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Biochemistry & Molecular Biology
Xu Chen, Yuanyuan Qin, Yuhong Zhang, Xinyi Yang, Zhengcao Xing, Yajie Shen, Jinke Cheng, Edward T. H. Yeh, Hongmei Wu, Yitao Qi
Summary: The research revealed that SENP2 deficiency leads to decreased PLC beta 4 expression, impacting intracellular calcium homeostasis and neurogenesis. The stability of PLC beta 4 is regulated by SUMO-dependent ubiquitin pathways, affecting its nuclear regulatory function. SENP2 and PLC beta 4 are stimulated by starvation and oxidative stress to maintain calcium homeostasis regulated neurogenesis.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cell Biology
Ying Liu, Kejia Liu, Rick F. Thorne, Ronghua Shi, Qingyuan Zhang, Mian Wu, Lianxin Liu
Summary: This article investigates the role of SUMOylation and deSUMOylation of Succinate dehydrogenase (SDH) in regulating cellular metabolism. The study reveals that SDHA is SUMOylated by PIAS3 and deSUMOylated by SENP2, which affects the assembly and activity of the SDH complex. Additionally, acetylation of SENP2 by CBP negatively regulates its deSUMOylation activity, thereby regulating the TCA cycle and electron transport chain activity. This mechanism avoids excessive ROS production and promotes cancer cell survival.
Article
Biochemistry & Molecular Biology
Jinyan Nan, Ji Seon Lee, Joon Ho Moon, Seung-Ah Lee, Young Joo Park, Dong-Sup Lee, Sung Soo Chung, Kyong Soo Park
Summary: SENP2 plays a crucial role in regulating mitochondrial function and insulin secretion in pancreatic beta cells. SENP2 deficiency leads to enlarged mitochondria and impaired insulin secretion, possibly by suppressing the phosphorylation of DRP1.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Minh T. H. Nguyen, Masaki Imanishi, Shengyu Li, Khanh Chau, Priyanka Banerjee, Loka reddy Velatooru, Kyung Ae Ko, Venkata S. K. Samanthapudi, Young J. Gi, Ling-Ling Lee, Rei J. Abe, Elena Mcbeath, Anita Deswal, Steven H. Lin, Nicolas L. Palaskas, Robert Dantzer, Keigi Fujiwara, Mae K. Borchrdt, Estefani Berrios Turcios, Elizabeth A. Olmsted-Davis, Sivareddy Kotla, John P. Cooke, Guangyu Wang, Jun-ichi Abe, Nhat-Tu Le
Summary: This study reveals that laminar flow induces phosphorylation of SENP2 at S344 through CHK1 activation, resulting in the suppression of EC inflammation, migration, proliferation, apoptosis, and fibrotic changes. In the absence of SENP2 S344 phosphorylation, enhanced EC activation and upregulated gene expression leading to endothelial-to-mesenchymal transition occur. Rating: 8/10.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biology
Yun Deng, Haihong Wang, Xiaohui Liu, Hao Yuan, Jin Xu, Hugues de The, Jun Zhou, Zhu Jun, Florent Ginhoux
Summary: This study discovers that the deficiency of ZBTB14 gene leads to an abnormal expansion of monocyte/macrophage population in zebrafish. ZBTB14 functions as a negative regulator of PU.1, and the repression activity of ZBTB14 depends on SUMOylation on a conserved lysine. Furthermore, a mutation can target ZBTB14 protein to autophagic degradation.
Article
Pharmacology & Pharmacy
Raffaella Soldi, Tithi Ghosh Halder, Samuel Sampson, Hariprasad Vankayalapati, Alexis Weston, Trason Thode, Kapil N. Bhalla, Serina Ng, Ryan Rodriguez Del Villar, Kevin Drenner, Mohan R. Kaadige, Stephen K. Horrigan, Surinder K. Batra, Ravi Salgia, Sunil Sharma
Summary: This study demonstrates that BC-2059 selectively targets the TBL1/beta-catenin protein complex, suggesting its potential as a therapeutic for tumors with deregulated Wnt signaling pathway.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Shixiu Liang, Zicong Zhou, Zili Zhou, Jieyi Liu, Wufeng Huang, Hangming Dong, Fei Zou, Haijin Zhao, Changhui Yu, Shaoxi Cai
Summary: This study reveals that small ubiquitin-like modifier (SUMOylation) is enhanced in the airway epithelium of house dust mite-induced allergic asthma. Inhibition of SUMOylation alleviates airway inflammation and lfTSLP expression. Mechanistically, SUMOylation enhances the transcription of MEX-3B through the transcription factor TFII-I, and MEX-3B promotes lfTSLP translation by binding to its mRNA. This finding highlights CBX4 as a potential therapeutic target for lfTSLP-mediated asthma.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Lu Yi, Haohui Wang, Wei Li, Kun Ye, Wei Xiong, Haixin Yu, Xin Jin
Summary: Bladder cancer is a lethal cancer with a relatively unchanged survival rate despite advancements in medical technologies. Bioinformatics analysis revealed RNF26 as a risk factor for bladder cancer, which is abnormally upregulated and associated with poor prognosis in bladder cancer. Activation of the FOXM1/RNF26/p57 signaling axis promotes bladder cancer progression and could be a potential target for treatment.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Prabhu Thirusangu, Upasana Ray, Sayantani Sarkar Bhattacharya, Derek B. Oien, Ling Jin, Julie Staub, Nagarajan Kannan, Julian R. Molina, Viji Shridhar
Summary: PFKFB3 is an important enzyme in glycolysis that is overexpressed in many human cancers. Its high expression promotes glycolysis and survival in cancer stem cells, while inhibition of PFKFB3 can reduce proliferation, spheroid formation, chemotherapy resistance, and invasion/migration in SCLC cells.
