DIFFUSION ON A SPHERE WITH LOCALIZED TRAPS: MEAN FIRST PASSAGE TIME, EIGENVALUE ASYMPTOTICS, AND FEKETE POINTS

A common scenario in cellular signal transduction is that a diffusing surface-bound molecule must arrive at a localized signaling region on the cell membrane before the signaling cascade can be completed. The question then arises of how quickly such signaling molecules can arrive at newly formed signaling regions. Here, we attack this problem by calculating asymptotic results for the mean first passage time for a diffusing particle confined to the surface of a sphere, in the presence of N partially absorbing traps of small radii. The rate at which the small diffusing molecule becomes captured by one of the traps is determined by asymptotically calculating the principal eigenvalue for the Laplace operator on the sphere with small localized traps. The asymptotic analysis relies on the method of matched asymptotic expansions, together with detailed properties of the Green's function for the Laplacian and the Helmholtz operators on the surface of the unit sphere. The asymptotic results compare favorably with full numerical results.