Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays

Pharmacogenomics of cantharidin in tumor cells

(2013) Onat Kadioglu et al.   BIOCHEMICAL PHARMACOLOGY

The Catalytic Mechanism of Protein Phosphatase 5 Established by DFT Calculations

(2013) António J. M. Ribeiro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair

(2013) D. Wei et al.   CLINICAL CANCER RESEARCH

The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain

(2013) Jamie N. Connarn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Theoretical studies on the reaction mechanism of PP1 and the effects of different oxidation states of the Mn–Mn center on the mechanism

(2013) Hao Zhang et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Parameters for Molecular Dynamics Simulations of Manganese-Containing Metalloproteins

(2013) Rui P. P. Neves et al.   Journal of Chemical Theory and Computation

Parameters for molecular dynamics simulations of iron-sulfur proteins

(2013) Alexandra T. P. Carvalho et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Exploiting Protein Phosphatase Inhibitors Based on Cantharidin Analogues for Cancer Drug Discovery

(2013) Liping Deng et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1)

(2011) Lauren Amable et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Dynamics of a Dizinc Metalloprotein: Effect of Charge Transfer and Polarization

(2011) Yong L. Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis

(2010) Wei Li et al.   CANCER SCIENCE

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Structural Survey of Zinc-Containing Proteins and Development of the Zinc AMBER Force Field (ZAFF)

(2010) Martin B. Peters et al.   Journal of Chemical Theory and Computation

Systematic Derivation of AMBER Force Field Parameters Applicable to Zinc-Containing Systems

(2010) Fu Lin et al.   Journal of Chemical Theory and Computation

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Structural Basis of Serine/Threonine Phosphatase Inhibition by the Archetypal Small Molecules Cantharidin and Norcantharidin

(2009) I. Bertini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Ser/Thr Protein Phosphatase 5 (PP5) Regulated Targets during DNA Damage Identified by Proteomics Analysis

(2009) Bryan M. Ham et al.   JOURNAL OF PROTEOME RESEARCH

Subnanomolar Inhibitor of Cytochromebc1Complex Designed by Optimizing Interaction with Conformationally Flexible Residues

(2009) Pei-Liang Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer

(2008) Teresa Golden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

(2008) Teresa Golden et al.   CANCER AND METASTASIS REVIEWS

Norcantharidin Analogues: Synthesis, Anticancer Activity and Protein Phosphatase 1 and 2A Inhibition

(2008) Timothy A. Hill et al.   ChemMedChem

Protein phosphatase 5

(2007) Terry D. Hinds Jr. et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY