Article
Chemistry, Analytical
Laura Kuger, Carsten-Rene Arlt, Matthias Franzreb
Summary: The use of magnetic nanoparticles is increasingly important, especially in medical technology. Researchers have developed a magnetic chromatography method for efficient separation of nanoparticles, providing potential for large-scale refinement of magnetic nanoparticles.
Article
Multidisciplinary Sciences
Chaofan Xie, Yang-jie Tang
Summary: The hierarchical fuzzy controller applied in the SMB system can achieve good control without needing highly accurate system parameters, in comparison to the PID and MPC controllers.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Chemical
I Mueller, A. Seidel-Morgenstern, C. Hamel
Summary: A commercial galacto-oligosaccharide (GOS) syrup with prebiotic properties was purified using simulated moving bed (SMB) chromatography to separate undesired side products induced by synthesis reaction mechanism. The chosen system allows pseudo binary separation of GOS syrup mixture, producing highly purified products with purities up to >99%, indicating significant potential for scale-up.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Chemical
Rami S. Arafah, Antonio E. Riberio, Alirio E. Rodrigues, Luis S. Pais
Summary: This study successfully separated multiple stereoisomers of nadolol using high pH reversed-phase fixed-bed and simulated moving bed preparative chromatographic techniques, and transformed them into two high-purity stereoisomers. The feasibility of this method was validated through experimental results.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Nillohit Mitra Ray, Ajay K. Ray
Summary: A multi-objective optimization study was conducted in a simulated moving bed reactor (SMBR) for biodiesel synthesis, leading to significant improvements in yield and purity. The mathematical model used in the study was modified and experimentally verified for multiple-column SMBR system, showing promise for optimizing both existing setups and designs.
Article
Biochemical Research Methods
Juliane Diehm, Tim Ballweg, Matthias Franzreb
Summary: The invention of simulated moving bed chromatography revolutionized the chromatography processes in the 1960s. While it is widely used in industrial applications, it has not been applied to the micro-scale. In this study, we implemented a micro simulated moving bed chromatography system (μSMB) using a 3D printed central rotary valve and a microfluidic flow controller. We achieved comparable results to lab scale processes with a significantly smaller system volume.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Engineering, Chemical
Carsten-Rene Arlt, Dominik Brekel, Stefan Neumann, David Rafaja, Matthias Franzreb
Summary: The size fractionation of magnetic nanoparticles using magnetic chromatography shows promising results in separating nanoparticles based on their size and magnetic properties, achieving high separation sharpness and 100% recovery rates. The continuous process demonstrated efficient fractionation of industrially relevant amounts of magnetic nanoparticles with a high space-time-yield.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2021)
Article
Agricultural Engineering
Frederik J. Wolfaardt, Thierry Ghislain, Maxime Lessard, Johann F. Gorgens, Jean -Michel Lavoie
Summary: The two-step concentrated acid hydrolysis process is highly efficient in producing fermentable sugars from lignocellulosic biomass. Acid recovery is crucial for the economic viability of the process. This study used size-exclusion chromatography to analyze the molecular size distribution of water-soluble sugar molecules generated during the acid swelling of lignocellulosic biomass. Changes in the distribution indicators could be linked to operating conditions and downstream hydrolysis performance, providing valuable information for optimizing the hydrolysis process and acid recovery.
BIOMASS & BIOENERGY
(2023)
Article
Biochemical Research Methods
Mutika Sumedha, Sharad Bhartiya
Summary: The study focuses on the working principle of Dual Switch SMBC and the impact of different operating conditions on the purity of the extracted fractions. By solving a multi-objective optimization problem, the research further validates the findings.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Engineering, Chemical
Isabella Correa, Rui P. Faria, Alirio E. Rodrigues
Summary: The unprecedented global biodiesel production has resulted in the generation of massive amounts of crude glycerol as a byproduct. Sorption-enhanced strategies can overcome the thermodynamic limitations of solketal production via glycerol ketalization. An experimental and fitting method was used to determine the adsorption equilibrium parameters and assess the influence of reaction temperature on the process. The study also investigated solketal synthesis on a larger scale using a simulated moving-bed reactor.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Engineering, Chemical
Rodrigo V. A. Santos, Anderson N. Prudente, Ana M. Ribeiro, Alirio E. Rodrigues, Jose M. Loureiro, Marcio A. F. Martins, Karen Pontes, Idelfonso B. R. Nogueira
Summary: A novel global parameter estimation procedure using particle swarm optimization was proposed for SMB chromatography, aiming to reduce necessary steps and improve efficiency. The method led to a more precise and reliable model, validated through uncertainty analysis and confidence region definition.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Serene W. Chen, Zi Ying Zheng, Farouq Bin Mahfut, Yuansheng Yang, Masahiro Ogino, Kazuo Okada, Kohei Sato, Wei Zhang
Summary: One key challenge in downstream bioprocessing is achieving high purity products through effective removal of impurities. A new simulated moving bed (SMB) approach is demonstrated to achieve a 3-component separation, enhancing the removal of strongly bound impurities. This approach can improve purity and recovery of biotherapeutic products.
