Article
Medicine, General & Internal
Tafadzwa Dhokotera, Julia Bohlius, Matthias Egger, Adrian Spoerri, Jabulani Ronnie Ncayiyana, Gita Naidu, Victor Olago, Marcel Zwahlen, Elvira Singh, Mazvita Muchengeti
Summary: This study aimed to determine the spectrum of cancers in adolescents and young adults living with and without HIV in South Africa. The results showed that young people living with HIV were more likely to have certain types of cancers compared to those without HIV.
Article
Immunology
Jitendra Singh, Niti Singh, Gayatri Suresh, Rahul Srivastava, Upasna Aggarwal, Digamber Behera, Murali Munisamy, Anvita Gupta Malhotra, Sarman Singh
Summary: This study aimed to identify the distribution of different genotypes of M. tuberculosis among HIV-positive and HIV-negative patients seen at a tertiary care dedicated TB hospital in New Delhi, India. The results showed that the Beijing lineage was predominant in HIV-TB coinfected cases, while the Central Asian Strain (CAS) was overall more predominant in the region.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Critical Care Medicine
Etienne de Montmollin, Claire Dupuis, Pierre Jaquet, Benjamine Sarton, Charline Sazio, Vincent Susset, Marie Conrad, Laurent Argaud, Sophie Demeret, Jean Marc Tadie, Francois Barbier, Michel Wolff, Jean-Francois Timsit, Benoit Visseaux, Romain Sonneville
Summary: This study retrospectively analyzed the prevalence, associated factors, and clinical impact of an initial negative HSV PCR in critically ill patients with PCR-proven HSV encephalitis. The results showed that an initial negative PCR was associated with worse neurologic outcome and highlighted the importance of a systematic multimodal diagnostic approach in these patients.
CRITICAL CARE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Hanna H. Schalkwijk, Robert Snoeck, Graciela Andrei
Summary: Herpes simplex viruses (HSV) can cause significant morbidity and mortality in both immunocompetent and immunocompromised individuals, and the nucleoside analogue acyclovir has greatly improved the management of HSV infections. However, acyclovir resistant strains have been reported, especially in immunocompromised patients. This review discusses the prevalence of acyclovir resistance in HSV infections and alternative antiviral treatments.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Mette Ratzer Freytag, Sofie Eg Jorgensen, Michelle Molgaard Thomsen, Ali Al-Mousawi, Alon Schneider Hait, David Olagnier, Jakob T. Bay, Marie Helleberg, Trine H. Mogensen
Summary: This study describes a 19-year-old woman with systemic HSV-1 infection and HLH, as well as a fatal course of neonatal herpesvirus infection postpartum. Investigation showed impaired antiviral responses in the mother's cells, potentially caused by variants in CASP8 or other noncoding regions of the genome.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Chemistry, Medicinal
Kai Jiang, Jing Feng, Xia Qi, Lili Ran, Lixin Xie
Summary: This study validated the inhibitory effect of oridonin on herpes simplex virus type 1 and demonstrated its potential in alleviating herpes simplex keratitis infection in mice.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Immunology
Lawrence Mbuagbaw, Cristian Garcia, Bluma Brenner, Diego Cecchini, Mohamed Chakroun, Pascal Djiadeu, Africa Holguin, Orna Mor, Neil Parkin, Maria M. Santoro, Santiago Avila-Rios, Joseph Fokam, Andrew Phillips, Robert W. Shafer, Michael R. Jordan
Summary: This study describes a checklist for reporting HIV drug resistance (HIVDR) studies, which aims to enhance transparency, interpretability, comparability, and replicability of HIVDR research. The checklist will assist researchers in preparing research reports and help reviewers and editors assess the completeness of reporting.
