Article
Biochemistry & Molecular Biology
Li-Min Mao, Shannon Demehri, John Q. Wang
Summary: This study investigates the role of A(2A) receptors in modulating the Src family kinase (SFK) signaling pathway in the striatum. The results indicate that activation of A(2A) receptors leads to increased phosphorylation of SFKs and enhanced kinase activity of these SFK members.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Jaec A. Emtage, Megan L. Shipman, Laura H. Corbit
Summary: This study confirms the role of A(2A) receptors in goal-directed responding, and investigates their effects on response-outcome encoding, updating representations of outcome value, and the ability to inhibit behavior when reward is not available.
PSYCHOPHARMACOLOGY
(2023)
Article
Cell Biology
Rouven Schoppmeyer, Abraham C. van Steen, Lanette Kempers, Anne L. Timmerman, Martijn A. Nolte, Pleun Hombrink, Jaap D. van Buul
Summary: This study investigates how cytotoxic T lymphocytes (CTLs) efficiently leave the circulation to target cancer cells or contribute to inflammation by crossing the endothelium. The researchers found that human central memory CTLs predominantly cross the endothelium in a paracellular fashion, while effector and effector memory CTLs preferentially cross in a transcellular fashion. The study also reveals the mechanism of CTL-endothelium interaction and the involvement of ICAM-1 and CX3CL1:CX3CR1 in transcellular migration.
Article
Cell Biology
Satoshi Takizawa, Atsushi Murao, Mahendar Ochani, Monowar Aziz, Ping Wang
Summary: The study reveals the important role of eCIRP in the heterogeneity of LDNs in sepsis, and targeting it may help reduce inflammatory responses.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Haleigh E. Conley, M. Katie Sheats
Summary: Neutrophils use beta(2)-integrin cell surface receptors to move out of blood vessels and respond to inflammation and infection. However, dysregulated neutrophil responses can contribute to disease pathophysiology. Investigating the function and signaling of beta(2)-integrins can help in designing future therapeutics.
Article
Oncology
Chenghui Yang, Zhen Wang, Lili Li, Zhigang Zhang, Xiaoyan Jin, Pin Wu, Shanshan Sun, Jun Pan, Ke Su, Fang Jia, Leyi Zhang, Haijun Wang, Xiuyan Yu, Xuan Shao, Ke Wang, Fuming Qiu, Jun Yan, Jian Huang
Summary: Naged, a subset of neutrophils, plays a crucial role in premetastatic niche formation during breast cancer metastasis. It is characterized by distinct cell markers and morphological features, and is maintained by the key transcription factor SIRT1 for their function in promoting tumor metastasis through mitochondria-dependent NETs formation. Therapeutic interventions targeting the SIRT1-Naged-NETs axis show promise for reducing breast cancer lung metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Weiwei Zhu, Huifang Zhang, Qiming Dong, Hongyong Song, Lin Zhao
Summary: This study reveals the dual wave of neutrophil recruitment during C. albicans infection, emphasizing the importance of early fungal clearance for favorable disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Quanyu Zhang, Huarong Zhang, Xiaowei Yan, Sicong Ma, Xiaohong Yao, Yu Shi, Yifang Ping, Mianfu Cao, Chengfei Peng, Shuai Wang, Min Luo, Chenghui Yan, Shuyang Zhang, Yaling Han, Xiuwu Bian
Summary: Active myocarditis is frequently associated with neutrophil infiltration in the hearts of deceased patients with severe COVID-19. Patients with neutrophil-infiltrated myocarditis had severely abnormal laboratory test results on admission and high maximum creatine kinase-MB during hospitalization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Swagata Dey, Omer Barkai, Irena Gokhman, Sapir Suissa, Rebecca Haffner-Krausz, Noa Wigoda, Ester Feldmesser, Shifra Ben-Dor, Andrew Kovalenko, Alexander Binshtok, Avraham Yaron
Summary: This study revealed that the microtubule destabilizer Kif2a plays a crucial role in regulating nociceptive terminal structures and pain sensitivity. Ablation of Kif2a in sensory neurons leads to hyperinnervation and hypersensitivity to noxious stimuli. Additionally, Kif2a deficiency triggers a transcriptional response involving sustained upregulation of injury-related genes and downregulation of specific channels and receptors. Despite the persistent morphological aberrations, the downregulation of channels and receptors can relieve the hyperexcitability of nociceptive neurons and correlates with the resolution of pain hypersensitivity.