Article
Computer Science, Information Systems
Chao-Fan Xie, Yang-Jie Tang
Summary: In this paper, a self-tuning advanced fuzzy controller is proposed to control the purity of the SMB outlet, showing smaller steady-state error and better adaptability in SMB compared to traditional and advance fuzzy type controllers.
Article
Engineering, Chemical
Woo-Sung Lee, Chang-Ha Lee
Summary: Analysis and improvement of simulated moving bed chromatography (SMB) were conducted to separate multi components of C10-14 normal paraffin (n-paraffin) from kerosene. Mathematical dynamic model and data-driven machine learning were employed to evaluate SMB performance. Results showed that the purity and recovery could be improved by adjusting the countercurrent ratio and increasing the zone flush.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Chemistry, Analytical
R. C. de Holanda, F. C. Cunha, A. R. Secchi, A. G. Barreto Jr
Summary: Praziquantel (PZQ) is a racemic mixture used for treating Schistosomiasis disease. The enantiomer (R)-PZQ is effective while the (S)-PZQ causes adverse effects. To separate PZQ and produce medication with proven efficiency and without side effects, a LabVIEW supervisory system was developed to control all equipment in the SMB process.
INSTRUMENTATION SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Chemical
Jari Heinonen, Juha Tamper, Markku Laatikainen, Tuomo Sainio
SEPARATION AND PURIFICATION TECHNOLOGY
(2019)
Article
Engineering, Chemical
Jari Heinonen, Tuomo Sainio
CHEMICAL ENGINEERING SCIENCE
(2019)
Article
Engineering, Environmental
Hoang S. H. Nguyen, Jari Heinonen, Markku Laatikainen, Tuomo Sainio
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Engineering, Environmental
Markku Laatikainen, Tuomo Sainio
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Chemistry, Applied
Johanna Jokioja, Kaisa M. Linderborg, Maaria Kortesniemi, Anu Nuora, Jari Heinonen, Tuomo Sainio, Matti Viitanen, Heikki Kallio, Baoru Yang
Article
Agriculture, Multidisciplinary
Kang Chen, Xuetao Wei, Jian Zhang, Raghunath Pariyani, Johanna Jokioja, Maaria Kortesniemi, Kaisa M. Linderborg, Jari Heinonen, Tuomo Sainio, Yumei Zhang, Baoru Yang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Engineering, Chemical
Jari Heinonen, Yan Zhao, Bart Van der Bruggen
SEPARATION AND PURIFICATION TECHNOLOGY
(2020)
Article
Engineering, Chemical
Tuomo Sainio, Malte Kaspereit
Summary: The study focuses on the integration of reaction and separation in the production of biobased oligomers and short polymers from polysaccharides and proteins via catalytic degradation. Theoretical analysis is conducted to address the challenge of controlling the molar mass distribution, with solutions obtained for different reactor configurations to improve process performance. Additionally, the use of an additional separator for solvent recycling is found to significantly enhance purity and productivity by decoupling feed rate and residence time of product molecules.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Engineering, Environmental
Jianzhi Song, Ligen Cha, Mika Sillanpaeae, Tuomo Sainio
Summary: Excessive phosphorus can cause eutrophication problems. A metal organic framework (MOF)-enhanced layered double hydroxide (LDH) adsorbent material was developed for phosphate adsorption. The composite beads of MOF/LDH/PAN showed well-dispersed adsorbent powder and achieved a maximum capacity of 74.96 mg P/g. In column study, the composite-packed fixed bed exhibited a removal efficiency of 96.42% before breakthrough and could be regenerated with 0.1 M NaOH to 70% efficiency within 30 BVs.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Santeri Kurkinen, Sami Virolainen, Tuomo Sainio
Summary: The chromatographic separation of rare earth elements (REE) using the chelating aminopolycarboxylate ligand methylglycine N,N-diacetate (MGDA) as anionic complexes was experimentally studied. A synthetic mixture of La, Nd, and Eu was used to simulate a REE mixture obtained from processed secondary sources. Successful separation of the REEs was achieved using different strong base anion exchange resins, and the pKa values of the complexes were determined. Fractionation of a ternary La-Nd-Eu mixture was investigated, with La being recovered at approximately 80% purity and yield. Chromatographic separation was found to be an efficient process option for the recovery of pure REE from phosphogypsum.
