Article
Chemistry, Analytical
Jiandong Liu, Bin Liu, Juan Liu, Xing-Dao He, Jinhui Yuan, Zabih Ghassemlooy, Hamdi Torun, Yong-Qing Fu, Xuewu Dai, Wai Pang Ng, Richard Binns, Qiang Wu
Summary: A high quality factor (Q-factor) optical fiber interferometer based biosensing platform, combining single mode-core-only-single mode fiber (SCS) and multimode interference effect, is developed for ultra-high sensitivity biosensing. This biosensor is capable of effectively detecting concentrations of Staphylococcus aureus from 10 to 105 CFU/mL, with good sensitivity, stability, reproducibility and specificity, showing great potentials in diagnostics.
Review
Chemistry, Analytical
Baocheng Li, Ruochong Zhang, Renzhe Bi, Malini Olivo
Summary: Biosensing and bioimaging play a crucial role in understanding biological and pathological processes, and optical fiber has emerged as a promising technology in these fields. This review provides an overview of seven common types of optical fiber biosensors and optical fiber-based ultrasound detection in photoacoustic imaging (PAI), discussing their applications and potential in biosensing and bioimaging. Furthermore, the challenges and future directions in this area are briefly discussed.
Article
Chemistry, Analytical
Minglu Yan, Ruiduo Wang, Qiang Wang, Yansong Li, Beibei Liu, Yangyang Li, Man Jiang
Summary: This article presents a label-free, selective, and rapid optical fiber interferometer biosensor for detecting protamine. The thickness of the coating layer is found to be a key factor in the sensor's performance. The proposed biosensor exhibits high sensitivity and stability, making it suitable for protamine detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Optics
Wei Cheng, Shuhui Liu, Shengguo Zhao, Litong LI
Summary: An optofluidic sensor based on a Bragg grating in hollow core fiber (HCF) is demonstrated. The grating is inscribed into the HCF using femtosecond laser illumination, causing cladding mode resonance. The refractive index sensing of high index liquid and temperature sensitivity are achieved with this device.
Article
Multidisciplinary Sciences
Ming Jin, Shui-Jing Tang, Jin-Hui Chen, Xiao-Chong Yu, Haowen Shu, Yuansheng Tao, Antony K. Chen, Qihuang Gong, Xingjun Wang, Yun-Feng Xiao
Summary: Optical evanescent sensors have proposed a 1/f-noise-free optical sensor through an up-converted detection system, achieving a significant suppression of sampling noise amplitude in a CMOS-compatible heterodyne interferometer. This advancement allows for label-free single-nanoparticle detection down to the attogram level, showing great potential for airborne biosensing and rapid sensing of diverse viruses or molecules.
NATURE COMMUNICATIONS
(2021)
Article
Optics
Yingxuan Liu, Ya-nan Zhang, Bo Han, Jincheng Zhao, Xuegang Li, Yong Zhao
Summary: This study proposes a gourd-type hollow-core fiber based Mach-Zehnder interferometer (MZI) and investigates its sensing properties. The MZI splices both ends of a section of HCF with single-mode fibers and forms a gourd-shaped structure. The MZI exhibits high refractive index sensitivity and low cross-sensitivity to temperature, making it suitable for biochemical sensing and physical sensing.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Chemistry, Analytical
Flavio Esposito, Lucia Sansone, Anubhav Srivastava, Angela Maria Cusano, Stefania Campopiano, Michele Giordano, Agostino Iadicicco
Summary: This study presents a fiber optic biosensor for label-free detection of vitamin D3, showing good sensitivity and stability in both laboratory and complex media.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Abdullah Al Noman, Jitendra Narayan Dash, Md Abdullah Al Maruf, Cheng Xin, Hwa-Yam Tam, Changyuan Yu
Summary: A label-free-based fiber optic biosensor based on etched tilted Bragg fiber grating (TFBG) is proposed and practically demonstrated. The hybridization of probe DNA with the complementary DNA (cDNA) has been monitored using wavelength-dependent interrogation. The reproducibility of the probes has been demonstrated and the response towards non-cDNA has also been investigated to establish its specificity.