Article
Dermatology
Sharon Baum, Itai Atar, Dan Coster, Sara Dovrat, Michal Solomon, Eli Sprecher, Tal Zeeli, Aviv Barzilai
Summary: This retrospective cohort study aimed to compare the characteristics of pemphigus vulgaris patients with positive and negative herpes simplex virus. The results showed that patients with positive herpes simplex virus had significantly elevated levels of inflammatory markers and disease activity. Routine testing for herpes simplex virus in pemphigus vulgaris patients is necessary.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Microbiology
Max E. Mertens, David M. Knipe
Summary: Cells activate DNA damage response when infected by DNA viruses such as herpes simplex virus 1, with different DDR kinase pathways in infected and uninfected cells. Key host gene products and DDR components have opposite effects on the replication of herpes simplex virus 1, suggesting the virus manipulates the host cell DDR to facilitate its replication while deactivating antiviral aspects.
Article
Virology
Suzy Teutsch, Angela Berkhout, Camille Raynes-Greenow, Yvonne Zurynski, Philip N. Britton, Cheryl A. Jones, APSU Neonatal HSV Study Advisory Grp
Summary: A study in Australia over 24 years reveals the characteristics of neonatal herpes simplex virus (HSV) central nervous system (CNS) disease. The incidence rate of HSV CNS disease is 1.29 cases per 100,000 live births per year, and male neonates are more susceptible to the disease. Despite the use of antiviral agents, morbidity and mortality from HSV CNS disease remain high, highlighting the need for evaluation of adjunctive therapies to improve outcomes.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Psychology, Clinical
Aidan Flatt, Tom Gentry, Johanna Kellett-Wright, Patrick Eaton, Marcella Joseph, Sarah Urasa, William Howlett, Marieke Dekker, Aloyce Kisoli, Jane Rogathe, Lindsay Henderson, Thomas Lewis, Jessica Thornton, Judith McCartney, Vanessa Yarwood, Charlotte Irwin, Elizabeta B. Mukaetova-Ladinska, Rufus Akinyemi, William K. Gray, Richard W. Walker, Catherine L. Dotchin, Andrew-Leon S. Quaker, Philip C. Makupa, Stella-Maria Paddick
Summary: In Tanzania, the prevalence of HAND is high at 47.0% among stable, cART-treated older PLWH, with a one-year incidence rate also being high. While most cases are mild neurocognitive disorders, some reversibility has been observed.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Ji Xiao, Miaomiao Cai, Yifei Wang, Ping Ding
Summary: The iridoid compounds in traditional Chinese medicine have significant antiviral effects. This study identified seven new iridoid compounds from the aerial parts of Morinda officinalis, with officinaloside C showing significant anti-HSV-1 activity.
Article
Immunology
Rachael M. Burke, Marc Y. R. Henrion, Jane Mallewa, Leo Masamba, Thokozani Kalua, McEwan Khundi, Ankur Gupta-Wright, Jamie Rylance, Stephen B. Gordon, Clemens Masesa, Elizabeth L. Corbett, Henry C. Mwandumba, Peter Macpherson
Summary: The study investigated trends in HIV-positive hospital admissions and risk of in-hospital death among adults living with HIV in Blantyre, Malawi from 2012 to 2019. It found a substantial decrease in HIV-positive admissions over the study period, likely due to increased community provision of HIV diagnosis, treatment, and care. However, in-hospital mortality for HIV-positive individuals remained unacceptably high, indicating a need for urgent research and implementation efforts to reduce inpatient deaths among this population.