Article
Engineering, Chemical
Jianzhi Song, Jari Heinonen, Tuomo Sainio
Summary: In this study, an ion-exchange column was used to treat industrial biomass-drying wastewater condensate and recover NH4+. The results showed that CS16GC resin achieved better separation and energy-efficient NH4+ removal at 60 degrees C. The regeneration process using K3PO4 successfully produced a liquid compound fertilizer containing N, K, and P as byproducts. Stability tests revealed the steady and repeatable nature of the column separation process.
Article
Engineering, Chemical
A. A. M. Abusultan, J. A. Wood, T. Sainio, A. J. B. Kemperman, W. G. J. van der Meer
Summary: Reverse osmosis (RO) membrane technology is increasingly used for large-scale production of potable water. However, the acidic and unbuffered RO permeate can damage water piping networks. Remineralization using an ion exchange resin - bipolar membrane electrodialysis hybrid process can protect the water distribution network. This study investigates the use of preparative ion exchange chromatography principles for monovalent-divalent ion separation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
A. A. M. Abusultan, J. A. Wood, T. Sainio, A. J. B. Kemperman, W. G. J. van der Meer
Summary: Reverse osmosis (RO) membrane technology is widely used for producing high-quality drinking water. An ion exchange resin - bipolar membrane electrodialysis hybrid process was developed for sustainable RO permeate remineralization. The most suitable resin for the remineralization process should have high selectivity for calcium and magnesium and low selectivity for monovalent ions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Yunfei Yu, Xue Yang, Chenchen Zhang, Jie Chen, Wei Lin, Jianqiang Meng
Summary: This study reports an environmentally friendly and simple approach for preparing double-network (DN) ion gel membranes with high strength and excellent gas separation performance. By optimizing crosslinking density, mass ratio, and the type and content of free ionic liquid, the mechanical and gas separation properties of the DN membrane are improved.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Si-qi Jiang, Qiang Gao, Xi-guang Li, Chao-zhu Deng, Jun Qiu, Xiang-nan Zhu
Summary: A dual-strengthening pretreatment method is proposed to remove PVDF more efficiently and enhance the leaching of LiCoO2. Experimental results show that dual-strengthening pretreatment can effectively remove PVDF and significantly improve the leaching efficiency compared to single pretreatment methods.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Zengchi Hu, Xiaoyu Wang, Xiaohui Zhang, Xue Li, Jiangbin Xia
Summary: The rapid fabrication of high-performance composite membranes based on CMPs using simple and low-cost methods is challenging. In this study, three CMPs-based composite membranes were rapidly fabricated with adjustable size using unidirectional diffusion synthesis. The microstructural design enhanced the rejection rates of the membranes and they showed strong hydrolytic resistance, thermal stability, and acid-base resistance. Electrostatic adsorption and the adjustable microstructures significantly varied the repellence of the membranes to different charged molecules.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Farzaneh Rouhani, Matineh Ayedi, Nasser Safari
Summary: Introducing defects into porous metal-organic frameworks is important for improving their adsorption performance. Quasi-MOFs, an underutilized variant of large-scale, fundamentally deficient MOFs, have been found to have substantial amounts of unsaturated metal sites to offset the drawbacks of MOFs. In this study, a quasi-MOF was produced using a water-stable MOF and demonstrated significantly improved phosphate adsorption capability due to the presence of defect sites.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Valentin Reungoat, Morad Chadni, Louis M. M. Mouterde, Fanny Brunissen, Florent Allais, Helene Ducatel, Irina Ioannou
Summary: This study focuses on the recovery of sinapic acid using liquid-liquid extraction assisted by a hollow fiber membrane contactor from an aqueous feed obtained through the hydrolysis of mustard bran. The screening of solvents of different chemical nature showed that all tested solvents had an extraction efficiency of more than 80% for pH < 5. Four solvents were selected for use in the hollow fiber membrane contactor, and the volatile solvents showed higher mass transfer coefficients compared to non-volatile solvents. The extraction efficiency was intensified by increasing the initial concentration of sinapic acid and the feed-to-solvent ratio. CPME was found to have optimal recovery efficiency at a phase ratio of 8:1, yielding 0.9 g of sinapic acid per liter of CPME used.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Takahiro Sakamoto, Takafumi Hanada, Hayate Sato, Mayu Kamisono, Masahiro Goto
Summary: The emergence of the battery society has led to a high demand for battery metals, resulting in a strain on their supply. This study introduces a novel technique using a hydrophobic deep eutectic solvent (DES) for leaching and recovering battery metals from low-grade nickel laterite ores. The DES enables selective leaching and recovery of the metals, offering a promising pathway for the extraction of critical battery metals.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Rongrong He, Jiarui Chen, Chunyao Zhang, Dan Lu, Lin Zhang, Tao He