Article
Plant Sciences
Ya-Li Zhang, Yi Tian, Yao-Yang Man, Chun-Ling Zhang, Yi Wang, Chun-Xiang You, Yuan-Yuan Li
Summary: SUMOylation plays a key role in optimizing plant growth and resistance to environmental stress. This study demonstrates that MdSIZ1 mediates the SUMOylation and accumulation of MdMYB30, leading to the activation of MdKCS1 expression and promotion of cuticular wax biosynthesis in apple.
Article
Biochemistry & Molecular Biology
Yi-Ping Tao, Heng-Yan Zhu, Qian-Yuan Shi, Cai-Xia Wang, Yu-Xin Hua, Han-Yin Hu, Qi-Yin Zhou, Zi-Lu Zhou, Ying Sun, Xiao-Min Wang, Yu Wang, Ya-Ling Zhang, Yan-Jun Guo, Zi-Ying Wang, Xuan Che, Chun-Wei Xu, Xian-Chao Zhang, Michal Heger, Su-Ping Tao, Xin Zheng, Ying Xu, Lei Ao, Ai-Jun Liu, Sheng-Bing Liu, Shu-Qun Cheng, Wei-Wei Pan
Summary: S1PR1 was found to be highly expressed in human ovarian cancer tissues and cells, and its deletion inhibited cancer cell proliferation and migration while promoting cell senescence and sensitivity to chemotherapy. S1P was shown to regulate ovarian cancer cell senescence by modulating the expression of PDK1, LATS1/2, and YAP. The study demonstrates the importance of the S1PR1-PDK1-LATS1/2-YAP signaling axis in the regulation of ovarian cancer cell senescence.
Article
Biochemistry & Molecular Biology
Helene Neyret-Kahn, Jacqueline Fontugne, Xiang Yu Meng, Clarice S. Groeneveld, Luc Cabel, Tao Ye, Elodie Guyon, Cle'mentine Krucker, Florent Dufour, Elodie Chapeaublanc, Audrey Rapinat, Daniel Jeffery, Laura Tanguy, Victoria Dixon, Yann Neuzillet, Thierry Lebret, David Gentien, Irwin Davidson, Yves Allory, Isabelle Bernard-Pierrot, Francois Radvanyi
Summary: Muscle-invasive bladder cancer (BLCA) has distinct molecular and clinical characteristics, with Luminal and Basal subtypes showing different gene expression profiles. In this study, the researchers established an integrated epigenetic map of BLCA, revealing the link between subtype and epigenetic control. They identified the activated super-enhancers and discovered the super-enhancer-regulated networks of candidate master transcription factors for Luminal and Basal subgroups. The study provides insights into the epigenetic regulation of BLCA and potential therapeutic targets.
Article
Endocrinology & Metabolism
Wanping Chen, Xilan Yu, Yinsheng Wu, Jie Tang, Qi Yu, Xiaodong Lv, Zitong Zha, Bicheng Hu, Xin Li, Jianguo Chen, Lixin Ma, Jerry L. Workman, Shanshan Li
Summary: Through studying budding yeast and human endothelial cells, the researchers found that increased synthesis of acetyl-CoA in the nucleus can promote histone acetylation at subtelomeric regions, leading to telomere silencing defects and cellular senescence.
Article
Cell Biology
Qian Nie, Huimin Chen, Ming Zou, Ling Wang, Min Hou, Jia-Wen Xiang, Zhongwen Luo, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Shu-Yu Zheng, Yuan Xiao, Yu-Wen Gan, Qian Gao, Yue-Yue Bai, Jing-Miao Wang, Lan Zhang, Xiang-Cheng Tang, Xuebin Hu, Lili Gong, Yizhi Liu, David Wan-Cheng Li
Summary: The protein PIAS1 plays a key role in regulating stress-induced lens pathogenesis by enhancing p53 transcription activity to promote Bax upregulation, thus facilitating stress-induced apoptosis in lens epithelial cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xinxin Li, Yufei Zhang, Minhua Zheng, Xiuli Cao, Min Guo, Xiangyu Gao, Hua Han
Summary: miR-582 functions as a negative regulator of pre-B cell proliferation and survival by targeting Hif1 alpha and mTORC2 signaling.
CELL DEATH & DISEASE
(2022)