Article
Biophysics
Yangxi Zhang, Hao Wu, Han Wang, Bohan Yin, Siu Hong Dexter Wong, A. Ping Zhang, Hwa-Yaw Tam
Summary: This study presents an ultraminiature biosensor based on nanoparticles and optical fibers, capable of detecting antibodies and testing SARS-CoV-2 mimetic DNA. The biosensor offers a cost-effective solution for various applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Electrical & Electronic
Brayan Patino-Jurado, Yamile Cardona-Maya, Marisol Jaramillo-Grajales, Y. J. Montagut-Ferizzola, Juan F. Botero-Cadavid
Summary: A novel, compact and highly sensitive BSA-anti-BSA biosensor based on an etched single-mode-multimode-single-mode optical fiber structure was developed. This biosensor showed high selectivity in detecting anti-BSA, with the ability to detect biological interactions up to 100 ng/mL and a sensitivity of 2.3 nm/(mu g/ml). It has potential applications in disease detection, medical diagnosis, and food safety inspection.
OPTICAL FIBER TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Mohammadreza Salehi Moghaddam, Hamid Latifi, Elham Abedini, Mohsen Ghazanfar, Ebrahim Behroodi, Mojde Salmani Sadeghi
Summary: The optical pH sensor based on smart hydrogel material was designed for microfluidic applications. The sensor made use of chitosan-TEOS interpenetrating network as a pH-sensitive component. By bonding the chitosan-TEOS-PDMS layer to a thin layer of PDMS, the sensor can be easily integrated into microfluidic chips. The thickness of the PDMS layer can be adjusted to control the sensitivity of the sensor. The sensor's response to pH changes was measured using the optical astigmatism method, and the experimental results showed its stability and sensitivity.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Dejun Liu, Wei Li, Qiang Wu, Haoyu Zhao, Fengzi Ling, Ke Tian, Changyu Shen, Wei Han, Fangfang Wei, Gerald Farrell, Yuliya Semenova, Pengfei Wang
Summary: In this paper, a microsized fiber sensor structure is proposed for sub-micrometer scale liquid level measurement in microfluidics, achieving high sensitivity, good repeatability of measurement, and low cross sensitivity to changes in the surrounding refractive index.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Biochemistry & Molecular Biology
Georgii Konoplev, Darina Agafonova, Liubov Bakhchova, Nikolay Mukhin, Marharyta Kurachkina, Marc-Peter Schmidt, Nikolay Verlov, Alexander Sidorov, Aleksandr Oseev, Oksana Stepanova, Andrey Kozyrev, Alexander Dmitriev, Soeren Hirsch
Summary: Proteins in biological fluids are important biomarkers for various pathological conditions. Portable diagnostic biosensor devices based on microfluidic technology are being used as an alternative to conventional laboratory protein assays. This review focuses on label-free techniques for protein detection and characterization in microfluidic structures, including optical and impedance spectroscopy techniques. The challenges of materials selection, surface tailoring, and sensitivity enhancement in biosensor systems are discussed.
Article
Engineering, Electrical & Electronic
Yu Wang, Jihong Tao, Weihao Yuan, Zhenggang Lian, Qiang Ling, Daru Chen, Zhangwei Yu, Chao Lu
Summary: In this study, a novel optical fiber sensor for simultaneous measurement of high temperature and gas pressure was proposed and experimentally demonstrated using a Regenerated Fiber Bragg grating (RFBG) cascaded with a homemade hollow core Bragg fiber (HCBF). The sensor exhibited high linear pressure and temperature sensitivity in a large dynamic range, and a 2x2 matrix obtained from experimental results enabled simultaneous measurement of temperature and gas pressure. Compact size, low cost, and high sensitivity make this sensor competitive for harsh environment applications.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Yuyuan Xie, Maoning Wang, Yuzhong Zhong, Lin Deng, Jianwei Zhang
Summary: Deep learning anomaly detection is crucial in distributed optical fiber acoustic sensing (DAS). To overcome the challenges posed by scarcity of true-positive data and imbalance and irregularity within datasets, an unsupervised deep learning method is proposed, which learns only the normal data features to detect anomalies.
