Review
Biochemistry & Molecular Biology
Tina Levstek, Katarina Trebusak Podkrajsek
Summary: Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes that maintain genomic stability. Shortened telomeres contribute to cellular senescence and degenerative diseases such as chronic kidney diseases (CKDs). Oxidative stress also accelerates telomere shortening. This review examines the association between telomere length and CKDs, particularly in patients receiving kidney replacement therapy. Understanding the relationship between telomere attrition and kidney disease can contribute to new strategies for managing CKDs.
Review
Genetics & Heredity
Olutope Arinola Akinnibosun, Michelle C. Maier, James Eales, Maciej Tomaszewski, Fadi J. Charchar
Summary: Chronic kidney disease (CKD) is a major cause of illness and death globally. Scarring of the kidney tissue in CKD is associated with shorter telomeres, and patients with CKD and shorter telomeres have reduced kidney function and increased mortality rate. Therefore, preserving telomere length may be a potential therapy to reduce the incidence of CKD worldwide.
Article
Urology & Nephrology
Roberto Alcazar, Carlos Escobar, Beatriz Palacios, Unai Aranda, Luis Varela, Margarita Capel, Antoni Sicras, Aram Sicras, Antonio Hormigo, Nicolas Manito, Manuel Botana
Summary: This study found that the presence of heart failure (HF) in patients with chronic kidney disease (CKD) significantly increases the risk of adverse outcomes. It also observed a high risk of HF among CKD patients, which might be partially related to insufficient treatment.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Rajat Deo, Ruth F. Dubin, Yue Ren, Ashwin C. Murthy, Jianqiao Wang, Haotian Zheng, Zihe Zheng, Harold Feldman, Haochang Shou, Josef Coresh, Morgan Grams, Aditya L. Surapaneni, Zeenat Bhat, Jordana B. Cohen, Mahboob Rahman, Jiang He, Santosh L. Saraf, Alan S. Go, Paul L. Kimmel, Ramachandran S. Vasan, Mark R. Segal, Hongzhe Li, Peter Ganz
Summary: Through large-scale proteomics discovery, this study aimed to create more accurate cardiovascular risk models for patients with chronic kidney disease (CKD). The proteomic risk model outperformed traditional clinical models in predicting cardiovascular risk and provided new biological insights for the development of cardiovascular risk management strategies in CKD patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yejin Mok, Shoshana H. Ballew, Kunihiro Matsushita
Summary: Chronic kidney disease is closely associated with cardiovascular disease, but there is currently no consensus in major clinical guidelines on how to predict CVD risk. Incorporating CKD measures in risk assessment and personalizing treatment will be an important opportunity.
Review
Biochemistry & Molecular Biology
Susana Coimbra, Flavio Reis, Maria Joao Valente, Susana Rocha, Cristina Catarino, Petronila Rocha-Pereira, Maria Sameiro-Faria, Elsa Bronze-da-Rocha, Luis Belo, Alice Santos-Silva
Summary: Dyslipidemia is a major risk factor for cardiovascular disease in chronic kidney disease patients, but the role of HDL in this population is complex and poorly understood. The unique proteome and lipid composition of large HDL in CKD patients may impair their cholesterol efflux capacity, contributing to a paradoxical coexistence of increased large HDL and enhanced risk for CVD events. Additional research is needed to better understand how these changes in HDL functionality impact cardiovascular risk in CKD patients.