Article
Biochemistry & Molecular Biology
Pu Huang, Xu Wang, Mengyue Lei, Ying Ma, Hongli Chen, Jing Sun, Yunzhang Hu, Jiandong Shi
Summary: This study investigates the metabolic interaction between host cells and HSV-1. By analyzing the metabolic profiles in HSV-1-infected lung fibroblasts, the researchers found that HSV-1 induces metabolic reprogramming in host cells to promote or resist viral replication. They confirmed that the addition of the tryptophan metabolite kynurenine promotes viral replication, while the addition of 25-Hydroxycholesterol inhibits replication. Additionally, HSV-1 replication was enhanced in choline metabolic rate-limiting enzyme-deficient mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Developmental
Jacob J. van den Berg, Kristi E. Gamarel, Andrew O. Westfall, J. Dennis Fortenberry, Sybil G. Hosek, Craig M. Wilson, Michelle A. Lally
JOURNAL OF ADOLESCENT HEALTH
(2020)
Article
Immunology
Anne M. Neilan, Alexander J. B. Bulteel, Sybil G. Hosek, Julia H. A. Foote, Kenneth A. Freedberg, Raphael J. Landovitz, Rochelle P. Walensky, Stephen C. Resch, Pooyan Kazemian, A. David Paltiel, Milton C. Weinstein, Craig M. Wilson, Andrea L. Ciaranello
Summary: The study shows that for high-risk YMSM in the US, HIV screening every 3 months is more clinically effective and cost-effective compared to screening at less frequent intervals.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
Rebecca Baqiyyah N. Conway, Staci Sudenga, Donald McClain, William J. Blot
Summary: The study from the Southern Community Cohort found a significant difference in the association between diabetes and liver cancer risk among African Americans and White/European Americans. Diabetes has a more significant impact on liver cancer risk among White/European Americans compared to African Americans.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Oncology
Yuanfan Ye, Greer A. Burkholder, Amrita Mukherjee, Daniel Chu, Anju Bansal, Staci L. Sudenga, Anna Junkins, Sameer Al Diffalha, Michael S. Saag, Sadeep Shrestha
Summary: Anal cancer is rare in the general US population, but there is an increased incidence among people living with HIV-1 infection, especially in the South US. Men who have sex with men are associated with high-grade squamous intraepithelial lesions and anal cancer. High-risk PLWH, such as MSM and those with lower CD4 counts, need to be targeted for early screening and intervention.
INFECTIOUS AGENTS AND CANCER
(2021)
Article
Immunology
Joel M. Palefsky, Shelly Y. Lensing, Marvin Belzer, Jeannette Lee, Aditya H. Gaur, Kenneth Mayer, Donna Futterman, Elizabeth A. Stier, Mary E. Paul, Elizabeth Y. Chiao, Daniel Reirden, Stephen E. Goldstone, Maribel Tirado, Edward R. Cachay, Luis F. Barroso, Maria Da Costa, Teresa M. Darragh, Bret J. Rudy, Craig M. Wilson, Jessic A. Kahn
Summary: This study aimed to evaluate the safety and efficacy of quadrivalent HPV vaccine on young MSM with HIV. The results showed that vaccination did not provide protection against vaccine-type HPV infection and related lesions. Therefore, it is recommended to vaccinate MSM before initiating sexual activity to prevent HPV-related diseases.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Vita W. Jongen, Maarten F. Schim Van der Loeff, Matthys H. Botha, Staci L. Sudenga, Martha E. Abrahamsen, Anna R. Giuliano
Summary: The incidence rate of bacterial STIs among young women in the Western Cape, South Africa is high, with prevalent CT infection and having more than three lifetime sex partners being major risk factors. Intensified prevention efforts and screening programs are needed to improve sexual health in the region.
Article
Infectious Diseases
Staci L. Sudenga, Sarah C. Lotspeich, Alan G. Nyitray, Bradley Sirak, Bryan E. Shepherd, Jane Messina, Karen A. Sereday, Roberto Carvalho Silva, Martha Abrahamsen, Maria Luiza Baggio, Manuel Quiterio, Eduardo Lazcano-Ponce, Luisa Villa, Anna R. Giuliano
Summary: This multinational study found no significant association between external genital lesions and HIV seroconversion. The limited number of HIV seroconversions may have affected the statistical power of the study, and results may differ in populations at higher risk for HIV.
SEXUALLY TRANSMITTED DISEASES
(2022)
Article
Oncology
Jaimie Z. Shing, Alicia Beeghly-Fadiel, Marie R. Griffin, Rachel S. Chang, Staci L. Sudenga, James C. Slaughter, Manideepthi Pemmaraju, Edward F. Mitchel, Pamela C. Hull
Summary: Disparities in HPV vaccination exist between urban and rural regions, with evidence of delayed impact of the vaccine in rural areas. Efforts to reduce barriers to HPV vaccination, particularly in rural areas, are crucial for improving the reduction of cervical precancer and cancer incidence.
