Article
Biochemistry & Molecular Biology
Stuart Farquharson, Chetan Shende, Jenelle Newcomb, Ismene L. Petrakis, Albert J. Arias
Summary: According to the Center for Disease Control, there were over 107,000 drug overdose deaths in the US in 2021, with opioids accounting for over 80,000 of them. Military veterans in the US are a vulnerable population, with nearly 250,000 suffering from substance-related disorders. Buprenorphine is prescribed to treat opioid use disorder, and current monitoring methods involve urinalysis. To address the issue of sample tampering, a prototype point-of-care analyzer has been developed to measure medications and detect illicit drugs in patient saliva.
Article
Chemistry, Analytical
Natalia E. Markina, Alexey V. Markin, Dana Cialla-May
Summary: This research focuses on the use of cyclodextrins (CDs) to improve the accuracy and sensitivity of determining fluoroquinolone antibiotics in human body fluids using surface-enhanced Raman spectroscopy (SERS). The study shows that CDs can be used to synthesize and stabilize silver nanoparticles to create a CD-SERS substrate, which enhances the interaction between analyte molecules and the substrate. The research also demonstrates that CD-SERS assay is effective for the analysis of fluoroquinolones in urine and blood plasma samples.
Article
Chemistry, Analytical
Libin Wan, Haidong Gao, Xiao Liu, Shucai Gao, Li Zhou, Fayun Wang, Mantang Chen
Summary: In this study, a simple, rapid, and sensitive method using electromembrane extraction combined with liquid chromatography-tandem mass spectrometry was developed for the determination of clenbuterol in swine urine. The proposed method showed great potential for monitoring the illegal use of clenbuterol in livestock.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yun-Chu Chen, Shang-Wen Hong, Huang-Hesin Wu, Yuh-Lin Wang, Yih-Fan Chen
Summary: A method based on SERS technology and sample pretreatment process enables rapid, sensitive, reproducible, multiplexed, and low-cost detection of illegal drugs in urine. By inducing AgNPs to form Ag nanoclusters with sodium bromide, the detection sensitivity of NPS is greatly improved, allowing for simultaneous detection of multiple drugs.
Article
Spectroscopy
Peng Wang, Jiansheng Chen, Xiaodong Wu, Yubing Tian, Rui Zhang, Jiaojiao Sun, Zhiqiang Zhang, Ce Wang, Pengli Bai, Liangsheng Guo, Jing Gao
Summary: A system using echelle Raman spectrometer combined with surface enhanced Raman spectroscopy (SERS) was proposed for accurate blood species identification of human and animals with high accuracy and reliability.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Dayu Hu, Xiaosong Xu, Zeyin Zhao, Changqi Li, Ye Tian, Qiang Liu, Bo Shao, Shuo Chen, Yue Zhao, Ling Li, Huan Bi, Ang Chen, Cheng Fu, Xiaoyu Cui, Yu Zeng
Summary: The study utilized SERS technology to detect metabolites in urine, reflecting the cancer status. Combining results from urine supernatant and sediment, SERS showed high diagnostic sensitivity and specificity for BCa.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Spectroscopy
Peng Wang, Jiansheng Chen, Xiaodong Wu, Yubing Tian, Rui Zhang, Jiaojiao Sun, Zhiqiang Zhang, Ce Wang, Pengli Bai, Liangsheng Guo, Jing Gao
Summary: This study proposed a system using echelle Raman spectrometer combined with surface enhanced Raman spectroscopy (SERS) for blood species identification, with an accuracy rate of over 94%. The technology combines the advantages of echelle Raman spectrometer and the spectral sensitivity of SERS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Lulu Xu, Ruimei Wu, Xiang Geng, Xiaoyu Zhu, Yao Xiong, Tao Chen, Shirong Ai
Summary: In this study, surface enhanced Raman spectroscopy (SERS) combined with a rapid pretreatment technique was used to determine sulfonamide antibiotics residue in swine urine. The results showed that the treatment with specific dosages of adsorbents (PSA, C-18, GCB) was an excellent approach for rapidly detecting the sulfonamide antibiotics residue. Qualitative and quantitative assessment of sulfadiazine and sulfathiazole was achieved by selecting specific Raman characteristic peaks. The study demonstrated the potential of SERS coupled with a quick, easy, cheap, effective, rugged, and safe (QuEChERS) method for monitoring the quality and safety of sulfonamide antibiotics residue in swine urine.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biophysics
