Article
Biology
Tao Jia, Thibault Jacquet, Fabien Dalonneau, Pauline Coudert, Elisabeth Vaganay, Chloe Exbrayat-Heritier, Julien Vollaire, Veronique Josserand, Florence Ruggiero, Jean-Luc Coll, Beatrice Eymin
Summary: In this study, it was demonstrated that FGF-2 promotes angiogenesis by activating a SRSF1/SRSF3/SRPK1 network that regulates VEGFR1 alternative splicing in endothelial cells, which could also contribute to lung tumor progression.
Review
Emergency Medicine
Keyang Chen, Zhiheng Rao, Siyang Dong, Yajing Chen, Xulan Wang, Yongde Luo, Fanghua Gong, Xiaokun Li
Summary: Following injury, the repair or regeneration process of tissues can lose control under chronic traumatic or pathological conditions, resulting in partial restoration of structure and function along with the development of fibrosis, scarring or even pathogenesis.
Article
Medicine, General & Internal
Dupiao Zhang, Mazhar Ali Raza, Jianpeng Chen, Baolong Li, Wenbin Liu, Tao Han, Hede Yan, Liangfu Jiang
Summary: In this study, the researchers used a mouse model to investigate the effects of FGF9 on random flap survival. The results showed that FGF9 can directly increase flap survival area and blood flow intensity by promoting angiogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Edward Hartsough, Rajani R. J. Shelke, Razie Amraei, Zahra Aryan, Saran Lotfollahzadeh, Nader Rahimi
Summary: Activation and signal transduction of vascular endothelial growth factor receptor-2 (VEGFR-2) play crucial roles in vasculogenesis and pathological angiogenesis. The study reveals that protein arginine methyltransferase 4 (PRMT4) mediates methylation of a specific site on VEGFR-2, which affects VEGFR-2-induced angiogenic responses. This finding may have implications for the development of targeted VEGFR-2 inhibitors.
Article
Hematology
Lan Xie, Xiying Wang, Yuankun Ma, Hong Ma, Jian Shen, Jinyong Chen, Yidong Wang, Sheng'an Su, Kaijie Chen, Lingxiao Xu, Yao Xie, Meixiang Xiang
Summary: This study reveals that tissue stiffness increases gradually after hindlimb ischemia, and Piezo1 expression and activation are upregulated in macrophages from ischemic tissues. Deletion of macrophage Piezo1 promotes perfusion recovery by enhancing FGF2 production and angiogenesis. This study uncovers the crucial role of microenvironmental stiffness in exacerbating the macrophage-dependent deficient angiogenic response.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Leah R. Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim
Summary: This study aimed to develop stable formulations of FGF-2 using pharmaceutical excipients to withstand physical stressors encountered in processing and storage. Formulations containing MC and alanine (F5) or MC and HSA (F6) were the most effective in stabilizing FGF-2 against thermal and processing stressors. These stabilized solutions have potential applications in medicinal products or in more advanced forms for wound healing and tissue regeneration.
Article
Oncology
Simin Zhang, Jiahui Huang, Ligang Zhang, Jiangtao Gu, Qifang Song, Yaxiong Cai, Jiangchuan Zhong, Hui Zhong, Yanrui Deng, Wenhui Zhu, Jianfu Zhao, Ning Deng
Summary: The study successfully produced a ds-Diabody against FGF-2 using Pichia pastoris fermentation, which showed inhibitory effects on melanoma and glioma tumor cells and potent antitumor activity in nude mice. The results suggest that the recombinant ds-Diabody against FGF-2 could be a promising anti-tumor drug for cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Fanrui Meng, Yukai Cao, Han Su, Tianyan Liu, Limin Tian, Yu Zhang, Jiarui Yang, Wei Xiao, Deshan Li
Summary: This study demonstrates that rNDV-VEGF-Trap significantly inhibits the growth and migration of tumor cells through anti-angiogenesis and apoptosis. It also reduces tumor volume and weight, suggesting its potential as a candidate for carcinoma therapy, especially for colon cancer.
