthalmology
Douglas R. Matsunaga, Mirataollah Salabati, Anthony Obeid, Turner D. Wibbelsman, Connie Wu, Raziyeh Mahmoudzadeh, Israel Ojalvo, Justin Bilello, Arunan Sivalingam, Allen C. Ho, Allen Chiang, Jason Hsu
Summary: The study found that diabetic macular edema patients who were lost to follow-up for a prolonged period experienced a decline in visual acuity after stopping treatment, but their vision recovered after restarting treatment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephen R. Russell, Arlene Drack, Artur Cideciyan, Samuel G. Jacobson, Bart P. Leroy, Caroline Van Cauwenbergh, Allen C. Ho, Alina Dumitrescu, Ian C. Han, Mitchell Martin, Wanda L. Pfeifer, Elliott H. Sohn, Jean Walshire, Alexandra Garafalo, Arun K. Krishnan, Christian A. Powers, Alexander Sumaroka, Alejandro J. Roman, Eva Vanhonsebrouck, Eltanara Jones, Fanny Nerinckx, Julie De Zaeytijd, Rob W. J. Collin, Carel Hoyng, Peter Adamson, Michael E. Cheetham, Michael R. Schwartz, Wilhelmina den Hollander, Friedrich Asmus, Gerard Platenburg, David Rodman, Aniz Girach
Summary: The translation content introduces the results of a clinical trial on the treatment of CEP290-associated LCA10 with sepofarsen. Although patients experienced ocular adverse events in the treated eye, the lower dose group showed a better benefit-risk profile. The trial results suggest that the use of sepofarsen may improve patients' visual acuity and retinal sensitivity.
Article
Ophthalmology
Rebecca Russ Soares, Nikita Mokhashi, James Sharpe, Qiang Zhang, John Hinkle, Samir N. Patel, Allen C. Ho, Yoshihiro Yonekawa, Jason Hsu
Summary: The purpose of this study was to determine the applicability of federal health provider shortage areas (HPSAs) to eye care providers (ECPs). The study found a weak correlation between current HPSAs and ECP supply. A new approach was proposed to identify counties with high need but limited access to eye care.
Article
Ophthalmology
Ava Torjani, Raziyeh Mahmoudzadeh, Mirataollah Salabati, Louis Cai, Jason Hsu, Sunir Garg, Allen C. Ho, Yoshihiro Yonekawa, Ajay E. Kuriyan, Matthew R. Starr
Summary: This study identified factors associated with central subfield thickness (CST) fluctuations in patients with diabetic macular edema (DME), including baseline visual acuity, renal disease, hypertension, gender, diabetes type, and anti-VEGF treatment. Addressing these factors may help limit CST fluctuations and identify patients who require more frequent monitoring or treatment.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Ophthalmology
Ferhina S. Ali, Thomas L. Jenkins, Ranjodh S. Boparai, Anthony Obeid, Martha E. Ryan, Turner D. Wibblesman, Allen Chiang, Sunir J. Garg
Summary: The study compared the effects of using topical povidone-iodine and aqueous chlorhexidine on patient pain scores, ocular surface characteristics, and antimicrobial efficacy during intravitreal injections. Results showed that povidone-iodine caused greater ocular discomfort and corneal epitheliopathy, while aqueous chlorhexidine may be a better tolerated alternative.
OPHTHALMOLOGY RETINA
(2021)
Article
Ophthalmology
Allen Chiang, Sunir J. Garg, Michael A. Klufas, Allen C. Ho, Lauren Hill, Min Tsuboi, Ivaylo Stoilov
Summary: The study analyzed the effectiveness of ranibizumab in treating patients with diabetic retinopathy, finding that approximately 30% of patients experienced at least a 4-step improvement in disease severity after treatment, accompanied by significant improvements in visual acuity.
OPHTHALMOLOGY RETINA
(2021)
Article
Ophthalmology
Samir N. Patel, Philip P. Storey, Hannah Levin, Maitri Pancholy, Anthony Obeid, Turner D. Wibbelsman, Brandon Kuley, Allen C. Ho, Jason Hsu, Sunir J. Garg, James F. Vander, James P. Dunn
Summary: Microbiologic culture data from vitreous samples of patients with endophthalmitis after cataract surgery were found to have prognostic value for final visual outcomes, but limited impact on clinical management. Culture-positive eyes were more likely to develop secondary retinal detachments compared to culture-negative eyes.
OPHTHALMOLOGY RETINA
(2021)
Article
Ophthalmology
Douglas R. Matsunaga, Daniel Su, Kareem Sioufi, Anthony Obeid, Turner Wibbelsman, Allen C. Ho, Carl D. Regillo
Summary: A study on 46 patients with neovascular AMD receiving anti-VEGF treatment found that most patients experienced large submacular hemorrhage while in the treatment naive state. It is speculated that the hemorrhages are unlikely to be associated with prolonged or shortened treatment intervals.
OPHTHALMOLOGY RETINA
(2021)
Article
Ophthalmology
David Xu, Joshua Uhr, Samir N. Patel, Ravi R. Pandit, Thomas L. Jenkins, M. Ali Khan, Allen C. Ho
Summary: The impact of sociodemographic factors on the presentation and outcomes of rhegmatogenous retinal detachment (RRD) in the United States has been explored in a retrospective study of 4061 patients, indicating that older age, male gender, non-White race, and lower household income are associated with worse presentation and outcomes. Factors such as fovea-off presentation, need for reoperation, and postoperative visual acuity were found to be influenced by these sociodemographic factors. Further study and efforts to address socioeconomic disparities in RRD outcomes are recommended.
OPHTHALMOLOGY RETINA
(2021)
Review
Ophthalmology
David Xu, M. Ali Khan, Allen C. Ho
Summary: Gene therapy holds promise for treating inherited and acquired retinal diseases by utilizing host cells to produce beneficial proteins. Improved viral vectors and surgical techniques are vital for successful delivery of therapeutic products. Various gene therapy programs are undergoing clinical testing for targeted delivery to different ocular spaces.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)