Article
Engineering, Biomedical
Yao Xiao, Chao Ren, Gan Chen, Pan Shang, Xiang Song, Guoxing You, Shaoduo Yan, Yongming Yao, Hong Zhou
Summary: This study explores the use of neutrophil membrane-mimicking nanodecoys (NM) as a biomimetic nanomedicine for the treatment of sepsis-associated liver injury. NM administration shows excellent biocompatibility and effectively reduces inflammatory cytokines and liver injury biomarkers, reduces hepatic malondialdehyde content and myeloperoxidase activity, and improves survival in a septic mouse model. In vitro studies also demonstrate that NM neutralizes neutrophil chemokines and inflammatory mediators, and mitigates neutrophil chemotaxis and adhesion. NM also attenuates lipopolysaccharide-induced reactive oxygen species generation, cyclooxygenase-2 expression, nitric oxide secretion, and subsequent hepatocyte injury. This study provides a promising therapeutic strategy for sepsis-induced acute liver injury.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Jingpiao Bao, Xiuli Zhang, Bin Li, Mengya Niu, Zengkai Wu, Pengli Song, Xiaoyu Guo, Sohail Z. Husain, Guoyong Hu, Liang Li, Li Wen
Summary: This study found that AXL and MERTK play important roles in AP, and their antagonists may be a novel and potential early treatment for AP. The level of MERTK in peripheral leukocytes may be a promising biomarker for predicting pancreatic severity in patients with AP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Materials Science, Multidisciplinary
Ningning Yan, Jiaping Zhang, Tianyu Liu, Wei Xie, Qiangang Fu, Jia Sun, Qingliang Shen
Summary: A ZrC-SiC-Si coating prepared by one-step vapor silicon infiltration was applied to improve the ablation resistance of nose-shaped ZrC/C composites. The coating exhibited good bonding strength, high hardness, and elastic modulus. It effectively reduced the ablation rate of the composites and maintained a high heat resistance capacity.
Article
Oncology
Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Jia Li, Zhiqiang Hu, Haoyang Xin, Chubin Luo, Jian Zhou, Jia Fan, Shaolai Zhou
Summary: The interaction between TANs and TAMs enhances the proliferation and invasion abilities of ICC cells, promoting ICC progression. They can produce Oncostatin M and interleukin-11 in co-culture, activating STAT3 signaling in ICC cells, and silencing STAT3 can disrupt the pro-tumor effect of TANs and TAMs on ICC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Christina S. E. Carroll, Erin R. Andrew, Laeeq Malik, Kathryn F. Elliott, Moira Brennan, James Meyer, Alexander Hintze, Andrew A. Almonte, Cassandra Lappin, Philip MacPherson, Klaus-Martin Schulte, Jane E. Dahlstrom, Rohit Tamhane, Teresa Neeman, Elizabeth W. Herbert, Maurice Orange, Desmond Yip, Rachel Allavena, Aude M. Fahrer
Summary: Intratumoral injection of a slow-release emulsion of killed mycobacteria shows significant antitumor effects in some animal models and is safe for use in human cancer patients. The treatment is simple and inexpensive, with potential for further trials in human cancer patients. This novel cancer immunotherapy is applicable to a wide range of solid tumors and suitable for patients in developing countries.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Daniel Alonso-Miguel, Guillermo Valdivia, Diego Guerrera, Maria Dolores Perez-Alenza, Stanislav Pantelyushin, Angela Alonso-Diez, Veronique Beiss, Steven Fiering, Nicole F. Steinmetz, Maria Suarez-Redondo, Johannes Vom Berg, Laura Pena, Hugo Arias-Pulido
Summary: In situ eCPMV immunotherapy has demonstrated anti-tumor efficacy and improved survival in IMC patients, suggesting its potential as a groundbreaking immunotherapy for both canine IMC and human IBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Health Care Sciences & Services
Rosaria De Luca, Carmela Rifici, Patrizia Pollicino, Marcella Di Cara, Sabrina Miceli, Giuseppina Sergi, Luisa Sorrenti, Michela Romano, Antonino Naro, Luana Billeri, Paola Lauria, Angelo Caminiti, Placido Bramanti, Michele Torrisi
Summary: This study aimed to investigate the effectiveness of online Skype therapy (OLST) in promoting cognitive and sensory-motor recovery in patients with severe acquired brain injury (SABI) and reducing caregiver distress. The results showed that OLST significantly reduced caregiver anxiety and burden, while improving trunk control, functional independence, cognitive functioning, and behavioral responsiveness in patients. The study also found significant changes in brain connectivity during the therapy. OLST could be a useful and complementary treatment for SABI patients and caregivers in the COVID-19 era.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Cell Biology
