Article
Biochemical Research Methods
Bo Peng, Shaoyan Wang
Summary: A simulated moving bed chromatography system using metal-organic framework as the stationary phase was designed to separate PX and MX with near boiling points at ambient temperature. The method achieved high purity, high recovery, and high productivity.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Engineering, Chemical
I Mueller, A. Seidel-Morgenstern, C. Hamel
Summary: A commercial galacto-oligosaccharide (GOS) syrup with prebiotic properties was purified using simulated moving bed (SMB) chromatography to separate undesired side products induced by synthesis reaction mechanism. The chosen system allows pseudo binary separation of GOS syrup mixture, producing highly purified products with purities up to >99%, indicating significant potential for scale-up.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Chemical
Carsten Rene Arlt, Dominik Brekel, Matthias Franzreb
Summary: The production of high-quality nanoparticles is important for various industrial applications. Current purification methods may not meet the required quality, leading to the need for additional steps. This study introduces a scalable system that can continuously fractionate nanoparticles based on their magnetic properties, offering a potential alternative to demanding and expensive nanoparticle fractionation methods.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Chemical
Rami S. Arafah, Antonio E. Riberio, Alirio E. Rodrigues, Luis S. Pais
Summary: This study successfully separated multiple stereoisomers of nadolol using high pH reversed-phase fixed-bed and simulated moving bed preparative chromatographic techniques, and transformed them into two high-purity stereoisomers. The feasibility of this method was validated through experimental results.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Chaofan Xie, Yang-jie Tang
Summary: The hierarchical fuzzy controller applied in the SMB system can achieve good control without needing highly accurate system parameters, in comparison to the PID and MPC controllers.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Hangil Park, Jae-Hwan Choi, Kyeong Woo Bae, Sungyong Mun
Summary: The study aimed to develop an efficient simulated-moving-bed (SMB) process for high-purity recovery of galactotriose (G3) from a crude galacto-oligosaccharides (GOS) mixture, achieving a purity of more than 98.9% while keeping the overall loss of G3 below 7.3%.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Engineering, Environmental
Pedro M. Walgode, Rui P. Faria, Alirio E. Rodrigues
Summary: The goal of this study was to separate dihydroxyacetone from glycerol oxidation products using a cascade of two simulated moving bed units. The results demonstrated that the SMB cascade with a strong cationic exchange resin efficiently achieved this separation process.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Rafael O. M. Dias, Idelfonso B. R. Nogueira, Alexandre F. P. Ferreira, Alirio E. Rodrigues, Ana M. M. Ribeiro
Summary: In a simulated moving bed (SMB), regeneration is achieved by using a desorbent and recovering it in downstream separations. The proper selection of an appropriate adsorbent/desorbent pair is crucial for the effectiveness of the SMB process. By developing a parameter called SMB performance indicator (SPI) using readily available literature data, the selection process can be fast and easily accomplished. This metric considers adsorption selectivity, adsorption capacity, and enthalpy ratio, and can determine the most suitable adsorbent/desorbent pair for a specific gas separation in SMB through simple calculations.
Article
Engineering, Chemical
Jonathan C. Goncalves, Marcelo F. T. Oliveira, Alexandre F. P. Ferreira, Alirio E. Rodrigues
Summary: The conversion of aromatics in the liquid phase was studied using different types of zeolites. MFI-type zeolites showed high selectivity and stability but low conversion. Large-pore zeolites exhibited high conversion but faster deactivation. MOR-type zeolite with a SiO2/Al2O3 ratio of 40 showed the best performance.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Engineering, Chemical
Ju Weon Lee, Achim Kienle, Andreas Seidel-Morgenstern
Summary: SMB chromatography is a promising separation process for fine chemical and pharmaceutical industries, with the triangle theory providing design rules for conventional four-zone SMB processes. A numerical shortcut method is introduced in this study to extend the theory to multicomponent systems.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Engineering, Chemical
Yaqing Zhang, Jialong Zhu, Peng Liang, Tiantian Jiao, Xiangping Li
Summary: This study describes the flow characteristics of solid-solid mixed particles in a cold two-dimensional moving bed and finds that the flow characteristics of mixed particles are better in the quartz sand-coal system compared to the cold circulating ash-coal system. Additionally, the study investigates the effect of mixture residence time on pyrolysis progress.
Article
Engineering, Chemical
Zhongfeng Geng, Yuzhu Yang, Shuyuan Yang, Jinyi Zhou, Huisheng Lyu
Summary: A simulated moving bed (SMB) chromatography process was proposed for the continuous production of rutin and K3R. Through numerical analysis and optimization, the optimal conditions for purity and yield were determined, providing guidance for future industrial applications.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Hsin-Chieh Kung, Ko-Yuan Liang, Justus Kavita Mutuku, Bo-Wun Huang, Guo-Ping Chang-Chien
Summary: The separation process of caulerpin from other phytoconstituents using simulated moving bed chromatography was successfully demonstrated in this study. The optimal switching time of 4.0 minutes achieved the highest purity and yield of caulerpin from Caulerpa racemose extract.