Summary: Researcher has developed a method to quantify the charge density in nanofiltration (NF) membrane separation layer and applied it in NF membranes that can separate Mg2+ and Li+. The results showed that overcompensated amine groups played a major role, and there was a linear relationship between charge density and coating bi-layers or PAH layers.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Zhijian Zhang, Min Chen, Zhe Lin, Zhichao Yang, Yafeng Du, Zhihui Chen, Zhenhao Yang, Kongyin Zhao, Ligang Lin
Summary: Membrane technology plays an important role in molecular/ion separation processes, but faces challenges such as membrane fouling. This study introduces a new ion-crosslinking method to fabricate copper alginate hydrogel membranes with improved mechanical strength and antimicrobial capabilities. The membranes exhibit excellent separation performance and enhanced long-term molecule/ion separation through improved anti-swelling properties. Molecular dynamics simulations and life cycle analysis highlight the pore structure and environmental friendliness of the hydrogel membranes. These findings provide valuable insights for developing sustainable hydrogel membranes with stable performance and high separation efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Dongmei Liu, Aiying Guo, Yanling Qi, Zhixin Ji, Hongjuan Li, Zhiwei Zhang, Xinyue Zhang, Kunze Wu, Aijun Cai
Summary: In this study, a stable magnetic Mg/Mn-layered double oxide-doped biochar composite (MgMnLDO-MBC) was prepared and successfully used for the removal of antibiotics and bacteria from wastewater. The composite exhibited enhanced surface areas, adsorption sites, and free radicals, leading to improved catalytic activity. The effects of different factors on the removal efficiency were evaluated, and the composite showed good reusability.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Feng Wang, Zhaoyong Bian, Yaru Zhang, Wenchao Yu, Qiang Zhang, Hui Wang
Summary: In this study, a nanofibrous layered structure of Ff-Ti3C2Tx-Co3O4 was prepared by self-assembling nanofibrous Co3O4 with lamellar fluorine-free MXene (Ff-Ti3C2Tx). The Ff-Ti3C2Tx-Co3O4 exhibited excellent catalytic activity for degradation, resistant to ionic interference, and maintained high removal efficiency of sulfamethoxazole (SMX) in municipal wastewater. The rapid SMX degradation involved fast electron transfer in redox cycles with PMS and the generation of 1O2 via PMS ->center dot O2 -> 1O2. This work provides new insights into antibiotic degradation mechanisms and electron transfer based on PMS activation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Weipeng He, Jiacheng Luo, Yujie Wu, Tianhao Luo, Chen Tang
Summary: This study comparatively evaluated the role of cationic, anionic, and nonionic polyacrylamides (PAMs) in ballasted flocculation of clay suspensions under different aluminum sulfate (AS) coagulant dosages. The selection of PAMs and AS dosage had a significant influence on the size and shear resistance of ballasted floc aggregates.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Lixian Wang, Lizhi Zhao, Didi Si, Zhixin Li, Huiqin An, Hui Ye, Qingping Xin, Hong Li, Yuzhong Zhang
Summary: Metalloporphyrin-based nanozymes integrated with poly (vinylidene fluoride) membrane show high catalytic activity and reusability for the decolorization of Congo Red dye in continuous flow process.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Yongfei Ma, Chenyu Zeng, Yongzhen Ding, Jiayi Tang, Ondrej Masek, Zhikang Deng, Rui Mu, Zulin Zhang
Summary: In this study, sludge-derived biochar (SBC) was functionalized with various iron salts to enhance its adsorption ability for sulfamethoxazole (SMX) and magnetic collection performance. Ball milling was further employed to treat the optimal iron salt functionalized SBC (MSBC), resulting in ball milled SBC (BMSBC) with improved adsorption performance for SMX. The dominant driving mechanism for SMX adsorption onto BMSBC was confirmed to be multiple physicochemical forces, including 7C-7C conjugation, pore filling, H-bonding, Fe-O complexation, and electrostatic interactions. BMSBC exhibited favorable adsorption ability for SMX in actual waters and could be easily collected within 1 min due to its magnetic sensitivity.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Jinglin Tan, Xiaohui Mao, Wenjihao Hu, Hongbo Zeng
Summary: This study investigates the influence of PDMS chain architectures on surface properties and reveals that PDMS coatings with looped structures exhibit superior hydrophobicity, self-cleaning, and water sliding compared to coatings with linear structures. Additionally, both looped and linear PDMS coated stainless steel mesh/polyester fibers show efficient separation of oil/water mixture.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Wei-Liang Chen, Chih-Chia Cheng, Chien-Hsing Lu, Jem-Kun Chen
Summary: This study designs a novel sandwich-structured capacitor that reduces the absorption time of pollutants using dielectrophoresis force. By coating graphene oxide on polystyrene microspheres as adsorbents and encapsulating them within the capacitor, the adsorption rate is significantly enhanced. Additionally, frequency manipulation allows for the recycling of adsorbents and concentration of dyes, minimizing secondary pollution.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