Irene Paterniti, Alessia Filippone, Irina Naletova, Valentina Greco, Sebastiano Sciuto, Emanuela Esposito, Salvatore Cuzzocrea, Enrico Rizzarelli
Summary: Spinal cord injury (SCI) can cause severe motor dysfunction and nervous system abnormalities. The conjugation of trehalose with l-carnosine (Tre-car) has been found to reduce inflammation in vitro and in vivo models of SCI. Tre-car decreased early inflammatory effects, oxidative stress, and apoptosis, and stimulated the release of neurotrophic factors and influenced Zn2+ homeostasis. Tre-car may be a promising therapeutic agent for treating SCI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Andrea Duranti, Francesco Monaco, Rosalba Siracusa, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Idiopathic pulmonary fibrosis (IPF), a deadly lung condition, worsens over time and has no known cause. Traditional treatments for IPF, such as corticosteroids and immunomodulatory drugs, often have noticeable side effects and are not very effective. By inhibiting the fatty acid amide hydrolase (FAAH) enzyme, which breaks down endocannabinoids, it is possible to increase the levels of these natural pain-relieving compounds and reduce inflammation. In our study, we used a bleomycin-induced IPF model and found that administering URB878, an FAAH inhibitor, reduced histological changes, cell infiltration, pro-inflammatory cytokine production, inflammation, and nitrosative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Roberta Fusco, Rosalba Siracusa, Marika Cordaro, Ramona D'Amico, Francesco Macri, Emanuela Raffone, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The study investigated the beneficial effects of fisetin, a naturally occurring polyphenol, on endometriosis. Fisetin treatment reduced the size and volume of endometriotic implants, as well as histological alterations and inflammatory responses. It also decreased markers of oxidative stress and increased apoptosis in endometrial lesions. Fisetin may represent a potential therapeutic strategy for endometriosis by targeting inflammatory pathways and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Daniela Impellizzeri, Ramona D'Amico, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The phytoconstituents in the Mediterranean diet (MD) have been extensively studied for their beneficial effects on human health. Olive oil, a key component of the MD, has been particularly investigated due to its high content of hydroxytyrosol (HT), which possesses protective properties in various chronic disorders, including intestinal and gastrointestinal diseases. However, there is currently no comprehensive review summarizing the role of HT in these disorders. This review provides an overview of the anti-inflammatory and antioxidant properties of HT against intestinal and gastrointestinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Gianluca Antonio Franco, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Neurodegenerative disorders are characterized by neuroinflammation, oxidative stress, and neuronal depletion, and there is currently no cure for these diseases. The Mediterranean diet, rich in antioxidants and omega-3 fatty acids, may have a protective effect on neurodegeneration. This review focuses on the therapeutic potential of natural products and the associations between the Mediterranean-style diet, neurodegenerative diseases, and markers and mechanisms of neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessio Ardizzone, Alberto Repici, Anna Paola Capra, Federica De Gaetano, Valentina Bova, Giovanna Casili, Michela Campolo, Emanuela Esposito
Summary: Atopic dermatitis (AD) is a common inflammatory skin disease that mainly affects children. This study evaluated the effects of a cream formulation containing tempol in a murine model of AD. The results demonstrated that tempol reduced histological damage, mast cell infiltration, and improved skin barrier function by restoring tight junctions and filaggrin. Furthermore, tempol modulated inflammation and oxidative stress through the NF-κB/Nrf2 signaling pathways.