FOOD AND BIOPRODUCTS PROCESSING
(2021)
Article
Chemistry, Physical
Mei-Yan Gao, Shi-Qiang Wang, Andrey A. Bezrukov, Shaza Darwish, Bai-Qiao Song, Chenghua Deng, Catiuprimecia R. M. O. Matos, Lunjie Liu, Boya Tang, Shan Dai, Sihai Yang, Michael J. Zaworotko
Summary: Separation of C-8 aromatic isomers is crucial to the petrochemical industry. This study introduces a new coordination network, sql-4,5-Zn, which exhibits high sorption capacity and selectivity for C-8 aromatics.
CHEMISTRY OF MATERIALS
(2023)
Article
Engineering, Chemical
Cheol Yeon Jo, Hyun Kyung Mo, Ki Bong Lee, Sungyong Mun
Summary: Xylitol, an industrially useful sugar-alcohol, can be produced economically from byproducts of bamboo hydrolysis treatments. An optimal simulated-moving-bed (SMB) process using a specific adsorbent condition was established for the separation of xylitol from a polyol mixture. Through comprehensive optimizations, the 5-2-7-2 configuration-based SMB showed improved xylitol product concentration and reduced desorbent usage while maintaining the same throughput and separation capability as the standard configuration-based SMB.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Rami S. Arafah, Antonio E. Riberio, Alirio E. Rodrigues, Luis S. Pais
Summary: This study successfully separated multiple stereoisomers of nadolol using high pH reversed-phase fixed-bed and simulated moving bed preparative chromatographic techniques, and transformed them into two high-purity stereoisomers. The feasibility of this method was validated through experimental results.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Thermodynamics
Alirio E. Rodrigues
Summary: In this article, the author reviews their work in the field of adsorption, summarizing their findings and suggesting a roadmap for future development. The author emphasizes the importance of understanding batch and continuous adsorption processes, as well as the prediction of adsorption equilibrium and the screening of adsorbents. They also discuss the challenges and opportunities associated with difficult separations and material choices, and highlight the significance of hybrid and data-driven modeling.
FLUID PHASE EQUILIBRIA
(2023)
Article
Engineering, Chemical
Lucas F. A. S. Zafanelli, Ezzeldin Aly, Alirio E. Rodrigues, Jose A. C. Silva
Summary: In this study, a fixed-bed adsorption apparatus was developed to investigate the adsorption breakthrough curve of green hydrogen blended in natural gas grids at cryogenic temperatures and high pressures. The results showed that the novel apparatus is a reliable tool for screening adsorbents and studying the dynamic separation of green hydrogen from natural gas.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Simon Vlad Luca, Gokhan Zengin, Kouadio Ibrahime Sinan, Izabela Korona-Glowniak, Mirjana Minceva, Krystyna Skalicka-Wozniak, Adriana Trifan
Summary: This study investigated the chemical profile and multi-biological activity of various raw rosemary materials and by-products/waste materials. The results showed the presence of numerous volatile organic compounds in the essential oil and SC-CO2 extracts, as well as specialized metabolites in solvent extracts. Some rosemary extracts exhibited antimicrobial activity and strong antioxidant potential, while others showed inhibitory effects on key enzymes. This research provides valuable insights into the valorization of rosemary by-products in different industries.
Article
Multidisciplinary Sciences
Verena Bernadette Pannusch, Lukas Viebahn, Heiko Briesen, Mirjana Minceva
Summary: Supercritical fluid extraction from hops extracts essential oil that can be used for the flavoring of beer. This study analyzes and models the extraction kinetics of seven oil components under different pressure and temperature conditions. The results show that the internal-mass-transfer-control (IMTC) model effectively describes the extraction kinetics and can be used for predicting extract composition at different pressures and temperatures.
Article
Engineering, Chemical
Rafael O. M. Dias, Idelfonso B. R. Nogueira, Alexandre F. P. Ferreira, Alirio E. Rodrigues, Ana M. M. Ribeiro
Summary: In a simulated moving bed (SMB), regeneration is achieved by using a desorbent and recovering it in downstream separations. The proper selection of an appropriate adsorbent/desorbent pair is crucial for the effectiveness of the SMB process. By developing a parameter called SMB performance indicator (SPI) using readily available literature data, the selection process can be fast and easily accomplished. This metric considers adsorption selectivity, adsorption capacity, and enthalpy ratio, and can determine the most suitable adsorbent/desorbent pair for a specific gas separation in SMB through simple calculations.