Xinyu Liu, Xiaoming Su, Mingyang Chen, Yangcenzi Xie, Ming Li
Summary: Rapid early diagnosis of Alzheimer's disease is crucial, but challenging. In this study, a self-calibrating biosensor based on SERS-LFIA technique is developed for accurate AD diagnosis. It has high sensitivity, excellent anti-interference capability, lowcost and easy operation.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Multidisciplinary Sciences
Zhongli Huang, Shijian Feng, Qiunong Guan, Tao Lin, Jianhua Zhao, Christopher Y. C. Nguan, Haishan Zeng, David Harriman, Hong Li, Caigan Du
Summary: This study aimed to develop a non-invasive tool for monitoring kidney transplant function using SERS. Results showed significant correlations between urine SERS spectra and conventional chemical markers of kidney transplant function, indicating a strong predictive ability of this method. The urine SERS spectral analysis could be used as a convenient method for rapid assessment of kidney transplant function.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Yaping Tian, Xinming Nie, Xun Wang, Zhengyi Chen, Si Chen, Shasha Lv, Shoufeng Tang
Summary: This study successfully detected methanol in alcoholic beverages by coupling the catalytic strategy with a thermal purge separation and enrichment device. A higher sensitivity MBTH was selected for the derivatization operation in low-alcohol beverages, while acetylacetonate derivatization was used in high-alcohol beverages to avoid interference. This method is convenient and rapid.
SURFACE INNOVATIONS
(2022)
Article
Biochemistry & Molecular Biology
Eric Boateng Osei, Liliia Paniushkina, Konrad Wilhelm, Juergen Popp, Irina Nazarenko, Christoph Krafft
Summary: Extracellular vesicles (EVs) ranging in size from 60 to 800 nm were isolated from plasma of control and prostate cancer patients using differential centrifugation and ultrafiltration techniques. Spontaneous Raman and surface-enhanced Raman spectroscopy (SERS) were employed to identify fractions that best discriminate between control and cancer patients, with results showing that EV12 and EV120 fractions provide the most effective separation.
Article
Chemistry, Applied
Shizhuang Weng, Xujin Hu, Wenxiu Zhu, Pan Li, Shouguo Zheng, Ling Zheng, Linsheng Huang, Dongyan Zhang
Summary: The study developed a detection method for DON residues in wheat using SERS and deep learning network, achieving rapid and accurate detection of DON at different concentrations through liquid-liquid interface self-extraction and SERS signal enhancement by gold nanorods. The fully convolutional network showed optimal quantitative performance, making the detection of DON in FHB-infected wheat kernels simple, sensitive, and intelligent.
Article
Food Science & Technology
Zhiming Guo, Ping Chen, Limei Yin, Min Zuo, Quansheng Chen, Hesham R. El-Seedi, Xiaobo Zou
Summary: A rapid and sensitive SERS method for detecting Pb2+ in food was established by aptamer regulating gold nanoparticles reduction. The method achieved a detection limit of 0.1 μg L-1 and shows promising potential for Pb2+ detection in food.
Article
Spectroscopy
Qiaoling Yang, Xiaojun Deng, Bing Niu, Hong Lin, Jing Jing, Qin Chen
Summary: In this study, melamine was used as the research object, and the surface enhanced Raman spectrum of melamine in liquid milk was collected using a portable Raman spectrometer. Melamine was qualitatively identified and semi-quantitatively analyzed based on Raman characteristic peak and intensity, and a simple and efficient rapid screening method for limited contaminations was developed. The proposed method can meet the rapid screening requirements of limited contaminations at the maximum residue limit and has good application prospects.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Liming Yu, Jie Cheng, Haosen Yang, Jie Lv, Peilong Wang, Jian-Rong Li, Xiaoou Su
Summary: The chemically stable Zr(IV)-based metal-organic framework BUT-17 shows excellent adsorption capacity and fluorescent performance for bisphenol compounds. The hydrogen bond interaction between BPs and BUT-17 contributes to its outstanding adsorption performance. Moreover, a BUT-17-based fluorescent sensing method has been established for rapid determination of BPs in water medium with a low detection limit and wide linear range.