Review
Biochemistry & Molecular Biology
Dipuo D. Motshwari, Don M. Matshazi, Rajiv T. Erasmus, Andre P. Kengne, Tandi E. Matsha, Cindy George
Summary: This review evaluated the expression profile of microRNAs (miRNAs) associated with chronic kidney disease (CKD) in the general population and high-risk subgroups. The findings showed consistent downregulation of miR-126 and miR-223 in CKD, and consistent upregulation of miR-21 and miR-29b in diabetic kidney disease (DKD), along with downregulation of miR-30e and let-7a in at least three studies. These miRNAs may be involved in the pathogenesis of CKD and further research is needed to explore their clinical utility for CKD prevention and control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Johannes Ruhe, Jennifer Nadal, Barbara Barthlein, Heike Meiselbach, Ulla T. Schultheiss, Fruzsina Kotsis, Helena Stockmann, Vera Krane, Claudia Sommerer, Ivonne Loeffler, Turgay Saritas, Jan T. Kielstein, Thomas Sitter, Markus P. Schneider, Matthias Schmid, Christoph Wanner, Kai-Uwe Eckardt, Gunter Wolf, Martin Busch
Summary: Diabetes mellitus (DM) and chronic kidney disease (CKD) are known risk factors for cardiovascular disease and mortality. This study found that DM significantly increased the risk of cardiovascular and non-cardiovascular death, major adverse cardiovascular events, and hospitalization for heart failure in patients with moderate to severe CKD. The increased risk was similar in patients with CKD caused by cardiovascular/metabolic diseases and those with genuine CKD. Patients with DM and CKD caused by cardiovascular/metabolic diseases were particularly susceptible to heart failure.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Critical Care Medicine
Anna Duckworth, Michael A. Gibbons, Richard J. Allen, Howard Almond, Robin N. Beaumont, Andrew R. Wood, Katie Lunnon, Mark A. Lindsay, Louise Wain, Jess Tyrrell, Chris J. Scotton
Summary: Using mendelian randomisation, this study found that shorter telomere length is associated with higher odds of IPF but not COPD, suggesting a potential contributory factor in IPF and differing mechanisms in COPD.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer, CRIC Study Investigators
Summary: The study investigated the associations of the vitamin D metabolite ratio (VDMR), 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH](2)D) with cardiovascular disease (CVD) in chronic kidney disease patients. The results showed that lower VDMR and 1,25(OH)(2)D were associated with incident CVD, while only 25(OH)D was associated with left ventricular mass index. However, none of these metabolites were found to be associated with incident CVD in chronic kidney disease after adjustment for relevant factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Ashton C. Lai, Solomon W. Bienstock, Raman Sharma, Karl Skorecki, Frans Beerkens, Rajeev Samtani, Andrew Coyle, Tonia Kim, Usman Baber, Anton Camaj, David Power, Valentin Fuster, Martin E. Goldman
Summary: Cardiovascular disease is the leading cause of death in end-stage renal disease patients, exacerbated by dialysis treatment. Multimodality imaging may offer additional prognostication and risk stratification for these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Hematology
Anne Cornelissen, Daniela T. Fuller, Raquel Fernandez, Xiaoqing Zhao, Robert Kutys, Elizabeth Binns-Roemer, Marco Delsante, Atsushi Sakamoto, Ka Hyun Paek, Yu Sato, Rika Kawakami, Masayuki Mori, Kenji Kawai, Teruhiko Yoshida, Khun Zaw Latt, Clint L. Miller, Paul S. de Vries, Frank D. Kolodgie, Renu Virmani, Myung Kyun Shin, Maarten Hoek, Jurgen Heymann, Jeffrey B. Kopp, Avi Z. Rosenberg, Harry R. Davis, Liang Guo, Aloke V. Finn
Summary: The study found that APOL1 risk alleles are associated with coronary artery disease, with carriers being more prone to thrombotic events. Individuals with 2 APOL1 risk alleles have larger necrotic cores in plaques, suggesting a role of APOL1 in determining plaque stability.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Medicine, General & Internal
Luis D'Marco, Maria Jesus Puchades, Nayara Panizo, Maria Romero-Parra, Lorena Gandia, Elena Gimenez-Civera, Elisa Perez-Bernat, Miguel Gonzalez-Rico, Jose Luis Gorriz
Summary: Adipose tissues around the heart and kidneys play a significant role in cardiovascular and renal diseases, especially in chronic kidney disease patients. Epicardial fat and perirenal fat may influence atherosclerosis and kidney diseases through the secretion of inflammatory factors and fatty acids, serving as modulators of cardiorenal dysfunction.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Marios Sagris, Panagiotis Theofilis, Alexios S. Antonopoulos, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Coronary artery disease is a common disease with a high prevalence, particularly in developing countries. The investigation of telomeres as a potential tool for the early detection of atherosclerosis seems promising. Telomeres, repetitive DNA sequences at the ends of chromosomes, are important for maintaining genetic stability. Telomere length has been associated with various diseases, and its rate of shortening varies in the population. This review explores the pathophysiology of telomere shortening, its association with cardiovascular disease, and potential treatment options based on telomere length and telomerase function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Adi-Lukas Kurniawan, Ya-Lan Yang, Mei-Yun Chin, Chien-Yeh Hsu, Rathi Paramastri, Hsiu-An Lee, Po-Yuan Ni, Jane Chao
Summary: The study showed that chronic kidney disease (CKD) patients can benefit from nutrition education (NE) and lifestyle adjustments in improving kidney function and cardiovascular risk factors, particularly for patients who smoke or have inactive physical activity. Nutrition education may play a positive role in enhancing kidney function and improving cardiovascular risk factors.