Review
Biochemistry & Molecular Biology
Federica Rey, Clarissa Berardo, Erika Maghraby, Alessia Mauri, Letizia Messa, Letizia Esposito, Giovanna Casili, Sara Ottolenghi, Eleonora Bonaventura, Salvatore Cuzzocrea, Gianvincenzo Zuccotti, Davide Tonduti, Emanuela Esposito, Irene Paterniti, Cristina Cereda, Stephana Carelli
Summary: Oxygen imbalance can have detrimental effects on the brain, leading to various neurological disorders. The dysfunctions caused by oxygen imbalance in neurodegenerative and pediatric neurological disorders result from redox imbalance. This review focuses on the underlying dysfunction in redox and potential therapeutic strategies for these conditions.
Retraction
Integrative & Complementary Medicine
Sabrina Giacoppo, Renato Iori, Patrick Rollin, Placido Bramanti, Emanuela Mazzon
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Biochemistry & Molecular Biology
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study aimed to evaluate the inhibitory effect of Antrodia camphorata (AC) administration on neuroinflammation and oxidative stress in a murine model of Parkinson's disease (PD). The results showed that AC treatment significantly reduced PD-related pathological changes, increased tyrosine hydroxylase expression, reduced alpha-synuclein-positive neurons, restored the myelination process of neurons associated with PD, and attenuated neuroinflammation. Furthermore, AC was able to reduce oxidative stress induced by MPTP injection. This study highlights AC as a potential therapeutic agent for neurodegenerative disorders such as PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Agnese Ragno, Marika Cordaro, Ramona D'Amico, Rosalba Siracusa, Roberta Fusco, Francesca Marino Merlo, Antonella Smeriglio, Daniela Impellizzeri, Salvatore Cuzzocrea, Giuseppina Mandalari, Rosanna Di Paola
Summary: The study evaluated the antioxidant and anti-inflammatory effects of almond skin extract (ASE) and found that it inhibited the formation of ROS and apoptosis in vitro, and restored tissue changes and decreased inflammation in an in vivo model. The mechanisms of action could be related to the inhibition of the pro-inflammatory nuclear factor NF-κB and activation of the Nrf2 antioxidant pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Alberto Repici, Alessio Ardizzone, Alessia Filippone, Cristina Colarossi, Marzia Mare, Gabriele Raciti, Deborah Mannino, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: Brain tumors are a heterogeneous group of neoplasms affecting populations of all ages. Glioblastoma (GB), the most common primary brain tumor, often leads to death within a few months after diagnosis. Immunotherapy, particularly targeting interleukin 21 (IL-21), appears to be a promising approach to improve the survival rate of GB patients. The review evaluates the potential use of IL-21 and its mechanisms in the progression of GB.
Article
Pharmacology & Pharmacy
Fabrizio Calapai, Ilaria Ammendolia, Luigi Cardia, Mariaconcetta Curro, Gioacchino Calapai, Emanuela Esposito, Carmen Mannucci
Summary: Risankizumab is a safe and effective treatment for moderate-to-severe plaque psoriasis and psoriatic arthritis, according to post-marketing analysis of real-world data. The most frequently reported serious adverse reactions to risankizumab include infections, cancer, nervous system and cardiac disorders. Despite the limitations of the study, the safety profile of risankizumab is consistent with previous clinical trials and further research is needed to explore the occurrence of malignancies and their sex distribution as adverse reactions.
Review
Integrative & Complementary Medicine
Giuseppa Maresca, Vanessa Nocito, Viviana Lo Buono, Desiree Latella, Marcella Di Cara, Caterina Formica, Lara Carnazza, Edoardo Sessa, Placido Bramanti, Francesco Corallo
Summary: This study conducted a systematic review on the symptoms of people with multiple sclerosis (MS), and found that hypnosis therapy has positive impacts on reducing pain, improving psychological well-being, and relieving fatigue in MS patients. Other nonpharmacological techniques did not have the same effects.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