Article
Oncology
Sylvie Muhimpundu, Rebecca Baqiyyah N. Conway, Shaneda Warren Andersen, Loren Lipworth, Mark D. Steinwandel, William J. Blot, Xiao-Ou Shu, Staci L. Sudenga
Summary: Liver cancer incidence is higher among African Americans compared to White Americans in the US, but the determinants of racial disparities in liver cancer incidence are unclear. This study found racial differences in both incidence rates and risk factors associated with hepatocellular carcinoma among White and African Americans.
Article
Public, Environmental & Occupational Health
Jaimie Z. Shing, Marie R. Griffin, Rachel S. Chang, Alicia Beeghly-Fadiel, Staci L. Sudenga, James C. Slaughter, Manideepthi Pemmaraju, Edward F. Mitchel, Pamela C. Hull
Summary: This study examines the trends in high-grade cervical lesion incidence among Tennessee Medicaid-enrolled women aged 18-39 years and the subset of women who were screened for cervical cancer. The results show reductions in high-grade cervical lesion incidence among ages most likely to have benefited from the human papillomavirus vaccine. Declines among young, screened women suggest causes other than reduction in screening. Evidence of vaccine impact in populations with low-vaccination coverage, such as Tennessee, is promising.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Oncology
Victoria Umutoni, Matthew B. Schabath, Alan G. Nyitray, Timothy J. Wilkin, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano, Staci L. Sudenga
Summary: Smoking is associated with higher prevalence, persistence, and incidence of anal HPV in men. However, no significant differences were found between former smokers and never smokers. Smoking does not impact the prevalence or persistence of anal HPV in men who have sex with men but is associated with higher incidence of high-risk HPV. Among men who have sex with women, current smokers have a higher prevalence and incidence of low-risk HPV.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Jessica L. Castilho, Aihua Bian, Cathy A. Jenkins, Bryan E. Shepherd, Keith Sigel, M. John Gill, Mari M. Kitahata, Michael J. Silverberg, Angel M. Mayor, Sally B. Coburn, Dorothy Wiley, Chad J. Achenbach, Vincent C. Marconi, Ronald J. Bosch, Michael A. Horberg, Charles S. Rabkin, Sonia Napravnik, Richard M. Novak, W. Christopher Mathews, Jennifer E. Thorne, Jing Sun, Keri N. Althoff, Richard D. Moore, Timothy R. Sterling, Staci L. Sudenga
Summary: Low CD4/CD8 ratio is associated with increased cancer risk in PWH in the USA and Canada.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Immunology
Alyssa K. Amick, G. Ege Eskibozkurt, Sybil G. Hosek, Clare F. Flanagan, Raphael J. Landovitz, Elena Y. Jin, Craig M. Wilson, Kenneth A. Freedberg, Milton C. Weinstein, Pooyan Kazemian, A. David Paltiel, Andrea L. Ciaranello, Anne M. Neilan
Summary: In young men who have sex with men at increased risk of HIV infection, the use of generic daily oral HIV pre-exposure prophylaxis and every-3-month HIV screening is cost-saving compared to annual HIV screening alone, resulting in reduced new infections and improved quality-adjusted life-years.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Wanshui Yang, Xufen Zeng, Jessica L. Petrick, Christopher J. Danford, Andrea A. Florio, Bing Lu, Hongmei Nan, Jiantao Ma, Liang Wang, Hongmei Zeng, Staci L. Sudenga, Peter T. Campbell, Edward Giovannucci, Katherine A. McGlynn, Xuehong Zhang
Summary: This study found that being overweight and/or obese at age 20 years and BMI trajectories that result in being overweight and/or obese may increase the risk of developing liver cancer and biliary tract cancer. With increasing weight, the risk of liver cancer and biliary tract cancer also increases.
JNCI CANCER SPECTRUM
(2022)
Article
Health Policy & Services
Cosmas M. Zyambo, Peter S. Hendricks, Karen L. Cropsey, James H. Willig, Craig M. Wilson, C. Ann. Gakumo, Tamhane Ashutosh, Andrew O. Westfall, Greer A. Burkholder
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2020)