Article
Engineering, Chemical
Tae Keun Kim, Chiara Botti, James Angelo, Xuankuo Xu, Sanchayita Ghose, Zheng Jian Li, Massimo Morbidelli, Mattia Sponchioni
Summary: The rapid growth and diffusion of biopharmaceuticals, including PEG-protein conjugates, has led to the need for stringent regulatory requirements regarding purity and clinical safety. To meet these requirements, the development of robust purification methods, such as MCSGP, plays a crucial role in improving process yield while maintaining purity specifications. By optimizing process parameters, superior performances can be achieved in the MCSGP unit compared to the batch process, leading to increased yield and productivity at fixed purity specifications.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Engineering, Environmental
Liqiang Shao, Chen Sheng, Mengxiang Lu, Ying Yang, Ping Li
Summary: The objective of this work is to develop an advanced adsorption process to continuously recover and remove boron from brines. The adsorption and desorption performances of boron on the D403 resin were evaluated, and a cyclic adsorption and desorption process was investigated experimentally for boron recovery. A seven-column SMB process with four zones was designed and experimentally investigated, and it was found that boron can be recovered continuously from brine and a boron-rich solution can be obtained. The proposed multicolumn SMB process achieved simultaneous recovery and removal of boron from brine.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Chemistry, Analytical
Daojin Li, Sihan Dong
Summary: Traditional boronate affinity materials for cis-diol-containing biomolecules suffer from low binding affinity and require a basic binding pH, while 6-aminopyridine-3-boronic acid functionalized magnetic nanoparticles show high binding affinity and a low binding pH. This new material allows for selective extraction of cis-diol-containing biomolecules from samples with low concentrations under neutral or acidic conditions, demonstrating practical applications for enrichment in real samples.
ANALYTICAL METHODS
(2021)
Review
Environmental Sciences
Aruna Yadav, Nisha Bagotia, Ashok K. Sharma, Surender Kumar
Summary: This study focuses on the removal of contaminants in multi-component systems, emphasizing the importance of simultaneous removal of multiple pollutants. It provides valuable insights for researchers in the field of wastewater treatment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Materials Science, Multidisciplinary
Krishan Kumar, Reddicherla Umapathi, Sanjay Mor, Seyed Majid Ghoreishian, Jitendra N. Tiwari, Marzieh Ramezani Farani, Yun Suk Huh, Pannuru Venkatesu
Summary: Thermoresponsive polymers (TRPs) have attracted attention for their applications in various fields, such as sensors, gels, drug delivery devices, biotechnology, and pharmacology. Certain biomolecules can modify the phase transition behavior of TRPs as external biological stimuli. This review summarizes recent findings and trends in TRP/biomolecule mixed systems, focusing on protein-polymer assembly formation, interactions, and temperature-dependent protein adsorption. By responding to biomolecules present in the human body, modifying polymer properties allows for the design of polymeric biomaterials with potential applications. This review aims to address scientific issues related to biomolecule-polymer mixed systems and contribute to the development of next-generation smart polymers.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Henrik-Alexander Christ, Nils Peter Daniel, Jennifer Solarczek, Leonard Sebastian Fresenborg, Anett Schallmey, Henning Menzel
Summary: This study demonstrates the successful immobilization of catalytically active biomolecules onto electrospun chitosan nanofiber meshes. The immobilized enzyme exhibited high stability and maintained its activity for over 7 days of storage. The hydrophilic chitosan support matrix enabled continuous oxidation reactions with constant turnover, showcasing the potential applications of these fibers.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Jiang Liu, Xin Ding, Yupeng Fu, Cen Xiang, Yuan Yuan, Yongmin Zhang, Peng Yu
Summary: Macro biomolecules like proteins and nucleic acids play a crucial role in drug delivery, and appropriate delivery systems are essential for protecting them from degradation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sooho Ko, Joo-Young Kim, Jung Yeon Park, You-jin Jung, Min-Jae Choi, Kyeong Sik Jin, Yongju Kim, Yong-beom Lim, Woo-jin Jeong
Summary: This study introduces a β-hairpin-based molecular tweezer (MT) that can manipulate the folding and binding of α-helical peptides. The folded β-hairpin stabilizes the conformation of the α-helix and enhances its affinity to the target (hDM2), while the unfolding of the hairpin reduces helicity and binding affinity. This stimulus-responsive MT is promising for capturing and releasing multivalent biomaterials and has potential applications in inhibiting protein interactions and detecting cancer biomarkers.