Article
Engineering, Electrical & Electronic
Peixuan Tian, Chunying Guan, Peng Ye, Tailei Cheng, Jing Yang, Zheng Zhu, Jinhui Shi, Jun Yang, Libo Yuan
Summary: A novel magnetic field sensor based on hollow suspended-core fiber (HSCF) has been proposed and fabricated. The sensor achieves high sensitivity by filling magnetic fluid into the microfluidic channel of the fiber and utilizing interference principle. With the advantages of robustness, high sensitivity, simple interference spectrum, and integrated microfluidic channel, the sensor has promising applications in various fields.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Haoliang Zhang, Yonggui Yuan, Yunlong Zhu, Fanyang Dang, Zhangjun Yu, Jun Yang, Yuncai Wang, Yuwen Qin
Summary: This paper proposes a new testing method for Sagnac optical closed loops, which splits the closed loop into semi-closed loop and full-closed loop structures, enabling accurate measurement of the distributed polarization characteristics of the optical devices and connection points. The testing results are highly consistent with single device testing and demonstrate good stability.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Shuxian Chen, Liang Zeng, Jiaqi Li, Jun Weng, Junyi Li, Zicong Guo, Pengbai Xu, Wenjie Liu, Jun Yang, Yuwen Qin, Kunhua Wen
Summary: The paper proposes a graphene-based metamaterial structure that generates the plasmon-induced transparency (PIT) effect. The physical properties and performance of the structure in an optical switch are analyzed, and the results demonstrate high modulation depth, polarization extinction ratio, and the potential for achieving dual and triple PIT effects.
RESULTS IN PHYSICS
(2022)
Article
Engineering, Electrical & Electronic
Cuofu Lin, Jun Yang, Zhangjun Yu, Chen Zou, Tieliang Mou, Yunlong Zhu, Fanyang Dang, Yonggui Yuan, Yuncai Wang, Yuwen Qin
Summary: In this study, we propose a new method to correct parasitic amplitude modulation and improve the spurious-free dynamic range in frequency sweeping interferometry. The method utilizes a Hilbert transform to obtain an amplitude fluctuation curve from an auxiliary interferometer, which is then used to detrend the parasitic amplitude modulation in the main interferometric signal. Experimental results demonstrate the effectiveness of the method and its optimal matching conditions.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Yibo Zhang, Wei Jin, Yu Zhang, Zhihai Liu, Yonggui Yuan, Zhangjun Yu, Jun Yang, Yuncai Wang, Yuwen Qin
Summary: This paper proposes a fast phase regulation method for the hybrid PDH multiplexing scheme based on space division multiplexing and time division multiplexing. The method allows for the reconstruction of the error signal points required for closed-loop control within a time period of less than 20 us using a phase rotation algorithm. The paper also presents the relationship between the multiplexing scale and parameters selection, showing that the system can achieve a larger multiplexing scale with appropriate parameters selection. A multi-channel strain array with a resolution better than 10 pe/root Hz@1 Hz over a 50 Hz band per channel has been realized, demonstrating its potential usage in the field of large-scale quasi-static strain measurement and earthquake observation.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Optics
Tingyi Zhu, Cuofu Lin, Jun Yang, Zhangjun Yu, Pengbai Xu, Kunhua Wen, Yuncai Wang, Yuwen Qin
Summary: In this paper, a spectral splicing method (SSM) for distributed strain sensing based on optical frequency domain reflectometry (OFDR) is proposed and demonstrated, achieving km level measurement length, RE level measurement sensitivity, and 104 RE level measurement range. The SSM replaces the centralized data processing method with a segmented processing method based on cross-correlation demodulation, achieving precise splicing of the spectrum corresponding to each signal segment by spatial position correction, thus enabling strain demodulation. The segmentation effectively suppresses phase noise and expands the sweep range, while spatial position correction rectifies the position error and extends the strain range.
Article
Optics
Qinqin Zhuang, Yicheng Lin, Cuofu Lin, Zhangjun Yu, Yonggui Yuan, Jun Yang, Kunhua Wen, Pengbai Xu, Yuncai Wang, Yuwen Qin
Summary: Optical frequency domain polarimetry (OFDP) is an emerging method for rapidly measuring distributed polarization crosstalk with a wide dynamic range. This Letter presents a solution to the trade-off between measurement length and dynamic range using a self-referenced unbalanced Mach-Zehnder interferometer. Experimental results demonstrate the method's ability to evaluate long polarization-maintaining fiber in rapidly changing environments, with a long distance capability (9.8 km), ultrawide dynamic range (107.8 dB), short measurement time (2 sec), and improved signal-to-noise ratio against ambient noise.
Article
Optics
Jilong Li, Yue Wang, Songnian Fu, Xiangzhi Xie, Meng Xiang, Feifei Yin, Yitang Dai, Jun Yang, Yuwen Qin
Summary: This study demonstrates a low-latency microwave photonic real-time Fourier transformation (RTFT) processing technique based on bandwidth slicing and equivalent dispersion. It achieves wide bandwidth spectrum analysis, high frequency resolution, high acquisition frame rate, and total latency of less than 200 ns.