Article
Engineering, Environmental
Shujun Dong, Su Zhang, Yun Zou, Mengdie Fan, Yaxin Wang, Jie Cheng, Ruiguo Wang, Tong Li, Xiaomin Li, Peilong Wang
Summary: This study analyzed the concentrations of short-chain CPs (SCCPs) and medium-chain CPs (MCCPs) in farmed crab samples, food web samples, and aquaculture environments in crab farms in Anhui Province, Jiangxi Province, and Shanghai, China. The results showed that SCCPs concentrations in the crab samples were higher than MCCPs concentrations, and SCCPs contamination in the crab food web samples was not directly related to CPs product use. Crab feed and the aquaculture environment could be sources of SCCPs to farmed crabs. No significant health risks to humans were found through consuming CPs in Chinese mitten crabs farmed in China.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jie Cheng, Bin Wang, Jie Lv, Ruiguo Wang, Qiuling Du, Jinghao Liu, Liming Yu, Shujun Dong, Jian-Rong Li, Peilong Wang
Summary: BUT-16 demonstrates excellent adsorption capacity for DON, with the ability to effectively adsorb and remove DON in simulated gastric fluid but showing low desorption in simulated intestinal fluid. This suggests promising applications for BUT-16 in controlling DON in foods and feeds.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Yue Wang, Dinghui Xiong, Jin Wang, Jie Cheng, Jiaxuan Xiao, Salome Yakubu, Kun Wang, Jungang Lv, Zhen Zhang
Summary: A novel electrochemical DNA sensor using a triblock polyadenine probe was developed for ultrasensitive and rapid detection of Pb2+. By introducing non-electrode modification signal-recognition-amplification strategies and TPP, complex electrode modifications were eliminated, while high sensitivity was ensured through multiple amplification strategies.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Environmental Sciences
Yaxin Wang, Su Zhang, Mengdie Fan, Ruiguo Wang, Yun Zou, Peilong Wang, Jie Cheng, Shujun Dong
Summary: PCNs are highly toxic and bioaccumulative environmental contaminants that can be found in aquatic foodstuffs like the popular Chinese mitten crab. Farmed crabs can be exposed to PCNs through both feed and environment, with higher concentrations found in the crabs compared to feed and sediment samples. However, selective bioaccumulation and metabolism may play a role in PCN homologue profiles in farmed crabs, as indicated by the different distribution of PCNs in crabs, feed, and sediment samples. Regional differences were not observed in the PCN congener profiles between Anhui Province and Shanghai, and the study found no significant health risks associated with PCN exposure through consumption of farmed Chinese mitten crabs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Yaxin Wang, Su Zhang, Yujiao Wang, Xingyi Wu, Yun Zou, Wenfeng Zhou, Peilong Wang, Jie Cheng, Shujun Dong
Summary: This study determined the concentrations and distributions of PCNs in green tea samples from 11 regions in China and conducted a risk assessment of human exposure to PCNs through tea consumption. The results showed that PCNs in green tea from China pose little risk to humans, as the concentrations were relatively low.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Boen Li, Yaling Liu, Jie Cheng
Summary: Metal-organic frameworks (MOFs)-based core-shell composites have shown promise in surface-enhanced Raman scattering (SERS) analysis. However, controlling the nanoscale thickness of the MOF shell remains a challenge. In this study, we report a method to encapsulate gold nanoparticles (Au NP) with various thicknesses of a zirconium-based MOF (BUT-17) by adjusting synthesis parameters, providing a potential strategy to optimize the activity of core-shell SERS substrates.
Article
Environmental Sciences
Shujun Dong, Su Zhang, Tong Li, Yun Zou, Jie Cheng, Peilong Wang
Summary: Animal derived foods serve as the main route of human exposure to polychlorinated naphthalenes (PCNs), and it is important to understand how PCN emission sources affect surrounding animal farms. This study investigated PCN levels in various samples collected from dairy farms near an iron smelting plant in China, finding that milk samples had higher PCN concentrations compared to other specimens. The study suggests that consuming milk from this region may lead to relatively higher human exposure risk to PCNs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Analytical
Dinghui Xiong, Jie Cheng, Fengxiang Ai, Xinyu Wang, Jiaxuan Xiao, Fang Zhu, Kun Zeng, Kun Wang, Zhen Zhang
Summary: Adsorption of DNA probes onto nanomaterials has great potential for bioassay establishment. However, there is a lack of systematic understanding of the sensing behaviors based on nanomaterial-DNA interactions, limiting design and applications. In this study, metal-organic frameworks (MOFs) were used to investigate the issue. The results revealed the quenching of fluorescently labeled DNA adsorbed onto MOFs and provided insights into the interaction mechanisms.
