Journal
ACTA MECHANICA SINICA
Volume 31, Issue 4, Pages 446-464Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10409-015-0416-7
Keywords
Multi-scale modeling; Macro-hemodynamics; Micro-hemodynamics; Cardiovascular system; Endothelial cell
Categories
Funding
- JSPS [17300141, 25630046]
- National Natural Science Foundation of China [81370438]
- SJTU Medical Engineering Cross-cutting Research Foundation [YG2012MS24]
- HKUST
- Grants-in-Aid for Scientific Research [17300141, 25630046] Funding Source: KAKEN
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The human cardiovascular system is a closed-loop and complex vascular network with multi-scaled heterogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale modeling of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arterial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study: recent progress of patient-specific hemodynamic modeling in clinical applications, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynamic modeling. Here we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale modeling of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arterial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study: recent progress of patient-specific hemodynamic modeling in clinical applications, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynamic modeling.
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