Article
Infectious Diseases
Lisa Pilgram, Lukas Eberwein, Bjoern-Erik O. Jensen, Carolin E. M. Jakob, Felix C. Koehler, Martin Hower, Jan T. Kielstein, Melanie Stecher, Bernd Hohenstein, Fabian Prasser, Timm Westhoff, Susana M. Nunes de Miranda, Maria J. G. T. Vehreschild, Julia Lanznaster, Sebastian Dolff
Summary: This multicentre cohort study aimed to evaluate the situation of CKD5D patients during the COVID-19 pandemic and investigate the association between dialysis dependency and mortality. The results showed that dialysis dependency was not related to mortality, but the mortality rate of CKD patients was high.
Article
Transplantation
Helena Baechle, Peggy Sekula, Pascal Schlosser, Inga Steinbrenner, Yurong Cheng, Fruzsina Kotsis, Heike Meiselbach, Helena Stockmann, Sebastian Schoenherr, Kai-Uwe Eckardt, Olivier Devuyst, Juergen Scherberich, Anna Koettgen, Ulla T. Schultheiss
Summary: This study aimed to explore metabolites associated with uromodulin concentrations and evaluate their association with the progression of chronic kidney disease (CKD) and adverse kidney events. The study found that higher levels of urinary and serum uromodulin were associated with a lower risk of adverse kidney events, suggesting a potential protective role of functional nephrons in CKD outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Inga Steinbrenner, Peggy Sekula, Fruzsina Kotsis, Maja von Cube, Yurong Cheng, Jennifer Nadal, Matthias Schmid, Markus P. Schneider, Vera Krane, Matthias Nauck, Kai-Uwe Eckardt, Ulla T. Schultheiss
Summary: In this study, higher levels of OPN were found to be associated with worsening kidney function markers and an increased risk of adverse outcomes in CKD patients. A larger proportion of KF events could be attributed to higher OPN levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kunihiro Matsushita, Stephen Kaptoge, Steven H. J. Hageman, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J. Brunskill, Alex R. Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T. Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H. Jafar, Simerjot K. Jassal, Takamasa Kayama, Csaba P. Kovesdy, Gijs W. Landman, Andrew S. Levey, Donald M. Lloyd-Jones, Rupert W. Major, Katsuyuki Miura, Paul Muntner, Girish N. Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J. Pena, Kevan R. Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P. Schneider, Varda Shalev, Michael G. Shlipak, Marit D. Solbu, Nikita Stempniewicz, James Tollitt, Jose M. Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick A. N. Dorresteijn, Emanuele Di Angelantonio, Frank L. J. Visseren, Lisa Pennells, Josef Coresh
Summary: This study developed an "Add-on" method to incorporate chronic kidney disease (CKD) measures into cardiovascular disease (CVD) risk prediction algorithms, which improved the predictive accuracy. This approach will assist clinicians and patients in more precise risk assessment and personalized preventive therapies for CKD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Joanne Trinh, Andrew A. Hicks, Inke R. Koenig, Sylvie Delcambre, Theresa Lueth, Susen Schaake, Kobi Wasner, Jenny Ghelfi, Max Borsche, Carles Vilarino-Gueell, Faycel Hentati, Elisabeth L. Germer, Peter Bauer, Masashi Takanashi, Vladimir Kostic, Anthony E. Lang, Norbert Brueggemann, Peter P. Pramstaller, Irene Pichler, Alex Rajput, Nobutaka Hattori, Matthew J. Farrer, Katja Lohmann, Hansi Weissensteiner, Patrick May, Christine Klein, Anne Gruenewald
Summary: Trinh et al. found that PINK1/PRKN mutations increase the risk of mitochondrial DNA variant accumulation in a dose- and disease-dependent manner. Monoallelic mutation carriers can be distinguished by the level of heteroplasmic mtDNA variants. Biallelic mutations in PINK1/PRKN lead to recessive Parkinson's disease.