Article
Optics
Mingyang Huang, Zhangjun Yu, Peijiong Li, Jun Yang, Kunhua Wen, Pengbai Xu, Yuncai Wang, Yuwen Qin
Summary: This paper presents an optical vector analyzer (OVA) based on orthogonal polarization interrogation and polarization diversity detection, which is used to measure the loss, delay, or polarization-dependent features of optical devices. Bayesian optimization is proposed as an online polarization error suppression method to improve the measurement reliability and efficiency. The OVA with online error suppression will be widely used in the production of optical devices, not just in the laboratory.
Review
Chemistry, Analytical
Junzhe Yu, Pengbai Xu, Zhangjun Yu, Kunhua Wen, Jun Yang, Yuncai Wang, Yuwen Qin
Summary: This paper reviews the principles and applications of four optical seismic sensors in submarine seismology over submarine optical cables. The advantages, disadvantages, and current technical requirements are discussed. This review can serve as a reference for studying submarine cable-based seismic monitoring.
Review
Optics
Leiming Wu, Xixi Yuan, Yuxuan Tang, S. Wageh, Omar A. A. Al-Hartomy, Abdullah G. G. Al-Sehemi, Jun Yang, Yuanjiang Xiang, Han Zhang, Yuwen Qin
Summary: Sensing devices play a crucial role in various fields and their increasing demand has led to the development of sensing materials and methods. Tin+1CnTx MXenes have emerged as ideal candidates for sensing materials due to their exceptional properties. In this review, the application of Tin+1CnTx in different sensor categories is systematically summarized, and their potential in emerging intelligent and bionic devices is discussed. The future challenges and perspectives of MXene-based sensors are also presented, highlighting their potential in driving the development of new technologies.
Article
Engineering, Electrical & Electronic
Jun Yang, Chen Zou, Cuofu Lin, Yunlong Zhu, Yao Zhu, Fanyang Dang, Yonggui Yuan, Zhangjun Yu, Yuncai Wang, Yuwen Qin
Summary: The impact of noise on the point spread function in optical fiber frequency sweeping interferometry (OFFSI) systems is significant. This paper reviews the development of noise compensation methods and provides a reference for selecting appropriate compensation methods in different applications. Discussions are made on the noise impacts, including laser source phase noise, laser source intensity noise, and ambient noise. The most serious noise is the laser source phase noise, and comprehensive classification and analysis of compensation strategies are provided. Future trends and developments are also discussed.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Xiang Zhang, Jun Yang, Yanyu Qian, Zhuo Zhang, Xiaozhang Wang, Yaohui Xue, Yonggui Yuan, Yuncai Wang, Yuwen Qin
Summary: This paper proposes a distributed stress analysis method for fiber winding structures. Compared with the traditional single-layer method, the stress of each turn in the fiber stacking state is quantitatively calculated, including the inclination angle, endplate, and layer transition. BOTDA tested the internal stress at high spatial resolution, which is consistent with the distributed method. The results proved the attenuation of internal stress under fiber stacking state in different winding parameters. For the first time, quantitative analysis of the stress increase characteristics of layer transition has been realized. Lastly, the discussion of rewinding, tension dropout, and extrusion defects provides a non-destructive and rapid method for defect recognition and winding quality improvement.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Pengbai Xu, Yihao Peng, Kunhua Wen, Yuehui Sun, Xinyong Dong, Jun Yang, Yuwen Qin
Summary: This paper proposes a novel bending-loss-resistant distributed temperature and strain discriminative sensor that is based on a 98 mol% germania-doped few-mode fiber and a standard Brillouin optical time-domain analysis setup. In a proof-of-concept demonstration, distributed temperature and strain discriminative measurements were conducted under a bending radius of 0.6 cm, where the maximum temperature and strain deviation were 2.78 degrees C and 33.2 mu epsilon, respectively.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Qinqin Zhuang, Cuofu Lin, Zhangjun Yu, Kunhua Wen, Pengbai Xu, Jun Yang, Yuncai Wang, Yuwen Qin
Summary: A high-precision measurement of distributed polarization crosstalk (DPC) is necessary for developing devices with ultrahigh polarization extinction ratios. Optical frequency domain polarimetry (OFDP) is a novel method with a potential ultra-wide dynamic range for DPC measurement. This research solved the phase error problem induced by the laser frequency sweep nonlinearity to improve the measurement precision of weak polarization crosstalk and enhanced the dynamic range.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)