Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2)

Pharmacologic Treatment of Type 2 Diabetes

(2015) Linda Tran et al.   ANNALS OF PHARMACOTHERAPY

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

(2015) Rebecca J. Ford et al.   BIOCHEMICAL JOURNAL

Coactivator SRC-2–dependent metabolic reprogramming mediates prostate cancer survival and metastasis

(2015) Subhamoy Dasgupta et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Steroid receptor coactivators: servants and masters for control of systems metabolism

(2014) Erin Stashi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SRC-2 Is an Essential Coactivator for Orchestrating Metabolism and Circadian Rhythm

(2014) Erin Stashi et al.   Cell Reports

Metformin Use and All-Cause and Prostate Cancer–Specific Mortality Among Men With Diabetes

(2013) David Margel et al.   JOURNAL OF CLINICAL ONCOLOGY

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

Downregulation of Steroid Receptor Coactivator-2 Modulates Estrogen-Responsive Genes and Stimulates Proliferation of MCF-7 Breast Cancer Cells

(2013) Ingvild S. Fenne et al.   PLoS One

Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2

(2013) Jifeng Zhang et al.   Scientific Reports

Distinct perturbation of the translatome by the antidiabetic drug metformin

(2012) O. Larsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Energy Depletion Resets Whole-Body Energy by Promoting Coactivator-Mediated Dietary Fuel Absorption

(2011) Atul R. Chopra et al.   Cell Metabolism

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Control of nuclear receptor activities in metabolism by post-translational modifications

(2011) Wahiba Berrabah et al.   FEBS LETTERS

Early Growth Response 1 (Egr1) Regulates Cholesterol Biosynthetic Gene Expression

(2011) Nolan G. Gokey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steroid receptor coactivators 1, 2, and 3: Critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy

(2011) Amber B. Johnson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia

(2010) P. Matafome et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Steroid Receptor Coactivator (SRC) Family: Masters of Systems Biology

(2010) Brian York et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

(2008) A. Nar et al.   ACTA DIABETOLOGICA

Recruitment of Coactivator Glucocorticoid Receptor Interacting Protein 1 to an Estrogen Receptor Transcription Complex Is Regulated by the 3′,5′-Cyclic Adenosine 5′-Monophosphate-Dependent Protein Kinase

(2008) Ingvild S. Fenne et al.   ENDOCRINOLOGY

Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease

(2008) A. R. Chopra et al.   SCIENCE