Article
Infectious Diseases
Jacob A. Tickner, Catriona S. Bradshaw, Gerald L. Murray, David M. Whiley, Emma L. Sweeney
Summary: This study developed two molecular tests to detect Mycoplasma genitalium and determine its susceptibility to fluoroquinolones. The tests showed promising results and have the potential to enhance individualized treatment and antimicrobial stewardship for M. genitalium infection.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Dermatology
J. S. Jensen, M. Cusini, M. Gomberg, H. Moi, J. Wilson, M. Unemo
Summary: Mycoplasma genitalium infection is responsible for a significant number of cases of non-chlamydial non-gonococcal urethritis in men and is associated with cervicitis and pelvic inflammatory disease in women. Transmission occurs through direct mucosal contact. Asymptomatic infections are common. Diagnosis is achieved through nucleic acid amplification testing, including investigation for macrolide resistance mutations.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Infectious Diseases
Emma L. Sweeney, Catriona S. Bradshaw, Gerald L. Murray, David M. Whiley
Summary: Mycoplasma genitalium poses an emerging global health threat with increasing antimicrobial resistance. The use of individualised treatment approaches has been successful for macrolides, but the rise of fluoroquinolone resistance and lack of alternative treatment options complicate treatment. This article discusses the available literature data and highlights issues surrounding individualised treatment using fluoroquinolones, including the hesitance to consider ParC fluoroquinolone resistance mutations in guiding antimicrobial treatments. The authors propose the use of diagnostics that focus on the absence of resistance mutations to inform microbial cure following fluoroquinolone antimicrobials, with Australian data supporting this approach. Development of molecular tests detecting both wild-type and the most common ParC mutation could greatly improve antimicrobial selection, individualise tests of cure, and aid in the care of patients with M genitalium infection.
LANCET INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Emma L. Sweeney, Catriona S. Bradshaw, Gerald L. Murray, David M. Whiley
Summary: Individualized treatment of Mycoplasma genitalium infection should focus on fluoroquinolone resistance mutations to guide antimicrobial treatment and post-treatment microbial cure. The development of molecular tests that can detect both wild-type sequences and common ParC mutations, such as Ser83Ile, could greatly improve antimicrobial selection and patient care.
LANCET INFECTIOUS DISEASES
(2022)
Review
Microbiology
Ken B. Waites, Donna M. Crabb, Amy E. Ratliff, William M. Geisler, T. Prescott Atkinson, Li Xiao
Summary: Mycoplasma genitalium is a sexually transmitted pathogen that affects both men and women. Molecular-based diagnostic tests are needed due to its slow growth and demanding culture requirements. The availability of FDA-cleared commercial molecular-based assays has expanded diagnostic testing in the United States, leading to updated guidelines for testing and treatment. This review summarizes the importance of M. genitalium as a human pathogen, explains the need for microbiological diagnosis, describes available diagnostic methods, and discusses the impact of antimicrobial resistance on treatment options.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Immunology
Michelle J. L. Scoullar, Philippe Boeuf, Elizabeth Peach, Ruth Fidelis, Kerryanne Tokmun, Pele Melepia, Arthur Elijah, Catriona S. Bradshaw, Glenda Fehler, Peter M. Siba, Simon Erskine, Elisa Mokany, Elissa Kennedy, Alexandra J. Umbers, Stanley Luchters, Leanne J. Robinson, Nicholas C. Wong, Andrew J. Vallely, Steven G. Badman, Lisa M. Vallely, Freya J. Fowkes, Christopher Morgan, William Pomat, Brendan S. Crabb, James G. Beeson
Summary: Many pregnant women in Papua New Guinea are affected by reproductive tract infections, including emerging pathogens like Mycoplasma genitalium. Most infections are treatable, but sexually transmitted infections remain prevalent. Syndromic management is inadequate and almost all women have never used barrier contraception. These findings will help improve reproductive healthcare in Papua New Guinea.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Stanislav Tjagur, Reet Maendar, Olev Poolamets, Kristjan Pomm, Margus Punab
Summary: The study aimed to investigate the prevalence of STIs among infertile males and their impact on semen parameters and blood PSA. The results showed that Mycoplasma genitalium is associated with seminal inflammation, and further research is needed to explore the impact of STIs on semen parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Ken B. Waites, Donna M. Crabb, T. Prescott Atkinson, William M. Geisler, Li Xiao
Summary: In this study, we tested the susceptibility of Mycoplasma genitalium isolates to various antibiotics and found that omadacycline showed the highest potency, even against resistant strains. This suggests that omadacycline could be a potential treatment option for urogenital infections caused by M. genitalium.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
Haiyang Hu, Ying Zhou, Lingen Shi, Jing Lu, Zhi Zhang, Xiaoqin Xu, Xiping Huan, Gengfeng Fu
Summary: The study revealed a high prevalence of Chlamydia trachomatis (CT) infection among women attending STD and gynecology clinics in Jiangsu province, China, with higher rates among participants from STD clinics and South Jiangsu. Factors associated with CT infection included being service personnel or farmers, living in South Jiangsu, and attending STD clinics. Public health interventions focusing on CT screening, surveillance, and treatment promotion are crucial for prevention efforts.