Article
Engineering, Chemical
Marcio A. F. Martins, Alirio E. Rodrigues, Jose M. Loureiro, Ana M. Ribeiro, Idelfonso B. R. Nogueira
Summary: This paper addresses the application of a robust model predictive control strategy to a pressure swing adsorption unit. Linear models are used to handle uncertainties and describe the nonlinear behavior of the unit. The control law incorporates a multi-model uncertainty description and a tracking scheme for steady states.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Physical
William Q. Rios, Bruno Antunes, Alirio E. Rodrigues, Ines Portugal, Carlos M. Silva
Summary: Analytical equations for effectiveness factors of reversible reactions are developed and numerically validated in this study. These equations are expressed in terms of irreversible nth order Thiele modulus, thermodynamic equilibrium constant, ratios of effective diffusivities, and ratios of surface concentrations. The application of these equations is demonstrated for two liquid phase reactions catalyzed by Amberlyst-15.
Article
Food Science & Technology
Luana P. Queiroz, Carine M. Rebello, Erbet A. Costa, Vinicius V. Santana, Bruno C. L. Rodrigues, Alirio E. Rodrigues, Ana M. Ribeiro, Idelfonso B. R. Nogueira
Summary: This work proposes a novel framework based on scientific machine learning to tackle an emerging problem in flavor engineering and industry. By combining generative and reinforcement learning models, new flavor molecules are designed. The potential of the framework is validated by evaluating the synthesis accessibility, number of atoms, and likeness to natural or pseudo-natural products of the designed molecules.
Article
Chemistry, Multidisciplinary
Vinicius V. Santana, Marcio A. F. Martins, Jose M. Loureiro, Ana M. Ribeiro, Luana P. Queiroz, Carine M. Rebello, Alirio E. Rodrigues, Idelfonso B. R. Nogueira
Summary: Model-based optimization of SMBRs requires efficient solvers and significant computational power. Despite the applications of artificial neural networks (ANNs) in modeling SMB units, their usage in reactive SMBRs is limited. The evaluation of the representation capability of ANNs is an open issue, and the optimal assessment using surrogate models remains unresolved. The main contributions of this study are the optimization of SMBRs based on deep recurrent neural networks (DRNNs) and the characterization of feasible operation regions using metaheuristic techniques. The results show that DRNN-based optimization can effectively address complex optimization problems while achieving optimality.
Article
Chemistry, Multidisciplinary
Beatriz C. Silva, Carine Menezes Rebello, Aliirio E. Rodrigues, Ana M. Ribeiro, Alexandre F. P. Ferreira, Idelfonso B. R. Nogueira
Summary: This study proposes a novel strategy for the design of adsorption heat pumps, which involves simultaneous optimization and material screening using the particle swarm optimization (PSO) approach. The proposed framework effectively evaluates different adsorbents and temperature intervals to find the optimal solution in terms of maximum performance and minimum heat supply cost. This approach provides a fast and intuitive evaluation of multiple design and operation variables.
Article
Engineering, Chemical
Carina A. E. Costa, Filipa M. Casimiro, Carlos Vega-Aguilar, Alirio E. Rodrigues
Summary: In this study, solvent fractionation was used to obtain lignin fractions with a narrowed molecular weight and specific structural characteristics, improving its homogeneity and purity. The water-soluble fraction had more phenolic OH, less aliphatic OH groups, and less aryl-ether linkages, indicating higher condensation degree. On the other hand, the insoluble fraction from the 60% acetone mixture had the lowest molecular weight and highest inorganic material content. The fraction with the highest potential (IF 30:70) showed an increase of about 13% for vanillin and 19% for syringaldehyde after alkaline oxidation, suggesting its potential as a source of high added-value monomeric phenolic compounds.
Article
Engineering, Environmental
A. Catarina Faria, C. V. Miguel, Alexandre F. P. Ferreira, A. E. Rodrigues, Luis M. Madeira
Summary: In this study, nickel-substituted hydrotalcites promoted with cesium were synthesized and their dual-function ability as a high-temperature CO2 adsorbent and methanation catalyst was evaluated. It was found that materials impregnated using the direct impregnation method had a higher number of basic sites, which facilitated greater CO2 sorption. However, these materials exhibited lower selectivity towards methane, resulting in a higher CO formation. Therefore, materials prepared using the powder impregnation method were chosen for further investigation in a parametric study.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Julia C. Kessler, Vanessa Vieira, Isabel M. Martins, Yaidelin A. Manrique, Patricia Ferreira, Ricardo C. Calhelha, Andreia Afonso, Lillian Barros, Alirio E. Rodrigues, Madalena M. Dias
Summary: This study explores the potential of almond, hazelnut, and walnut extracts as food flavouring agents, suggesting a new added-value application for lower quality or excess production fruits. The extracts were characterized and evaluated, and almond extract was identified as the most promising ingredient to increase the sensory value of food products.
Article
Biochemistry & Molecular Biology
Ines F. Mota, Filipa Antunes, Joana F. Fangueiro, Carina A. E. Costa, Alirio E. Rodrigues, Manuela E. Pintado, Patricia S. Costa
Summary: Lignin has been investigated as a potential ingredient for cosmetics due to its UV protection, antioxidant, and antimicrobial properties. This study presents a simple method to obtain light-colored lignin from sugarcane bagasse and demonstrates its excellent antioxidant and emulsifying capabilities. The safety and stability of lignin in an oil-in-water emulsion are also confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