Article
Chemistry, Multidisciplinary
Sooho Ko, Joo-Young Kim, Jung Yeon Park, You-jin Jung, Min-Jae Choi, Kyeong Sik Jin, Yongju Kim, Yong-beom Lim, Woo-jin Jeong
Summary: This study develops a molecular tweezer (MT) based on the & beta;-hairpin (tryptophan zipper, Trpzip), which can control the folding and binding of & alpha;-helical peptides. The optimized macrocyclic structure of the MT stabilizes the conformation of the & alpha;-helix and enhances its affinity to the target peptide. The stimulus-responsive property of the hairpin allows for the capture and release of model multivalent biomaterials.
Article
Chemistry, Multidisciplinary
Suchetha Shetty, Karam B. Idrees, Haomiao Xie, Bassam Alameddine, Omar K. Farha
Summary: Zirconium-based metal organic frameworks (MOFs) have been synthesized using hexanuclear zirconium inorganic nodes and iron(ii) clathrochelate-based ditopic carboxylic acid ligands with different lateral moieties. Among them, Zr-GU-1, with butyl side chains, forms stable crystalline MOFs with high chemical stability and structural diversity. The activated Zr-GU-1 exhibits promising porosity with a BET surface area of about 650 m(2) g(-1) through supercritical CO2 activation.
Article
Chemistry, Multidisciplinary
Lukas Kung, Silvan Aeschlimann, Charithea Charalambous, Fergus Mcilwaine, John Young, Noah Shannon, Karen Strassel, Cara Nichole Maesano, Rudy Kahsar, Daniel Pike, Mijndert van der Spek, Susana Garcia
Summary: Direct air carbon capture and storage (DACCS) is a method of capturing CO2 directly from the air and storing it for a long time. Despite being in the early stages of technical development, DACCS faces challenges such as high cost and energy requirements. This paper provides an overview and classification of DACCS systems, harmonizes the technical and economic performance of direct air capture technologies, lists technical and infrastructure-based obstacles to scaling DACCS systems, and provides a roadmap and priority initiatives for research, development, demonstration, and deployment of DACCS.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Biophysics
Madalina Elena Culica, Andreea-Laura Chibac-Scutaru, Tamilselvan Mohan, Sergiu Coseri
Summary: Cellulose has played a crucial role in human history, from ancient times in construction and paper making to modern scientific research and technological applications. The increasing interest in cellulose in modern society is due to the development of new types of papers and paper-based biosensors.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Multidisciplinary
Lukas Kung, Silvan Aeschlimann, Charithea Charalambous, Fergus Mcilwaine, John Young, Noah Shannon, Karen Strassel, Cara Nichole Maesano, Rudy Kahsar, Daniel Pike, Mijndert van der Spek, Susana Garcia
Summary: This paper provides an overview of direct air carbon capture and storage (DACCS), including technical classification, coordination of technical and economic performance, obstacle listing, and research roadmap. It aims to promote the research, development, and deployment of safe, scalable, and low-cost DACCS.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Elena Lopez-Maya, Natalia M. Padial, Javier Castells-Gil, Carolina R. Ganivet, Ana Rubio-Gaspar, Francisco G. Cirujano, Neyvis Almora-Barrios, Sergio Tatay, Sergio Navalon, Carlos Marti-Gastaldo
Summary: The study demonstrates how the different affinity of metal sites can be utilized for selective grafting of molecules, allowing for cooperative reactions between Lewis acid titanium centers and available -NH sites in the framework. This approach provides a method for controlling the positioning and distribution of chemical functions in precise locations for cooperative reactions of epoxides and CO2.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Emmanuel Delamarche, Iago Pereiro, Aditya Kashyap, Govind Kaigala
Summary: This article summarizes the themes presented in a recent Langmuir Lecture on patterning biomolecules on surfaces, miniaturizing surface assays, and interacting with biointerfaces using microcontact printing, microfluidic networks, and microfluidic probes.