Article
Cell Biology
Xiuqin Jia, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Yuhan Jiao, Lulin Wang, Jingjing Jiang, Feng Pang, Xianzhen Zhang, Jian Zhang
Summary: In this study, the FGFRs inhibitor FIIN-2 was found to inhibit the proliferation, colony formation, and migration of platinum-resistant LUAD cells while inducing mitochondria-mediated apoptosis. Furthermore, FIIN-2 was shown to enhance autophagy flux in these cells, suggesting its potential as a treatment strategy for LUAD, especially in combination with autophagy inhibitors.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Katiuscia Pagano, Laura Carminati, Simona Tomaselli, Henriette Molinari, Giulia Taraboletti, Laura Ragona
Summary: This study discusses the ability of rosmarinic acid (RA) to induce the dissociation of the FGF2/FGFR complex, showing that RA competes with FGF2 for binding to FGFR-D2 domain and destabilizes the complex. Cellular studies confirmed that RA inhibits FGF2-induced endothelial cell proliferation and FGFR activation, suggesting the potential for developing new extracellular inhibitors targeting the FGF/FGFR pathways based on these findings.
Article
Engineering, Biomedical
Zhouguang Wang, Yan Huang, Yan He, Sinan Khor, Xingxing Zhong, Jian Xiao, Qingsong Ye, Xiaokun Li
Summary: The use of an injectable coacervate to protect growth factor FGF10 has shown to significantly improve heart condition in a mouse acute myocardial infarction model, with better outcomes compared to free FGF10 or heparin+FGF10 treatment, especially in the long term. The coacervate treatment effectively inhibited cardiac deterioration, reduced myocardial inflammation and fibrosis, improved arterioles and capillaries stabilization, and activated signaling pathways related to cardiac function and angiogenesis.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Mei-Chi Chang, Nai-Yuan Chen, Jen-Hao Chen, Wei-Ling Huang, Chi -Yu Chen, Chih-Chia Huang, Yu-Hwa Pan, Hsiao-Hua Chang, Jiiang-Huei Jeng
Summary: The effects of bFGF on stem cells from apical papilla (SCAP) were investigated in this study. The results showed that bFGF can modulate fibrinolysis and matrix turnover, inhibit the differentiation of SCAP, and exert its effects through the MEK/ERK, p38, and TAK1 signaling pathways.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dezhong Wang, Yuan Yin, Shuyi Wang, Tianyang Zhao, Fanghua Gong, Yushuo Zhao, Beibei Wang, Yuli Huang, Zizhao Cheng, Guanghui Zhu, Zengshou Wang, Yang Wang, Jun Ren, Guang Liang, Xiaokun Li, Zhifeng Huang
Summary: Research has shown that FGF1 levels are decreased in DCM patients and positively correlated with fraction shortening, potentially making it a therapeutic target. Treatment with FGF1 variant FGF1( increment HBS) can prevent diabetes-induced cardiac injury and remodeling through effects on anti-oxidative gene expression and Nur77 levels. FGF1( increment HBS) exerts its beneficial effects by reducing mitochondrial fragmentation, ROS generation, and cytochrome c leakage, as well as enhancing mitochondrial respiration and beta-oxidation, all in an AMPK/Nur77-dependent manner.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Clinical Neurology
Eli R. Lebowitz, Meital Orbach, Carla E. Marin, Natalina Salmaso, Flora M. Vaccarino, Wendy K. Silverman
Summary: This study found that fibroblast growth factor 2 (FGF2) is associated with anxiety and depression in children, with FGF2 showing negative correlations with anxiety, depression, and behavioral avoidance, and positive correlations with the Reward-Responsiveness facet of behavioral activation. Additionally, FGF2 levels remained stable over a six-month period.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Juliete A. F. Silva, Xiaoping Qi, Maria B. Grant, Michael E. Boulton
Summary: The study demonstrates that VEGF induces rapid translocation of VEGFRs to the nucleus, with distinct characteristics between VEGFR1 and VEGFR2 in different cell types and a key role of the endosomal pathway in this process.
SCIENTIFIC REPORTS
(2021)