Article
Infectious Diseases
Yan Han, Yue-Ping Yin, Jing-Wei Liu, Kai Chen, Bang-Yong Zhu, Ke Zhou, Mei-Qin Shi, Wen-Qi Xu, Tulip A. Jhaveri, Xiang-Sheng Chen
Summary: This study investigated the prevalence of rectal MG infection and its potential risk factors among individuals attending STD clinics in China. The results showed that males, homosexual or bisexual individuals, and those infected with urogenital MG were more likely to have rectal MG infection. Appropriate strategies for screening and treating rectal MG in this population need to be developed.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Biotechnology & Applied Microbiology
Krishnendu Barik, Praffulla Kumar Arya, Ajay Kumar Singh, Anil Kumar
Summary: Mycoplasma genitalium (M. genitalium) is a sexually transmitted infection that has emerged globally in the last three decades. It has been identified as a cause of male urethritis and has also been associated with cervicitis and pelvic inflammatory disease in women. However, its precise role in these diseases is still unknown and requires further research.
Article
Immunology
Kelly A. Johnson, Madeline Sankaran, Robert P. Kohn, Oliver Bacon, Stephanie E. Cohen
Summary: The odds of return clinic visits for persistent non-gonococcal urethritis were significantly lower after implementing testing for Mycoplasma genitalium during initial evaluations and switching from azithromycin to doxycycline as first-line treatment.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Gwendolyn E. Wood, Nicole L. Jensen, Sabina Astete, Jorgen S. Jensen, George E. Kenny, Christine M. Khosropour, Catherine W. Gillespie, Lisa E. Manhart, Patricia A. Totten, Erik Munson
Summary: Mycoplasma genitalium exhibits high levels of antibiotic resistance, particularly to azithromycin, impacting treatment efficacy. Treatment failure with azithromycin was more likely with isolates having MICs >8 μg/ml, while doxycycline MICs showed no correlation with treatment outcomes. Monitoring MICs and exploring alternative treatments are crucial in addressing emerging resistance in M. genitalium.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Microbiology
Naomi C. A. Juliana, Abdulla Mbaruk Omar, Jolein Pleijster, Fahad Aftab, Nina B. Uijldert, Said M. Ali, Sander Ouburg, Sunil Sazawal, Servaas A. Morre, Saikat Deb, Elena Ambrosino
Summary: This study examined the persistence of Chlamydia trachomatis and Trichomonas vaginalis infections in pregnant women from Pemba Island, Tanzania, finding that both infections showed persistence during and after pregnancy. The results highlight the importance of analyzing biobanked samples for investigating the natural history of curable pathogens.
Review
Infectious Diseases
Rachel Pitt, Dolcibella Boampong, Michaela Day, Jorgen Skov Jensen, Michelle Cole
Summary: Mycoplasma genitalium, a sexually transmitted bacterial pathogen, is difficult to work with in the laboratory setting. Antimicrobial resistance is commonly reported and phenotypic susceptibility testing plays a crucial role in evaluating potential therapeutics for this pathogen.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