Article
Medical Laboratory Technology
L. Renee Ruhaak, Fred P. H. T. M. Romijn, Ilijana Begcevic Brkovic, Zsusanna Kuklenyik, Julia Dittrich, Uta Ceglarek, Andrew N. Hoofnagle, Harald Althaus, Eduardo Angles-Cano, Stefan Coassin, Vincent Delatour, Liesbet Deprez, Ioannis Dikaios, Gerhard M. Kostner, Florian Kronenberg, Alicia Lyle, Urban Prinzing, Hubert W. Vesper, Christa M. Cobbaert, Int Federation Clinical Chem Lab Med Working Grp Apolipoproteins Mass Spect
Summary: In order to ensure the accuracy and reliability of medical results from in vitro diagnostic and in-house tests, a higher order reference measurement system traceable to endorsed reference measurement procedures and reference materials is needed. A candidate reference measurement procedure for serum apolipoprotein(a) [apo(a)] based on mass spectrometry was developed and provisionally validated. The method demonstrated accurate quantitation of serum apo(a) and fulfilled predefined analytical performance specifications.
CLINICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Florian Kronenberg, Samia Mora, Erik S. G. Stroes, Brian A. Ference, Benoit J. Arsenault, Lars Berglund, Marc R. Dweck, Marlys L. Koschinsky, Gilles Lambert, Francois Mach, Catherine J. McNeal, Patrick M. Moriarty, Pradeep Natarajan, Borge G. Nordestgaard, Klaus G. Parhofer, Salim S. Virani, Arnold von Eckardstein, Gerald F. Watts, Jane K. Stock, Kausik K. Ray, Lale S. Tokgozoglu, Alberico L. Catapano
Summary: In 2022, the European Atherosclerosis Society (EAS) released a new consensus statement on the relationship between lipoprotein(a) [Lp(a)] and atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. This statement highlights the importance of understanding Lp(a) concentration and its impact on lifetime risk for ASCVD. It also provides practical advice on using Lp(a) concentration to manage risk factors, despite the lack of currently available targeted therapies to lower Lp(a).
Article
Nutrition & Dietetics
Vladimir Cejka, Stefan Stoerk, Jennifer Nadal, Matthias Schmid, Claudia Sommerer, Thomas Sitter, Heike Meiselbach, Martin Busch, Markus P. Schneider, Turgay Saritas, Ulla T. Schultheiss, Fruzsina Kotsis, Christoph Wanner, Kai-Uwe Eckardt, Vera Krane
Summary: This study found that neck circumference and waist circumference were associated with increased risk of all-cause death in patients with chronic kidney disease, especially in women. However, body mass index was not associated with any of the analyzed outcomes.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Sebastian Schoenherr, Hansi Weissensteiner, Florian Kronenberg, Lukas Forer
Summary: This paper presents a major upgrade to the Haplogrep software, including added features such as haplogroup summary statistics and variant annotations from various genome databases, improved algorithms for large-scale data, and a new web framework. These improvements allow researchers to classify and investigate thousands of samples more conveniently.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Marlys L. Koschinsky, Erik S. G. Stroes, Florian Kronenberg
Summary: This review focuses on the causal association between Lipoprotein(a) (Lp(a)) and cardiovascular outcomes, the mechanisms by which elevated Lp(a) contributes to cardiovascular diseases, the metabolic insights on the production and clearance of Lp(a), and the current and future therapeutic approaches to lower Lp(a) concentrations.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Iris Friedli, Seema Baid-Agrawal, Robert Unwin, Arvid Morell, Lars Johansson, Paul D. Hockings
Summary: Diabetic kidney disease (DKD) is a serious healthcare problem worldwide, and non-invasive biomarkers are needed for early diagnosis and disease monitoring. Magnetic resonance imaging (MRI) may provide a solution for DKD diagnosis and assessment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Matthias Axelsson, Per Lindner, Nils-Gunnar Pehrsson, Seema Baid-Agrawal
Summary: This retrospective observational study evaluated the effect of hypothermic machine perfusion (HMP) on delayed graft function (DGF) and graft survival in kidneys from expanded criteria donors (ECD). The results showed that HMP can reduce DGF rates but does not have a significant impact on graft survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Adriana Koller, Claudia Lamina, Caroline Brandl, Martina E. Zimmermann, Klaus J. Stark, Hansi Weissensteiner, Reinhard Wuerzner, Iris M. Heid, Florian Kronenberg, Jay Stewart
Summary: This study suggests that mtDNA copy number in blood may serve as a more accessible biomarker for age-related macular degeneration (AMD) than mtDNA copy number in the retina, providing new insights into the relationship between mtDNA-CN and AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)