ANALYTICAL CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Tong Li, Ruiguo Wang, Ruijie Yin, Hongyan Xu, Xiaoxu Han, Qiuling Du, Jie Cheng, Zhenyu Lin, Peilong Wang
Summary: A novel Zr(IV)-based metal-organic framework (MOF), named BUT-16, was synthesized and utilized for the extraction and enrichment of bisphenol compounds (BPs) in milk samples. The method showed a detection limit as low as 0.05 ng/mL and was successfully applied to the detection of BPs in real milk samples, yielding results consistent with previous methods.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Yanfen Hao, Chu Wang, Pu Wang, Jie Cheng, Hao Xian, Mei Liu, Zengwei Li, Jie Ma, Yingming Li, Ruiqiang Yang, Qinghua Zhang, Xiaoou Su, Guibin Jiang
Summary: Guideline levels of PCDD/Fs have been recommended for food safety control, but the transfer effect from feed to food and the resulting human exposure risk have been less considered. Controlled feeding experiments were conducted on dairy cows to evaluate the kinetics of PCDD/Fs. The results showed that even though the PCDD/F level in feed met the EU regulations, the TEQ levels in milk and tissues exceeded the EU maximum level after one-week exposure. The study revealed the necessity for re-evaluation of regulations on pollutants in cow feed and cow-origin food in terms of biotransfer and bioaccumulation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Jie Cheng, Bo-en Li, Jinghui He, Peilong Wang
Summary: The detection of trace polychlorinated dibenzo-p-dioxins (PCDDs) in milk samples using surface-enhanced Raman spectroscopy (SERS) with a bifunctional substrate consisting of Au nanoparticles embedded in a zirconium-based metal-organic framework shell (AuNP/Zr-MOF) is reported for the first time. The detection limit for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most toxic PCDD, is as low as 1.2 parts per trillion (ppt) in real milk samples with interfering substances, making it the lowest among all reported methods.
Article
Materials Science, Multidisciplinary
Lei Hu, Yi-Feng Sun, Jie Cheng, Xi Qin, Xin-Yi Yang, Song Wu, Ru-Fei Tang, Zhi Long, Ming-Xia Tang, Zheng-Quan Hu, Xing Zou, An-Rong Wang, Shi-Fa Wang, Yong Wei, Li-Li Liu, Xiao-Zhi Wu
Summary: This study investigates the possible applications of single-layer GaInO3 in optoelectronics and piezoelectricity through first-principles study. The findings show that single-layer GaInO3 exhibits a large vertical dipole moment, a direct bandgap, and high transport mobility for both electrons and holes. The strong inside electric field and spatially isolated conduction and valence bands confirm the effective separation of charge carriers. Single-layer GaInO3 is a promising candidate for optical absorbers and detectors, and it possesses a significantly stronger out-of-plane piezoelectric effect compared to previous 2D materials, making it important for modern top-bottom gate technologies.
RESULTS IN PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Jie Cheng, Yaling Liu, Peilong Wang, Zhiyong Tang
Summary: This study presents a hot zone empowered analysis strategy for surface-enhanced Raman spectroscopy (SERS) detection using metal-organic frameworks (MOFs)-based core-shell hybrid substrates. The excellent SERS performance of the prepared Au@HOF is attributed to the effective delivery of the analyte to the hot zone and its subsequent enhancement. The proposed Au@HOF film also demonstrates reliability in detecting pesticide residues in a real system.
ACS MATERIALS LETTERS
(2023)
Article
Food Science & Technology
Xianhong Jiang, Jie Cheng, Qiuling Du, Peilong Wang
Summary: An efficient adsorbent composed of magnetic Fe3O4 particles and Al-based metal-organic framework (BUT-18) was prepared for magnetic dispersive solid-phase extraction (MDSPE) of four aflatoxins in edible vegetable oils. The method showed good limits of detections and quantifications, as well as satisfactory linearity and recoveries.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
